BRPI0514357A - combinações para o tratamento de doenças que envolvem a proliferação de células - Google Patents

combinações para o tratamento de doenças que envolvem a proliferação de células

Info

Publication number
BRPI0514357A
BRPI0514357A BRPI0514357-8A BRPI0514357A BRPI0514357A BR PI0514357 A BRPI0514357 A BR PI0514357A BR PI0514357 A BRPI0514357 A BR PI0514357A BR PI0514357 A BRPI0514357 A BR PI0514357A
Authority
BR
Brazil
Prior art keywords
cell proliferation
diseases involving
involving cell
treatment
combinations
Prior art date
Application number
BRPI0514357-8A
Other languages
English (en)
Inventor
Gerd Munzert
Martin Steegmaier
Anke Baum
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35241347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0514357(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BRPI0514357A publication Critical patent/BRPI0514357A/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

COMBINAçõES PARA O TRATAMENTO DE DOENçAS QUE ENVOLVEM A PROLIFERAçãO DE CéLULAS. A presente invenção refere-se a uma composição farmacêutica para o tratamento de doenças que envolvem proliferação de célula. A invenção também refere-se a um método para o tratamento das ditas doenças, compreendendo co-administração de um composto 1 da Fórmula (I) em que os grupos L, R¬ ¹¬, R¬ ²¬, R¬ ³¬, R¬ 4¬ e R¬ 5¬ têm os significados dados nas reivindicações e relatório descritivo, opcionalmente na forma de seus tautómeros, racematos, diastereómeros e as misturas dos mesmos e opcionalmente na forma de sais de adição de ácido farmacologicamente aceitáveis, solvatos, hidratos, polimorfos, derivados fisiologicamente funcionais ou pró-drogas dos mesmos, e de uma quantidade eficaz de um composto ativo 2 e/ou co-tratamento com radioterapia em uma razão que provê um efeito aditivo e sinergístico, e ao uso combinado de um composto 1 da Fórmula (I) e de uma quantidade eficaz de um composto ativo 2 e/ou radioterapia para a fabricação de preparações de combinação farmacêutica correspondentes.
BRPI0514357-8A 2004-08-14 2005-08-09 combinações para o tratamento de doenças que envolvem a proliferação de células BRPI0514357A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04019361 2004-08-14
EP04019448 2004-08-17
PCT/EP2005/008623 WO2006018182A1 (en) 2004-08-14 2005-08-09 Combinations for the treatment of diseases involving cell proliferation

Publications (1)

Publication Number Publication Date
BRPI0514357A true BRPI0514357A (pt) 2008-06-10

Family

ID=35241347

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514357-8A BRPI0514357A (pt) 2004-08-14 2005-08-09 combinações para o tratamento de doenças que envolvem a proliferação de células

Country Status (26)

Country Link
US (3) US20060058311A1 (pt)
EP (2) EP1827441B1 (pt)
JP (1) JP5043660B2 (pt)
KR (1) KR101258426B1 (pt)
CN (1) CN101039673B (pt)
AR (1) AR050521A1 (pt)
AT (1) ATE512663T1 (pt)
AU (1) AU2005274384B2 (pt)
BR (1) BRPI0514357A (pt)
CA (1) CA2576269C (pt)
CY (1) CY1112200T1 (pt)
DK (2) DK1827441T3 (pt)
ES (1) ES2602465T3 (pt)
HR (1) HRP20110578T1 (pt)
HU (1) HUE032436T2 (pt)
IL (1) IL181305A (pt)
ME (1) ME01209B (pt)
MX (2) MX2007001853A (pt)
NZ (1) NZ553729A (pt)
PL (2) PL2275107T3 (pt)
PT (1) PT1827441E (pt)
RS (1) RS51807B (pt)
RU (2) RU2407532C9 (pt)
SI (1) SI1827441T1 (pt)
TW (2) TW201201810A (pt)
WO (1) WO2006018182A1 (pt)

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CN101039673B (zh) 2013-10-16
EP1827441B1 (en) 2011-06-15
KR101258426B1 (ko) 2013-04-30
EP1827441A1 (en) 2007-09-05
MX2007001853A (es) 2007-03-28
WO2006018182A8 (en) 2006-06-08
RU2407532C9 (ru) 2011-12-20
ATE512663T1 (de) 2011-07-15
NZ553729A (en) 2011-01-28
TWI361071B (en) 2012-04-01
KR20070050478A (ko) 2007-05-15
RU2407532C2 (ru) 2010-12-27
US8591895B2 (en) 2013-11-26
CN101039673A (zh) 2007-09-19
PT1827441E (pt) 2011-07-14
US20060058311A1 (en) 2006-03-16
TW201201810A (en) 2012-01-16
ES2602465T3 (es) 2017-02-21
DK2275107T3 (en) 2017-01-09
JP5043660B2 (ja) 2012-10-10
PL2275107T3 (pl) 2017-05-31
EP2275107A3 (en) 2013-06-26
RU2521394C2 (ru) 2014-06-27
JP2008509948A (ja) 2008-04-03
CA2576269C (en) 2014-01-28
RS51807B (en) 2011-12-31
US8143247B2 (en) 2012-03-27
SI1827441T1 (sl) 2011-09-30
MX340965B (es) 2016-08-02
US20120107312A1 (en) 2012-05-03

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