AR067528A1 - Eteres heterociclicos sustituidos y su uso en trastornos del snc - Google Patents
Eteres heterociclicos sustituidos y su uso en trastornos del sncInfo
- Publication number
- AR067528A1 AR067528A1 ARP080103007A ARP080103007A AR067528A1 AR 067528 A1 AR067528 A1 AR 067528A1 AR P080103007 A ARP080103007 A AR P080103007A AR P080103007 A ARP080103007 A AR P080103007A AR 067528 A1 AR067528 A1 AR 067528A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- haloalkyl
- cyano
- halo
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Reivindicacion 1: Un compuesto caracterizado porque tiene la formula (1) en la que R1 es hidrogeno o alquilo; R2 es hidrogeno o alquilo, cianoalquilo, haloalquilo, hidroxilalquilo, alcoxialquilo, aminoalquilo, alquilaminoalquilo, dialquilaminoalquilo, ciano, carboxi, alcoxicarbonilo, aminocarbonilo, N-alquilaminocarbonilo o N,N-dialquilaminocarbonilo; R3 es hidrogeno o alquilo; Ar1 es fenilo o piridinilo y está sustituido con 0-3 sustituyentes seleccionados del grupo constituido por halo, alquilo, haloalquilo y ciano; Ar2 es indolilo, indazolilo, bencimidazolilo o benzotriazolilo y está sustituido con 0-3 sustituyentes seleccionados del grupo constituido por halo, alquilo, cicloalquilo, (cicloalquil)alquilo, haloalquilo, cianoalquilo, hidroxi, alcoxi, haloalcoxi, ciano, amino, alquilamino, dialquilamino, pirrolidinilo, piperidinilo, piperazinilo, (alquiI)piperazinilo, morfolinilo, tiomorfolinilo y Ar3, y Ar3 es fenilo sustituido con 0-3 sustituyentes seleccionados del grupo constituido por halo, alquilo, haloalquilo, alcoxi, haloalcoxi y ciano; o una de sus sales farmacéuticamente aceptables.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94901307P | 2007-07-11 | 2007-07-11 | |
US12/165,967 US8026257B2 (en) | 2007-07-11 | 2008-07-01 | Substituted heterocyclic ethers and their use in CNS disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
AR067528A1 true AR067528A1 (es) | 2009-10-14 |
Family
ID=39764827
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080103007A AR067528A1 (es) | 2007-07-11 | 2008-07-11 | Eteres heterociclicos sustituidos y su uso en trastornos del snc |
Country Status (6)
Country | Link |
---|---|
US (1) | US8026257B2 (es) |
AR (1) | AR067528A1 (es) |
CL (1) | CL2008002041A1 (es) |
PE (1) | PE20090444A1 (es) |
TW (1) | TW200906407A (es) |
WO (1) | WO2009009411A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7861969B2 (en) | 2007-05-24 | 2011-01-04 | The Boeing Company | Shaped composite stringers and methods of making |
US7879276B2 (en) | 2007-11-08 | 2011-02-01 | The Boeing Company | Foam stiffened hollow composite stringer |
US7632861B2 (en) * | 2007-11-13 | 2009-12-15 | Bristol-Myers Squibb Company | Substituted heterocyclic ethers and their use in CNS disorders |
JP5598798B2 (ja) | 2008-11-14 | 2014-10-01 | セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー | 4−[2−(2−フルオロフェノキシメチル)フェニル]ピペリジン化合物を調製するためのプロセス |
US8500066B2 (en) | 2009-06-12 | 2013-08-06 | The Boeing Company | Method and apparatus for wireless aircraft communications and power system using fuselage stringers |
US8617687B2 (en) | 2009-08-03 | 2013-12-31 | The Boeing Company | Multi-functional aircraft structures |
EP2308866A1 (de) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide |
WO2011085291A1 (en) * | 2010-01-11 | 2011-07-14 | Theravance, Inc. | 1 - (2 - phenoxymethylphenyl) piperazine compounds as serotonin and norepinephrine reuptake inhibitors |
WO2011119461A1 (en) * | 2010-03-22 | 2011-09-29 | Theravance, Inc. | 1-(2-phenoxymethylheteroaryl)piperidine and piperazine compounds |
CN105793252B (zh) | 2013-12-13 | 2018-01-30 | 豪夫迈·罗氏有限公司 | 布鲁顿氏酪氨酸激酶抑制剂 |
JP6294490B2 (ja) | 2013-12-13 | 2018-03-14 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ブルトン型チロシンキナーゼの阻害剤 |
DK3307734T3 (da) | 2015-06-09 | 2020-01-27 | Abbvie Inc | Nukleære receptormodulatorer (ror) til behandling af inflammatoriske og autoimmune sygdomme |
WO2016198908A1 (en) | 2015-06-09 | 2016-12-15 | Abbvie Inc. | Ror nuclear receptor modulators |
KR101966736B1 (ko) * | 2015-09-15 | 2019-04-09 | 주식회사 엘지화학 | 변성 폴리이미드 및 이를 포함하는 경화성 수지 조성물 |
US10765116B2 (en) | 2016-11-23 | 2020-09-08 | Bayer Cropscience Aktiengesellschaft | 2-[3-(alkylsulfonyl)-2H-indazol-2-yl]-3H-imidazo[4,5-B]pyridine derivatives and similar compounds as pesticides |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1337418C (en) | 1988-03-28 | 1995-10-24 | Engelbert Ciganek | 4-aryl-4-piperiding (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof |
EP0666856B1 (en) * | 1992-10-28 | 2000-01-05 | MERCK SHARP & DOHME LTD. | 4-arylmethyloxymethyl piperidines as tachykinin antagonists |
EP0739336B1 (en) * | 1994-01-13 | 1998-08-26 | MERCK SHARP & DOHME LTD. | Gem-disubstituted azacyclic tachykinin antagonists |
CN100506776C (zh) | 2002-03-13 | 2009-07-01 | 先灵公司 | Nk1拮抗剂 |
ATE358482T1 (de) * | 2002-07-03 | 2007-04-15 | Schering Corp | 1-amido-4-phenyl-4-benzyloxymethyl-piperidin derivative und verwandte verbindungen als neurokinin-1 (nk-1) antagonsisten zur behandlung von erbrechen, depressionen, angstzustände und husten |
EP1546101A1 (en) | 2002-09-09 | 2005-06-29 | AstraZeneca AB | Naphthyl ether compounds and their use |
US7494986B2 (en) * | 2004-07-20 | 2009-02-24 | Bristol-Myers Squibb Company | Cycloalkylamine derivatives as NK-1/SSRI antagonists |
FR2883876B1 (fr) * | 2005-03-30 | 2007-05-04 | Servier Lab | Derives d'indanyl-piperazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US20070249607A1 (en) * | 2006-04-17 | 2007-10-25 | Bristol-Myers Squibb Company | Nk-1 and serotonin transporter inhibitors |
US20080027056A1 (en) * | 2006-07-27 | 2008-01-31 | Bristol-Myers Squibb Company | Substituted heterocyclic ethers and their use in cns disorders |
-
2008
- 2008-07-01 US US12/165,967 patent/US8026257B2/en active Active
- 2008-07-03 WO PCT/US2008/069133 patent/WO2009009411A1/en active Application Filing
- 2008-07-11 PE PE2008001169A patent/PE20090444A1/es not_active Application Discontinuation
- 2008-07-11 AR ARP080103007A patent/AR067528A1/es not_active Application Discontinuation
- 2008-07-11 CL CL2008002041A patent/CL2008002041A1/es unknown
- 2008-07-11 TW TW097126559A patent/TW200906407A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
US20090018132A1 (en) | 2009-01-15 |
WO2009009411A1 (en) | 2009-01-15 |
PE20090444A1 (es) | 2009-04-18 |
US8026257B2 (en) | 2011-09-27 |
CL2008002041A1 (es) | 2009-01-09 |
TW200906407A (en) | 2009-02-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |