CL2011002990A1 - Compuestos derivados de bifenilo, inhibidores de endopeptidasa neutra (nep); composición farmacéutica; combinación farmacéutica; uso del compuesto para tratar un trastorno o enfermedad tal como la hipertensión, insuficiencia cardiaca, insuficiencia renal, glaucoma, trastornos reproductivos, entre otros. - Google Patents

Compuestos derivados de bifenilo, inhibidores de endopeptidasa neutra (nep); composición farmacéutica; combinación farmacéutica; uso del compuesto para tratar un trastorno o enfermedad tal como la hipertensión, insuficiencia cardiaca, insuficiencia renal, glaucoma, trastornos reproductivos, entre otros.

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Publication number
CL2011002990A1
CL2011002990A1 CL2011002990A CL2011002990A CL2011002990A1 CL 2011002990 A1 CL2011002990 A1 CL 2011002990A1 CL 2011002990 A CL2011002990 A CL 2011002990A CL 2011002990 A CL2011002990 A CL 2011002990A CL 2011002990 A1 CL2011002990 A1 CL 2011002990A1
Authority
CL
Chile
Prior art keywords
nep
glaucoma
hypertension
inhibitors
compound
Prior art date
Application number
CL2011002990A
Other languages
English (en)
Inventor
Gary Mark Coppola
Yuki Iwaki
Rajeshri Ganesh Karki
Toshio Kawanami
Gary Michael Ksander
Muneto Mogi
Robert Sun
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42313042&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2011002990(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2011002990A1 publication Critical patent/CL2011002990A1/es

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    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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Abstract

LA PRESENTE INVENCIÓN PROPORCIONA COMPUESTOS DERIVADOS DE BIFENILO INHIBIDORES DE LA ENDOPEPTIDASA NEUTRA (NEP ) ; COMPOSICIÓN FARMACÉUTICA ; COMBINACIÓN FARMA ÉUTICA; USO DEL COMPUESTO PARA TRATAR TRASTORNO O ENFERMEDAD TAL COMO HIPERTENSIÓN , INSUFICIENCIA CARDIACA , INSUFICIENCIA RENAL , GLAUCOMA , TRASTORNOS REPRODUCTIVOS , ENTRE OTROS , EL CUAL TIENE LA FÓRMULA I' ; EN DONDE R1 , R2, R3, R5, B1 , X Y N SON C OMO SE DEFINEN EN LA PRESENTE .<br />  
CL2011002990A 2009-05-28 2011-11-25 Compuestos derivados de bifenilo, inhibidores de endopeptidasa neutra (nep); composición farmacéutica; combinación farmacéutica; uso del compuesto para tratar un trastorno o enfermedad tal como la hipertensión, insuficiencia cardiaca, insuficiencia renal, glaucoma, trastornos reproductivos, entre otros. CL2011002990A1 (es)

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US26314509P 2009-11-20 2009-11-20
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CL2011002990A1 true CL2011002990A1 (es) 2012-08-31

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CL2011002990A CL2011002990A1 (es) 2009-05-28 2011-11-25 Compuestos derivados de bifenilo, inhibidores de endopeptidasa neutra (nep); composición farmacéutica; combinación farmacéutica; uso del compuesto para tratar un trastorno o enfermedad tal como la hipertensión, insuficiencia cardiaca, insuficiencia renal, glaucoma, trastornos reproductivos, entre otros.

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