AR070463A1 - Compuestos de amina y eter que modulan el receptor cb2 - Google Patents

Compuestos de amina y eter que modulan el receptor cb2

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Publication number
AR070463A1
AR070463A1 ARP090100612A ARP090100612A AR070463A1 AR 070463 A1 AR070463 A1 AR 070463A1 AR P090100612 A ARP090100612 A AR P090100612A AR P090100612 A ARP090100612 A AR P090100612A AR 070463 A1 AR070463 A1 AR 070463A1
Authority
AR
Argentina
Prior art keywords
aryl
alkyl
optionally halogenated
substituted
cycloalkyl
Prior art date
Application number
ARP090100612A
Other languages
English (en)
Inventor
Monika Ermann
Innocent Mushi
Pier Francesco Cirillo
Eugene Richard Hickey
Doris Riether
Original Assignee
Boehringer Ingelheim Int
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Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR070463A1 publication Critical patent/AR070463A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C07D261/16—Benzene-sulfonamido isoxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Compuestos que modulan el receptor CB2. Composiciones farmacéuticas. Reivindicacion 1: Un compuesto caracterizado porque tiene la formula (1), en la que R1 es hidrogeno, alquilo C1-10 o cicloalquilo C3-10, cada uno opcionalmente halogenado o sustituido con 1-3 grupos alquilo C1-10 opcionalmente halogenados; R2 es alquilo C1-10, cicloalquilo C3-10, arilsulfonilo, arilcarbonilo, acilo C1-10, cicloalquilcarbonilo C3-10, heterociclilcarbonilo, heteroarilcarbonilo, heterociclilo, bencilo, fenetilo, arilo o heteroarilo y cada uno opcionalmente sustituido independientemente con 1 a 3 sustituyentes elegidos entre alquilo C1-6, cicloalquilo C3-10, alcoxi C1-6, alquiltio C1-6, alquilsulfonilo C1-6, alcoxicarbonilo C1-6, alquilamino C1-6, cicloalquilamino C3-6, dialquilamino C1-6, alquilaminocarbonilo C1-6, acilamino C1-6, dialquilaminocarbonilo C1-6, hidroxilo, halogeno, ciano, nitro, oxo, heterociclilo, arilo y heteroarilo y cada sustituyente sobre R2, cuando sea posible, está opcionalmente halogenado o sustituido con 1 a 3 grupos alquilo C1-6, acilo C1-6, alquilsulfonilo C1-6, ciano, arilo, oxo o hidroxilo; o R1 y R2 junto con el átomo de nitrogeno al que están unidos forman un heterociclo monociclico, bicíclico o espirocíclico o un anillo heteroarilo monocíclico o bicíclico, cada uno opcionalmente sustituido con 1 a 3 grupos alquilo C1-6, alcoxi C1-6, acilo C1-6, alquilsulfonilo C1-6, ciano, arilo, oxo, hidroxilo o halogeno, estando cada sustituyente del anillo opcionalmente halogenado adicionalmente cuando sea posible; R3 y R4 son independientemente hidrogeno o alquilo C1-6 opcionalmente halogenado con la condicion de que R3 y R4 no pueden ser simultáneamente hidrogeno; o R3 y R4 junto con el átomo de carbono al que están unidos forman un anillo cicloalquilo o heterocíclico de 3 a 6 miembros, cada uno opcionalmente halogenado; R5 es arilo o heteroarilo de 5 a 6 miembros, cada uno sustituido con 1 a 3 sustituyentes elegidos entre alquilo C1-6, heterociclilo, alcoxi C1-6, cicloalquilo C3-6, ariloxi, halogeno, ciano, dimetilaminoalquilo C1-4, arilo, tienilo y piridinilo; y cada sustituyente sobre R5 está opcionalmente halogenado o sustituido con 1 a 3 grupos alquilo C1-4 opcionalmente halogenados; o una sal farmacéuticamente aceptable del mismo. Reivindicacion 8: Un compuesto caracterizado porque tiene la formula (2) en la que R2 es alquilo C1-10, cicloalquilo C3-10, heterociclilo, bencilo, fenetilo, arilo o heteroarilo y cada uno opcionalmente sustituido independientemente con 1 a 3 sustituyentes elegidos entre alquilo C1-6, cicloalquilo C3-10, alcoxi C1-6, alquiltio C1-6, alquilsulfonilo C1-6, alcoxicarbonilo C1-6, alquilamino C1-6, cicloalquilamino C3-6, dialquilamino C1-6, alquilaminocarbonilo C1-6, acilamino C1-6, dialquilaminocarbonilo C1-6, hidroxilo, halogeno, ciano, nitro, oxo, heterociclilo, arilo y heteroarilo, cada sustituyente sobre R2, cuando sea posible, está opcionalmente halogenado o sustituido con 1 a 3 grupos alquilo C1-6, acilo C1-6, alquilsulfonilo C1-6, ciano, arilo, oxo o hidroxilo; R3 y R4 son independientemente hidrogeno o alquilo C1-6 opcionalmente halogenado con la condicion de que R3 y R4 no pueden ser simultáneamente hidrogeno; o R3 y R4 junto con el átomo de carbono al que están unidos forman un anillo cicloalquilo o heterocíclico de 3 a 6 miembros, cada uno opcionalmente halogenado; R5 es arilo o heteroarilo de 5 a 6 miembros, cada uno sustituido con 1 a 3 sustituyentes elegidos entre alquilo C1-6, heterociclilo, alcoxi C1-6, cicloalquilo C3-6, ariloxi, halogeno, ciano, dimetilaminoalquilo C1-4, arilo, tienilo y piridinilo, y cada sustituyente sobre R5 está opcionalmente halogenado o sustituido con 1 a 3 grupos alquilo C1-4 opcionalmente halogenados; o una sal farmacéuticamente aceptable del mismo. Reivindicacion 14: Un compuesto caracterizado porque tiene la formula (3) donde para la formula (3) el resto de formula (4) se elige independientemente entre los miembros de la columna A de la Tabla 1, y el resto de formula (5) se elige independientemente entre los miembros de la columna B de la Tabla 1; donde X en cada caso es halogeno o CH3 opcionalmente halogenado, o una sal farmacéuticamente aceptable de los mismos.
ARP090100612A 2008-02-21 2009-02-20 Compuestos de amina y eter que modulan el receptor cb2 AR070463A1 (es)

Applications Claiming Priority (1)

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US3038608P 2008-02-21 2008-02-21

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AR070463A1 true AR070463A1 (es) 2010-04-07

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ARP090100612A AR070463A1 (es) 2008-02-21 2009-02-20 Compuestos de amina y eter que modulan el receptor cb2

Country Status (8)

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US (1) US8957063B2 (es)
EP (1) EP2265585B1 (es)
JP (1) JP5496918B2 (es)
AR (1) AR070463A1 (es)
CA (1) CA2716515A1 (es)
CL (1) CL2009000402A1 (es)
TW (1) TW200940533A (es)
WO (1) WO2009105509A1 (es)

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JP5756800B2 (ja) 2009-06-16 2015-07-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節するアゼチジン２−カルボキサミド誘導体
EP2480544A1 (en) * 2009-09-22 2012-08-01 Boehringer Ingelheim International GmbH Compounds which selectively modulate the cb2 receptor
EP2523936A1 (en) * 2010-01-15 2012-11-21 Boehringer Ingelheim International GmbH Compounds which modulate the cb2 receptor
WO2011109324A1 (en) 2010-03-05 2011-09-09 Boehringer Ingelheim International Gmbh Tetrazole compounds which selectively modulate the cb2 receptor
EP2595959B1 (en) 2010-07-22 2015-11-04 Boehringer Ingelheim International GmbH Sulfonyl compounds which modulate the cb2 receptor

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US8957063B2 (en) 2015-02-17
US20110190256A1 (en) 2011-08-04
CL2009000402A1 (es) 2010-03-05
CA2716515A1 (en) 2009-08-27
JP5496918B2 (ja) 2014-05-21
EP2265585A1 (en) 2010-12-29
JP2011513226A (ja) 2011-04-28
WO2009105509A1 (en) 2009-08-27
TW200940533A (en) 2009-10-01

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