MXPA04000411A - Tiazolidinonas arilo sustituidas y uso de las mismas. - Google Patents
Tiazolidinonas arilo sustituidas y uso de las mismas.Info
- Publication number
- MXPA04000411A MXPA04000411A MXPA04000411A MXPA04000411A MXPA04000411A MX PA04000411 A MXPA04000411 A MX PA04000411A MX PA04000411 A MXPA04000411 A MX PA04000411A MX PA04000411 A MXPA04000411 A MX PA04000411A MX PA04000411 A MXPA04000411 A MX PA04000411A
- Authority
- MX
- Mexico
- Prior art keywords
- treatment
- prevention
- formula
- aryl substituted
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
- C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
Esta invencion se refiere a tiazolidinonas arilo sustituidas de formula I (I) (ver formula) o una sal farmaceuticamente aceptable, o solvato de las mismas, en donde n es un entero de 1 a 2; R1 se selecciona del grupo que consiste de: (I) donde Y es alquileno y R3 y R4 son iguales o diferentes y se seleccionan de hidrogeno, alquilo o arilo, o R3 y R4 juntos forman una cadena de alquileno que tiene 4 a 5 atomos de carbono opcionalmente interrumpidos por un nitrogeno u oxigeno; (ii) piridilalquilo; y (iii) piperidin-4-ilo, fenilo opcionalmente sustituido; 2,2-difeniletenilo; furanilo; carbozolilo. La invencion esta dirigida tambien al uso de compuestos de formula (I) para el tratamiento de dano neuronal despues de isquemia global y focal, para el tratamiento o prevencion de condiciones neurodegenerativas tales como esclerosis lateral amiotrofica (ALS), y para el tratamiento, prevencion o mejora de dolor tanto agudo como cronico, como farmacos contra el trastorno maniaco depresivo como anestesicos locales, como antiarrltmicos y para el tratamiento o prevencion de neuropatia diabetica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30509901P | 2001-07-16 | 2001-07-16 | |
PCT/US2002/022367 WO2003008398A1 (en) | 2001-07-16 | 2002-07-16 | Aryl substituted thiazolidinones and the use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA04000411A true MXPA04000411A (es) | 2004-03-18 |
Family
ID=23179332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA04000411A MXPA04000411A (es) | 2001-07-16 | 2002-07-16 | Tiazolidinonas arilo sustituidas y uso de las mismas. |
Country Status (7)
Country | Link |
---|---|
US (2) | US7169782B2 (es) |
EP (1) | EP1417187A1 (es) |
JP (1) | JP2004538285A (es) |
CA (1) | CA2453633A1 (es) |
IL (1) | IL159765A0 (es) |
MX (1) | MXPA04000411A (es) |
WO (1) | WO2003008398A1 (es) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL159765A0 (en) * | 2001-07-16 | 2004-06-20 | Euro Celtique Sa | Aryl substituted thiazolidinone derivatives and pharmaceutical compositions containing the same |
PT1483247E (pt) * | 2002-03-13 | 2009-08-18 | Euro Celtique Sa | Pirimidinas substituídas por arilo e a sua utilização |
AU2003257033A1 (en) * | 2002-07-31 | 2004-02-16 | Euro-Celtique S.A. | Aryl substituted benzimidazoles and their use as sodium channel blockers |
US20050227974A9 (en) * | 2002-08-01 | 2005-10-13 | Euro-Celtique S.A. | Aminoalkyl-substituted aryl compounds and their use as sodium channel blockers |
US20040152696A1 (en) * | 2002-08-01 | 2004-08-05 | Euro-Celtique S.A. | 2-substituted bicyclic benzoheterocyclic compounds and their use as sodium channel blockers |
GB2396613A (en) * | 2002-08-23 | 2004-06-30 | Ionix Pharmaceuticals Ltd | Five-membered heterocyclic compounds in the treatment of chronic and acute pain |
CN102413828A (zh) * | 2009-05-12 | 2012-04-11 | 埃科特莱茵药品有限公司 | 作为食欲素受体拮抗剂的噻唑烷-4-酮和[1,3]-噻嗪烷-4-酮化合物 |
US9120752B2 (en) | 2010-07-16 | 2015-09-01 | Purdue Pharma, L.P. | Pyridine compounds as sodium channel blockers |
CA2811479A1 (en) | 2010-09-17 | 2012-03-22 | Purdue Pharma L.P. | Pyridine compounds and the uses thereof |
US9045435B2 (en) | 2010-10-05 | 2015-06-02 | Purdue Pharma, L.P. | Quinazoline compounds as sodium channel blockers |
AU2011346751A1 (en) | 2010-12-22 | 2013-05-02 | Purdue Pharma L.P. | Substituted pyridines as sodium channel blockers |
JP5941546B2 (ja) | 2011-09-02 | 2016-06-29 | パーデュー、ファーマ、リミテッド、パートナーシップ | ナトリウムチャネル遮断剤としてのピリミジン |
US9181185B2 (en) | 2011-10-31 | 2015-11-10 | Purdue Pharma L.P. | Heteroaryl compounds as sodium channel blockers |
US9388137B2 (en) | 2011-10-31 | 2016-07-12 | Purdue Pharma L.P. | Quaternized amines as sodium channel blockers |
WO2013072758A1 (en) | 2011-11-15 | 2013-05-23 | Purdue Pharma L.P. | Pyrimidine diol amides as sodium channel blockers |
CN103130793B (zh) * | 2011-11-30 | 2016-09-21 | 中国人民解放军军事医学科学院毒物药物研究所 | 3-(1-芳基哌啶-4-基)-2-芳基噻唑啉-4-酮类化合物、其制备方法及用途 |
WO2013136170A1 (en) | 2012-03-16 | 2013-09-19 | Purdue Pharma L.P. | Substituted pyridines as sodium channel blockers |
EP2935257B1 (en) | 2012-12-20 | 2018-02-07 | Purdue Pharma LP | Cyclic sulfonamides as sodium channel blockers |
US9120786B2 (en) | 2013-03-04 | 2015-09-01 | Purdue Pharma, L.P. | Triazine carboxamides as sodium channel blockers |
ES2680246T3 (es) | 2013-03-04 | 2018-09-05 | Purdue Pharma Lp | Pirimidincarboxamidas como bloqueantes de canal de sodio |
EP2968307A4 (en) | 2013-03-15 | 2017-01-04 | Purdue Pharma LP | Carboxamide derivatives and use thereof |
US9359330B2 (en) | 2013-08-26 | 2016-06-07 | Purdue Pharma L.P. | Substituted piperidines as sodium channel blockers |
US9884865B2 (en) | 2013-08-26 | 2018-02-06 | Purdue Pharma L.P. | Azaspiro[4.5] decane derivatives and use thereof |
US9828348B2 (en) | 2013-11-08 | 2017-11-28 | Purdue Pharma L.P. | Benzimidazole derivatives and use thereof |
US9340504B2 (en) | 2013-11-21 | 2016-05-17 | Purdue Pharma L.P. | Pyridine and piperidine derivatives as novel sodium channel blockers |
US9745287B2 (en) | 2013-12-20 | 2017-08-29 | Purdue Pharma L.P. | Pyrimidines and use thereof |
JP6337124B2 (ja) | 2013-12-23 | 2018-06-06 | パーデュー、ファーマ、リミテッド、パートナーシップ | インダゾール及びその使用 |
US9695144B2 (en) | 2013-12-23 | 2017-07-04 | Purdue Pharma L.P. | Dibenzazepine derivatives and use thereof |
EP3089978B1 (en) | 2013-12-30 | 2018-08-29 | Purdue Pharma L.P. | Pyridone-sulfone morphinan analogs as opioid receptor ligands |
EP3097078B1 (en) | 2014-01-24 | 2022-05-25 | Purdue Pharma LP | Pyridines and pyrimidines and use thereof |
US10738026B2 (en) | 2014-02-12 | 2020-08-11 | Purdue Pharma L.P. | Isoquinoline derivatives and use thereof |
US10730866B2 (en) | 2014-04-07 | 2020-08-04 | Purdue Pharma L.P. | Indole derivatives and use thereof |
CA2948144A1 (en) | 2014-05-06 | 2015-11-12 | Purdue Pharma L.P. | Benzomorphan analogs and use thereof |
MA40170A (fr) | 2014-06-13 | 2017-04-19 | Purdue Pharma Lp | Dérivés hétérocycliques de morphinan et leur utilisation |
EP3154972A4 (en) | 2014-06-13 | 2017-11-22 | Purdue Pharma L.P. | Azamophinan derivatives and use thereof |
CN107613965A (zh) | 2015-02-19 | 2018-01-19 | 普渡制药公司 | 用于减少胃排空的方法和组合物 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US40025A (en) * | 1863-09-22 | Improvement in wheel-vehicles | ||
US6947A (en) * | 1849-12-11 | Self-acting car-coupling | ||
US55088A (en) * | 1866-05-29 | Improved buckle | ||
US3309377A (en) * | 1964-10-19 | 1967-03-14 | Sterling Drug Inc | 3-[(2-oxazolidinone-3-yl)-alkyl]-4-thiazolidinones and their preparation |
US3377355A (en) * | 1967-06-30 | 1968-04-09 | Sterling Drug Inc | 4-thiazolidones and oxide derivatives thereof |
CH548411A (de) | 1971-12-06 | 1974-04-30 | Ciba Geigy Ag | Verfahren zur herstellung von neuen 1,1-dioxothiazolidin4-onen. |
JPS5764685A (en) * | 1980-10-09 | 1982-04-19 | Kureha Chem Ind Co Ltd | 2-(substituted phenyl)-1,3-thiazin-4(3,5,6h)-one and remedy for peptic ulcer containing said compound as active component |
US4992455A (en) | 1987-05-22 | 1991-02-12 | Sumitomo Pharmaceuticals Company, Limited | Thiazolidin-4-one derivatives useful for treating diseases caused by platelet activating factor |
ES2052675T3 (es) * | 1987-11-20 | 1994-07-16 | Hoechst Roussel Pharma | 3-(4-piperazinil-sustituido en 1)butil)-4-tiazolidinonas, un procedimiento para su preparacion y su uso como medicamentos. |
US5061720A (en) * | 1989-09-13 | 1991-10-29 | A. H. Robins Company, Inc. | Substituted-4-thiazolidinone derivatives |
CZ14294A3 (en) | 1991-07-23 | 1994-07-13 | Schering Corp | Substituted beta-lactam compounds usable as hypocholesterol pharmaceutical preparations and process for preparing thereof |
KR100262419B1 (ko) | 1993-06-23 | 2000-09-01 | 나가야마 오사무 | 허혈성 질환에 유용한 벤젠 유도체 |
CA2157348A1 (en) | 1994-09-01 | 1996-03-02 | Aventis Pharmaceuticals Inc. | 3-¬4-(1-substituted-4-piperazinyl)butyl|-4-thiazolidinone and related compounds |
CA2334258A1 (en) | 1998-06-05 | 1999-12-09 | Icagen, Inc. | Potassium channel inhibitors |
WO2000057877A1 (en) * | 1999-03-26 | 2000-10-05 | Euro-Celtique S.A. | Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof |
AU4249700A (en) | 1999-04-19 | 2000-11-02 | Sumitomo Pharmaceuticals Company, Limited | Hydroxamic acid derivative |
AR029489A1 (es) * | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
CN1321112C (zh) * | 2000-03-24 | 2007-06-13 | 欧洲凯尔特股份有限公司 | 作为钠通道阻滞剂的芳基取代的吡唑、三唑和四唑化合物 |
MXPA02009619A (es) * | 2000-03-31 | 2004-07-30 | Eruro Celtique S A | Aminopiridinas y su uso como anticonvulsivos y bloqueadores del canal de sodio. |
IL159765A0 (en) * | 2001-07-16 | 2004-06-20 | Euro Celtique Sa | Aryl substituted thiazolidinone derivatives and pharmaceutical compositions containing the same |
AR037233A1 (es) * | 2001-09-07 | 2004-11-03 | Euro Celtique Sa | Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento |
AR036873A1 (es) * | 2001-09-07 | 2004-10-13 | Euro Celtique Sa | Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento |
PT1483247E (pt) * | 2002-03-13 | 2009-08-18 | Euro Celtique Sa | Pirimidinas substituídas por arilo e a sua utilização |
-
2002
- 2002-07-16 IL IL15976502A patent/IL159765A0/xx unknown
- 2002-07-16 MX MXPA04000411A patent/MXPA04000411A/es unknown
- 2002-07-16 US US10/195,530 patent/US7169782B2/en not_active Expired - Lifetime
- 2002-07-16 CA CA002453633A patent/CA2453633A1/en not_active Abandoned
- 2002-07-16 EP EP02763275A patent/EP1417187A1/en not_active Withdrawn
- 2002-07-16 WO PCT/US2002/022367 patent/WO2003008398A1/en not_active Application Discontinuation
- 2002-07-16 JP JP2003513957A patent/JP2004538285A/ja not_active Withdrawn
-
2004
- 2004-03-18 US US10/802,765 patent/US20040176364A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1417187A1 (en) | 2004-05-12 |
WO2003008398A1 (en) | 2003-01-30 |
JP2004538285A (ja) | 2004-12-24 |
US20040176364A1 (en) | 2004-09-09 |
US20030109521A1 (en) | 2003-06-12 |
IL159765A0 (en) | 2004-06-20 |
US7169782B2 (en) | 2007-01-30 |
CA2453633A1 (en) | 2003-01-30 |
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