WO1999026922A1 - Derives de pyrrole a substitution tenant lieu d'inhibiteurs d'adhesion cellulaire - Google Patents
Derives de pyrrole a substitution tenant lieu d'inhibiteurs d'adhesion cellulaire Download PDFInfo
- Publication number
- WO1999026922A1 WO1999026922A1 PCT/US1998/024635 US9824635W WO9926922A1 WO 1999026922 A1 WO1999026922 A1 WO 1999026922A1 US 9824635 W US9824635 W US 9824635W WO 9926922 A1 WO9926922 A1 WO 9926922A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- independently selected
- optionally substituted
- mammal
- ioalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
L'invention concerne des dérivés de pyrrole à substitution représentés par la formule (I), qui sont des antagonistes pour VLA-4 et/ou α4β7, agissant donc utilement dans l'inhibition ou la prévention de l'adhésion cellulaire et des pathologies dont la médiation est assurée par cette adhésion. Les composés considérés peuvent être formulés en compositions pharmaceutiques appropriées au traitement de l'asthme, de l'allergie, de l'inflammation, de la sclérose en plaques et autres maladies inflammatoires et auto-immunes.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU14634/99A AU1463499A (en) | 1997-11-21 | 1998-11-18 | Substituted pyrrole derivatives as cell adhesion inhibitors |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6636697P | 1997-11-21 | 1997-11-21 | |
US60/066,366 | 1997-11-21 | ||
GBGB9804400.1A GB9804400D0 (en) | 1998-03-02 | 1998-03-02 | Substituted pyrrole derivatives as cell adhesion inhibitors |
GB9804400.1 | 1998-03-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999026922A1 true WO1999026922A1 (fr) | 1999-06-03 |
Family
ID=26313205
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/024635 WO1999026922A1 (fr) | 1997-11-21 | 1998-11-18 | Derives de pyrrole a substitution tenant lieu d'inhibiteurs d'adhesion cellulaire |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU1463499A (fr) |
WO (1) | WO1999026922A1 (fr) |
Cited By (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2354440A (en) * | 1999-07-20 | 2001-03-28 | Merck & Co Inc | Aryl amides as cell adhesion inhibitors |
US6329362B1 (en) | 1998-03-16 | 2001-12-11 | Celltech Therapeutics Limited | Cinnamic acid derivatives |
US6403608B1 (en) | 2000-05-30 | 2002-06-11 | Celltech R&D, Ltd. | 3-Substituted isoquinolin-1-yl derivatives |
US6455539B2 (en) | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
US6465471B1 (en) | 1998-07-03 | 2002-10-15 | Celltech Therapeutics Limited | Cinnamic acid derivatives |
US6469025B1 (en) | 2000-08-02 | 2002-10-22 | Celltech R&D Ltd. | 3-substituted isoquinolin-1-yl derivatives |
US6482849B1 (en) | 1997-06-23 | 2002-11-19 | Tanabe Seiyaku Co., Ltd. | Inhibitors of α4β1 mediated cell adhesion |
US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
US6521666B1 (en) | 1998-01-20 | 2003-02-18 | Tanabe Seiyaku Co., Ltd. | Inhibitors of α4 mediated cell adhesion |
US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
US6534513B1 (en) | 1999-09-29 | 2003-03-18 | Celltech R&D Limited | Phenylalkanoic acid derivatives |
US6545013B2 (en) | 2000-05-30 | 2003-04-08 | Celltech R&D Limited | 2,7-naphthyridine derivatives |
US6610700B2 (en) | 2000-04-17 | 2003-08-26 | Celltech R & D Limited | Enamine derivatives |
US6630503B1 (en) | 1999-08-13 | 2003-10-07 | Biogen, Inc. | Cell adhesion inhibitors |
US6667331B2 (en) | 1999-12-28 | 2003-12-23 | Pfizer Inc | Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases |
US6677339B2 (en) | 1998-09-28 | 2004-01-13 | Celltech R & D Limited | Phenylalanine derivatives |
US6685617B1 (en) | 1998-06-23 | 2004-02-03 | Pharmacia & Upjohn Company | Inhibitors of α4β1 mediated cell adhesion |
US6740654B2 (en) | 2000-07-07 | 2004-05-25 | Celltech R & D Limited | Squaric acid derivatives |
US6953798B1 (en) | 1998-11-30 | 2005-10-11 | Celltech R&D Limited | β-alanine derivates |
JP2005535710A (ja) * | 2002-08-09 | 2005-11-24 | トランス テック ファーマ,インコーポレイテッド | アリールおよびヘテロアリール化合物ならびに凝固を調節する方法 |
US7026501B2 (en) | 2000-08-31 | 2006-04-11 | Tanabe Seiyaku Co., Ltd. | Inhibitors of α4 mediated cell adhesion |
US7196112B2 (en) | 2004-07-16 | 2007-03-27 | Biogen Idec Ma Inc. | Cell adhesion inhibitors |
WO2009126920A2 (fr) | 2008-04-11 | 2009-10-15 | Merrimack Pharmaceuticals, Inc. | Lieurs d'albumine de sérum humain, et ses conjugués |
US8222286B2 (en) | 2009-11-20 | 2012-07-17 | Novartis Ag | Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors |
US8263629B2 (en) | 2009-05-28 | 2012-09-11 | Novartis Ag | Substituted aminobutyric derivatives as neprilysin inhibitors |
EP2510941A2 (fr) | 2007-02-20 | 2012-10-17 | Merrimack Pharmaceuticals, Inc. | Procédés de traitement de la sclérose en plaques par administration d'une alpha-foetoprotéine combinée à un antagoniste de l'intégrine |
US8394853B2 (en) | 2009-05-28 | 2013-03-12 | Novartis Ag | Substituted aminopropionic derivatives as neprilysin inhibitors |
US9102635B2 (en) | 2013-02-14 | 2015-08-11 | Novartis Ag | Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo efficacy |
US9163040B2 (en) | 2013-02-14 | 2015-10-20 | Novartis Ag | Substituted bisphenyl butanoic phosphonic acid derivatives as NEP inhibitors |
-
1998
- 1998-11-18 AU AU14634/99A patent/AU1463499A/en not_active Abandoned
- 1998-11-18 WO PCT/US1998/024635 patent/WO1999026922A1/fr active Application Filing
Non-Patent Citations (1)
Title |
---|
ARTICO et al., "Synthesis of Pyrryl Aryl Sulfones", ARCH. PHARM., December 1995, Vol. 328, No. 3, pages 223-229. * |
Cited By (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6482849B1 (en) | 1997-06-23 | 2002-11-19 | Tanabe Seiyaku Co., Ltd. | Inhibitors of α4β1 mediated cell adhesion |
US6596752B1 (en) | 1997-06-23 | 2003-07-22 | Tanabe Seiyaku Co., Ltd. | Inhibitors of α4β1 mediated cell adhesion |
US6855843B2 (en) | 1998-01-20 | 2005-02-15 | Tanabe Seiyaku Co., Ltd. | Inhibitors of α4 mediated cell adhesion |
US6521666B1 (en) | 1998-01-20 | 2003-02-18 | Tanabe Seiyaku Co., Ltd. | Inhibitors of α4 mediated cell adhesion |
US6329362B1 (en) | 1998-03-16 | 2001-12-11 | Celltech Therapeutics Limited | Cinnamic acid derivatives |
US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
US6685617B1 (en) | 1998-06-23 | 2004-02-03 | Pharmacia & Upjohn Company | Inhibitors of α4β1 mediated cell adhesion |
US6465471B1 (en) | 1998-07-03 | 2002-10-15 | Celltech Therapeutics Limited | Cinnamic acid derivatives |
US6677339B2 (en) | 1998-09-28 | 2004-01-13 | Celltech R & D Limited | Phenylalanine derivatives |
US6953798B1 (en) | 1998-11-30 | 2005-10-11 | Celltech R&D Limited | β-alanine derivates |
US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
GB2354440A (en) * | 1999-07-20 | 2001-03-28 | Merck & Co Inc | Aryl amides as cell adhesion inhibitors |
US6630503B1 (en) | 1999-08-13 | 2003-10-07 | Biogen, Inc. | Cell adhesion inhibitors |
US7034043B2 (en) | 1999-08-13 | 2006-04-25 | Biogen Idec Ma Inc. | Cell adhesion inhibitors |
US6534513B1 (en) | 1999-09-29 | 2003-03-18 | Celltech R&D Limited | Phenylalkanoic acid derivatives |
US6455539B2 (en) | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
US6667331B2 (en) | 1999-12-28 | 2003-12-23 | Pfizer Inc | Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases |
US6668527B2 (en) | 1999-12-28 | 2003-12-30 | Pfizer Inc. | Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases |
US6903128B2 (en) | 1999-12-28 | 2005-06-07 | Pfizer Inc | Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases |
US6610700B2 (en) | 2000-04-17 | 2003-08-26 | Celltech R & D Limited | Enamine derivatives |
US6780874B2 (en) | 2000-04-17 | 2004-08-24 | Celltech R & D Limited | Enamine derivatives |
US6545013B2 (en) | 2000-05-30 | 2003-04-08 | Celltech R&D Limited | 2,7-naphthyridine derivatives |
US6403608B1 (en) | 2000-05-30 | 2002-06-11 | Celltech R&D, Ltd. | 3-Substituted isoquinolin-1-yl derivatives |
US6740654B2 (en) | 2000-07-07 | 2004-05-25 | Celltech R & D Limited | Squaric acid derivatives |
US6469025B1 (en) | 2000-08-02 | 2002-10-22 | Celltech R&D Ltd. | 3-substituted isoquinolin-1-yl derivatives |
US7026501B2 (en) | 2000-08-31 | 2006-04-11 | Tanabe Seiyaku Co., Ltd. | Inhibitors of α4 mediated cell adhesion |
US7456217B2 (en) | 2000-08-31 | 2008-11-25 | Mitsubishi Tanabe Pharma Corporation | Inhibitors of alpha4 mediated cell adhesion |
US8501809B2 (en) | 2000-08-31 | 2013-08-06 | Mitsubishi Tanabe Pharma Corporation | Inhibitors of α4 mediated cell adhesion |
US7671090B2 (en) | 2000-08-31 | 2010-03-02 | Mitsubishi Tanabe Pharma Corporation | Inhibitors of α4 mediated cell adhesion |
US7872151B2 (en) | 2000-08-31 | 2011-01-18 | Mitsubishi Tanabe Pharma Corporation | Inhibitors of α4 mediated cell adhesion |
JP2005535710A (ja) * | 2002-08-09 | 2005-11-24 | トランス テック ファーマ,インコーポレイテッド | アリールおよびヘテロアリール化合物ならびに凝固を調節する方法 |
US7196112B2 (en) | 2004-07-16 | 2007-03-27 | Biogen Idec Ma Inc. | Cell adhesion inhibitors |
EP2510941A2 (fr) | 2007-02-20 | 2012-10-17 | Merrimack Pharmaceuticals, Inc. | Procédés de traitement de la sclérose en plaques par administration d'une alpha-foetoprotéine combinée à un antagoniste de l'intégrine |
EP2860260A1 (fr) | 2008-04-11 | 2015-04-15 | Merrimack Pharmaceuticals, Inc. | Lieurs d'albumine de sérum humain et de leurs conjugués |
WO2009126920A2 (fr) | 2008-04-11 | 2009-10-15 | Merrimack Pharmaceuticals, Inc. | Lieurs d'albumine de sérum humain, et ses conjugués |
US8263629B2 (en) | 2009-05-28 | 2012-09-11 | Novartis Ag | Substituted aminobutyric derivatives as neprilysin inhibitors |
US9603819B2 (en) | 2009-05-28 | 2017-03-28 | Novartis Ag | Substituted aminobutyric derivatives as neprilysin inhibitors |
US8394853B2 (en) | 2009-05-28 | 2013-03-12 | Novartis Ag | Substituted aminopropionic derivatives as neprilysin inhibitors |
US9006249B2 (en) | 2009-05-28 | 2015-04-14 | Novartis Ag | Substituted aminobutyric derivatives as neprilysin inhibitors |
US8877786B2 (en) | 2009-11-20 | 2014-11-04 | Novartis Ag | Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors |
US8642635B2 (en) | 2009-11-20 | 2014-02-04 | Novartis Ag | Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors |
US8377978B2 (en) | 2009-11-20 | 2013-02-19 | Novartis Ag | Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors |
US8222286B2 (en) | 2009-11-20 | 2012-07-17 | Novartis Ag | Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors |
US9102635B2 (en) | 2013-02-14 | 2015-08-11 | Novartis Ag | Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo efficacy |
US9163040B2 (en) | 2013-02-14 | 2015-10-20 | Novartis Ag | Substituted bisphenyl butanoic phosphonic acid derivatives as NEP inhibitors |
US9480693B2 (en) | 2013-02-14 | 2016-11-01 | Novartis Ag | Substituted bisphenyl butanoic phosphonic acid derivatives as NEP inhibitors |
US10112963B2 (en) | 2013-02-14 | 2018-10-30 | Novartis Ag | Substituted bisphenyl butanoic phosphonic acid derivatives as NEP inhibitors |
Also Published As
Publication number | Publication date |
---|---|
AU1463499A (en) | 1999-06-15 |
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