BRPI0514036A - composto, sais farmaceuticamente aceitáveis do mesmo, diastereÈmeros, enanciÈmeros ou misturas do mesmo, uso de um composto, composição farmacêutica, método para a terapia de depressão em um animal de sangue quente, e, processo para preparar um composto - Google Patents

composto, sais farmaceuticamente aceitáveis do mesmo, diastereÈmeros, enanciÈmeros ou misturas do mesmo, uso de um composto, composição farmacêutica, método para a terapia de depressão em um animal de sangue quente, e, processo para preparar um composto

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Publication number
BRPI0514036A
BRPI0514036A BRPI0514036-6A BRPI0514036A BRPI0514036A BR PI0514036 A BRPI0514036 A BR PI0514036A BR PI0514036 A BRPI0514036 A BR PI0514036A BR PI0514036 A BRPI0514036 A BR PI0514036A
Authority
BR
Brazil
Prior art keywords
compound
depression
therapy
diastereomers
enantiomers
Prior art date
Application number
BRPI0514036-6A
Other languages
English (en)
Inventor
James Folmer
Simon Fraser Hunt
Peter Hamley
Steven Wesolowski
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BRPI0514036A publication Critical patent/BRPI0514036A/pt

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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
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    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/182—Radicals derived from carboxylic acids
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
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    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

COMPOSTO, SAIS FARMACEUTICAMENTE ACEITáVEIS DO MESMO, DIASTEREóMEROS, ENANCIÈMEROS OU MISTURAS DO MESMO, USO DE UM COMPOSTO, COMPOSIçãO FARMACêUTICA, MéTODO PARA A TERAPIA DE DEPRESSãO EM UM ANIMAL DE SANGUE QUENTE, E, PROCESSO PARA PREPARAR UM COMPOSTO Compostos da fórmula: (fórmula química a ser inserida aqui-por favor vide cópia do relatório) I em que Ar¬ 1¬ é como definido no relatório, assim como os seus sais, enanciómeros dos mesmos, e composições terapêuticas incluindo os compostos são preparados. Eles são úteis em terapia, em particular no tratamento de depressão.
BRPI0514036-6A 2004-08-02 2005-07-27 composto, sais farmaceuticamente aceitáveis do mesmo, diastereÈmeros, enanciÈmeros ou misturas do mesmo, uso de um composto, composição farmacêutica, método para a terapia de depressão em um animal de sangue quente, e, processo para preparar um composto BRPI0514036A (pt)

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SE0401969A SE0401969D0 (sv) 2004-08-02 2004-08-02 Piperidine derivatives
PCT/SE2005/001187 WO2006014134A1 (en) 2004-08-02 2005-07-27 Novel piperidine derivative for the treatment of depression

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BRPI0514036A true BRPI0514036A (pt) 2008-05-27

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US (1) US20070191358A1 (pt)
EP (1) EP1781630A1 (pt)
JP (1) JP2008508351A (pt)
KR (1) KR20070038136A (pt)
CN (1) CN101014581A (pt)
AU (1) AU2005267930A1 (pt)
BR (1) BRPI0514036A (pt)
CA (1) CA2576073A1 (pt)
IL (1) IL180546A0 (pt)
MX (1) MX2007001225A (pt)
NO (1) NO20071137L (pt)
RU (1) RU2007105968A (pt)
SE (1) SE0401969D0 (pt)
WO (1) WO2006014134A1 (pt)
ZA (1) ZA200700685B (pt)

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JP6929276B2 (ja) 2015-10-06 2021-09-01 プロテオステイシス セラピューティクス，インコーポレイテッド 化合物、医薬的に許容される塩又はその立体異性体及び医薬組成物
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AU2005267930A1 (en) 2006-02-09
NO20071137L (no) 2007-04-19
ZA200700685B (en) 2008-09-25
CA2576073A1 (en) 2006-02-09
CN101014581A (zh) 2007-08-08
JP2008508351A (ja) 2008-03-21
MX2007001225A (es) 2007-03-23
SE0401969D0 (sv) 2004-08-02
WO2006014134A1 (en) 2006-02-09
RU2007105968A (ru) 2008-09-10
EP1781630A1 (en) 2007-05-09
IL180546A0 (en) 2007-06-03
KR20070038136A (ko) 2007-04-09

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