MA33636B1 - Dérivés aminopropioniques substitués comme inhibiteurs de néprilysine - Google Patents

Dérivés aminopropioniques substitués comme inhibiteurs de néprilysine

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Publication number
MA33636B1
MA33636B1 MA34458A MA34458A MA33636B1 MA 33636 B1 MA33636 B1 MA 33636B1 MA 34458 A MA34458 A MA 34458A MA 34458 A MA34458 A MA 34458A MA 33636 B1 MA33636 B1 MA 33636B1
Authority
MA
Morocco
Prior art keywords
neprilysine
inhibitors
substituted aminopropionic
derivatives
relates
Prior art date
Application number
MA34458A
Other languages
Arabic (ar)
English (en)
Inventor
Rajeshri Ganesh Karki
Gary Mark Coppola
Yuki Iwaki
Toshio Kawanami
Gary Michael Ksander
Muneto Mogi
Robert Sun
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42313042&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33636(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA33636B1 publication Critical patent/MA33636B1/fr

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    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • C07C233/49—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
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Abstract

La présente invention porte sur un composé de formule i' ou d'un sel acceptable sur le plan pharmaceutique dudit composé et dans laquelle formule r1, r2, r3, r5, b1, x et n sont tels que définis dans la description. L'invention porte également sur un procédé pour la fabrication des composés de l'invention et sur leurs utilisations thérapeutiques. La présente invention porte en outre sur une association d'agents actifs et sur une composition pharmaceutique.
MA34458A 2009-05-28 2011-12-16 Dérivés aminopropioniques substitués comme inhibiteurs de néprilysine MA33636B1 (fr)

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US18175609P 2009-05-28 2009-05-28
US26314509P 2009-11-20 2009-11-20
US32494310P 2010-04-16 2010-04-16
PCT/EP2010/057247 WO2010136493A1 (fr) 2009-05-28 2010-05-26 Dérivés aminopropioniques substitués comme inhibiteurs de néprilysine

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EA201101671A1 (ru) 2012-07-30
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