WO2008146919A1 - リンコサミド誘導体及びこれを有効成分とする抗菌剤 - Google Patents
リンコサミド誘導体及びこれを有効成分とする抗菌剤 Download PDFInfo
- Publication number
- WO2008146919A1 WO2008146919A1 PCT/JP2008/060045 JP2008060045W WO2008146919A1 WO 2008146919 A1 WO2008146919 A1 WO 2008146919A1 JP 2008060045 W JP2008060045 W JP 2008060045W WO 2008146919 A1 WO2008146919 A1 WO 2008146919A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group
- derivative
- lincosamide
- membered monocyclic
- monocyclic heterocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
- C07H15/16—Lincomycin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08777056A EP2166015A4 (en) | 2007-05-31 | 2008-05-30 | LINCOSAMIDE DERIVATIVE AND ANTIBACTERIAL AGENT CONTAINING ACTIVE SUBSTANCE |
US12/451,752 US7867980B2 (en) | 2007-05-31 | 2008-05-30 | Lincosamide derivatives and antimicrobial agents comprising the same as active ingredient |
JP2009516374A JP5290166B2 (ja) | 2007-05-31 | 2008-05-30 | リンコサミド誘導体及びこれを有効成分とする抗菌剤 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-146200 | 2007-05-31 | ||
JP2007146200 | 2007-05-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008146919A1 true WO2008146919A1 (ja) | 2008-12-04 |
Family
ID=40075149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/060045 WO2008146919A1 (ja) | 2007-05-31 | 2008-05-30 | リンコサミド誘導体及びこれを有効成分とする抗菌剤 |
Country Status (4)
Country | Link |
---|---|
US (1) | US7867980B2 (ja) |
EP (1) | EP2166015A4 (ja) |
JP (1) | JP5290166B2 (ja) |
WO (1) | WO2008146919A1 (ja) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2492263A1 (en) * | 2006-07-25 | 2012-08-29 | Cephalon, Inc. | Pyridizinone Derivatives |
US9533973B2 (en) | 2011-12-08 | 2017-01-03 | The Board Of Regents Of The University Of Texas System | Allosteric modulators of 5-hydroxytryptamine 2C receptor (5-HT2CR) |
CZ307305B6 (cs) * | 2017-03-10 | 2018-05-23 | Mikrobiologický ústav AV ČR, v. v. i. | Linkosamidy, jejich příprava a použití |
US11566039B2 (en) | 2017-08-10 | 2023-01-31 | President And Fellows Of Harvard College | Lincosamide antibiotics and uses thereof |
EP3664799A4 (en) * | 2017-08-10 | 2021-04-21 | President And Fellows Of Harvard College | LINCOSAMIDE ANTIBIOTICS AND THEIR USES |
CN108226324B (zh) * | 2017-12-14 | 2021-01-12 | 兆科(广州)眼科药物有限公司 | 一种盐酸克林霉素的杂质控制方法 |
CN108203404A (zh) * | 2018-03-02 | 2018-06-26 | 上海博邦医药科技有限公司 | (r)-3-苯基哌啶或/和(s)-3-苯基哌啶以及尼拉帕尼的手性中间体的合成方法 |
CN112110898B (zh) * | 2020-09-25 | 2022-07-05 | 西南大学 | 辛弗林磺酰化衍生物及其中间体、制备方法和应用 |
Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3418414A (en) | 1966-08-31 | 1968-12-24 | Upjohn Co | Trimethylsilyl ethers of lincomycin and its compounds |
US3544551A (en) | 1968-04-30 | 1970-12-01 | Upjohn Co | 7-mercapto-7-deoxylincomycins and process for preparing the same |
US3689474A (en) | 1970-08-04 | 1972-09-05 | Upjohn Co | 7-mercapto-7-deoxylincomycins and process for preparing the same |
DE2229950A1 (de) | 1971-06-23 | 1972-12-28 | The Upjohn Co., Kalamazoo, Mich. (V.St.A.) | Verfahren zur Herstellung von Alkyl-7-deoxy-7RS tief n -alpha-thiolincosaminiden |
US3767649A (en) | 1971-11-15 | 1973-10-23 | Upjohn Co | Process for making derivatives of lincomycin and its analogs |
US3870699A (en) | 1973-03-06 | 1975-03-11 | Upjohn Co | Lincomycin analogs |
US3915954A (en) | 1971-11-15 | 1975-10-28 | Upjohn Co | Derivatives of lincomycin and its analogs and process |
WO2005007665A2 (en) * | 2003-06-17 | 2005-01-27 | Vicuron Pharmaceuticals Inc. | Lincomycin derivatives possessing antibacterial activity |
WO2005012320A2 (en) | 2003-06-17 | 2005-02-10 | Vicuron Pharmaceuticals, Inc. | Novel lincomycin derivatives possessing antimicrobial activity |
JP2006504673A (ja) * | 2002-08-15 | 2006-02-09 | バイクロン ファーマシューティカルズ, インコーポレイテッド | 抗菌活性を有するリンコマイシン誘導体 |
WO2006055070A2 (en) * | 2004-11-17 | 2006-05-26 | Vicuron Pharmaceuticals Inc. | Novel lincomycin derivatives possessing antibacterial activity |
JP2007146200A (ja) | 2005-11-25 | 2007-06-14 | Nisshin Steel Co Ltd | アルミニウム材料に対するスポット溶接性に優れた溶融アルミニウムめっき鋼板 |
WO2007066805A1 (ja) * | 2005-12-09 | 2007-06-14 | Meiji Seika Kaisha, Ltd. | リンコマイシン誘導体およびこれを有効成分とする抗菌剤 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7199105B2 (en) * | 2002-08-15 | 2007-04-03 | Vicuron Pharmaceuticals, Inc. | Lincomycin derivatives possessing antibacterial activity |
US7256177B2 (en) * | 2003-06-17 | 2007-08-14 | Vicuron Pharmaceuticals, Inc. | Lincomycin derivatives possessing antibacterial activity |
US7199106B2 (en) * | 2003-06-17 | 2007-04-03 | Vicuron Pharmaceuticals, Inc. | Lincomycin derivatives possessing antimicrobial activity |
-
2008
- 2008-05-30 WO PCT/JP2008/060045 patent/WO2008146919A1/ja active Application Filing
- 2008-05-30 JP JP2009516374A patent/JP5290166B2/ja not_active Expired - Fee Related
- 2008-05-30 EP EP08777056A patent/EP2166015A4/en not_active Withdrawn
- 2008-05-30 US US12/451,752 patent/US7867980B2/en not_active Expired - Fee Related
Patent Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3418414A (en) | 1966-08-31 | 1968-12-24 | Upjohn Co | Trimethylsilyl ethers of lincomycin and its compounds |
US3544551A (en) | 1968-04-30 | 1970-12-01 | Upjohn Co | 7-mercapto-7-deoxylincomycins and process for preparing the same |
US3689474A (en) | 1970-08-04 | 1972-09-05 | Upjohn Co | 7-mercapto-7-deoxylincomycins and process for preparing the same |
DE2229950A1 (de) | 1971-06-23 | 1972-12-28 | The Upjohn Co., Kalamazoo, Mich. (V.St.A.) | Verfahren zur Herstellung von Alkyl-7-deoxy-7RS tief n -alpha-thiolincosaminiden |
US3915954A (en) | 1971-11-15 | 1975-10-28 | Upjohn Co | Derivatives of lincomycin and its analogs and process |
US3767649A (en) | 1971-11-15 | 1973-10-23 | Upjohn Co | Process for making derivatives of lincomycin and its analogs |
US3870699A (en) | 1973-03-06 | 1975-03-11 | Upjohn Co | Lincomycin analogs |
JP2006504673A (ja) * | 2002-08-15 | 2006-02-09 | バイクロン ファーマシューティカルズ, インコーポレイテッド | 抗菌活性を有するリンコマイシン誘導体 |
WO2005007665A2 (en) * | 2003-06-17 | 2005-01-27 | Vicuron Pharmaceuticals Inc. | Lincomycin derivatives possessing antibacterial activity |
WO2005012320A2 (en) | 2003-06-17 | 2005-02-10 | Vicuron Pharmaceuticals, Inc. | Novel lincomycin derivatives possessing antimicrobial activity |
WO2006055070A2 (en) * | 2004-11-17 | 2006-05-26 | Vicuron Pharmaceuticals Inc. | Novel lincomycin derivatives possessing antibacterial activity |
JP2007146200A (ja) | 2005-11-25 | 2007-06-14 | Nisshin Steel Co Ltd | アルミニウム材料に対するスポット溶接性に優れた溶融アルミニウムめっき鋼板 |
WO2007066805A1 (ja) * | 2005-12-09 | 2007-06-14 | Meiji Seika Kaisha, Ltd. | リンコマイシン誘導体およびこれを有効成分とする抗菌剤 |
Non-Patent Citations (14)
Title |
---|
BIRKENMEYER R.D. ET AL.: "Synthesis and antimicrobial activity of clindamycin analogues: Pirlimycin, a potent antibacterial agent", J. MED. CHEM., vol. 27, no. 2, 1984, pages 216 - 223, XP002174848 * |
CHEM. PHARM. BULL., vol. 32, 1984, pages 2241 |
CHEMOTHERAPY, vol. 16, no. 1, 1968, pages 99 |
J. AM. CHEM. SOC., vol. 110, 1998, pages 3894 |
J. ANTIBIOTICS, vol. 49, 1996, pages 941 |
J. CHEM. SOC., PERKIN TRANS 1, 1984, pages 435 |
J. MED. CHEM., 1984, pages 27 |
J. MED. CHEM., vol. 13, 1970, pages 616 |
J. MED. CHEM., vol. 32, 1989, pages 829 |
J. MED. CHEM., vol. 39, 1996, pages 480 |
See also references of EP2166015A4 * |
SZTARICSKAI F. ET AL.: "Semisynthetic modification of antibiotic lincomycin", J. ANTIBIOTICS, vol. 49, no. 9, 1996, pages 941 - 943, XP009044907 * |
TETRAHEDRON LETT., vol. 35, 1994, pages 2053 |
TETRAHEDRON LETT., vol. 43, 2002, pages 3499 |
Also Published As
Publication number | Publication date |
---|---|
US7867980B2 (en) | 2011-01-11 |
EP2166015A4 (en) | 2012-09-05 |
JP5290166B2 (ja) | 2013-09-18 |
JPWO2008146919A1 (ja) | 2010-08-19 |
US20100184746A1 (en) | 2010-07-22 |
EP2166015A1 (en) | 2010-03-24 |
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