BRPI0515567A - combinações terapêuticas compreendendo inibidor de poli (adp-ribose) polimerase - Google Patents

combinações terapêuticas compreendendo inibidor de poli (adp-ribose) polimerase

Info

Publication number
BRPI0515567A
BRPI0515567A BRPI0515567-3A BRPI0515567A BRPI0515567A BR PI0515567 A BRPI0515567 A BR PI0515567A BR PI0515567 A BRPI0515567 A BR PI0515567A BR PI0515567 A BRPI0515567 A BR PI0515567A
Authority
BR
Brazil
Prior art keywords
combinations
adp
ribose
poly
polymerase inhibitor
Prior art date
Application number
BRPI0515567-3A
Other languages
English (en)
Inventor
Heidi Marie Steinfeldt
Theodore James Boritzki
Zdenek Hostomsky
Karen J Klamerus
Alan Hilary Calvert
Nicola Jane Curtin
Mohamed Raza Dewji
Chistopher Jones
Rhonda Kaufman
David Richard Newell
Elizabeth Ruth Plummer
Steven David Reich
Ian J Stratford
Huw David Thomas
Kaye Janine Williams
Original Assignee
Pfizer
Cancer Rec Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer, Cancer Rec Tech Ltd filed Critical Pfizer
Publication of BRPI0515567A publication Critical patent/BRPI0515567A/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/244—Lanthanides; Compounds thereof

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  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"COMBINAçõES TERAPêUTICAS COMPREENDENDO INBIDOR DE POLI (ADP-RIBOSE) POLIMERASE". Esta invenção está relacionada de modo geral ao uso de 8-flúor-2-{ 4 - ¢ (metilamino)metil! fenil) } -1,3,4,5-tetraidro-6H-azepino ¢5,4,3-cd! indol-6-ona representado pela Fórmula (1) como um químio-sensibilizador que aumenta o nível da eficácia das drogas citotóxicas ou da radioterapia. Essa invenção proporciona combinações farmacêuticas de 8-flúor-2- { 4 - ¢ (metilamino)metil} fenil } -1,3,4,5-tetraidro-6H-azepino ¢5,4,3-cd! indol-6-ona, ou um sal farmaceuticamente aceitável do mesmo e pelo menos um agente terapêutico adicional, kits contendo tais combinações e utilização de tais combinações para tratar indivíduos que sofrem de doenças tais como câncer.
BRPI0515567-3A 2004-09-22 2005-09-09 combinações terapêuticas compreendendo inibidor de poli (adp-ribose) polimerase BRPI0515567A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61245804P 2004-09-22 2004-09-22
US68300605P 2005-05-19 2005-05-19
PCT/IB2005/002900 WO2006033006A2 (en) 2004-09-22 2005-09-09 Therapeutic combinations comprising poly(adp-ribose) polymerases inhibitor

Publications (1)

Publication Number Publication Date
BRPI0515567A true BRPI0515567A (pt) 2008-07-29

Family

ID=35539252

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515567-3A BRPI0515567A (pt) 2004-09-22 2005-09-09 combinações terapêuticas compreendendo inibidor de poli (adp-ribose) polimerase

Country Status (15)

Country Link
US (1) US20060074073A1 (pt)
EP (1) EP1793830A2 (pt)
JP (1) JP2008513435A (pt)
KR (2) KR20090130156A (pt)
AR (1) AR051099A1 (pt)
AU (1) AU2005286190A1 (pt)
BR (1) BRPI0515567A (pt)
CA (1) CA2581200A1 (pt)
IL (1) IL181681A0 (pt)
MX (1) MX2007003314A (pt)
NO (1) NO20071512L (pt)
NZ (1) NZ553295A (pt)
RU (1) RU2361592C2 (pt)
TW (1) TW200626159A (pt)
WO (1) WO2006033006A2 (pt)

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NO20071512L (no) 2007-06-11
MX2007003314A (es) 2007-08-06
IL181681A0 (en) 2007-07-04
AU2005286190A1 (en) 2006-03-30
AR051099A1 (es) 2006-12-20
RU2361592C2 (ru) 2009-07-20
NZ553295A (en) 2010-04-30
EP1793830A2 (en) 2007-06-13
CA2581200A1 (en) 2006-03-30
WO2006033006A3 (en) 2006-07-06
KR20070046183A (ko) 2007-05-02
WO2006033006A2 (en) 2006-03-30
JP2008513435A (ja) 2008-05-01

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