ATE551333T1 - Biphenylderivate als modulatoren von spannungsabhängigen ionenkanälen - Google Patents
Biphenylderivate als modulatoren von spannungsabhängigen ionenkanälenInfo
- Publication number
- ATE551333T1 ATE551333T1 AT06816908T AT06816908T ATE551333T1 AT E551333 T1 ATE551333 T1 AT E551333T1 AT 06816908 T AT06816908 T AT 06816908T AT 06816908 T AT06816908 T AT 06816908T AT E551333 T1 ATE551333 T1 AT E551333T1
- Authority
- AT
- Austria
- Prior art keywords
- modulators
- biphenyl derivatives
- ion channels
- voltage dependent
- dependent ion
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Amplifiers (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72568605P | 2005-10-12 | 2005-10-12 | |
PCT/US2006/040156 WO2007047474A2 (en) | 2005-10-12 | 2006-10-12 | Biphenyl derivatives as modulators of voltage gated ion channels |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE551333T1 true ATE551333T1 (de) | 2012-04-15 |
Family
ID=37836784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06816908T ATE551333T1 (de) | 2005-10-12 | 2006-10-12 | Biphenylderivate als modulatoren von spannungsabhängigen ionenkanälen |
Country Status (15)
Country | Link |
---|---|
US (2) | US7683083B2 (de) |
EP (1) | EP1934191B1 (de) |
JP (1) | JP2009511599A (de) |
KR (1) | KR20080059292A (de) |
CN (1) | CN101365690A (de) |
AT (1) | ATE551333T1 (de) |
AU (1) | AU2006304283B2 (de) |
CA (1) | CA2624831A1 (de) |
ES (1) | ES2383090T3 (de) |
IL (1) | IL190632A0 (de) |
NO (1) | NO20082165L (de) |
NZ (1) | NZ567570A (de) |
RU (1) | RU2008118350A (de) |
WO (1) | WO2007047474A2 (de) |
ZA (1) | ZA200803704B (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
CN101218235A (zh) * | 2005-05-10 | 2008-07-09 | 沃泰克斯药物股份有限公司 | 作为离子通道调控剂的二环衍生物 |
RU2007146769A (ru) * | 2005-05-16 | 2009-06-27 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Бициклические производные и их применение в качестве модуляторов ионых каналов |
CA2622076A1 (en) * | 2005-09-09 | 2007-03-15 | Vertex Pharmaceuticals Incorporated | Bicyclic derivatives as modulators of voltage gated ion channels |
ES2383090T3 (es) * | 2005-10-12 | 2012-06-18 | Vertex Pharmaceuticals, Inc. | Derivados de bifenilo como moduladores de los canales iónicos dependientes de voltaje |
EP1948597A1 (de) * | 2005-10-21 | 2008-07-30 | Vertex Pharmaceuticals Incorporated | Derivate zur modulation von ionenkanälen |
TW200740803A (en) * | 2005-12-21 | 2007-11-01 | Vertex Pharma | Heterocyclic derivatives as modulators of ion channels |
EP2158183A2 (de) | 2007-05-25 | 2010-03-03 | Vertex Pharmaceuticals Incorporated | Ionenkanalmodulatoren und verfahren zur verwendung |
US7994174B2 (en) * | 2007-09-19 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyridyl sulfonamides as modulators of ion channels |
RU2010123781A (ru) | 2007-11-13 | 2011-12-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Производные 4-(2-фенил)-морфолино)-2-оксопирролидин-1-ил)-n-(тиазол-2-ил)бензолсульфонамида и родственные соединения в качестве модуляторов ионных каналов для лечения боли |
EP2220080B1 (de) * | 2007-11-13 | 2012-01-04 | Vertex Pharmaceuticals Incorporated | Heterocyclische derivate als ionenkanalmodulatoren |
CN101978787A (zh) * | 2008-04-30 | 2011-02-16 | 夏普株式会社 | 照明装置和显示装置 |
KR20110025855A (ko) * | 2008-07-01 | 2011-03-11 | 버텍스 파마슈티칼스 인코포레이티드 | 이온 채널의 조절제로서의 헤테로사이클릭 유도체 |
GB201209015D0 (en) * | 2012-05-22 | 2012-07-04 | Convergence Pharmaceuticals | Novel compounds |
WO2014096941A1 (en) * | 2012-12-20 | 2014-06-26 | Purdue Pharma L.P. | Cyclic sulfonamides as sodium channel blockers |
PE20151781A1 (es) | 2013-01-31 | 2015-12-02 | Vertex Pharma | Piridonamidas como moduladores de canales de sodio |
WO2019077106A1 (en) * | 2017-10-19 | 2019-04-25 | Esteve Pharmaceuticals, S.A. | NOVEL ALKOXYAMINO COMPOUNDS FOR TREATING PAIN AND PAIN DISEASES ASSOCIATED WITH PAIN |
KR20210019119A (ko) | 2018-07-09 | 2021-02-19 | 리버 인스티튜트, 아이엔씨 | Nav1.8을 억제하기 위한 피리다진(PYRIDAZINE) 화합물 |
WO2020163236A1 (en) * | 2019-02-04 | 2020-08-13 | The General Hospital Corporation | Treating long qt syndrome |
CR20230576A (es) | 2021-06-14 | 2024-04-05 | Scorpion Therapeutics Inc | Derivados de la urea que pueden ser utilizados para tratar el cáncer |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5514696A (en) * | 1992-05-06 | 1996-05-07 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
SE0001899D0 (sv) * | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
AU2002223492A1 (en) * | 2000-11-14 | 2002-05-27 | Neurosearch A/S | Use of malaria parasite anion channel blockers for treating malaria |
CN1633428A (zh) * | 2001-11-22 | 2005-06-29 | 比奥维特罗姆股份公司 | 11-β-羟基类固醇脱氢酶1型抑制剂 |
CA2466491A1 (en) * | 2001-11-22 | 2003-05-30 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
CA2539227A1 (en) * | 2003-08-08 | 2005-02-17 | Vertex Pharmaceuticals Incorporated | Heteroarylaminosulfonylphenyl derivatives for use as sodium or calcium channel blockers in the treatment of pain |
OA13344A (en) * | 2003-12-19 | 2007-04-13 | Pfizer | Benzenesulfonylamino-pyridin-2-yl derivatives and related compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 (11-beta-HSD-1) for the treatment of diabetes and obesity. |
WO2006089871A2 (en) * | 2005-02-23 | 2006-08-31 | Neurosearch A/S | Diphenylurea derivatives useful as erg channel openers for the treatment of cardiac arrhythmias |
ES2383090T3 (es) * | 2005-10-12 | 2012-06-18 | Vertex Pharmaceuticals, Inc. | Derivados de bifenilo como moduladores de los canales iónicos dependientes de voltaje |
-
2006
- 2006-10-12 ES ES06816908T patent/ES2383090T3/es active Active
- 2006-10-12 AU AU2006304283A patent/AU2006304283B2/en not_active Ceased
- 2006-10-12 AT AT06816908T patent/ATE551333T1/de active
- 2006-10-12 JP JP2008535728A patent/JP2009511599A/ja active Pending
- 2006-10-12 EP EP06816908A patent/EP1934191B1/de not_active Not-in-force
- 2006-10-12 NZ NZ567570A patent/NZ567570A/en not_active IP Right Cessation
- 2006-10-12 RU RU2008118350/04A patent/RU2008118350A/ru not_active Application Discontinuation
- 2006-10-12 KR KR1020087011101A patent/KR20080059292A/ko not_active Application Discontinuation
- 2006-10-12 CN CNA2006800448581A patent/CN101365690A/zh active Pending
- 2006-10-12 WO PCT/US2006/040156 patent/WO2007047474A2/en active Application Filing
- 2006-10-12 US US11/546,669 patent/US7683083B2/en active Active
- 2006-10-12 CA CA002624831A patent/CA2624831A1/en not_active Abandoned
-
2008
- 2008-04-06 IL IL190632A patent/IL190632A0/en unknown
- 2008-04-29 ZA ZA2008/03704A patent/ZA200803704B/en unknown
- 2008-05-13 NO NO20082165A patent/NO20082165L/no not_active Application Discontinuation
-
2010
- 2010-02-01 US US12/697,671 patent/US8236833B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
KR20080059292A (ko) | 2008-06-26 |
ES2383090T3 (es) | 2012-06-18 |
EP1934191B1 (de) | 2012-03-28 |
US8236833B2 (en) | 2012-08-07 |
NO20082165L (no) | 2008-07-09 |
US7683083B2 (en) | 2010-03-23 |
AU2006304283A1 (en) | 2007-04-26 |
AU2006304283B2 (en) | 2012-01-19 |
RU2008118350A (ru) | 2009-11-20 |
US20080113990A1 (en) | 2008-05-15 |
NZ567570A (en) | 2011-02-25 |
US20100130548A1 (en) | 2010-05-27 |
EP1934191A2 (de) | 2008-06-25 |
WO2007047474A3 (en) | 2007-07-05 |
JP2009511599A (ja) | 2009-03-19 |
IL190632A0 (en) | 2008-11-03 |
CN101365690A (zh) | 2009-02-11 |
CA2624831A1 (en) | 2007-04-26 |
ZA200803704B (en) | 2009-09-30 |
WO2007047474A2 (en) | 2007-04-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE551333T1 (de) | Biphenylderivate als modulatoren von spannungsabhängigen ionenkanälen | |
AU2006287480A8 (en) | Bicyclic derivatives as modulators of voltage gated ion channels | |
ATE548374T1 (de) | 2'-fluor-2'-desoxytetrahydrouridine als cytidindeaminaseinhibitoren | |
ATE527251T1 (de) | Bicyclische derivate als modulatoren von ionenkanälen | |
EA200701396A1 (ru) | Триазолофталазины в качестве ингибиторов pde-2 | |
ATE548358T1 (de) | Tetrahydrochinazolin-verbindungen als inhibitoren von spannungsabhängigen ionenkanälen | |
BRPI0514893A (pt) | quinazolinas úteis como moduladores de canais de ìon | |
NO20076306L (no) | Bicykliske derivater som modulatorer av ionekanaler | |
BRPI0605921A2 (pt) | compostos orgánicos | |
BRPI0408026A (pt) | Quinazolinas úteis como moduladores de canais de ìon | |
DK1682530T3 (da) | Pyrrolsubstituerede indoler som inhibitorer af PAI-1 | |
CR20120421A (es) | Compuestos de aminohetetoarilo o sustituidos con pirazol como inhibidores de proteina quinasa | |
CR9869A (es) | Compuestos activos en ppar | |
ATE473744T1 (de) | Modifizierte pyrimidin-glucocorticoid-rezeptor- modulatoren | |
UA101478C2 (ru) | Соединения, полезные как ингибиторы raf-киназы | |
ATE472529T1 (de) | Prolinamidderivate als natriumkanalmodulatoren | |
EA200601568A1 (ru) | Новые гидрокси-8-гетероарилфенантридины и их применение в качестве ингибиторов pde4 | |
EP2101772A4 (de) | Neuromuskuläre blocker mit mittlerer dauer und antagonisten advon | |
ATE538084T1 (de) | Bicyclische 1,4-retigabin-analoga als kaliumkanalhemmer | |
WO2010053573A3 (en) | Screen for inhibitors of filovirus and uses therefor | |
BRPI0516602A (pt) | composto, e, composição farmacêutica | |
PA8792401A1 (es) | Fenilendiaminas | |
ATE430148T1 (de) | Neue pyrrolodihydroisochinoline als pde10- inhibitoren | |
EA201000069A1 (ru) | Новые гербициды | |
DK1926732T3 (da) | Fremgangsmåde til fremstillingen af carbapenemforbindelser |