BR0015051A - Compostos inibidores tricìclicos de poli(adp-ribose) polimerase, seu sal farmaceuticamente aceitável, pró-droga, metabólito ativo, ou solvato, composição farmacêutica, método de inibição da atividade de parp de uma enzima e método de inibição da atividade de enzima parp em tecido de mamìfero - Google Patents

Compostos inibidores tricìclicos de poli(adp-ribose) polimerase, seu sal farmaceuticamente aceitável, pró-droga, metabólito ativo, ou solvato, composição farmacêutica, método de inibição da atividade de parp de uma enzima e método de inibição da atividade de enzima parp em tecido de mamìfero

Info

Publication number
BR0015051A
BR0015051A BR0015051-7A BR0015051A BR0015051A BR 0015051 A BR0015051 A BR 0015051A BR 0015051 A BR0015051 A BR 0015051A BR 0015051 A BR0015051 A BR 0015051A
Authority
BR
Brazil
Prior art keywords
inhibiting parp
enzyme
activity
adp
poly
Prior art date
Application number
BR0015051-7A
Other languages
English (en)
Inventor
Stephen Evan Webber
Donald James Skalitzky
Jayashree Girish Tikhe
Robert Arnold Kumpf
Joseph Timothy Marakovits
Walter Brian Eastman
Original Assignee
Agouron Pharma
Cancer Res Campaign Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma, Cancer Res Campaign Tech filed Critical Agouron Pharma
Publication of BR0015051A publication Critical patent/BR0015051A/pt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06Peri-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"COMPOSTOS INIBIDORES TRICìCLICOS DE POLI(ADP-RIBOSE) POLIMERASE, SEU SAL FARMACEUTICAMENTE ACEITáVEL, PRóDROGA, METABóLITO ATIVO, OU SOLVATO, COMPOSIçãO FARMACêUTICA, MéTODO DE INIBIçãO DA ATIVIDADE DE PARA DE UMA ENZIMA E MéTODO DE INIBIçãO DA ATIVIDADE DE ENZIMA PARA EM TECIDO DE MAMìFERO". Os compostos da fórmula ( I ) são inibidores da poli(ADP-ribosil)transferase. Esses compostos são úteis como agentes terapêuticos no tratamento de cânceres e no alívio dos efeitos de derrame cerebral, trauma na cabeça e doença neurodegenerativa.
BR0015051-7A 1999-08-31 2000-08-31 Compostos inibidores tricìclicos de poli(adp-ribose) polimerase, seu sal farmaceuticamente aceitável, pró-droga, metabólito ativo, ou solvato, composição farmacêutica, método de inibição da atividade de parp de uma enzima e método de inibição da atividade de enzima parp em tecido de mamìfero BR0015051A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15214299P 1999-08-31 1999-08-31
PCT/US2000/023882 WO2001016136A2 (en) 1999-08-31 2000-08-31 Tricyclic inhibitors of poly(adp-ribose) polymerases

Publications (1)

Publication Number Publication Date
BR0015051A true BR0015051A (pt) 2002-06-25

Family

ID=22541675

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0015051-7A BR0015051A (pt) 1999-08-31 2000-08-31 Compostos inibidores tricìclicos de poli(adp-ribose) polimerase, seu sal farmaceuticamente aceitável, pró-droga, metabólito ativo, ou solvato, composição farmacêutica, método de inibição da atividade de parp de uma enzima e método de inibição da atividade de enzima parp em tecido de mamìfero

Country Status (48)

Country Link
US (1) US6548494B1 (pt)
EP (1) EP1208104B1 (pt)
JP (1) JP4272375B2 (pt)
KR (1) KR20020038742A (pt)
CN (1) CN1384835A (pt)
AP (1) AP1553A (pt)
AR (1) AR035162A1 (pt)
AT (1) ATE287406T1 (pt)
AU (1) AU781826B2 (pt)
BG (1) BG106562A (pt)
BR (1) BR0015051A (pt)
CA (1) CA2382404C (pt)
CO (1) CO5200769A1 (pt)
CR (1) CR6577A (pt)
CZ (1) CZ2002613A3 (pt)
DE (1) DE60017575T2 (pt)
DK (1) DK1208104T3 (pt)
DO (1) DOP2000000069A (pt)
DZ (1) DZ3216A1 (pt)
EA (1) EA200200306A1 (pt)
EC (1) ECSP003637A (pt)
EE (1) EE200200100A (pt)
ES (1) ES2234657T3 (pt)
GE (1) GEP20043268B (pt)
GT (1) GT200000145A (pt)
HK (1) HK1045509B (pt)
HR (1) HRP20020271A2 (pt)
HU (1) HUP0202703A3 (pt)
IL (1) IL147863A0 (pt)
IS (1) IS6289A (pt)
MA (1) MA25876A1 (pt)
MX (1) MXPA02002138A (pt)
MY (1) MY135910A (pt)
NO (1) NO322475B1 (pt)
NZ (1) NZ516793A (pt)
OA (1) OA12016A (pt)
PA (1) PA8501801A1 (pt)
PE (1) PE20010538A1 (pt)
PL (1) PL354242A1 (pt)
PT (1) PT1208104E (pt)
SI (1) SI1208104T1 (pt)
SK (1) SK2592002A3 (pt)
SV (1) SV2003000162A (pt)
UA (1) UA73144C2 (pt)
UY (1) UY26323A1 (pt)
WO (1) WO2001016136A2 (pt)
YU (1) YU15102A (pt)
ZA (1) ZA200200830B (pt)

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