ES2159648T3 - Derivado de indol. - Google Patents

Derivado de indol.

Info

Publication number
ES2159648T3
ES2159648T3 ES95937182T ES95937182T ES2159648T3 ES 2159648 T3 ES2159648 T3 ES 2159648T3 ES 95937182 T ES95937182 T ES 95937182T ES 95937182 T ES95937182 T ES 95937182T ES 2159648 T3 ES2159648 T3 ES 2159648T3
Authority
ES
Spain
Prior art keywords
lower alkoxy
alkoxy
alkoxycarbonyl
carboxy
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95937182T
Other languages
English (en)
Inventor
Shiro Kato
Hiroshi Harada
Yoshimi Hirokawa
Naoyuki Yoshida
Hitoshi Kawashima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2159648T3 publication Critical patent/ES2159648T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

UN DERIVADO DE INDOL DE FORMULA: DONDE R 1 ES ALCOXI DE BAJO PESO MOLECULAR, ALCOXICARBONILO DE BAJO PESO MOLECULAR - ALCOXI DE BAJO PESO MOLECULAR, CARBOXI ALCOXI DE BAJO PESO MOLECULAR, ALCOXICARBONILO DE BAJO PESO MOLECULAR, FENILO - ALCOXI DE BAJO PESO MOLECULAR, ALQUILO DE BAJO PESO MOLECULAR ESTANDO OPCIONALMENTE SUSTITUIDO POR HIDROXI, DI - ALQUILAMINOSULFONILO DE BAJO PESO MOLECULAR, ETC.; R{SUB,2} ES HIDROGENO, HALOGENO, ALCOXI DE BAJO PESO MOLECULAR, ALCOXICARBONILO DE BAJO PESO MOLECULAR - ALCOXI DE BAJO PESO MOLECULAR, CARBOXI - ALCOXI DE BAJO PESO MOLECULAR, ETC.; R{SUB,3} ES HIDROGENO O ALQUILO DE BAJO PESO MOLECULAR, R{SUB,4} ES HALOGENO O TRIFLUOROMETILO, R{SUB,5} ES ALQUILO DE BAJO PESO MOLECULAR O UNA SAL DE LOS MISMOS. ESTOS COMPUESTOS SON AGENTES ESTIMULANTES POTENTES DEL RECEPTOR {BE}{SUB,3} - ADRENERGICO CON UNA EXCELENTE SELECTIVIDAD DE ADRENOCEPTOR, Y UTILES EN LA PROFILAXIS O EL TRATAMIENTO DE OBESIDAD Y DIABETES MELLITUS.
ES95937182T 1994-11-29 1995-11-27 Derivado de indol. Expired - Lifetime ES2159648T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP06321402 1994-11-29

Publications (1)

Publication Number Publication Date
ES2159648T3 true ES2159648T3 (es) 2001-10-16

Family

ID=18132155

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95937182T Expired - Lifetime ES2159648T3 (es) 1994-11-29 1995-11-27 Derivado de indol.

Country Status (29)

Country Link
US (1) US5817689A (es)
EP (1) EP0801059B1 (es)
JP (1) JP3100165B2 (es)
KR (1) KR100388747B1 (es)
CN (1) CN1070477C (es)
AT (1) ATE202559T1 (es)
AU (1) AU688165B2 (es)
BR (1) BR9509827A (es)
CA (1) CA2206307A1 (es)
CY (1) CY2247B1 (es)
CZ (1) CZ290871B6 (es)
DE (1) DE69521529T2 (es)
DK (1) DK0801059T3 (es)
ES (1) ES2159648T3 (es)
FI (1) FI972275A (es)
GR (1) GR3036148T3 (es)
HK (1) HK1003886A1 (es)
HU (1) HUT77308A (es)
IL (1) IL116178A (es)
NO (1) NO309648B1 (es)
NZ (1) NZ295749A (es)
PL (1) PL181963B1 (es)
PT (1) PT801059E (es)
RO (1) RO118426B1 (es)
RU (1) RU2137759C1 (es)
SK (1) SK281865B6 (es)
TW (1) TW349091B (es)
WO (1) WO1996016938A1 (es)
ZA (1) ZA9510130B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20010580A1 (es) * 1999-09-03 2001-05-25 Takeda Chemical Industries Ltd Composicion farmaceutica para tratar la diabetes
CN1433403A (zh) * 1999-11-30 2003-07-30 大日本制药株式会社 固体制剂
US6458824B1 (en) * 1999-11-30 2002-10-01 Dainippon Pharmaceutical Co., Ltd. Solid preparation
JP2004331500A (ja) * 2001-02-16 2004-11-25 Dainippon Pharmaceut Co Ltd 血中濃度制御製剤
EP2335700A1 (en) * 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
US20040018959A1 (en) * 2002-05-02 2004-01-29 Randall S. Hickle System and methods of lipid removal from the body
KR20050010512A (ko) * 2002-06-12 2005-01-27 스미또모 세이야꾸 가부시키가이샤 인돌, 인다졸 및 벤즈아졸류
PL377847A1 (pl) * 2003-01-14 2006-02-20 Arena Pharmaceuticals Inc. 1,2,3-Tripodstawione pochodne arylowe i heteroarylowe jako modulatory metabolizmu oraz profilaktyka i leczenie związanych z nim zaburzeń takich jak cukrzyca i hiperglikemia
EP1927594A1 (en) * 2003-01-14 2008-06-04 Arena Pharmaceuticals, Inc. 1,2,3-Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
US7098231B2 (en) 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7223785B2 (en) 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
WO2004089936A1 (ja) * 2003-04-10 2004-10-21 Dainippon Pharmaceutical Co., Ltd. ヘテロアリールスルホン酸アニリド誘導体及びそれを含有する医薬組成物
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
ES2431314T3 (es) * 2004-02-20 2013-11-26 Boehringer Ingelheim International Gmbh Inhibidores de polimerasa vírica
MY148521A (en) 2005-01-10 2013-04-30 Arena Pharm Inc Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
DOP2006000010A (es) 2005-01-10 2006-07-31 Arena Pharm Inc Procedimiento para preparar eteres aromáticos
EP1915378A4 (en) 2005-08-12 2009-07-22 Boehringer Ingelheim Int VIRUS POLYMERASE INHIBITORS
BR112013008100A2 (pt) 2010-09-22 2016-08-09 Arena Pharm Inc "moduladores do receptor de gpr19 e o tratamento de distúrbios relacionados a eles."
ES2394349B1 (es) 2012-08-29 2013-11-04 Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii Uso de agonistas selectivos de receptores beta-3 adrenérgicos para el tratamiento de hipertensión pulmonar
WO2015199097A1 (ja) * 2014-06-24 2015-12-30 花王株式会社 Ｕｃｐ－１発現促進剤
JP6660668B2 (ja) * 2014-06-24 2020-03-11 花王株式会社 Ｕｃｐ−１発現促進剤
US10758519B2 (en) 2014-06-24 2020-09-01 Kao Corporation UCP-1 expression promoter
AU2016205361C1 (en) 2015-01-06 2021-04-08 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
SI3310760T1 (sl) 2015-06-22 2023-02-28 Arena Pharmaceuticals, Inc. Kristalinična L-argininska sol (R)-2-(7-(4-ciklopentil-3-(trifluorometil)benziloksi)-1,2,3,4- tetrahidrociklo-penta(b)indol-3-il)ocetne kisline za uporabo pri motnjah, povezanih z receptorjem S1P1

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB861428A (en) * 1958-07-14 1961-02-22 Searle & Co Improvements in or relating to indole derivatives
US4055658A (en) * 1976-05-17 1977-10-25 Mead Johnson & Company Cyanomethylphenethanolamines
DE3061334D1 (en) * 1979-06-16 1983-01-20 Beecham Group Plc Ethanamine derivatives, their preparation and use in pharmaceutical compositions
FR2541999B1 (fr) * 1983-03-04 1986-09-19 Bristol Myers Co Phenethanolamines et leurs utilisations
JPH06345731A (ja) * 1992-04-28 1994-12-20 Dainippon Pharmaceut Co Ltd ２−〔２−（インドール−３−イル）エチルアミノ〕−１−フェニルエタノール誘導体
JPH0634531A (ja) * 1992-07-14 1994-02-08 Yokogawa Electric Corp 赤外線水分計

Also Published As

Publication number Publication date
CA2206307A1 (en) 1996-06-06
HUT77308A (hu) 1998-03-30
PL181963B1 (pl) 2001-10-31
ZA9510130B (en) 1996-06-11
GR3036148T3 (en) 2001-09-28
BR9509827A (pt) 1997-09-30
ATE202559T1 (de) 2001-07-15
EP0801059A4 (en) 1998-01-21
HK1003886A1 (en) 1998-11-13
KR100388747B1 (ko) 2004-03-30
PT801059E (pt) 2001-10-30
AU3936695A (en) 1996-06-19
EP0801059A1 (en) 1997-10-15
DE69521529T2 (de) 2001-10-11
IL116178A0 (en) 1996-01-31
CN1070477C (zh) 2001-09-05
JP3100165B2 (ja) 2000-10-16
NZ295749A (en) 1998-05-27
TW349091B (en) 1999-01-01
RO118426B1 (ro) 2003-05-30
DK0801059T3 (da) 2001-09-24
RU2137759C1 (ru) 1999-09-20
NO309648B1 (no) 2001-03-05
CN1174549A (zh) 1998-02-25
CZ165597A3 (en) 1997-11-12
NO972427L (no) 1997-07-28
SK281865B6 (sk) 2001-08-06
NO972427D0 (no) 1997-05-28
PL320461A1 (en) 1997-09-29
US5817689A (en) 1998-10-06
DE69521529D1 (de) 2001-08-02
FI972275A0 (fi) 1997-05-29
CZ290871B6 (cs) 2002-11-13
FI972275A (fi) 1997-05-29
MX9703858A (es) 1997-09-30
IL116178A (en) 2000-07-26
WO1996016938A1 (fr) 1996-06-06
AU688165B2 (en) 1998-03-05
EP0801059B1 (en) 2001-06-27
SK65697A3 (en) 1998-01-14
CY2247B1 (en) 2003-07-04

Similar Documents

Publication Publication Date Title
ES2159648T3 (es) Derivado de indol.
BR9302068A (pt) Processo para preparar compostos de n-iodopropargil hidantoina e composicao fungicida ou microbiocida
DK0846686T3 (da) 1-phenylpyrazolderivater og deres anvendelse som parasiticide midler
HK1022639A1 (en) New use for 1,3-propanediol derivatives.
NZ513561A (en) Pyridopyranoazepine derivatives, preparation and therapeutic use
ATE263771T1 (de) Totalsynthese von acylfulvenen mit antitumorwirkung
ATE172463T1 (de) Pyrrolocarbazol
ATE231487T1 (de) 2-phenoxyanilin-derivate
NO894563D0 (no) Substituerte imidazolderivater og fremstilling og anvendelse derav.
NZ336091A (en) Aqueous disinfecting cleaning composition
ZA812541B (en) Benzothiazole derivatives and salts thereof,processes for their preparation,and their use as sweetening agents
DK0413278T3 (da) Anvendelse af xanthinderivater mod mavesår
DE69500758T2 (de) Substituierte bizyklische Oxazol- und Thiazol-Äther
CA2258960A1 (en) A process for preparing naphthyridones and intermediates
DK0427484T3 (da) Hidtil ukendte benzoxazolonforbindelser og deres anvendelse som mikrobicider
TH101171B (th) สารประกอบพิวรีนและการใช้สารนั้น
TH19060A (th) อนุพันธุ์คาร์โบสไตริล วิธีการเตรียมสารดังกล่าวและตัวยับยั้งแมทตริกซ์เมทัลโลโปรตีเนสภายนอกเซล

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 801059

Country of ref document: ES