WO1999026923A1 - Derives de carboxamide de para-aminomethylaryl - Google Patents

Derives de carboxamide de para-aminomethylaryl Download PDF

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Publication number
WO1999026923A1
WO1999026923A1 PCT/US1998/024410 US9824410W WO9926923A1 WO 1999026923 A1 WO1999026923 A1 WO 1999026923A1 US 9824410 W US9824410 W US 9824410W WO 9926923 A1 WO9926923 A1 WO 9926923A1
Authority
WO
WIPO (PCT)
Prior art keywords
dicl
biphenylmethyl
optionally substituted
independently selected
compound
Prior art date
Application number
PCT/US1998/024410
Other languages
English (en)
Inventor
Stephen E. Delaszlo
William K. Hagmann
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9727220.7A external-priority patent/GB9727220D0/en
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Priority to AU14114/99A priority Critical patent/AU1411499A/en
Publication of WO1999026923A1 publication Critical patent/WO1999026923A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms

Abstract

L'invention concerne des carboxamides de para-aminométhylaryl selon la formule (I), qui sont des antagonistes de VLA-4 et/ou α4β7, et en tant que tels sont utiles pour inhiber ou prévenir l'adhésion cellulaire et les pathologies induites par les adhésions cellulaires. Ces composés peuvent être formulés en compositions pharmaceutiques et peuvent être utilisés pour traiter l'asthme, les allergies, l'inflammation, la sclérose en plaques, et d'autres troubles inflammatoires et autoimmunes.
PCT/US1998/024410 1997-11-20 1998-11-17 Derives de carboxamide de para-aminomethylaryl WO1999026923A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU14114/99A AU1411499A (en) 1997-11-20 1998-11-17 Para-aminomethylaryl carboxamide derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6622897P 1997-11-20 1997-11-20
US60/066,228 1997-11-20
GB9727220.7 1997-12-23
GBGB9727220.7A GB9727220D0 (en) 1997-12-23 1997-12-23 Para-aminomethylaryl carboxamide derivatives

Publications (1)

Publication Number Publication Date
WO1999026923A1 true WO1999026923A1 (fr) 1999-06-03

Family

ID=26312839

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/024410 WO1999026923A1 (fr) 1997-11-20 1998-11-17 Derives de carboxamide de para-aminomethylaryl

Country Status (2)

Country Link
AU (1) AU1411499A (fr)
WO (1) WO1999026923A1 (fr)

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999049856A2 (fr) * 1998-03-27 1999-10-07 Genentech, Inc. Antagonistes destines au traitement de troubles induits par le recepteur d'adhesion de cd11/cd18
WO2001070670A1 (fr) * 2000-03-23 2001-09-27 Ajinomoto Co., Inc. Nouveau derive de phenylalanine
WO2002030875A1 (fr) * 2000-10-09 2002-04-18 Bayer Aktiengesellschaft Derives de beta-amino-acide utilises comme antagonistes du recepteur de l'integrine
EP1243577A1 (fr) * 1999-12-28 2002-09-25 Ajinomoto Co., Inc. Nouveaux derives de phenylalanine
US6630503B1 (en) 1999-08-13 2003-10-07 Biogen, Inc. Cell adhesion inhibitors
US6667331B2 (en) 1999-12-28 2003-12-23 Pfizer Inc Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases
WO2004014844A2 (fr) * 2002-08-09 2004-02-19 Transtech Pharma, Inc. Composes aryle et heteroaryle et procedes de modulation de la coagulation
US6855843B2 (en) 1998-01-20 2005-02-15 Tanabe Seiyaku Co., Ltd. Inhibitors of α4 mediated cell adhesion
WO2005014534A1 (fr) * 2003-08-08 2005-02-17 Transtech Pharma, Inc. Composes aryle et heteroaryle, compositions, et methodes d'utilisation
WO2005014533A2 (fr) * 2003-08-08 2005-02-17 Transtech Pharma, Inc. Composes aryle et heteroaryle, compositions et procedes d'utilisation
US6916933B2 (en) 1999-12-06 2005-07-12 Hoffman-La Roche Inc. 4-pyridinyl-n-acyl-l-phenylalanines
JP2006515276A (ja) * 2002-10-22 2006-05-25 オスコテック株式会社 骨粗鬆症の予防及び治療効果を有するフラン誘導体並びにこれを含む薬学的組成物
US7064229B2 (en) 2001-07-06 2006-06-20 Bayer Healthcare Ag Succinic acid derivatives
WO2006068213A1 (fr) 2004-12-24 2006-06-29 Toray Industries, Inc. Derive de la glycine et son utilisation
US7196112B2 (en) 2004-07-16 2007-03-27 Biogen Idec Ma Inc. Cell adhesion inhibitors
US7208601B2 (en) 2003-08-08 2007-04-24 Mjalli Adnan M M Aryl and heteroaryl compounds, compositions, and methods of use
WO2007145282A1 (fr) 2006-06-14 2007-12-21 Toray Industries, Inc. Agent thérapeutique ou prophylactique destiné à traiter une dermatite allergique
WO2007148648A1 (fr) 2006-06-19 2007-12-27 Toray Industries, Inc. Agent thérapeutique ou prophylactique pour la sclérose en plaques
WO2007148676A1 (fr) 2006-06-20 2007-12-27 Toray Industries, Inc. Agent thérapeutique ou prophylactique pour la leucémie
WO2009126920A2 (fr) 2008-04-11 2009-10-15 Merrimack Pharmaceuticals, Inc. Lieurs d'albumine de sérum humain, et ses conjugués
JP2009536961A (ja) * 2006-05-12 2009-10-22 イエリニ・アクチェンゲゼルシャフト インテグリンを阻害する新規複素環化合物及びその使用
WO2010020556A1 (fr) * 2008-08-22 2010-02-25 Evotec Neurosciences Gmbh Nouveaux antagonistes du récepteur de la bradykinine b1
US7691843B2 (en) 2002-07-11 2010-04-06 Pfizer Inc. N-hydroxyamide derivatives possessing antibacterial activity
US8222286B2 (en) 2009-11-20 2012-07-17 Novartis Ag Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
US8263629B2 (en) 2009-05-28 2012-09-11 Novartis Ag Substituted aminobutyric derivatives as neprilysin inhibitors
EP2510941A2 (fr) 2007-02-20 2012-10-17 Merrimack Pharmaceuticals, Inc. Procédés de traitement de la sclérose en plaques par administration d'une alpha-foetoprotéine combinée à un antagoniste de l'intégrine
US8394853B2 (en) 2009-05-28 2013-03-12 Novartis Ag Substituted aminopropionic derivatives as neprilysin inhibitors
US9102635B2 (en) 2013-02-14 2015-08-11 Novartis Ag Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo efficacy
US9163040B2 (en) 2013-02-14 2015-10-20 Novartis Ag Substituted bisphenyl butanoic phosphonic acid derivatives as NEP inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039805A (en) * 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039805A (en) * 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives

Cited By (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6855843B2 (en) 1998-01-20 2005-02-15 Tanabe Seiyaku Co., Ltd. Inhibitors of α4 mediated cell adhesion
WO1999049856A3 (fr) * 1998-03-27 1999-11-18 Genentech Inc Antagonistes destines au traitement de troubles induits par le recepteur d'adhesion de cd11/cd18
WO1999049856A2 (fr) * 1998-03-27 1999-10-07 Genentech, Inc. Antagonistes destines au traitement de troubles induits par le recepteur d'adhesion de cd11/cd18
EA007852B1 (ru) * 1998-03-27 2007-02-27 Джинентех, Инк. Соединения для лечения расстройств, опосредованных рецепторами адгезии cd11/cd18
US7034043B2 (en) 1999-08-13 2006-04-25 Biogen Idec Ma Inc. Cell adhesion inhibitors
US6630503B1 (en) 1999-08-13 2003-10-07 Biogen, Inc. Cell adhesion inhibitors
US6916933B2 (en) 1999-12-06 2005-07-12 Hoffman-La Roche Inc. 4-pyridinyl-n-acyl-l-phenylalanines
EP1243577A4 (fr) * 1999-12-28 2005-06-08 Ajinomoto Kk Nouveaux derives de phenylalanine
EP1243577A1 (fr) * 1999-12-28 2002-09-25 Ajinomoto Co., Inc. Nouveaux derives de phenylalanine
US6667331B2 (en) 1999-12-28 2003-12-23 Pfizer Inc Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases
US6668527B2 (en) 1999-12-28 2003-12-30 Pfizer Inc. Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases
US6903128B2 (en) 1999-12-28 2005-06-07 Pfizer Inc Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases
US7105520B2 (en) 2000-03-23 2006-09-12 Ajinomoto Co., Inc. Phenylalanine derivatives
WO2001070670A1 (fr) * 2000-03-23 2001-09-27 Ajinomoto Co., Inc. Nouveau derive de phenylalanine
US7091242B2 (en) 2000-10-09 2006-08-15 Bayer Aktiengesellschaft Beta-amino acid derivatives as integrin receptor antagonists
WO2002030875A1 (fr) * 2000-10-09 2002-04-18 Bayer Aktiengesellschaft Derives de beta-amino-acide utilises comme antagonistes du recepteur de l'integrine
US7064229B2 (en) 2001-07-06 2006-06-20 Bayer Healthcare Ag Succinic acid derivatives
US7691843B2 (en) 2002-07-11 2010-04-06 Pfizer Inc. N-hydroxyamide derivatives possessing antibacterial activity
JP2005535710A (ja) * 2002-08-09 2005-11-24 トランス　テック　ファーマ，インコーポレイテッド アリールおよびヘテロアリール化合物ならびに凝固を調節する方法
WO2004014844A3 (fr) * 2002-08-09 2005-04-28 Transtech Pharma Inc Composes aryle et heteroaryle et procedes de modulation de la coagulation
WO2004014844A2 (fr) * 2002-08-09 2004-02-19 Transtech Pharma, Inc. Composes aryle et heteroaryle et procedes de modulation de la coagulation
US7122580B2 (en) 2002-08-09 2006-10-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds and methods to modulate coagulation
JP2006515276A (ja) * 2002-10-22 2006-05-25 オスコテック株式会社 骨粗鬆症の予防及び治療効果を有するフラン誘導体並びにこれを含む薬学的組成物
US7459472B2 (en) 2003-08-08 2008-12-02 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
WO2005014533A3 (fr) * 2003-08-08 2005-04-07 Transtech Pharma Inc Composes aryle et heteroaryle, compositions et procedes d'utilisation
WO2005014533A2 (fr) * 2003-08-08 2005-02-17 Transtech Pharma, Inc. Composes aryle et heteroaryle, compositions et procedes d'utilisation
WO2005014532A1 (fr) * 2003-08-08 2005-02-17 Transtech Pharma, Inc. Composes aryle et heteroaryle, compositions et procedes associes
US7544699B2 (en) 2003-08-08 2009-06-09 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
US7208601B2 (en) 2003-08-08 2007-04-24 Mjalli Adnan M M Aryl and heteroaryl compounds, compositions, and methods of use
US7501538B2 (en) 2003-08-08 2009-03-10 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions and methods of use
WO2005014534A1 (fr) * 2003-08-08 2005-02-17 Transtech Pharma, Inc. Composes aryle et heteroaryle, compositions, et methodes d'utilisation
US7196112B2 (en) 2004-07-16 2007-03-27 Biogen Idec Ma Inc. Cell adhesion inhibitors
KR101250889B1 (ko) 2004-12-24 2013-04-04 도레이 카부시키가이샤 글리신 유도체 및 그 용도
JP4862655B2 (ja) * 2004-12-24 2012-01-25 東レ株式会社 グリシン誘導体及びその用途
US7566724B2 (en) 2004-12-24 2009-07-28 Toray Industries, Inc. Glycine derivative and use thereof
WO2006068213A1 (fr) 2004-12-24 2006-06-29 Toray Industries, Inc. Derive de la glycine et son utilisation
JP2009536961A (ja) * 2006-05-12 2009-10-22 イエリニ・アクチェンゲゼルシャフト インテグリンを阻害する新規複素環化合物及びその使用
WO2007145282A1 (fr) 2006-06-14 2007-12-21 Toray Industries, Inc. Agent thérapeutique ou prophylactique destiné à traiter une dermatite allergique
WO2007148648A1 (fr) 2006-06-19 2007-12-27 Toray Industries, Inc. Agent thérapeutique ou prophylactique pour la sclérose en plaques
US7879837B2 (en) 2006-06-19 2011-02-01 Toray Industries, Inc. Therapeutic or prophylactic agent for multiple sclerosis
EP2033637A1 (fr) * 2006-06-20 2009-03-11 Toray Industries, Inc. Agent thérapeutique ou prophylactique pour la leucémie
WO2007148676A1 (fr) 2006-06-20 2007-12-27 Toray Industries, Inc. Agent thérapeutique ou prophylactique pour la leucémie
US7893046B2 (en) 2006-06-20 2011-02-22 Toray Industries, Inc. Therapeutic or prophylactic agent for leukemia
EP2033637A4 (fr) * 2006-06-20 2009-11-11 Toray Industries Agent thérapeutique ou prophylactique pour la leucémie
EP2510941A2 (fr) 2007-02-20 2012-10-17 Merrimack Pharmaceuticals, Inc. Procédés de traitement de la sclérose en plaques par administration d'une alpha-foetoprotéine combinée à un antagoniste de l'intégrine
EP2860260A1 (fr) 2008-04-11 2015-04-15 Merrimack Pharmaceuticals, Inc. Lieurs d'albumine de sérum humain et de leurs conjugués
WO2009126920A2 (fr) 2008-04-11 2009-10-15 Merrimack Pharmaceuticals, Inc. Lieurs d'albumine de sérum humain, et ses conjugués
WO2010020556A1 (fr) * 2008-08-22 2010-02-25 Evotec Neurosciences Gmbh Nouveaux antagonistes du récepteur de la bradykinine b1
JP2012500783A (ja) * 2008-08-22 2012-01-12 エヴォテック・アクチエンゲゼルシャフト 新しいブラジキニンｂ１拮抗薬
US8623859B2 (en) 2008-08-22 2014-01-07 Evotec Ag Bradykinin B1 antagonists
US8263629B2 (en) 2009-05-28 2012-09-11 Novartis Ag Substituted aminobutyric derivatives as neprilysin inhibitors
US8394853B2 (en) 2009-05-28 2013-03-12 Novartis Ag Substituted aminopropionic derivatives as neprilysin inhibitors
US9603819B2 (en) 2009-05-28 2017-03-28 Novartis Ag Substituted aminobutyric derivatives as neprilysin inhibitors
US9006249B2 (en) 2009-05-28 2015-04-14 Novartis Ag Substituted aminobutyric derivatives as neprilysin inhibitors
US8377978B2 (en) 2009-11-20 2013-02-19 Novartis Ag Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
US8877786B2 (en) 2009-11-20 2014-11-04 Novartis Ag Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
US8642635B2 (en) 2009-11-20 2014-02-04 Novartis Ag Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
US8222286B2 (en) 2009-11-20 2012-07-17 Novartis Ag Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
US9102635B2 (en) 2013-02-14 2015-08-11 Novartis Ag Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo efficacy
US9163040B2 (en) 2013-02-14 2015-10-20 Novartis Ag Substituted bisphenyl butanoic phosphonic acid derivatives as NEP inhibitors
US9480693B2 (en) 2013-02-14 2016-11-01 Novartis Ag Substituted bisphenyl butanoic phosphonic acid derivatives as NEP inhibitors
US10112963B2 (en) 2013-02-14 2018-10-30 Novartis Ag Substituted bisphenyl butanoic phosphonic acid derivatives as NEP inhibitors

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Publication number Publication date
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