DK1684736T3 - Inhibitorer af DNA-skadereparation til behandling af cancer - Google Patents

Inhibitorer af DNA-skadereparation til behandling af cancer

Info

Publication number
DK1684736T3
DK1684736T3 DK04798705.2T DK04798705T DK1684736T3 DK 1684736 T3 DK1684736 T3 DK 1684736T3 DK 04798705 T DK04798705 T DK 04798705T DK 1684736 T3 DK1684736 T3 DK 1684736T3
Authority
DK
Denmark
Prior art keywords
cancer treatment
dna damage
damage repair
repair inhibitors
deficient
Prior art date
Application number
DK04798705.2T
Other languages
English (en)
Inventor
Alan Ashworth
Stephen Jackson
Niall Martin
Graeme Smith
Original Assignee
Kudos Pharm Ltd
Cancer Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34655227&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1684736(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0327844A external-priority patent/GB0327844D0/en
Application filed by Kudos Pharm Ltd, Cancer Res Inst filed Critical Kudos Pharm Ltd
Application granted granted Critical
Publication of DK1684736T3 publication Critical patent/DK1684736T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
DK04798705.2T 2003-12-01 2004-11-30 Inhibitorer af DNA-skadereparation til behandling af cancer DK1684736T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52624403P 2003-12-01 2003-12-01
GB0327844A GB0327844D0 (en) 2003-12-01 2003-12-01 Therapeutic methods and means
PCT/GB2004/005025 WO2005053662A1 (en) 2003-12-01 2004-11-30 Dna damage repair inhibitors for treatment of cancer

Publications (1)

Publication Number Publication Date
DK1684736T3 true DK1684736T3 (da) 2011-11-21

Family

ID=34655227

Family Applications (2)

Application Number Title Priority Date Filing Date
DK04798705.2T DK1684736T3 (da) 2003-12-01 2004-11-30 Inhibitorer af DNA-skadereparation til behandling af cancer
DK10178515.2T DK2305221T3 (da) 2003-12-01 2004-11-30 DNA-skadereparationshæmmere til behandling af cancer

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK10178515.2T DK2305221T3 (da) 2003-12-01 2004-11-30 DNA-skadereparationshæmmere til behandling af cancer

Country Status (23)

Country Link
US (5) US8071579B2 (da)
EP (2) EP1684736B1 (da)
JP (2) JP5545690B2 (da)
KR (1) KR20060123403A (da)
CN (1) CN102107008B (da)
AT (1) ATE521341T1 (da)
AU (2) AU2004294790B2 (da)
BR (1) BRPI0417056A (da)
CA (1) CA2547077C (da)
DK (2) DK1684736T3 (da)
ES (2) ES2371469T3 (da)
HK (1) HK1089358A1 (da)
HU (1) HUE025996T2 (da)
IL (1) IL176013A (da)
MX (1) MXPA06006120A (da)
NO (1) NO335959B1 (da)
NZ (1) NZ547984A (da)
PL (2) PL2305221T3 (da)
PT (2) PT1684736E (da)
RU (3) RU2413515C2 (da)
SG (1) SG150548A1 (da)
TW (1) TWI338000B (da)
WO (1) WO2005053662A1 (da)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7151102B2 (en) * 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
US6956035B2 (en) 2001-08-31 2005-10-18 Inotek Pharmaceuticals Corporation Isoquinoline derivatives and methods of use thereof
US7196085B2 (en) 2002-04-30 2007-03-27 Kudos Pharmaceuticals Limited Phthalazinone derivatives
BRPI0407757A (pt) 2003-02-28 2006-02-14 Inotek Pharmaceuticals Corp derivados de benzamida tetracìclica e métodos de uso dos mesmos
US7449464B2 (en) * 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0305681D0 (en) 2003-03-12 2003-04-16 Kudos Pharm Ltd Phthalazinone derivatives
KR101138471B1 (ko) * 2003-07-25 2012-04-25 화이자 인코포레이티드 트리시클로 ｐａｒｐ 저해제
GB0317466D0 (en) * 2003-07-25 2003-08-27 Univ Sheffield Use
CN102107008B (zh) * 2003-12-01 2013-04-03 库多斯药物有限公司 用于治疗癌症的dna损伤修复抑制剂
GB0419072D0 (en) * 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
GB0428111D0 (en) * 2004-12-22 2005-01-26 Kudos Pharm Ltd Pthalazinone derivatives
MX2007008771A (es) 2005-01-19 2007-09-11 Mgi Gp Inc Compuestos de diazabenzo [des] antracen-3-ona y metodos para inhibir parp.
US7381722B2 (en) 2005-02-25 2008-06-03 Inotek Pharmaceuticals Corporation Tetracyclic amino and carboxamido compounds and methods of use thereof
KR20080031266A (ko) * 2005-06-10 2008-04-08 바이파 사이언스 인코포레이티드 Ｐａｒｐ 조절제 및 암의 치료
JP5177429B2 (ja) * 2005-07-18 2013-04-03 バイパー サイエンシズ，インコーポレイティド 癌の治療
KR20080039508A (ko) 2005-08-24 2008-05-07 이노텍 파마슈티컬스 코포레이션 인데노이소퀴놀리논 유사체 및 이의 사용 방법
GB0521373D0 (en) 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
WO2007144652A2 (en) * 2006-06-15 2007-12-21 Kudos Pharmaceuticals Limited Parp inhibitors
CN101484421A (zh) * 2006-06-15 2009-07-15 库多斯药物有限公司 作为parp抑制剂的2-氧基苯甲酰胺衍生物
EP2041110A1 (en) * 2006-06-15 2009-04-01 Kudos Pharmaceuticals Limited 2 -oxyheteroarylamide derivatives as parp inhibitors
WO2008020180A2 (en) * 2006-08-17 2008-02-21 Kudos Pharmaceuticals Limited Methods of increasing the sensitivity of cancer cells to dna damage
US7994222B2 (en) 2006-09-05 2011-08-09 Bipar Sciences, Inc. Monitoring of the inhibition of fatty acid synthesis by iodo-nitrobenzamide compounds
EP2059802A4 (en) * 2006-09-05 2010-09-08 Bipar Sciences Inc METHODS FOR DESIGNING PARP INHIBITORS AND USES THEREOF
CN101522609A (zh) 2006-09-05 2009-09-02 彼帕科学公司 癌症的治疗
AU2007303846B2 (en) 2006-10-04 2011-03-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as calcium receptor antagonists
UY30639A1 (es) 2006-10-17 2008-05-31 Kudos Pharm Ltd Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones
AU2007325900A1 (en) 2006-10-20 2008-06-05 Dnar, Inc. DNA damage repair inhibitors and methods for treating cancer
JP5249239B2 (ja) * 2006-12-29 2013-07-31 トラコン ファーマシューティカルズ，インク． 癌の治療における葉酸代謝拮抗剤の併用
CA2677046A1 (en) 2007-02-28 2008-09-04 Inotek Pharmaceuticals Corporation Indenoisoquinolinone analogs and methods of use thereof
TW200900396A (en) * 2007-04-10 2009-01-01 Kudos Pharm Ltd Phthalazinone derivatives
BRPI0811059A2 (pt) * 2007-05-25 2017-05-09 Astrazeneca Ab combinação, composição farmacêutica, método para tratar câncer em um animal de sangue quente, e, uso de uma combinação
US20090023727A1 (en) * 2007-07-05 2009-01-22 Muhammad Hashim Javaid Phthalazinone derivatives
AU2008299721A1 (en) 2007-09-14 2009-03-19 Astrazeneca Ab Phthalazinone derivatives
JP5439380B2 (ja) * 2007-10-03 2014-03-12 エーザイ インク． Ｐａｒｐ阻害化合物、組成物及び使用方法
KR101598231B1 (ko) * 2007-10-17 2016-02-26 쿠도스 파마슈티칼스 리미티드 4-[3-(4-시클로프로판카르보닐-피페라진-1-카르보닐)-4-플루오로-벤질]-2ｈ-프탈라진-1-온
EA201000673A1 (ru) * 2007-11-05 2011-04-29 Новартис Аг СПОСОБЫ И КОМПОЗИЦИИ ДЛЯ ИЗМЕРЕНИЯ АКТИВАЦИИ Wnt И ДЛЯ ЛЕЧЕНИЯ Wnt-ОПОСРЕДОВАННЫХ РАКОВЫХ ЗАБОЛЕВАНИЙ
US7732491B2 (en) 2007-11-12 2010-06-08 Bipar Sciences, Inc. Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents
UY31603A1 (es) 2008-01-23 2009-08-31 Derivados de ftalazinona
JP5436786B2 (ja) * 2008-03-06 2014-03-05 オリンパス株式会社 細胞周期計測方法
WO2010042514A1 (en) * 2008-10-06 2010-04-15 Arizona Board Of Regents Nanopore and carbon nanotube based dna sequencer and a serial recognition elements
HUE030800T2 (en) * 2008-10-07 2017-05-29 Astrazeneca Uk Ltd Pharmaceutical Form No. 514
US20120148564A1 (en) * 2009-02-27 2012-06-14 Hawtin Rachael E Methods of using sns-595 for treatment of cancer subjects with reduced brca2 activity
US8435961B2 (en) * 2009-06-26 2013-05-07 Massachusetts Institute Of Technology Methods and compositions for increasing the activity of inhibitory RNA
US20110097329A1 (en) 2009-06-26 2011-04-28 Massachusetts Institute Of Technology Compositions and methods for treating cancer and modulating stress granule formation
UY32790A (es) * 2009-07-15 2011-02-28 Astrazeneca Ab Compuesto de ftalazinona
EP2322658A1 (en) 2009-11-13 2011-05-18 Centre National de la Recherche Scientifique (CNRS) Signature for the diagnosis of breast cancer aggressiveness and genetic instability
WO2011058367A2 (en) 2009-11-13 2011-05-19 Astrazeneca Ab Diagnostic test for predicting responsiveness to treatment with poly(adp-ribose) polymerase (parp) inhibitor
CA2811015A1 (en) 2010-09-15 2012-03-22 Almac Diagnostics Limited Molecular diagnostic test for cancer
EP2683825B1 (en) * 2011-03-11 2017-01-04 Sarissa Inc. Methods of treating cancer by inhibition of dna repair proteins
WO2012156501A1 (en) 2011-05-18 2012-11-22 Centre National De La Recherche Scientifique (Cnrs) Signature for the diagnosis of cancer aggressiveness and genetic instability
JP6270719B2 (ja) 2011-07-22 2018-01-31 パシレックス・ファーマシューティカルズ・インコーポレイテッド 合成致死性および癌の治療
CN103130723B (zh) 2011-11-30 2015-01-14 成都地奥制药集团有限公司 一种多聚(adp-核糖)聚合酶抑制剂
US9790556B2 (en) 2012-01-05 2017-10-17 Centre National De La Recherche Scientifique (Cnrs) Signature for the diagnosis of lung cancer aggressiveness and genetic instability
US10220051B2 (en) 2012-03-29 2019-03-05 Institute For Cancer Research Combination of DNA repair inhibition with bendamustine or gemcitabine in the treatment of cancer
US8927516B2 (en) * 2012-03-29 2015-01-06 Institute For Cancer Research Combination of DNA repair inhibition with bendamustine or gemcitabine in the treatment of cancer
RU2492242C1 (ru) * 2012-04-24 2013-09-10 Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) Способ оценки активности системы эксцизионной репарации нуклеотидов млекопитающих
US9359367B2 (en) 2012-07-09 2016-06-07 Lupin Limited Tetrahydroquinazolinone derivatives as PARP inhibitors
US9512486B2 (en) * 2012-08-06 2016-12-06 The Institute Of Cancer Research: Royal Cancer Hospital Materials, methods, and systems for treating cancer
AU2014218621B2 (en) * 2013-02-25 2019-11-07 Sangamo Therapeutics, Inc. Methods and compositions for enhancing nuclease-mediated gene disruption
EP3052655B1 (en) 2013-09-30 2018-11-07 Institute For Cancer Research D/b/a The Research Institute of Fox Chase Cancer Center Closantel in combination with temozolomide for use in the treatment of a cancer in which is thymine dna glycosylase expressed
PT3157566T (pt) 2014-06-17 2019-07-11 Vertex Pharma Método para tratamento de cancro utilizando uma combinação de inibidores chk1 e atr
WO2016028870A1 (en) * 2014-08-20 2016-02-25 Albert Einstein College Of Medicine, Inc. Methods and compositions for assessing germline risk of cancer
LT3221457T (lt) 2014-11-21 2019-06-10 Regeneron Pharmaceuticals, Inc. Nukreipiančios genetinės modifikacijos būdai ir kompozicijos, naudojant suporuotas kreipiančiąsias rnr sekas
WO2016112177A1 (en) * 2015-01-08 2016-07-14 Yale University Novel Compositions Useful for Killing DNA Repair-Deficient Cancer Cells, and Methods Using Same
CN105985294B (zh) * 2015-02-11 2020-12-25 四川科伦药物研究院有限公司 一种奥拉帕尼的制备方法
RU2686317C2 (ru) * 2015-04-24 2019-04-25 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" Замещенные 1,2,5-триметил- и 2,2,6,6-тетраметил-4-аминопиперидины, обладающие антиишемическим действием
US20180148792A1 (en) 2015-05-19 2018-05-31 T.S. Sridhar Method for Identification of a Deficient BRCA1 Function
EP3325662B1 (en) 2015-07-17 2023-08-30 Pacylex Pharmaceuticals Inc. Epigenetic silencing of nmt2
CA3000684A1 (en) 2015-09-30 2017-04-06 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of dna damaging agents and atr inhibitors
CN106699672B (zh) * 2015-11-16 2019-10-29 上海博邦医药科技有限公司 一种奥拉帕尼无定型物及其制备方法
WO2017087235A1 (en) 2015-11-20 2017-05-26 Senhwa Biosciences, Inc. Combination therapy of tetracyclic quinolone analogs for treating cancer
RU2639535C2 (ru) * 2015-12-07 2017-12-21 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ скрининга противоопухолевых препаратов - ингибиторов parp1 на основе биохимических методов анализа
US10823738B2 (en) * 2015-12-07 2020-11-03 George Mason Research Foundation, Inc. Methods for breast cancer treatment
ITUB20159206A1 (it) 2015-12-22 2017-06-22 Olon Spa Forme cristalline e amorfe di olaparib
JP2019505562A (ja) * 2016-02-22 2019-02-28 ニューヨーク インスティチュート オブ テクノロジーＮｅｗ Ｙｏｒｋ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ｔｅｃｈｎｏｌｏｇｙ Ｂｒｃａ１／ｆａｎｃｍ相互作用を無効化することによってがんを治療する方法
KR20240016444A (ko) 2016-05-20 2024-02-06 리제너론 파마슈티칼스 인코포레이티드 다중 가이드 RNAs를 이용한 면역학적 내성 파괴 방법
WO2018165615A1 (en) 2017-03-09 2018-09-13 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Parp-1 and methods of use thereof
CN107384916A (zh) * 2017-08-03 2017-11-24 中国科学院成都生物研究所 一种广谱性的癌症治疗基因靶点及其应用
WO2019084086A1 (en) * 2017-10-25 2019-05-02 Dana-Farber Cancer Institute, Inc. CANCER VACCINE COMPOSITIONS AND METHODS FOR USE IN THE TREATMENT OF CANCER
US10519136B2 (en) 2017-12-29 2019-12-31 Accutar Biotechnology Dual inhibitors of PARP1 and CDK
CN111989137A (zh) 2018-01-05 2020-11-24 赛博克萨1公司 用于治疗涉及酸性或缺氧性患病组织的疾病的化合物、组合物和方法
US11149300B1 (en) * 2018-01-26 2021-10-19 Cedars-Sinai Medical Center Methods of treating gastrointestinal malignancies
TW202000195A (zh) 2018-02-15 2020-01-01 生華生物科技股份有限公司 喹啉酮類似物及其鹽、組合物及其使用方法
SG11202111402PA (en) * 2019-05-14 2021-11-29 Nuvation Bio Inc Anti-cancer nuclear hormone receptor-targeting compounds
BR112022000297A2 (pt) 2019-07-10 2022-03-15 Cybrexa 3 Inc Conjugados de peptídeos de agentes de alvo de microtúbulos como terapêuticos
CN114341162A (zh) 2019-07-10 2022-04-12 赛博克萨2公司 作为治疗剂的细胞毒素的肽缀合物
GB201913030D0 (en) * 2019-09-10 2019-10-23 Francis Crick Institute Ltd Treatment of hr deficient cancer
US11952349B2 (en) 2019-11-13 2024-04-09 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
EP4072551A4 (en) * 2019-12-11 2023-11-15 Repare Therapeutics Inc. USE OF ATR INHIBITORS IN COMBINATION WITH PARP INHIBITORS
CA3161892A1 (en) 2019-12-23 2021-07-01 Jie Fan Combinations of estrogen receptor degraders and cyclin-dependent kinase inhibitors for treating cancer
US20230119558A1 (en) * 2020-03-06 2023-04-20 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Dna damage repair genes in cancer
WO2021220120A1 (en) 2020-04-28 2021-11-04 Rhizen Pharmaceuticals Ag Novel compounds useful as poly(adp-ribose) polymerase (parp) inhibitors
US20230250145A1 (en) * 2020-06-24 2023-08-10 Moma Therapeutics, Inc. Compositions and methods for the treatment of cancer
WO2022090938A1 (en) 2020-10-31 2022-05-05 Rhizen Pharmaceuticals Ag Phthalazinone derivatives useful as parp inhibitors
CN114805263B (zh) * 2021-01-18 2023-05-05 四川大学 3-(羟基苄基)苯酞类化合物、其制备方法和用途
BR112023019420A2 (pt) 2021-03-23 2023-10-24 Nuvation Bio Inc Compostos de direcionamento ao receptor de hormônio nuclear anticâncer
JP2024511109A (ja) * 2021-03-25 2024-03-12 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 合成ペプチド治療薬のｃａｒ－ｔ送達の方法
CN113024516B (zh) * 2021-03-29 2022-05-17 中国药科大学 双靶点parp/ezh2抑制剂、制备方法及用途
WO2022215034A1 (en) 2021-04-08 2022-10-13 Rhizen Pharmaceuticals Ag Inhibitors of poly(adp-ribose) polymerase
WO2023064619A1 (en) * 2021-10-17 2023-04-20 University of South Alabama Foundation for Research and Commercialization Cancer treatment
WO2023201338A1 (en) 2022-04-15 2023-10-19 Ideaya Biosciences, Inc. Combination therapy comprising a mat2a inhibitor and a parp inhibitor
WO2023233295A1 (en) 2022-06-01 2023-12-07 Ideaya Biosciences, Inc. Thiadiazolyl derivatives as dna polymerase theta inhibitors and uses thereof
CN115960018B (zh) * 2022-12-19 2024-01-05 湖南岳靶生物医药有限公司 一种egfr抑制剂、组合物及其应用

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2707069A1 (de) * 1977-02-18 1978-08-24 Blaszczak Joseph W Polymerisationsprodukt von formaldehyd und kohlehydraten, verfahren zu seiner herstellung und arzneimittel
US5484951A (en) 1990-10-19 1996-01-16 Octamer, Incorporated 5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents
US5260195A (en) 1991-01-03 1993-11-09 Boehringer Mannheim Corporation Nonaqueous polymeric reagent compositions and applications thereof
US5464871A (en) 1993-05-12 1995-11-07 Octamer, Inc. Aromatic nitro and nitroso compounds and their metabolites useful as anti-viral and anti-tumor agents
US6153193A (en) * 1993-04-28 2000-11-28 Supratek Pharma Inc. Compositions for targeting biological agents
EP0600831A1 (de) 1992-11-27 1994-06-08 Ciba-Geigy Ag Phthalazinonderivate
US5587384A (en) 1994-02-04 1996-12-24 The Johns Hopkins University Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity
GB9404485D0 (en) 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
JP2002503943A (ja) 1994-08-12 2002-02-05 ミリアド・ジェネティックス・インコーポレイテッド １７ｑ−連鎖乳癌および卵巣癌感受性遺伝子におけるイン・ビボ突然変異および多形性
ES2154712T5 (es) 1994-08-12 2009-12-14 The University Of Utah Research Foundation Metodo para diagnosticar la predisposicion al cancer de mama y de ovarios.
US5908861A (en) 1997-05-13 1999-06-01 Octamer, Inc. Methods for treating inflammation and inflammatory disease using pADPRT inhibitors
US6514983B1 (en) 1997-09-03 2003-02-04 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
US6426415B1 (en) 1997-09-03 2002-07-30 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity
US6635642B1 (en) 1997-09-03 2003-10-21 Guilford Pharmaceuticals Inc. PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
SI20691B (sl) 1999-01-11 2008-10-31 Agouron Pharma Triciklični inhibitorji poli(ADP-riboza) polimeraz
US6465448B1 (en) 1999-08-13 2002-10-15 Case Western Reserve University Methoxyamine potentiation of temozolomide anti-cancer activity
US6635677B2 (en) 1999-08-13 2003-10-21 Case Western Reserve University Methoxyamine combinations in the treatment of cancer
ECSP003637A (es) 1999-08-31 2002-03-25 Agouron Pharma Inhibidores triciclicos de poli (adp-ribosa) polimerasas
WO2001021615A1 (en) 1999-09-17 2001-03-29 Yamanouchi Pharmaceutical Co., Ltd. Benzimidazole derivatives
KR20010087401A (ko) 1999-09-28 2001-09-15 스타르크, 카르크 아제피노인돌 유도체, 그의 제법 및 용도
US6476048B1 (en) 1999-12-07 2002-11-05 Inotek Pharamaceuticals Corporation Substituted phenanthridinones and methods of use thereof
GB9930519D0 (en) 1999-12-24 2000-02-16 Phogen Limited Uses of transport proteins
WO2001057038A1 (de) 2000-02-01 2001-08-09 Basf Aktiengesellschaft Heterozyklische verbindungen und deren anwendung als parp-inhibitoren
US20020032319A1 (en) * 2000-03-07 2002-03-14 Whitehead Institute For Biomedical Research Human single nucleotide polymorphisms
JPWO2001079184A1 (ja) 2000-04-18 2004-03-18 住友製薬株式会社 置換ピペラジン類
US7122679B2 (en) 2000-05-09 2006-10-17 Cephalon, Inc. Multicyclic compounds and the use thereof
DE10022925A1 (de) * 2000-05-11 2001-11-15 Basf Ag Substituierte Indole als PARP-Inhibitoren
AU2001264595A1 (en) 2000-05-19 2001-12-03 Guilford Pharmaceuticals Inc. Sulfonamide and carbamide derivatives of 6(5h)phenanthridinones and their uses
MXPA03000753A (es) 2000-08-08 2003-10-15 Sanofi Synthelabo Derivados de benzimidazola, su preparacion y su aplicacion terapeutica.
GB2384776C (en) * 2000-10-30 2006-02-03 Kudos Pharm Ltd Phthalazinone derivatives
US7151102B2 (en) * 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
CA2326464A1 (en) * 2000-11-20 2002-05-20 Aldo Perrone Improved electrically operated paintball gun
CZ20032233A3 (cs) * 2001-02-20 2004-12-15 Bristol-Myers Squibb Company Derivát 2,4-disubstituovaného pyrimidin-5-karboxamidu jako modulátor draslíkového kanálku KCNQ
WO2002068407A1 (fr) 2001-02-28 2002-09-06 Yamanouchi Pharmaceutical Co., Ltd. Compose benzimidazole
DE60218458T2 (de) 2001-05-08 2007-11-15 Kudos Pharmaceuticals Ltd. Isochinolinon derivate als parp inhibitoren
JPWO2002094790A1 (ja) 2001-05-23 2004-09-09 三菱ウェルファーマ株式会社 縮合ヘテロ環化合物およびその医薬用途
US7072771B2 (en) 2001-06-07 2006-07-04 University Of Kentucky Research Foundation Selective PARP-1 targeting for designing chemo/radio sensitizing agents
US6644295B2 (en) * 2001-07-03 2003-11-11 Smart Parts, Inc. Pneumatic assembly for a paintball gun
WO2003007959A1 (en) 2001-07-16 2003-01-30 Fujisawa Pharmaceutical Co., Ltd. Quinoxaline derivatives which have parp inhibitory action
US20030073692A1 (en) 2001-08-07 2003-04-17 Pharmacia & Upjohn S.P.A. Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them
US20030034020A1 (en) * 2001-08-14 2003-02-20 Mario Irizarry Components made of polymers with high luminous transmittance for compressed-gas-powered guns
AU2002358650A1 (en) 2001-12-14 2003-06-30 Altana Pharma Ag Known and novel 4,5-dihydro-imidazo(4,5,1-ij)quinolin-6-ones useful as poly(adp-ribose)polymerase inhibitors
US7351530B1 (en) 2001-12-20 2008-04-01 Health Research, Inc. Prognostic significance of molecular genetic aberrations on chromosome segment 11p15.5 in non-small-cell lung cancer
AUPR975601A0 (en) 2001-12-24 2002-01-31 Fujisawa Pharmaceutical Co., Ltd. Quinazolinone derivatives
US7157452B2 (en) 2001-12-31 2007-01-02 Mgi Gp, Inc. Substituted 4,9-dihydrocyclopenta{imn}phenanthridine-5-ones derivatives thereof and their uses
AUPS019702A0 (en) 2002-01-29 2002-02-21 Fujisawa Pharmaceutical Co., Ltd. Condensed heterocyclic compounds
BR0307780A (pt) 2002-02-19 2004-12-28 Ono Pharmaceutical Co Compostos derivados de piridazina fundida e medicamentos contendo os compostos como o ingrediente ativo
DK1485377T5 (da) 2002-02-25 2010-12-06 Kudos Pharm Ltd Pyranoner egnede som ATM-inhibitorer
US7237545B2 (en) * 2002-03-06 2007-07-03 Aj Acquisition I Llc Compressed gas-powered projectile accelerator
US7886731B2 (en) * 2002-03-06 2011-02-15 Kee Action Sports I Llc Compressed gas gun having reduced breakaway-friction and high pressure dynamic separable seal flow control device
US6708685B2 (en) * 2002-03-06 2004-03-23 National Paintball Supply, Inc. Compressed gas-powered projectile accelerator
US20030229004A1 (en) 2002-03-20 2003-12-11 Pangene Corporation Modulation of tumor cells using BER inhibitors in combination with a sensitizing agent and DSBR inhibitors
AUPS137402A0 (en) 2002-03-26 2002-05-09 Fujisawa Pharmaceutical Co., Ltd. Novel tricyclic compounds
US7196085B2 (en) * 2002-04-30 2007-03-27 Kudos Pharmaceuticals Limited Phthalazinone derivatives
AU2003253906A1 (en) 2002-07-19 2004-02-09 Osteotech, Inc. Chisels and procedure for insertion of spinal implant in a spinal disc space
US6732726B2 (en) * 2002-08-28 2004-05-11 Avalon Manufacturing Company Paint ball gun having a front mounted gas cylinder
GB0305681D0 (en) * 2003-03-12 2003-04-16 Kudos Pharm Ltd Phthalazinone derivatives
CA2517629C (en) * 2003-03-12 2011-07-12 Kudos Pharmaceuticals Limited Phthalazinone derivatives
US7176188B2 (en) 2003-05-07 2007-02-13 UniversitéLaval Method of lethally sensitizing human and animal cells
KR101138471B1 (ko) 2003-07-25 2012-04-25 화이자 인코포레이티드 트리시클로 ｐａｒｐ 저해제
GB0317466D0 (en) 2003-07-25 2003-08-27 Univ Sheffield Use
CN102107008B (zh) 2003-12-01 2013-04-03 库多斯药物有限公司 用于治疗癌症的dna损伤修复抑制剂
US20050155591A1 (en) * 2003-12-29 2005-07-21 Glenn Forster Electronically controlled gas-powered guns for firing paintballs
US20060011185A1 (en) * 2004-06-18 2006-01-19 Npf Limited Paintball marker with an air balanced exhaust poppet valve with bias closure
US20060185657A1 (en) * 2005-02-24 2006-08-24 Stanley Gabrel Paintball gun with power assisted trigger

Also Published As

Publication number Publication date
RU2006121459A (ru) 2008-01-10
KR20060123403A (ko) 2006-12-01
ES2545613T3 (es) 2015-09-14
RU2413515C2 (ru) 2011-03-10
MXPA06006120A (es) 2007-04-16
ES2371469T3 (es) 2012-01-03
HK1089358A1 (en) 2006-12-01
RU2010149166A (ru) 2012-06-10
CN102107008B (zh) 2013-04-03
RU2017101713A (ru) 2018-07-19
NZ547984A (en) 2009-03-31
AU2004294790A1 (en) 2005-06-16
RU2017101713A3 (da) 2020-02-17
CA2547077C (en) 2015-11-03
TWI338000B (en) 2011-03-01
EP1684736B1 (en) 2011-08-24
CA2547077A1 (en) 2005-06-16
NO20063078L (no) 2006-08-28
JP2007516241A (ja) 2007-06-21
US8071579B2 (en) 2011-12-06
EP2305221A1 (en) 2011-04-06
RU2755865C2 (ru) 2021-09-22
US20050227919A1 (en) 2005-10-13
PL2305221T3 (pl) 2015-11-30
ATE521341T1 (de) 2011-09-15
SG150548A1 (en) 2009-03-30
BRPI0417056A (pt) 2007-02-06
AU2010202197B2 (en) 2013-05-23
US20210244706A1 (en) 2021-08-12
NO335959B1 (no) 2015-03-30
WO2005053662A1 (en) 2005-06-16
EP1684736A1 (en) 2006-08-02
DK2305221T3 (da) 2015-08-24
EP2305221B1 (en) 2015-05-20
HUE025996T2 (en) 2016-05-30
JP2012067092A (ja) 2012-04-05
US20170319543A1 (en) 2017-11-09
IL176013A0 (en) 2006-10-05
AU2010202197A1 (en) 2010-06-17
JP5545690B2 (ja) 2014-07-09
CN102107008A (zh) 2011-06-29
PT1684736E (pt) 2011-11-10
US8143241B2 (en) 2012-03-27
US20120135983A1 (en) 2012-05-31
IL176013A (en) 2015-10-29
PL1684736T3 (pl) 2012-01-31
TW200530196A (en) 2005-09-16
JP5545772B2 (ja) 2014-07-09
US20060142231A1 (en) 2006-06-29
AU2004294790B2 (en) 2010-03-11
PT2305221E (pt) 2015-09-03

Similar Documents

Publication Publication Date Title
DK1684736T3 (da) Inhibitorer af DNA-skadereparation til behandling af cancer
CY1117108T1 (el) Ιμιδαζοτριαζινες και ιμιδαζοπυριμιδινες ως αναστολeiς κινασης
BR0315689A (pt) Alvo para terapia de dano cognitivo
EA200702048A1 (ru) Фармакокинетически улучшенные соединения
EA200501928A1 (ru) Пирролодигидроизохинолины как ингибиторы pde10
DK1836169T5 (da) Sammensætninger og fremgangsmåder til behandling af celleproliferationslidelser
NO20092657L (no) Bicyclic heterocyclic compounds as FGFR inhibitors
BRPI0512547A (pt) pirimidinas
DK1954274T3 (da) Substituerede quinoloner og fremgangsmåder til anvendelse
BRPI0506958A (pt) derivados de indolilmaleimida
ATE378337T1 (de) Zusammensetzungen, die sich als inhibitoren von proteinkinasen eignen
DE602006007037D1 (de) Pyrrolotriazin-kinasehemmer
IS8125A (is) Kínasólínafleiður til að meðhöndla krabbamein
ATE497496T1 (de) 2,4-pyridimediamon-derivate als hemmer von jak- kinasen zur behandlung von autoimmunerkrankungen
DE60205776T2 (de) Indolinon-derivative als protein-kinasehemmer
EA201070127A1 (ru) Способы лечения легочной гипертензии, родственных заболеваний и нарушений и композиции для их осуществления
ATE551333T1 (de) Biphenylderivate als modulatoren von spannungsabhängigen ionenkanälen
NO20073368L (no) Amid-promedikament av gemcitabin, sammensetninger og anvendelse derav
ATE527251T1 (de) Bicyclische derivate als modulatoren von ionenkanälen
EA200801430A1 (ru) Производные триазола
DE502005007105D1 (de) 4-amino-5-oxo-8-phenyl-5h-pyrido-ä2,3-dü-pyrimidin-derivate als inhibitoren der tyrosinkinasen und der raf-kinasen zur behandlung von tumoren
WO2006015191A3 (en) Multicyclic lonidamine analogs
WO2005089730A3 (en) Dna pkinase inhibitors for treating cancer and diabetes
DE60143023D1 (de) Tumorhemmende nitroacridin-zusammensetzungen
CY1114825T1 (el) Συνθεσεις και μεθοδοι αγωγης διαταραχων υπερπλασιας κυτταρων