CL2004000076A1 - Compuestos derivados de indol, inhibidores de polimerasa, sales; composicion farmaceutica que los comprende; procedimiento de preparacion de dichos compuestos; compuestos intermediarios; y uso del compuesto para tratar una infeccion causada por el vi - Google Patents
Compuestos derivados de indol, inhibidores de polimerasa, sales; composicion farmaceutica que los comprende; procedimiento de preparacion de dichos compuestos; compuestos intermediarios; y uso del compuesto para tratar una infeccion causada por el viInfo
- Publication number
- CL2004000076A1 CL2004000076A1 CL200400076A CL2004000076A CL2004000076A1 CL 2004000076 A1 CL2004000076 A1 CL 2004000076A1 CL 200400076 A CL200400076 A CL 200400076A CL 2004000076 A CL2004000076 A CL 2004000076A CL 2004000076 A1 CL2004000076 A1 CL 2004000076A1
- Authority
- CL
- Chile
- Prior art keywords
- compounds
- compound
- indol
- understands
- treat
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
UN ISOMERO ENANTIOMERO, DIASTEREOMERO O TAUTOMERO DE UN COMPUESTO, REPRESENTADO POR LA FORMULA I; EN LA QUE A,B,R2,R3,L,M1,M2,M3,M4,Y1,Y0,Z,Y Sp SON COMO SE HAN DEFINIDO EN LA REIVINDICACION 1, UNA SAL DEL MISMO, COMO INHIBIDOR DE NS5B POLIMERASA DE HCV.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44187103P | 2003-01-22 | 2003-01-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2004000076A1 true CL2004000076A1 (es) | 2005-01-14 |
Family
ID=32771985
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL200400076A CL2004000076A1 (es) | 2003-01-22 | 2004-01-20 | Compuestos derivados de indol, inhibidores de polimerasa, sales; composicion farmaceutica que los comprende; procedimiento de preparacion de dichos compuestos; compuestos intermediarios; y uso del compuesto para tratar una infeccion causada por el vi |
Country Status (25)
Country | Link |
---|---|
US (2) | US7223785B2 (es) |
EP (1) | EP1587787A1 (es) |
JP (2) | JP4585507B2 (es) |
KR (1) | KR20050095863A (es) |
CN (1) | CN1764641A (es) |
AR (1) | AR047754A1 (es) |
AU (1) | AU2004205429A1 (es) |
BR (1) | BRPI0406926A (es) |
CA (1) | CA2511307C (es) |
CL (1) | CL2004000076A1 (es) |
CO (1) | CO5590912A2 (es) |
EA (1) | EA009323B1 (es) |
EC (1) | ECSP055913A (es) |
HR (1) | HRP20050662A2 (es) |
IL (1) | IL169777A0 (es) |
MX (1) | MXPA05007754A (es) |
NO (1) | NO20053892L (es) |
NZ (1) | NZ541852A (es) |
PE (1) | PE20040940A1 (es) |
PL (1) | PL378194A1 (es) |
RS (1) | RS20050556A (es) |
TW (1) | TW200418843A (es) |
UA (1) | UA83651C2 (es) |
WO (1) | WO2004065367A1 (es) |
ZA (1) | ZA200504893B (es) |
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PL194025B1 (pl) | 1996-10-18 | 2007-04-30 | Vertex Pharma | Inhibitory proteaz serynowych, a zwłaszcza proteazy wirusa NS3 zapalenia wątroby C, kompozycja farmaceutyczna i zastosowanie inhibitorów proteaz serynowych |
SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
EP2335700A1 (en) * | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
US20050075279A1 (en) * | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
US7223785B2 (en) * | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
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GB0307891D0 (en) * | 2003-04-04 | 2003-05-14 | Angeletti P Ist Richerche Bio | Chemical compounds,compositions and uses |
WO2004099241A1 (en) * | 2003-05-09 | 2004-11-18 | Boehringer Ingelheim International Gmbh | Hepatitis c virus ns5b polymerase inhibitor binding pocket |
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PE20050374A1 (es) | 2003-09-05 | 2005-05-30 | Vertex Pharma | Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc |
GB0323845D0 (en) * | 2003-10-10 | 2003-11-12 | Angeletti P Ist Richerche Bio | Chemical compounds,compositions and uses |
PL1706403T3 (pl) * | 2003-12-22 | 2012-07-31 | K U Leuven Res & Development | Związki imidazo[4,5-c]pirydynowe i sposoby leczenia przeciwwirusowego |
ES2358333T3 (es) | 2004-01-21 | 2011-05-09 | Boehringer Ingelheim International Gmbh | Péptidos macrocíclicos con acción contra el virus de la hepatitis c. |
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2004
- 2004-01-12 US US10/755,256 patent/US7223785B2/en active Active
- 2004-01-19 EA EA200501065A patent/EA009323B1/ru not_active IP Right Cessation
- 2004-01-19 WO PCT/CA2004/000018 patent/WO2004065367A1/en active Search and Examination
- 2004-01-19 JP JP2006500429A patent/JP4585507B2/ja not_active Expired - Fee Related
- 2004-01-19 CN CNA2004800078316A patent/CN1764641A/zh active Pending
- 2004-01-19 RS YUP-2005/0556A patent/RS20050556A/sr unknown
- 2004-01-19 CA CA2511307A patent/CA2511307C/en not_active Expired - Fee Related
- 2004-01-19 NZ NZ541852A patent/NZ541852A/en unknown
- 2004-01-19 KR KR1020057013544A patent/KR20050095863A/ko not_active Application Discontinuation
- 2004-01-19 PL PL378194A patent/PL378194A1/pl not_active Application Discontinuation
- 2004-01-19 UA UAA200508155A patent/UA83651C2/ru unknown
- 2004-01-19 MX MXPA05007754A patent/MXPA05007754A/es active IP Right Grant
- 2004-01-19 BR BR0406926-9A patent/BRPI0406926A/pt not_active IP Right Cessation
- 2004-01-19 AU AU2004205429A patent/AU2004205429A1/en not_active Abandoned
- 2004-01-19 EP EP04703130A patent/EP1587787A1/en not_active Withdrawn
- 2004-01-20 PE PE2004000084A patent/PE20040940A1/es not_active Application Discontinuation
- 2004-01-20 CL CL200400076A patent/CL2004000076A1/es unknown
- 2004-01-20 TW TW093101632A patent/TW200418843A/zh unknown
- 2004-01-21 AR ARP040100155A patent/AR047754A1/es unknown
-
2005
- 2005-06-15 ZA ZA200504893A patent/ZA200504893B/en unknown
- 2005-07-11 EC EC2005005913A patent/ECSP055913A/es unknown
- 2005-07-20 IL IL169777A patent/IL169777A0/en unknown
- 2005-07-21 HR HR20050662A patent/HRP20050662A2/xx not_active Application Discontinuation
- 2005-08-19 NO NO20053892A patent/NO20053892L/no not_active Application Discontinuation
- 2005-08-22 CO CO05083254A patent/CO5590912A2/es not_active Application Discontinuation
-
2007
- 2007-02-07 US US11/672,293 patent/US7888363B2/en active Active
-
2009
- 2009-11-11 JP JP2009258002A patent/JP2010077139A/ja not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
IL169777A0 (en) | 2007-07-04 |
MXPA05007754A (es) | 2005-09-30 |
CA2511307A1 (en) | 2004-08-05 |
PL378194A1 (pl) | 2006-03-06 |
CN1764641A (zh) | 2006-04-26 |
US20070142380A1 (en) | 2007-06-21 |
CO5590912A2 (es) | 2005-12-30 |
AU2004205429A1 (en) | 2004-08-05 |
WO2004065367A1 (en) | 2004-08-05 |
EA009323B1 (ru) | 2007-12-28 |
EP1587787A1 (en) | 2005-10-26 |
ECSP055913A (es) | 2006-03-01 |
US20040171626A1 (en) | 2004-09-02 |
RS20050556A (en) | 2007-06-04 |
NZ541852A (en) | 2009-03-31 |
ZA200504893B (en) | 2006-11-29 |
NO20053892L (no) | 2005-10-05 |
UA83651C2 (en) | 2008-08-11 |
JP2006517536A (ja) | 2006-07-27 |
EA200501065A1 (ru) | 2006-02-24 |
CA2511307C (en) | 2011-09-27 |
AR047754A1 (es) | 2006-02-22 |
JP2010077139A (ja) | 2010-04-08 |
BRPI0406926A (pt) | 2006-01-03 |
US7223785B2 (en) | 2007-05-29 |
WO2004065367A8 (en) | 2006-07-13 |
HRP20050662A2 (en) | 2006-07-31 |
PE20040940A1 (es) | 2005-01-11 |
TW200418843A (en) | 2004-10-01 |
US7888363B2 (en) | 2011-02-15 |
KR20050095863A (ko) | 2005-10-04 |
JP4585507B2 (ja) | 2010-11-24 |
NO20053892D0 (no) | 2005-08-19 |
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