MX2015007406A - NUEVOS COMPUESTOS BICICLICOS Y SU USO COMO AGENTES ANTIBACTERIANOS E INHIBIDORES DE ß-LACTAMASA. - Google Patents

NUEVOS COMPUESTOS BICICLICOS Y SU USO COMO AGENTES ANTIBACTERIANOS E INHIBIDORES DE ß-LACTAMASA.

Info

Publication number
MX2015007406A
MX2015007406A MX2015007406A MX2015007406A MX2015007406A MX 2015007406 A MX2015007406 A MX 2015007406A MX 2015007406 A MX2015007406 A MX 2015007406A MX 2015007406 A MX2015007406 A MX 2015007406A MX 2015007406 A MX2015007406 A MX 2015007406A
Authority
MX
Mexico
Prior art keywords
antibacterial agents
lactamase inhibitors
bicyclic compounds
new bicyclic
new
Prior art date
Application number
MX2015007406A
Other languages
English (en)
Inventor
Samarendra N Maiti
Jehangir Khan
Dai Nguyen
Rong Ling
Original Assignee
Fedora Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fedora Pharmaceuticals Inc filed Critical Fedora Pharmaceuticals Inc
Publication of MX2015007406A publication Critical patent/MX2015007406A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un compuesto de Fórmula (I) (ver Fórmula) en donde: M es hidrógeno o un catión formador de sales farmacéuticamente aceptable; Y es OR1 o NR2R3. Y R1, R2, R3 y M son se definen en el presente documento. Además, los métodos de tratamiento de la infección bacteriana, composiciones farmacéuticas, complejos moleculares y procesos para la preparación de compuestos.
MX2015007406A 2012-12-11 2012-12-11 NUEVOS COMPUESTOS BICICLICOS Y SU USO COMO AGENTES ANTIBACTERIANOS E INHIBIDORES DE ß-LACTAMASA. MX2015007406A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2012/002675 WO2014091268A1 (en) 2012-12-11 2012-12-11 NEW BICYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND β-LACTAMASE INHIBITORS

Publications (1)

Publication Number Publication Date
MX2015007406A true MX2015007406A (es) 2015-12-03

Family

ID=50933808

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015007406A MX2015007406A (es) 2012-12-11 2012-12-11 NUEVOS COMPUESTOS BICICLICOS Y SU USO COMO AGENTES ANTIBACTERIANOS E INHIBIDORES DE ß-LACTAMASA.

Country Status (18)

Country Link
EP (1) EP2931723B1 (es)
JP (1) JP2016503000A (es)
KR (1) KR20150093809A (es)
CN (1) CN105873930B (es)
AU (1) AU2012396338B2 (es)
BR (1) BR112015013450A8 (es)
CA (1) CA2893804C (es)
CR (1) CR20150359A (es)
EA (1) EA028633B1 (es)
EC (1) ECSP15029636A (es)
ES (1) ES2817785T3 (es)
IL (1) IL239116B (es)
MA (1) MA38227B1 (es)
MX (1) MX2015007406A (es)
PH (1) PH12015501303A1 (es)
SG (1) SG11201504540TA (es)
UA (1) UA111925C2 (es)
WO (1) WO2014091268A1 (es)

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CN105801579A (zh) * 2014-12-31 2016-07-27 卢来春 一种β-内酰胺酶抑制剂
WO2016120752A1 (en) * 2015-01-28 2016-08-04 Wockhardt Limited A process for preparation of (2s, 5r)-n-(2-amino ethoxy)-6-(sulfooxy)-7-oxo-1,6- diazabicyclo [3.2.1] octane-2-carboxamide
WO2017002087A1 (en) * 2015-07-02 2017-01-05 Wockhardtlimited Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
KR20170131661A (ko) 2015-09-16 2017-11-29 수안주 파마 코포레이션 리미티드 β-락타메이즈 억제제 및 이의 용도
US9951072B2 (en) 2015-10-02 2018-04-24 Legochem Biosciences, Inc. Compositions and methods for inhibiting beta-lactamase
US20180282331A1 (en) * 2015-11-09 2018-10-04 Wockhardt Limited 7-Oxo -6-(sulfooxy)- 1,6-diazabicyclo [3.2.1] octane containing compounds and their use in treatment of bacterial infections (changed by PCT to: 7-OXO -6-(SULFOOXY)- 1,6-DIAZABICYCLO [3.2.1] OCTANE CONTAINING COMPOUNDS AND THEIR USE IN TREATMENT OF BACTERIAL INFECTIONS
EP3386982A1 (en) * 2015-12-11 2018-10-17 The Wockhardt Limited 7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide containing compounds and their use in treating bacterial infections
CN109563144B (zh) 2016-06-01 2023-03-28 雅斯娜 化合物
WO2017206948A1 (zh) * 2016-06-03 2017-12-07 南京明德新药研发股份有限公司 新型二氮杂二环β-内酰胺酶抑制剂
SG11201810725WA (en) * 2016-06-03 2018-12-28 Medshine Discovery Inc Novel β-lactamase inhibitors
WO2017216764A1 (en) * 2016-06-17 2017-12-21 Wockhardt Limited N-(alkanoyl)-7-oxo-6-sulfooxy-1,6-diazabicyclo[3.2.1]octane-2-carbonylhydrazide derivatives and their use as antibacterial agents
WO2017216763A1 (en) * 2016-06-17 2017-12-21 Wockhardt Limited N-phenylalkoxy-7-oxo-6-sulfooxy-1,6-diazabicyclo[3.2.1]octane-2-carboxamide derivatives and their use as antibacterial agents
CN110352194A (zh) * 2017-03-02 2019-10-18 沃克哈特有限公司 用作抗菌化合物的杂环衍生物
CN106831772B (zh) * 2017-03-04 2019-12-17 丽珠医药集团股份有限公司 一种阿维巴坦中间体的合成方法
WO2018203194A1 (en) * 2017-05-02 2018-11-08 Wockhardt Limited Diazabicyclooctane derivatives comprising a quaternery ammonium group for use as antibacterial agents
WO2018203197A1 (en) * 2017-05-02 2018-11-08 Wockhardt Limited Diazabicyclooctane derivatives comprising an oxyimino group for use as antibacterial agents
CN107383034A (zh) * 2017-06-29 2017-11-24 上海药明康德新药开发有限公司 外消旋‑5‑(叔丁氧羰基)‑八氢呋喃并[3,2‑c]吡啶‑3a‑羧酸的合成方法
CA3070036A1 (en) 2017-07-21 2019-01-24 Antabio Sas Chemical compounds
WO2019064071A1 (en) * 2017-09-27 2019-04-04 F. Hoffmann-La Roche Ag CRYSTALLINE FORMS OF DIAZABICYCLOOCTANE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
US11180501B2 (en) 2017-12-01 2021-11-23 Qilu Pharmaceutical Co., Ltd. Crystal form of β-lactamase inhibitor and preparation method therefor
EP3572411A1 (en) 2018-05-21 2019-11-27 Antabio SAS Thiazole derivatives as metallo-beta-lactamase inhibitors
TWI764030B (zh) * 2018-08-09 2022-05-11 法商安塔比奧公司 化合物
EP3608318A1 (en) * 2018-08-09 2020-02-12 Antabio SAS Diaazabicyclooctanone derivatives as antibacterials
US11905286B2 (en) 2018-08-09 2024-02-20 Antabio Sas Diazabicyclooctanones as inhibitors of serine beta-lactamases
CN113292499B (zh) * 2020-02-24 2024-05-28 齐鲁制药有限公司 一种β-内酰胺酶抑制剂的新制备方法及其中间体
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Also Published As

Publication number Publication date
IL239116A0 (en) 2015-07-30
NZ709355A (en) 2017-09-29
JP2016503000A (ja) 2016-02-01
KR20150093809A (ko) 2015-08-18
SG11201504540TA (en) 2015-07-30
CR20150359A (es) 2015-08-20
CA2893804A1 (en) 2014-06-19
PH12015501303A1 (en) 2015-08-24
EA028633B1 (ru) 2017-12-29
WO2014091268A1 (en) 2014-06-19
CA2893804C (en) 2021-05-18
CN105873930A (zh) 2016-08-17
BR112015013450A2 (pt) 2017-07-11
UA111925C2 (uk) 2016-06-24
EP2931723B1 (en) 2020-08-26
ECSP15029636A (es) 2016-01-29
CN105873930B (zh) 2019-02-19
MA38227B1 (fr) 2017-10-31
IL239116B (en) 2019-05-30
MA38227A1 (fr) 2016-12-30
EA201500544A1 (ru) 2015-12-30
BR112015013450A8 (pt) 2019-10-08
EP2931723A1 (en) 2015-10-21
EP2931723A4 (en) 2016-06-01
ES2817785T3 (es) 2021-04-08
AU2012396338B2 (en) 2017-09-28
AU2012396338A1 (en) 2015-07-16

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