NO20092657L - Bicyclic heterocyclic compounds as FGFR inhibitors - Google Patents
Bicyclic heterocyclic compounds as FGFR inhibitorsInfo
- Publication number
- NO20092657L NO20092657L NO20092657A NO20092657A NO20092657L NO 20092657 L NO20092657 L NO 20092657L NO 20092657 A NO20092657 A NO 20092657A NO 20092657 A NO20092657 A NO 20092657A NO 20092657 L NO20092657 L NO 20092657L
- Authority
- NO
- Norway
- Prior art keywords
- bicyclic heterocyclic
- heterocyclic compounds
- fgfr inhibitors
- compounds
- fgfr
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
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- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
Abstract
Det beskrives nye bisykliske, heterosykliske derivatforbindelser. Det beskrives videre farmasøytiske preparater omfattende disse forbindelser samt anvendelsen av disse forbindelser ved behandling av sykdommer, for eksempel cancer.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87154306P | 2006-12-22 | 2006-12-22 | |
GB0625826A GB0625826D0 (en) | 2006-12-22 | 2006-12-22 | New compounds |
US97958707P | 2007-10-12 | 2007-10-12 | |
GB0720000A GB0720000D0 (en) | 2007-10-12 | 2007-10-12 | New compounds |
US98103907P | 2007-10-18 | 2007-10-18 | |
PCT/GB2007/004934 WO2008078091A1 (en) | 2006-12-22 | 2007-12-21 | Bicyclic heterocyclic compounds as fgfr inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20092657L true NO20092657L (no) | 2009-09-17 |
NO343370B1 NO343370B1 (no) | 2019-02-11 |
Family
ID=39260738
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20092657A NO343370B1 (no) | 2006-12-22 | 2009-07-13 | Bisykliske heterosykliske forbindelser som FGFR-inhibitorer, farmasøytisk sammensetning og terapeutisk anvendelse |
Country Status (11)
Country | Link |
---|---|
US (1) | US8895745B2 (no) |
EP (1) | EP2114941B1 (no) |
JP (1) | JP5442448B2 (no) |
CN (1) | CN101679408B (no) |
AR (1) | AR064491A1 (no) |
AU (1) | AU2007337886C1 (no) |
CA (1) | CA2672172C (no) |
HR (1) | HRP20150642T1 (no) |
MX (1) | MX2009006706A (no) |
NO (1) | NO343370B1 (no) |
WO (1) | WO2008078091A1 (no) |
Families Citing this family (149)
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GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途 |
CN101679409B (zh) | 2006-12-22 | 2014-11-26 | Astex治疗学有限公司 | 双环杂环衍生化合物、其医药组合物和其用途 |
CA2672172C (en) | 2006-12-22 | 2016-05-03 | Astex Therapeutics Limited | Bicyclic heterocyclic compounds as fgfr inhibitors |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
JP5366269B2 (ja) | 2007-09-14 | 2013-12-11 | ジャンセン ファーマシューティカルズ, インコーポレイテッド. | 1,3−二置換4−(アリル−x−フェニル)−1h−ピリジン−2−オン |
US9114138B2 (en) | 2007-09-14 | 2015-08-25 | Janssen Pharmaceuticals, Inc. | 1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′] bipyridinyl-2′-ones |
CN101801930B (zh) | 2007-09-14 | 2013-01-30 | 奥梅-杨森制药有限公司 | 1,3-二取代的-4-苯基-1h-吡啶-2-酮 |
GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
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MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
JP5819831B2 (ja) | 2009-08-17 | 2015-11-24 | インテリカイン, エルエルシー | 複素環式化合物およびそれらの使用 |
FR2950345B1 (fr) * | 2009-09-18 | 2011-09-23 | Sanofi Aventis | Derives acetyleniques de 5-phenyl-pyrazolopyridine, leur preparation et leur application en therapeutique |
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-
2007
- 2007-12-21 CA CA2672172A patent/CA2672172C/en active Active
- 2007-12-21 AU AU2007337886A patent/AU2007337886C1/en active Active
- 2007-12-21 JP JP2009542223A patent/JP5442448B2/ja active Active
- 2007-12-21 EP EP07848659.4A patent/EP2114941B1/en active Active
- 2007-12-21 MX MX2009006706A patent/MX2009006706A/es active IP Right Grant
- 2007-12-21 WO PCT/GB2007/004934 patent/WO2008078091A1/en active Application Filing
- 2007-12-21 US US12/520,481 patent/US8895745B2/en active Active
- 2007-12-21 AR ARP070105856A patent/AR064491A1/es active IP Right Grant
- 2007-12-21 CN CN200780047672.6A patent/CN101679408B/zh active Active
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Also Published As
Publication number | Publication date |
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EP2114941B1 (en) | 2015-03-25 |
WO2008078091A1 (en) | 2008-07-03 |
AU2007337886B2 (en) | 2014-01-30 |
NO343370B1 (no) | 2019-02-11 |
CN101679408B (zh) | 2016-04-27 |
AU2007337886C1 (en) | 2014-10-16 |
JP2010513447A (ja) | 2010-04-30 |
US8895745B2 (en) | 2014-11-25 |
EP2114941A1 (en) | 2009-11-11 |
US20100120761A1 (en) | 2010-05-13 |
AR064491A1 (es) | 2009-04-08 |
CA2672172C (en) | 2016-05-03 |
JP5442448B2 (ja) | 2014-03-12 |
CA2672172A1 (en) | 2008-07-03 |
HRP20150642T1 (hr) | 2015-08-14 |
MX2009006706A (es) | 2009-07-02 |
CN101679408A (zh) | 2010-03-24 |
AU2007337886A1 (en) | 2008-07-03 |
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