IL160329A0 - 2-amino-4,5-trisubstituted thiazolyl derivatives - Google Patents
2-amino-4,5-trisubstituted thiazolyl derivativesInfo
- Publication number
- IL160329A0 IL160329A0 IL16032902A IL16032902A IL160329A0 IL 160329 A0 IL160329 A0 IL 160329A0 IL 16032902 A IL16032902 A IL 16032902A IL 16032902 A IL16032902 A IL 16032902A IL 160329 A0 IL160329 A0 IL 160329A0
- Authority
- IL
- Israel
- Prior art keywords
- amino
- thiazolyl derivatives
- trisubstituted
- trisubstituted thiazolyl
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01203087 | 2001-08-13 | ||
| PCT/EP2002/008955 WO2003015773A2 (en) | 2001-08-13 | 2002-08-09 | 2-amino-4,5-trisubstituted thiazolyl derivatives and their use against autoimmune diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL160329A0 true IL160329A0 (en) | 2004-07-25 |
Family
ID=8180790
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16032902A IL160329A0 (en) | 2001-08-13 | 2002-08-09 | 2-amino-4,5-trisubstituted thiazolyl derivatives |
| IL160329A IL160329A (en) | 2001-08-13 | 2004-02-11 | 2-amino-4,5-trisubstituted thiazolyl derivatives, uses thereof for the manufacture of a medicament, pharmaceutical compositions containing them and process of preparation thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL160329A IL160329A (en) | 2001-08-13 | 2004-02-11 | 2-amino-4,5-trisubstituted thiazolyl derivatives, uses thereof for the manufacture of a medicament, pharmaceutical compositions containing them and process of preparation thereof |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7232838B2 (es) |
| EP (1) | EP1418909B1 (es) |
| JP (1) | JP4388805B2 (es) |
| KR (2) | KR101034489B1 (es) |
| CN (1) | CN100496493C (es) |
| AU (1) | AU2002324045C1 (es) |
| BR (1) | BR0211887A (es) |
| CA (1) | CA2451980C (es) |
| EA (1) | EA007717B1 (es) |
| ES (1) | ES2407807T3 (es) |
| HK (1) | HK1069997A1 (es) |
| HR (1) | HRP20040097B1 (es) |
| HU (1) | HUP0401748A3 (es) |
| IL (2) | IL160329A0 (es) |
| MX (1) | MXPA04001399A (es) |
| NO (1) | NO327409B1 (es) |
| NZ (1) | NZ530950A (es) |
| PL (1) | PL368130A1 (es) |
| UA (1) | UA82176C2 (es) |
| WO (1) | WO2003015773A2 (es) |
| ZA (1) | ZA200401162B (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3836019B2 (ja) * | 2001-11-21 | 2006-10-18 | 松下電器産業株式会社 | 受信装置、送信装置及び送信方法 |
| AR044519A1 (es) * | 2003-05-02 | 2005-09-14 | Novartis Ag | Derivados de piridin-tiazol amina y de pirimidin-tiazol amina |
| KR20060129413A (ko) * | 2004-01-30 | 2006-12-15 | 에이비 사이언스 | 티로신 키나제 억제제로서의2-(3-치환된-아릴)아미노-4-아릴-티아졸 |
| EA200702445A1 (ru) | 2005-05-09 | 2008-04-28 | Ачиллион Фармасьютикалз, Инк. | Соединения тиазола и способы их применения |
| WO2006128172A2 (en) * | 2005-05-26 | 2006-11-30 | Synta Pharmaceuticals Corp. | Method for treating b cell regulated autoimmune disorders |
| EA015034B1 (ru) * | 2005-09-13 | 2011-04-29 | Янссен Фармацевтика Н.В. | 2-анилин-4-арилзамещенные тиазольные производные |
| CN101384568B (zh) * | 2006-02-15 | 2012-12-12 | 雅培制药有限公司 | 乙酰辅酶a羧化酶(acc)抑制剂及其在糖尿病、肥胖症和代谢综合征中的应用 |
| WO2007095602A2 (en) | 2006-02-15 | 2007-08-23 | Abbott Laboratories | Novel acetyl-coa carboxylase (acc) inhibitors and their use in diabetes, obesity and metabolic syndrome |
| JP2009529059A (ja) * | 2006-03-08 | 2009-08-13 | アキリオン ファーマシューティカルズ，インコーポレーテッド | 抗ｃ型肝炎ウイルス活性を有する置換アミノチアゾール誘導体 |
| PL2402319T3 (pl) | 2006-03-31 | 2018-02-28 | Novartis Ag | Inhibitory DGAT |
| JP2010528019A (ja) | 2007-05-22 | 2010-08-19 | アキリオン ファーマシューティカルズ，インコーポレーテッド | ヘテロアリール置換チアゾール |
| JP5457344B2 (ja) * | 2007-07-17 | 2014-04-02 | アセア バイオサイエンシズ インコーポレイテッド | 複素環式化合物および抗がん剤としての使用 |
| AR066169A1 (es) | 2007-09-28 | 2009-07-29 | Novartis Ag | Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat |
| CA2697974C (en) | 2007-10-18 | 2015-06-30 | Janssen Pharmaceutica Nv | Trisubstituted 1,2,4-triazoles |
| JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
| PE20091523A1 (es) | 2007-12-20 | 2009-10-29 | Novartis Ag | Derivados de tiazol como inhibidores de la enzima fosfatidilinositol 3-cinasa (pi3k) |
| US20110105436A1 (en) * | 2008-03-10 | 2011-05-05 | Auckland Uniservices Limited | Heteroaryl compounds, compositions, and methods of use in cancer treatment |
| MX2010010127A (es) | 2008-03-19 | 2010-10-25 | Janssen Pharmaceutica Nv | 1,2,4-triazoles trisustituidos como moduladores de receptores de acetilcolina nicotinicos. |
| AU2009245715B2 (en) | 2008-05-09 | 2014-01-09 | Janssen Pharmaceutica Nv | Trisubstituted pyrazoles as acetylcholine receptor modulators |
| US8106209B2 (en) * | 2008-06-06 | 2012-01-31 | Achillion Pharmaceuticals, Inc. | Substituted aminothiazole prodrugs of compounds with anti-HCV activity |
| WO2010002985A1 (en) | 2008-07-01 | 2010-01-07 | Ptc Therapeutics, Inc. | Bmi-1 protein expression modulators |
| UA104147C2 (uk) | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
| CA2739322A1 (en) * | 2008-10-01 | 2010-04-08 | Synta Pharmaceuticals Corp. | Compounds for inflammation and immune-related uses |
| US8293753B2 (en) * | 2009-07-02 | 2012-10-23 | Novartis Ag | Substituted 2-carboxamide cycloamino ureas |
| SG11201401207XA (en) * | 2011-10-04 | 2014-05-29 | Inst Hepatitis & Virus Res | Substituted aminothiazoles as inhibitors of cancers, including hepatocellular carcinoma, and as inhibitors of hepatitis virus replication |
| CN103159695B (zh) * | 2011-12-08 | 2015-08-12 | 首都师范大学 | 可抑制hiv复制并对耐药hiv病毒株有效的噻唑类化合物及其制备方法和用途 |
| CN102863435B (zh) * | 2012-09-25 | 2015-02-18 | 盐城工学院 | 一种2-[[4-氟-3-(三氟甲基)苯基]氨基]-4-吡啶基-5-噻唑甲醛及其还原产物的制备方法 |
| US9453002B2 (en) | 2013-08-16 | 2016-09-27 | Janssen Pharmaceutica Nv | Substituted imidazoles as N-type calcium channel blockers |
| US11072592B2 (en) | 2015-02-27 | 2021-07-27 | The Regents Of The University Of California | Small molecules that enable cartilage rejuvenation |
| KR20170001969U (ko) | 2015-11-27 | 2017-06-07 | 주식회사 바이오해저드특수청소 | 조류 퇴치기 |
| CN105524056A (zh) * | 2016-01-05 | 2016-04-27 | 中山大学肿瘤防治中心 | 一种氨基噻唑化合物及其制备方法和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3459731A (en) | 1966-12-16 | 1969-08-05 | Corn Products Co | Cyclodextrin polyethers and their production |
| BE795907A (fr) * | 1972-02-25 | 1973-06-18 | Luso Farmaco Inst | 2-amino-4-arylthiazoles 5-substitues et leur preparation |
| US4649146A (en) * | 1983-01-31 | 1987-03-10 | Fujisawa Pharmaceutical Co., Ltd. | Thiazole derivatives and pharmaceutical composition comprising the same |
| EP0149884B1 (en) * | 1983-09-09 | 1992-12-16 | Takeda Chemical Industries, Ltd. | 5-pyridyl-1,3-thiazole derivatives, their production and use |
| DE3406232A1 (de) | 1984-02-21 | 1985-08-29 | Bayer Ag, 5090 Leverkusen | Faserreaktive formazanfarbstoffe |
| DE3406329A1 (de) * | 1984-02-22 | 1985-08-22 | Merck Patent Gmbh, 6100 Darmstadt | Pyridone |
| JPS6267022A (ja) | 1985-09-18 | 1987-03-26 | Otsuka Pharmaceut Factory Inc | 抗炎症剤 |
| US5000775A (en) * | 1985-12-31 | 1991-03-19 | Monsanto Company | 2-amino-4,5-disubstituted-oxazole/thiazole compounds as herbicide antidotes |
| JPH07149745A (ja) | 1993-11-30 | 1995-06-13 | Hisamitsu Pharmaceut Co Inc | 新規な２−アミノチアゾール誘導体 |
| CA2206315A1 (en) * | 1994-11-29 | 1996-06-06 | Hisamitsu Pharmaceutical Co., Inc. | Antibacterial preparation or bactericide comprising 2-aminothiazole derivative and/or salt thereof |
| JP3310299B2 (ja) | 1995-11-23 | 2002-08-05 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 溶融−押し出しにより調製されるシクロデキストリンの固体混合物 |
| WO1999064418A1 (en) | 1998-06-05 | 1999-12-16 | Novartis Ag | Aryl pyridinyl thiazoles |
| CA2397661C (en) | 2000-03-01 | 2012-01-03 | Janssen Pharmaceutica N.V. | 2,4-disubstituted thiazolyl derivatives |
| US6403588B1 (en) * | 2000-04-27 | 2002-06-11 | Yamanouchi Pharmaceutical Co., Ltd. | Imidazopyridine derivatives |
| AU2001295992A1 (en) | 2000-10-24 | 2002-05-06 | Sankyo Company Limited | Imidazopyridine derivatives |
-
2002
- 2002-08-09 JP JP2003520732A patent/JP4388805B2/ja not_active Expired - Fee Related
- 2002-08-09 US US10/486,819 patent/US7232838B2/en not_active Expired - Lifetime
- 2002-08-09 AU AU2002324045A patent/AU2002324045C1/en not_active Ceased
- 2002-08-09 BR BR0211887-4A patent/BR0211887A/pt not_active IP Right Cessation
- 2002-08-09 ES ES02758455T patent/ES2407807T3/es not_active Expired - Lifetime
- 2002-08-09 CN CNB028157990A patent/CN100496493C/zh not_active Expired - Fee Related
- 2002-08-09 NZ NZ530950A patent/NZ530950A/xx not_active IP Right Cessation
- 2002-08-09 HU HU0401748A patent/HUP0401748A3/hu unknown
- 2002-08-09 MX MXPA04001399A patent/MXPA04001399A/es active IP Right Grant
- 2002-08-09 KR KR1020107011315A patent/KR101034489B1/ko active IP Right Grant
- 2002-08-09 EA EA200400306A patent/EA007717B1/ru not_active IP Right Cessation
- 2002-08-09 CA CA2451980A patent/CA2451980C/en not_active Expired - Lifetime
- 2002-08-09 KR KR1020037017268A patent/KR100979988B1/ko active IP Right Grant
- 2002-08-09 WO PCT/EP2002/008955 patent/WO2003015773A2/en active Application Filing
- 2002-08-09 PL PL02368130A patent/PL368130A1/xx not_active Application Discontinuation
- 2002-08-09 EP EP02758455A patent/EP1418909B1/en not_active Expired - Lifetime
- 2002-08-09 IL IL16032902A patent/IL160329A0/xx unknown
- 2002-09-08 UA UA2004031904A patent/UA82176C2/uk unknown
-
2004
- 2004-01-29 HR HRP20040097AA patent/HRP20040097B1/hr not_active IP Right Cessation
- 2004-02-11 IL IL160329A patent/IL160329A/en active IP Right Grant
- 2004-02-12 ZA ZA2004/01162A patent/ZA200401162B/en unknown
- 2004-02-12 NO NO20040632A patent/NO327409B1/no not_active IP Right Cessation
-
2005
- 2005-04-01 HK HK05102761.8A patent/HK1069997A1/xx not_active IP Right Cessation
-
2007
- 2007-05-01 US US11/742,741 patent/US7803823B2/en not_active Expired - Fee Related
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