AR067528A1 - Eteres heterociclicos sustituidos y su uso en trastornos del snc - Google Patents

Eteres heterociclicos sustituidos y su uso en trastornos del snc

Info

Publication number
AR067528A1
AR067528A1 ARP080103007A ARP080103007A AR067528A1 AR 067528 A1 AR067528 A1 AR 067528A1 AR P080103007 A ARP080103007 A AR P080103007A AR P080103007 A ARP080103007 A AR P080103007A AR 067528 A1 AR067528 A1 AR 067528A1
Authority
AR
Argentina
Prior art keywords
alkyl
haloalkyl
cyano
halo
hydrogen
Prior art date
Application number
ARP080103007A
Other languages
English (en)
Inventor
Andrew P Degnan
George O Tora
John E Macor
Derek John Denhart
Vivekananda Y Vrudhula
Joanne J Bronson
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR067528A1 publication Critical patent/AR067528A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Reivindicacion 1: Un compuesto caracterizado porque tiene la formula (1) en la que R1 es hidrogeno o alquilo; R2 es hidrogeno o alquilo, cianoalquilo, haloalquilo, hidroxilalquilo, alcoxialquilo, aminoalquilo, alquilaminoalquilo, dialquilaminoalquilo, ciano, carboxi, alcoxicarbonilo, aminocarbonilo, N-alquilaminocarbonilo o N,N-dialquilaminocarbonilo; R3 es hidrogeno o alquilo; Ar1 es fenilo o piridinilo y está sustituido con 0-3 sustituyentes seleccionados del grupo constituido por halo, alquilo, haloalquilo y ciano; Ar2 es indolilo, indazolilo, bencimidazolilo o benzotriazolilo y está sustituido con 0-3 sustituyentes seleccionados del grupo constituido por halo, alquilo, cicloalquilo, (cicloalquil)alquilo, haloalquilo, cianoalquilo, hidroxi, alcoxi, haloalcoxi, ciano, amino, alquilamino, dialquilamino, pirrolidinilo, piperidinilo, piperazinilo, (alquiI)piperazinilo, morfolinilo, tiomorfolinilo y Ar3, y Ar3 es fenilo sustituido con 0-3 sustituyentes seleccionados del grupo constituido por halo, alquilo, haloalquilo, alcoxi, haloalcoxi y ciano; o una de sus sales farmacéuticamente aceptables.
ARP080103007A 2007-07-11 2008-07-11 Eteres heterociclicos sustituidos y su uso en trastornos del snc AR067528A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94901307P 2007-07-11 2007-07-11
US12/165,967 US8026257B2 (en) 2007-07-11 2008-07-01 Substituted heterocyclic ethers and their use in CNS disorders

Publications (1)

Publication Number Publication Date
AR067528A1 true AR067528A1 (es) 2009-10-14

Family

ID=39764827

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080103007A AR067528A1 (es) 2007-07-11 2008-07-11 Eteres heterociclicos sustituidos y su uso en trastornos del snc

Country Status (6)

Country Link
US (1) US8026257B2 (es)
AR (1) AR067528A1 (es)
CL (1) CL2008002041A1 (es)
PE (1) PE20090444A1 (es)
TW (1) TW200906407A (es)
WO (1) WO2009009411A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7861969B2 (en) 2007-05-24 2011-01-04 The Boeing Company Shaped composite stringers and methods of making
US7879276B2 (en) 2007-11-08 2011-02-01 The Boeing Company Foam stiffened hollow composite stringer
US7632861B2 (en) * 2007-11-13 2009-12-15 Bristol-Myers Squibb Company Substituted heterocyclic ethers and their use in CNS disorders
CA2742114C (en) 2008-11-14 2016-09-13 Theravance, Inc. Crystalline form of a 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compound
US8500066B2 (en) 2009-06-12 2013-08-06 The Boeing Company Method and apparatus for wireless aircraft communications and power system using fuselage stringers
US8617687B2 (en) 2009-08-03 2013-12-31 The Boeing Company Multi-functional aircraft structures
EP2308866A1 (de) 2009-10-09 2011-04-13 Bayer CropScience AG Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide
EP2523945A1 (en) * 2010-01-11 2012-11-21 Theravance, Inc. 1 - (2 - phenoxymethylphenyl) piperazine compounds as serotonin and norepinephrine reuptake inhibitors
EP2550252B1 (en) * 2010-03-22 2015-05-06 Theravance Biopharma R&D IP, LLC 1-(2-phenoxymethylheteroaryl)piperidine and piperazine compounds
JP6219523B2 (ja) 2013-12-13 2017-10-25 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ブルトンチロシンキナーゼの阻害剤
CN105722834B (zh) 2013-12-13 2017-12-22 豪夫迈·罗氏有限公司 酪氨酸蛋白激酶抑制剂
JP6549735B2 (ja) 2015-06-09 2019-07-24 アッヴィ・インコーポレイテッド 核内受容体調節剤
WO2016198908A1 (en) 2015-06-09 2016-12-15 Abbvie Inc. Ror nuclear receptor modulators
KR101966736B1 (ko) * 2015-09-15 2019-04-09 주식회사 엘지화학 변성 폴리이미드 및 이를 포함하는 경화성 수지 조성물
BR112019010511A2 (pt) 2016-11-23 2019-09-17 Bayer Ag derivados de heterociclo bicíclico fundido como pesticidas

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337418C (en) 1988-03-28 1995-10-24 Engelbert Ciganek 4-aryl-4-piperiding (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof
US5620989A (en) * 1992-10-28 1997-04-15 Merck Sharp & Dohme Limited 4-Arylmethyloxymethyl piperidines as tachykinin antagonsits
WO1995019344A1 (en) * 1994-01-13 1995-07-20 Merck Sharp & Dohme Limited Gem-disubstituted azacyclic tachykinin antagonists
WO2003078376A1 (en) 2002-03-13 2003-09-25 Schering Corporation Nk1 antagonists
US7041682B2 (en) * 2002-07-03 2006-05-09 Schering Corporation NK1 antagonists
JP2006502157A (ja) 2002-09-09 2006-01-19 アストラゼネカ・アクチエボラーグ ナフチルエーテル化合物及びそれらの使用
US7494986B2 (en) * 2004-07-20 2009-02-24 Bristol-Myers Squibb Company Cycloalkylamine derivatives as NK-1/SSRI antagonists
FR2883876B1 (fr) * 2005-03-30 2007-05-04 Servier Lab Derives d'indanyl-piperazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20070249607A1 (en) * 2006-04-17 2007-10-25 Bristol-Myers Squibb Company Nk-1 and serotonin transporter inhibitors
KR20090043497A (ko) * 2006-07-27 2009-05-06 브리스톨-마이어스 스큅 컴퍼니 4-아릴알콕시메틸-4-페닐피페리딘 및 ｃｎｓ 장애의 치료를위한 뉴로키닌 수용체 길항제로서의 그의 용도

Also Published As

Publication number Publication date
US8026257B2 (en) 2011-09-27
CL2008002041A1 (es) 2009-01-09
PE20090444A1 (es) 2009-04-18
US20090018132A1 (en) 2009-01-15
WO2009009411A1 (en) 2009-01-15
TW200906407A (en) 2009-02-16

Similar Documents

Publication Publication Date Title
AR067528A1 (es) Eteres heterociclicos sustituidos y su uso en trastornos del snc
MX2010003366A (es) Derivados de piperidina y piperazina para el tratamiento de tumores.
WO2007003525A3 (en) Cyclic anilino-pyridinotriazines as gsk-3 inhibitors
TW200728277A (en) Bicyclic derivatives as P38 inhibitors
TW200618800A (en) Heterocyclic compounds
UA112428C2 (uk) Пестицидні композиції і пов'язані з ними способи
DK2134691T3 (da) Quinolinonderivativer som parp- og tank-inhibitorer
TN2009000107A1 (en) New sulfonamide derivatives as bradykinin antagonists
CO5640136A2 (es) Derivados de hexahidropiridoisoquinolinas inhibidores de dpp-iv y composiciones farmaceuticas que los contienen
BRPI0608886B8 (pt) derivados de n-sulfonilpirróis e seus usos
ATE346070T1 (de) Purinderivate als kinaseinhibitoren
DE602005014382D1 (de) 2-pyrimidinyl-pyrazolopyridin-erbb-kinaseinhibitoren
MX2007011695A (es) Derivados de oxindol sustituido, medicamentos que contienen dichos derivados y uso de los mismos.
CO6180426A2 (es) Compuesto para el tratamiento de la hepatitis b
MX2015009270A (es) Pirazoles sustituidos en posicion 3 y uso de los mismos como inhibidores de la cinasa cremallera de leucinas dual (dlk).
TW200607805A (en) Novel pyridazinone derivatives, methods for producing them and their use as pharmaceuticals
TW200722424A (en) Substituted piperidines
EA201070395A1 (ru) Ингибиторы polo-подобных киназ
ECSP099335A (es) Compuestos heterocíclicos que contienen nitrógeno y métodos de uso de los mismos
ATE553106T1 (de) Heteroarylpyrrolopyridinone als kinaseinhibitoren
UA85505C2 (en) Kinase inhibitors
SG155946A1 (en) Novel bis-azaindole derivatives, preparation and pharmaceutical use thereof as kinase inhibitors
ATE553093T1 (de) Indazolderivate zur hemmung von trpv1 und verwendungen davon
SG196785A1 (en) 3,4,4a,10b-tetrahydro-1h-thiopyrano-[4, 3-c] isoquinoline derivatives
IL200469A0 (en) Benzimidazole derivatives

Legal Events

Date Code Title Description
FA Abandonment or withdrawal