BR112015014458A8 - compostos derivados de manose, seus intermediários, composição, uso e processos de preparação - Google Patents

compostos derivados de manose, seus intermediários, composição, uso e processos de preparação Download PDF

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Publication number
BR112015014458A8
BR112015014458A8 BR112015014458A BR112015014458A BR112015014458A8 BR 112015014458 A8 BR112015014458 A8 BR 112015014458A8 BR 112015014458 A BR112015014458 A BR 112015014458A BR 112015014458 A BR112015014458 A BR 112015014458A BR 112015014458 A8 BR112015014458 A8 BR 112015014458A8
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Brazil
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intermediates
composition
compounds
preparation processes
mannose derivatives
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BR112015014458A
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BR112015014458B1 (pt
BR112015014458A2 (pt
Inventor
Liu Bingcan
Poisson Carl
Cadilhac Caroline
Dietrich Evelyne
Vallee Frederic
Martel Julien
Vaillancourt Louis
Gallant Michel
Kumar Das Sanjoy
Jagadeeswar Reddy Thumkunta
K Ramtohul Yeeman
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Vertex Pharma
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Publication of BR112015014458A2 publication Critical patent/BR112015014458A2/pt
Publication of BR112015014458A8 publication Critical patent/BR112015014458A8/pt
Publication of BR112015014458B1 publication Critical patent/BR112015014458B1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
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  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
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  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"derivados de manose para o tratamento de infecções bacterianas". a presente invenção refere-se a compostos úteis para o tratamento ou prevenção de infecções por bactérias. estes compostos têm a fórmula (i). a invenção também fornece composições farmaceuticamente aceitáveis contendo os compostos e métodos de uso das composições no tratamento de infecções por bactérias. finalmente, a invenção fornece processos para a preparação de compostos da invenção.
BR112015014458-6A 2012-12-18 2013-12-18 Compostos derivados de manose, seus intermediários, composição, uso e processos de preparação BR112015014458B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261738620P 2012-12-18 2012-12-18
US61/738,620 2012-12-18
US201361788241P 2013-03-15 2013-03-15
US61/788,241 2013-03-15
US201361874501P 2013-09-06 2013-09-06
US61/874,501 2013-09-06
PCT/US2013/076086 WO2014100158A1 (en) 2012-12-18 2013-12-18 Mannose derivatives for treating bacterial infections

Publications (3)

Publication Number Publication Date
BR112015014458A2 BR112015014458A2 (pt) 2017-07-11
BR112015014458A8 true BR112015014458A8 (pt) 2019-10-15
BR112015014458B1 BR112015014458B1 (pt) 2022-06-21

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CA2894536A1 (en) 2014-06-26
CN104936969B (zh) 2018-08-17
US20160235775A1 (en) 2016-08-18
BR112015014458A2 (pt) 2017-07-11
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CN104936969A (zh) 2015-09-23
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IL239481A0 (en) 2015-07-30
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US10669298B2 (en) 2020-06-02
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US10913761B2 (en) 2021-02-09
US9598454B2 (en) 2017-03-21
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