EA200501065A1 - Ингибиторы вирусной полимеразы - Google Patents
Ингибиторы вирусной полимеразыInfo
- Publication number
- EA200501065A1 EA200501065A1 EA200501065A EA200501065A EA200501065A1 EA 200501065 A1 EA200501065 A1 EA 200501065A1 EA 200501065 A EA200501065 A EA 200501065A EA 200501065 A EA200501065 A EA 200501065A EA 200501065 A1 EA200501065 A1 EA 200501065A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- polymerase inhibitors
- viral polymerase
- represented
- international
- application
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
- Indole Compounds (AREA)
Abstract
В заявке описаны изомер, энантиомер, диастереоизомер или таутомер соединения, представленного формулой Iв которой A, B, R, R, L, M, M, M, M, Y, Y, Z и Sp представлены в п.1, или его соль в качестве ингибитора HCV NS5B полимеразы.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44187103P | 2003-01-22 | 2003-01-22 | |
PCT/CA2004/000018 WO2004065367A1 (en) | 2003-01-22 | 2004-01-19 | Viral polymerase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200501065A1 true EA200501065A1 (ru) | 2006-02-24 |
EA009323B1 EA009323B1 (ru) | 2007-12-28 |
Family
ID=32771985
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200501065A EA009323B1 (ru) | 2003-01-22 | 2004-01-19 | Ингибиторы вирусной полимеразы |
Country Status (25)
Country | Link |
---|---|
US (2) | US7223785B2 (ru) |
EP (1) | EP1587787A1 (ru) |
JP (2) | JP4585507B2 (ru) |
KR (1) | KR20050095863A (ru) |
CN (1) | CN1764641A (ru) |
AR (1) | AR047754A1 (ru) |
AU (1) | AU2004205429A1 (ru) |
BR (1) | BRPI0406926A (ru) |
CA (1) | CA2511307C (ru) |
CL (1) | CL2004000076A1 (ru) |
CO (1) | CO5590912A2 (ru) |
EA (1) | EA009323B1 (ru) |
EC (1) | ECSP055913A (ru) |
HR (1) | HRP20050662A2 (ru) |
IL (1) | IL169777A0 (ru) |
MX (1) | MXPA05007754A (ru) |
NO (1) | NO20053892L (ru) |
NZ (1) | NZ541852A (ru) |
PE (1) | PE20040940A1 (ru) |
PL (1) | PL378194A1 (ru) |
RS (1) | RS20050556A (ru) |
TW (1) | TW200418843A (ru) |
UA (1) | UA83651C2 (ru) |
WO (1) | WO2004065367A1 (ru) |
ZA (1) | ZA200504893B (ru) |
Families Citing this family (130)
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MXPA05003026A (es) | 1996-10-18 | 2005-06-15 | Vertex Pharma | Inhibidores de proteasas de serina, particularmente proteasas ns3 del virus de hepatitis c. |
SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
EP2335700A1 (en) * | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
US20050075279A1 (en) * | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
US7223785B2 (en) * | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7098231B2 (en) * | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
GB0307891D0 (en) * | 2003-04-04 | 2003-05-14 | Angeletti P Ist Richerche Bio | Chemical compounds,compositions and uses |
AU2004235848B2 (en) * | 2003-05-09 | 2011-08-04 | Boehringer Ingelheim International Gmbh | Hepatitis C virus NS5B polymerase inhibitor binding pocket |
EP1651631A1 (en) | 2003-08-01 | 2006-05-03 | Genelabs Technologies, Inc. | Bicyclic imidazol derivatives against flaviviridae |
WO2005014543A1 (ja) * | 2003-08-06 | 2005-02-17 | Japan Tobacco Inc. | 縮合環化合物及びそのhcvポリメラーゼ阻害剤としての利用 |
AR045596A1 (es) | 2003-09-05 | 2005-11-02 | Vertex Pharma | Inhibidores de proteasas de serina en particular proteasa ns3-ns4a del vhc |
GB0323845D0 (en) * | 2003-10-10 | 2003-11-12 | Angeletti P Ist Richerche Bio | Chemical compounds,compositions and uses |
WO2005063744A2 (en) * | 2003-12-22 | 2005-07-14 | K.U. Leuven Research & Development | IMIDAZO[4,5-c]PYRIDINE COMPOUNDS AND METHODS OF ANTIVIRAL TREATMENT |
EP1730167B1 (en) | 2004-01-21 | 2011-01-12 | Boehringer Ingelheim International GmbH | Macrocyclic peptides active against the hepatitis c virus |
EA013207B1 (ru) * | 2004-02-20 | 2010-04-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Ингибиторы вирусной полимеразы |
US20070049593A1 (en) | 2004-02-24 | 2007-03-01 | Japan Tobacco Inc. | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor |
GB0413087D0 (en) * | 2004-06-11 | 2004-07-14 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
KR20070083484A (ko) * | 2004-07-14 | 2007-08-24 | 피티씨 테라퓨틱스, 인크. | C형 간염 치료 방법 |
WO2007084413A2 (en) * | 2004-07-14 | 2007-07-26 | Ptc Therapeutics, Inc. | Methods for treating hepatitis c |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
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US7795247B2 (en) | 2004-10-26 | 2010-09-14 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Tetracyclic indole derivatives as antiviral agents |
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JP2008524335A (ja) * | 2004-12-21 | 2008-07-10 | ギリアド サイエンシズ, インコーポレイテッド | イミダゾ[4,5−c]ピリジン化合物および抗ウイルス処置法 |
JP2008526980A (ja) * | 2005-01-14 | 2008-07-24 | ジェネラブズ テクノロジーズ インコーポレーティッド | ウイルス感染症を治療するためのインドール誘導体 |
CA2597680A1 (en) | 2005-02-11 | 2006-08-17 | Boehringer Ingelheim International Gmbh | Process for preparing 2,3-disubstituted indoles |
CA2618682C (en) * | 2005-08-12 | 2011-06-21 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
CN102304075A (zh) * | 2005-10-11 | 2012-01-04 | 因特蒙公司 | 病毒复制抑制剂 |
JP2009523732A (ja) * | 2006-01-13 | 2009-06-25 | ピーティーシー セラピューティクス,インコーポレーテッド | C型肝炎の治療方法 |
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EP1991229A2 (en) | 2006-02-27 | 2008-11-19 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
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JP4879160B2 (ja) * | 2004-03-16 | 2012-02-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 2−ブロモ又はクロロアニリンのパラジウム触媒インドール化 |
UY29017A1 (es) * | 2004-07-16 | 2006-02-24 | Boehringer Ingelheim Int | Inhibidores de polimerasa viral |
CA2597680A1 (en) * | 2005-02-11 | 2006-08-17 | Boehringer Ingelheim International Gmbh | Process for preparing 2,3-disubstituted indoles |
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2004
- 2004-01-12 US US10/755,256 patent/US7223785B2/en active Active
- 2004-01-19 WO PCT/CA2004/000018 patent/WO2004065367A1/en active Search and Examination
- 2004-01-19 PL PL378194A patent/PL378194A1/pl not_active Application Discontinuation
- 2004-01-19 UA UAA200508155A patent/UA83651C2/ru unknown
- 2004-01-19 MX MXPA05007754A patent/MXPA05007754A/es active IP Right Grant
- 2004-01-19 BR BR0406926-9A patent/BRPI0406926A/pt not_active IP Right Cessation
- 2004-01-19 JP JP2006500429A patent/JP4585507B2/ja not_active Expired - Fee Related
- 2004-01-19 NZ NZ541852A patent/NZ541852A/en unknown
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- 2004-01-19 RS YUP-2005/0556A patent/RS20050556A/sr unknown
- 2004-01-19 EA EA200501065A patent/EA009323B1/ru not_active IP Right Cessation
- 2004-01-19 AU AU2004205429A patent/AU2004205429A1/en not_active Abandoned
- 2004-01-19 CN CNA2004800078316A patent/CN1764641A/zh active Pending
- 2004-01-19 KR KR1020057013544A patent/KR20050095863A/ko not_active Application Discontinuation
- 2004-01-20 TW TW093101632A patent/TW200418843A/zh unknown
- 2004-01-20 CL CL200400076A patent/CL2004000076A1/es unknown
- 2004-01-20 PE PE2004000084A patent/PE20040940A1/es not_active Application Discontinuation
- 2004-01-21 AR ARP040100155A patent/AR047754A1/es unknown
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2005
- 2005-06-15 ZA ZA200504893A patent/ZA200504893B/en unknown
- 2005-07-11 EC EC2005005913A patent/ECSP055913A/es unknown
- 2005-07-20 IL IL169777A patent/IL169777A0/en unknown
- 2005-07-21 HR HR20050662A patent/HRP20050662A2/xx not_active Application Discontinuation
- 2005-08-19 NO NO20053892A patent/NO20053892L/no not_active Application Discontinuation
- 2005-08-22 CO CO05083254A patent/CO5590912A2/es not_active Application Discontinuation
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2007
- 2007-02-07 US US11/672,293 patent/US7888363B2/en active Active
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2009
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Also Published As
Publication number | Publication date |
---|---|
IL169777A0 (en) | 2007-07-04 |
US20040171626A1 (en) | 2004-09-02 |
US7223785B2 (en) | 2007-05-29 |
BRPI0406926A (pt) | 2006-01-03 |
UA83651C2 (en) | 2008-08-11 |
WO2004065367A1 (en) | 2004-08-05 |
TW200418843A (en) | 2004-10-01 |
PE20040940A1 (es) | 2005-01-11 |
NZ541852A (en) | 2009-03-31 |
CO5590912A2 (es) | 2005-12-30 |
NO20053892D0 (no) | 2005-08-19 |
AU2004205429A1 (en) | 2004-08-05 |
NO20053892L (no) | 2005-10-05 |
EA009323B1 (ru) | 2007-12-28 |
RS20050556A (en) | 2007-06-04 |
JP2010077139A (ja) | 2010-04-08 |
ZA200504893B (en) | 2006-11-29 |
JP2006517536A (ja) | 2006-07-27 |
WO2004065367A8 (en) | 2006-07-13 |
CL2004000076A1 (es) | 2005-01-14 |
JP4585507B2 (ja) | 2010-11-24 |
ECSP055913A (es) | 2006-03-01 |
HRP20050662A2 (en) | 2006-07-31 |
CA2511307A1 (en) | 2004-08-05 |
KR20050095863A (ko) | 2005-10-04 |
MXPA05007754A (es) | 2005-09-30 |
US7888363B2 (en) | 2011-02-15 |
CN1764641A (zh) | 2006-04-26 |
EP1587787A1 (en) | 2005-10-26 |
AR047754A1 (es) | 2006-02-22 |
PL378194A1 (pl) | 2006-03-06 |
CA2511307C (en) | 2011-09-27 |
US20070142380A1 (en) | 2007-06-21 |
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