BRPI0412899A - composto para inibir a atividade de parp, usos de uma quantidade terapêutica e uma quantidade terapeuticamente efetiva de um composto e de seus sais farmaceuticamente aceitáveis, uso de um composto, composição farmacêutica, e, método para o tratamento de cáncer em mamìferos - Google Patents
composto para inibir a atividade de parp, usos de uma quantidade terapêutica e uma quantidade terapeuticamente efetiva de um composto e de seus sais farmaceuticamente aceitáveis, uso de um composto, composição farmacêutica, e, método para o tratamento de cáncer em mamìferosInfo
- Publication number
- BRPI0412899A BRPI0412899A BRPI0412899-0A BRPI0412899A BRPI0412899A BR PI0412899 A BRPI0412899 A BR PI0412899A BR PI0412899 A BRPI0412899 A BR PI0412899A BR PI0412899 A BRPI0412899 A BR PI0412899A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- pharmaceutically acceptable
- pharmaceutical composition
- therapeutically effective
- acceptable salts
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 7
- 230000000694 effects Effects 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 101100462870 Drosophila melanogaster Parp gene Proteins 0.000 title 1
- 241000124008 Mammalia Species 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 101710179684 Poly [ADP-ribose] polymerase Proteins 0.000 abstract 2
- 102100023712 Poly [ADP-ribose] polymerase 1 Human genes 0.000 abstract 2
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 abstract 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/02—Pentosyltransferases (2.4.2)
- C12Y204/0203—NAD+ ADP-ribosyltransferase (2.4.2.30), i.e. tankyrase or poly(ADP-ribose) polymerase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Abstract
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0317466.1A GB0317466D0 (en) | 2003-07-25 | 2003-07-25 | Use |
GB0317466.1 | 2003-07-25 | ||
GB0408524.7 | 2004-04-16 | ||
GB0408524A GB0408524D0 (en) | 2004-04-16 | 2004-04-16 | Use |
PCT/GB2004/003183 WO2005012305A2 (en) | 2003-07-25 | 2004-07-23 | Tricyclic parp inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI0412899A true BRPI0412899A (pt) | 2006-10-03 |
BRPI0412899B1 BRPI0412899B1 (pt) | 2021-10-05 |
Family
ID=34117642
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0412899-0A BRPI0412899B1 (pt) | 2003-07-25 | 2004-07-23 | Uso de um composto ou um sal farmaceuticamente aceitável do mesmo para a manufatura de um medicamento citotóxico para o tratamento de câncer de ovário, câncer de mama, câncer de próstata ou câncer pancreático |
Country Status (23)
Country | Link |
---|---|
US (2) | US7531530B2 (pt) |
EP (1) | EP1660095B1 (pt) |
JP (2) | JP5466814B2 (pt) |
KR (1) | KR101138471B1 (pt) |
AT (1) | ATE454893T1 (pt) |
AU (1) | AU2004261462B2 (pt) |
BR (1) | BRPI0412899B1 (pt) |
CA (1) | CA2533332C (pt) |
CY (1) | CY1110335T1 (pt) |
DE (1) | DE602004025123D1 (pt) |
DK (1) | DK1660095T3 (pt) |
ES (1) | ES2339663T3 (pt) |
HK (1) | HK1084602A1 (pt) |
IL (1) | IL173336A (pt) |
MX (1) | MXPA06000993A (pt) |
NO (1) | NO334610B1 (pt) |
NZ (1) | NZ544989A (pt) |
PL (1) | PL1660095T3 (pt) |
PT (1) | PT1660095E (pt) |
RU (1) | RU2404183C2 (pt) |
SI (1) | SI1660095T1 (pt) |
WO (1) | WO2005012305A2 (pt) |
ZA (1) | ZA200600679B (pt) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
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KR20030020488A (ko) * | 2001-08-29 | 2003-03-10 | 강정훈 | 대나무 추출물을 유효성분으로 하는 화상치료용 조성물 |
JP2006522088A (ja) * | 2003-03-31 | 2006-09-28 | ファイザー・インク | ポリ(adp−リボース)ポリメラーゼの三環系阻害剤の塩 |
US7531530B2 (en) | 2003-07-25 | 2009-05-12 | Cancer Research Technology Limited | Therapeutic compounds |
GB0317466D0 (en) * | 2003-07-25 | 2003-08-27 | Univ Sheffield | Use |
DK1684736T3 (da) * | 2003-12-01 | 2011-11-21 | Kudos Pharm Ltd | Inhibitorer af DNA-skadereparation til behandling af cancer |
JP2008513436A (ja) * | 2004-09-22 | 2008-05-01 | ファイザー・インク | 8−フルオロ−2−{4−[(メチルアミノ)メチル]フェニル}−1,3,4,5−テトラヒドロ−6h−アゼピノ[5,4,3−cd]インドール−6−オンのリン酸塩の多形性及び非晶質形態 |
KR20090130156A (ko) * | 2004-09-22 | 2009-12-17 | 화이자 인코포레이티드 | 폴리(에이디피-리보오스) 폴리머라제 저해제를 포함하는 치료 배합물 |
US7820668B2 (en) | 2005-01-19 | 2010-10-26 | Eisai Inc. | Diazabenzo[de]anthracen-3-one compounds and methods for inhibiting PARP |
NZ565654A (en) * | 2005-07-18 | 2010-10-29 | Bipar Sciences Inc | Use of iodonitrobenzamide compounds for the treatment of ovarian cancer |
US20100279327A1 (en) * | 2006-06-12 | 2010-11-04 | Bipar Sciences, Inc. | Method of treating diseases with parp inhibitors |
CN102379884A (zh) | 2006-09-05 | 2012-03-21 | 彼帕科学公司 | Parp抑制剂对脂肪酸合成的抑制及其治疗方法 |
CN101522609A (zh) | 2006-09-05 | 2009-09-02 | 彼帕科学公司 | 癌症的治疗 |
RU2485122C2 (ru) | 2007-10-03 | 2013-06-20 | Эйсэй Инк. | Соединения и композиции, ингибирующие parp, и способы их применения |
CA2705417A1 (en) * | 2007-11-12 | 2009-05-22 | Bipar Sciences, Inc. | Treatment of uterine cancer and ovarian cancer with a parp inhibitor alone or in combination with anti-tumor agents |
KR20100102609A (ko) | 2007-11-12 | 2010-09-24 | 바이파 사이언스 인코포레이티드 | Parp 억제제를 단독으로 사용하거나 항종양제와 병용하여 유방암을 치료하는 방법 |
WO2009100159A2 (en) * | 2008-02-04 | 2009-08-13 | Bipar Sciences, Inc. | Methods of diagnosing and treating parp-mediated diseases |
GB0804755D0 (en) | 2008-03-14 | 2008-04-16 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
WO2011058367A2 (en) | 2009-11-13 | 2011-05-19 | Astrazeneca Ab | Diagnostic test for predicting responsiveness to treatment with poly(adp-ribose) polymerase (parp) inhibitor |
KR20120127495A (ko) | 2010-02-12 | 2012-11-21 | 화이자 인코포레이티드 | 8-플루오로-2-{4-[(메틸아미노)메틸]페닐}-1,3,4,5-테트라하이드로-6h-아제피노[5,4,3-cd]인돌-6-온의 염 및 다형체 |
DK2582847T3 (en) | 2010-06-18 | 2016-12-19 | Myriad Genetics Inc | METHODS AND MATERIALS TO ASSESS loss of heterozygosity |
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PL3325623T6 (pl) | 2015-07-23 | 2022-05-30 | Institut Curie | Zastosowanie skojarzenia cząsteczki dbait i inhibitorów parp do leczenia nowotworu |
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EP4141127A1 (en) | 2021-08-30 | 2023-03-01 | Zentrum Familiärer Brust- und Eierstockkrebs Universitätsklinik Köln | Method for assessing homologous recombination deficiency in ovarian cancer cells |
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Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1140936T3 (da) * | 1999-01-11 | 2004-06-21 | Cancer Rec Tech Ltd | Tricykliske inhibitorer af poly(ADP-ribose)polymerase |
ECSP003637A (es) * | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
US7449464B2 (en) | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
JP2006522088A (ja) * | 2003-03-31 | 2006-09-28 | ファイザー・インク | ポリ(adp−リボース)ポリメラーゼの三環系阻害剤の塩 |
US7531530B2 (en) | 2003-07-25 | 2009-05-12 | Cancer Research Technology Limited | Therapeutic compounds |
GB0317466D0 (en) | 2003-07-25 | 2003-08-27 | Univ Sheffield | Use |
DK1684736T3 (da) | 2003-12-01 | 2011-11-21 | Kudos Pharm Ltd | Inhibitorer af DNA-skadereparation til behandling af cancer |
KR20090130156A (ko) | 2004-09-22 | 2009-12-17 | 화이자 인코포레이티드 | 폴리(에이디피-리보오스) 폴리머라제 저해제를 포함하는 치료 배합물 |
-
2004
- 2004-07-23 US US10/565,308 patent/US7531530B2/en not_active Expired - Lifetime
- 2004-07-23 RU RU2006105652/04A patent/RU2404183C2/ru active
- 2004-07-23 ES ES04743516T patent/ES2339663T3/es not_active Expired - Lifetime
- 2004-07-23 KR KR1020067001725A patent/KR101138471B1/ko active IP Right Grant
- 2004-07-23 AT AT04743516T patent/ATE454893T1/de active
- 2004-07-23 EP EP04743516A patent/EP1660095B1/en not_active Expired - Lifetime
- 2004-07-23 AU AU2004261462A patent/AU2004261462B2/en not_active Expired
- 2004-07-23 JP JP2006521648A patent/JP5466814B2/ja not_active Expired - Lifetime
- 2004-07-23 MX MXPA06000993A patent/MXPA06000993A/es active IP Right Grant
- 2004-07-23 NZ NZ544989A patent/NZ544989A/en unknown
- 2004-07-23 US US10/898,653 patent/US7351701B2/en active Active
- 2004-07-23 CA CA2533332A patent/CA2533332C/en not_active Expired - Lifetime
- 2004-07-23 WO PCT/GB2004/003183 patent/WO2005012305A2/en active Application Filing
- 2004-07-23 DE DE602004025123T patent/DE602004025123D1/de not_active Expired - Lifetime
- 2004-07-23 BR BRPI0412899-0A patent/BRPI0412899B1/pt not_active IP Right Cessation
- 2004-07-23 PL PL04743516T patent/PL1660095T3/pl unknown
- 2004-07-23 DK DK04743516.9T patent/DK1660095T3/da active
- 2004-07-23 SI SI200431370T patent/SI1660095T1/sl unknown
- 2004-07-23 PT PT04743516T patent/PT1660095E/pt unknown
-
2006
- 2006-01-24 ZA ZA2006/00679A patent/ZA200600679B/en unknown
- 2006-01-24 IL IL173336A patent/IL173336A/en active IP Right Grant
- 2006-02-24 NO NO20060928A patent/NO334610B1/no unknown
- 2006-06-19 HK HK06106961.6A patent/HK1084602A1/xx not_active IP Right Cessation
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2010
- 2010-03-31 CY CY20101100309T patent/CY1110335T1/el unknown
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2011
- 2011-11-29 JP JP2011260401A patent/JP5580280B2/ja not_active Expired - Lifetime
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