CU24441B1 - Compuestos orgánicos de monobactam para el tratamiento de infecciones bacterianas - Google Patents
Compuestos orgánicos de monobactam para el tratamiento de infecciones bacterianasInfo
- Publication number
- CU24441B1 CU24441B1 CU2016000131A CU20160131A CU24441B1 CU 24441 B1 CU24441 B1 CU 24441B1 CU 2016000131 A CU2016000131 A CU 2016000131A CU 20160131 A CU20160131 A CU 20160131A CU 24441 B1 CU24441 B1 CU 24441B1
- Authority
- CU
- Cuba
- Prior art keywords
- bacterial infections
- organic
- treatment
- compounds
- monobactam compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
<p>Esta invención se refiere en general a compuestos antibacterianos de Ia Formula I,</p> <p>ESPACIO PARA FÓRMULA</p> <p>como se describe adicionalmente en este documento, y las sales trifluoroacetato y formato de los mismos. Los compuestos de la presente invención son activos para tratar infecciones bacterianas tales como las causadas por bacterias Gram-negativas.</p>
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461969735P | 2014-03-24 | 2014-03-24 | |
US201462088304P | 2014-12-05 | 2014-12-05 | |
PCT/US2015/022011 WO2015148379A1 (en) | 2014-03-24 | 2015-03-23 | Monobactam organic compounds for the treatment of bacterial infections |
Publications (2)
Publication Number | Publication Date |
---|---|
CU20160131A7 CU20160131A7 (es) | 2017-02-02 |
CU24441B1 true CU24441B1 (es) | 2019-09-04 |
Family
ID=52808201
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU2016000131A CU24441B1 (es) | 2014-03-24 | 2015-03-23 | Compuestos orgánicos de monobactam para el tratamiento de infecciones bacterianas |
Country Status (36)
Country | Link |
---|---|
US (4) | US9174978B2 (es) |
EP (2) | EP3122745B1 (es) |
JP (1) | JP6153674B2 (es) |
KR (1) | KR101733441B1 (es) |
CN (1) | CN106164072B (es) |
AP (1) | AP2016009374A0 (es) |
AU (1) | AU2015236369B2 (es) |
BR (1) | BR112016020333B1 (es) |
CA (1) | CA2939254C (es) |
CL (1) | CL2016002285A1 (es) |
CU (1) | CU24441B1 (es) |
CY (1) | CY1121701T1 (es) |
DK (2) | DK3511328T3 (es) |
EA (1) | EA030850B1 (es) |
EC (1) | ECSP16073620A (es) |
ES (2) | ES2719136T3 (es) |
GT (1) | GT201600183A (es) |
HR (1) | HRP20190501T1 (es) |
HU (1) | HUE042134T2 (es) |
IL (1) | IL247259B (es) |
LT (1) | LT3122745T (es) |
MA (1) | MA39777B1 (es) |
MX (1) | MX2016011822A (es) |
MY (1) | MY179292A (es) |
PE (1) | PE20161371A1 (es) |
PH (1) | PH12016501577A1 (es) |
PL (1) | PL3122745T3 (es) |
PT (1) | PT3122745T (es) |
RS (1) | RS58509B1 (es) |
SG (1) | SG11201606711UA (es) |
SI (1) | SI3122745T1 (es) |
SV (1) | SV2016005274A (es) |
TW (1) | TWI714525B (es) |
UA (1) | UA121383C2 (es) |
WO (1) | WO2015148379A1 (es) |
ZA (1) | ZA201605565B (es) |
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EA202092620A1 (ru) * | 2015-09-23 | 2021-06-30 | Новартис Аг | Соли и твердые формы монобактамного антибиотика |
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BR112018010962A8 (pt) * | 2015-12-15 | 2023-04-11 | Merck Sharp & Dohme | Composto, sal de ácido trifluoroacético, composição farmacêutica, método para tratar uma infecção bacteriana, e, uso de um composto |
BR112018067930B1 (pt) | 2016-03-07 | 2024-02-15 | Merck Sharp & Dohme Llc | Composto, sal de ácido trifluoroacético, composição farmacêutica, e, uso de um composto |
JP7306997B2 (ja) | 2017-03-20 | 2023-07-11 | ザ・ブロード・インスティテュート・インコーポレイテッド | 寄生虫性疾患の処置のための化合物および方法 |
JP7235718B2 (ja) * | 2017-08-02 | 2023-03-08 | ノバルティス アーゲー | モノバクタム系抗生物質およびその中間体を製造するための化学的方法 |
WO2019058346A1 (en) * | 2017-09-22 | 2019-03-28 | Novartis Ag | MONOBACTAM ADMINISTRATION IN ASSOCIATION WITH ANTIBIOTIC AGENT FOR THE TREATMENT OF COMPLICATED INTRA-ABDOMINAL INFECTION |
JP6991345B2 (ja) * | 2017-10-02 | 2022-01-12 | アリクサ ファーマシューティカルズ、インコーポレイテッド | アズトレオナム誘導体およびその使用 |
PE20201256A1 (es) | 2017-10-02 | 2020-11-16 | Merck Sharp & Dohme | Compuestos monobactamicos cromanos para el tratamiento de infecciones bacterianas |
US20200360349A1 (en) * | 2017-11-10 | 2020-11-19 | Novartis Ag | Administration of monobactam for the treatment of urinary tract infection |
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