PE20120937A1 - Compuestos derivados de quinolina y quinoxalina como agentes antivirales - Google Patents
Compuestos derivados de quinolina y quinoxalina como agentes antiviralesInfo
- Publication number
- PE20120937A1 PE20120937A1 PE2011002042A PE2011002042A PE20120937A1 PE 20120937 A1 PE20120937 A1 PE 20120937A1 PE 2011002042 A PE2011002042 A PE 2011002042A PE 2011002042 A PE2011002042 A PE 2011002042A PE 20120937 A1 PE20120937 A1 PE 20120937A1
- Authority
- PE
- Peru
- Prior art keywords
- oxo
- alcoxy
- dihydro
- ilo
- pyridin
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 2
- XSCHRSMBECNVNS-UHFFFAOYSA-N quinoxaline Chemical compound N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 title 2
- 239000003443 antiviral agent Substances 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 1
- FIULGFJIHJJXMT-UHFFFAOYSA-N [C]1[N]C=CC=C1 Chemical group [C]1[N]C=CC=C1 FIULGFJIHJJXMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: X1, X2, X3 Y X4 SON CADA UNO N, CR5; R1 ES PIRIDINILO, 2-OXO-1,2-DIHIDRO-PIRIDIN-3-ILO; 3-OXO-3,4-DIHIDRO-PIRAZIN-2-ILO, 2-OXO-TETRAHIDRO-PIPERIDIN-1-ILO, ENTRE OTROS; R2 ES H, ALCOXI C1-C6, ALQUILO C1-C6, HALOALQUILO C1-C6, ENTRE OTROS; R3 ES ARILO, HETEROARILO OPCIONALMENTE SUSTITUIDO 1-3 VECES POR HIDROXI, ALCOXI C1-C6, HIDROXIALQUILO C1-C6, ENTRE OTROS; R4 ES CF3, CH2CF3, CICLOALQUILO C3-5, HALOGENO, ALCOXI C1-6, ENTRE OTROS; R5 ES H, HALOGENO, ALCOXI C1-C6, ALQUILO C1-C6. SON COMPUESTOS PREFERIDOS: N-{4-[6-TERT-BUTIL-2-METOXI-8-(2-OXO-1,2-DIHIDRO-PIRIDIN-3-IL)-QUINOLIN-3-IL]-FENIL}-METANOSULFONAMIDA; N-{(S)-1-[6-TERT-BUTIL-8-(6-HIDROXIMETIL-2-OXO-1,2-DIHIDRO-PIRIDIN-3-IL)-5-METOXI-QUINOLIN-3-IL]-PIRROLIDIN-3-ILMETIL}-METANOSULFONAMIDA; ENTRE OTROS. REFERIDA ADEMAS A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN INHIBIDOR DE LA POLIMERASA NS5b UTIL EN EL TRATAMIENTO DE HEPATITIS C
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18546009P | 2009-06-09 | 2009-06-09 | |
US26335109P | 2009-11-21 | 2009-11-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20120937A1 true PE20120937A1 (es) | 2012-08-01 |
Family
ID=42288900
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2011002042A PE20120937A1 (es) | 2009-06-09 | 2010-06-08 | Compuestos derivados de quinolina y quinoxalina como agentes antivirales |
PE2015001204A PE20151092A1 (es) | 2009-06-09 | 2010-06-08 | Compuestos derivados de quinolina y quinoxalina como agentes antivirales |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2015001204A PE20151092A1 (es) | 2009-06-09 | 2010-06-08 | Compuestos derivados de quinolina y quinoxalina como agentes antivirales |
Country Status (25)
Country | Link |
---|---|
US (2) | US8026253B2 (es) |
EP (1) | EP2440528B1 (es) |
JP (1) | JP5612678B2 (es) |
KR (1) | KR101431343B1 (es) |
CN (1) | CN102803216B (es) |
AR (1) | AR077004A1 (es) |
AU (1) | AU2010257592B2 (es) |
BR (1) | BRPI1010852A2 (es) |
CA (1) | CA2764141C (es) |
CO (1) | CO6400218A2 (es) |
CR (1) | CR20110605A (es) |
EC (1) | ECSP11011513A (es) |
ES (1) | ES2525254T3 (es) |
HK (1) | HK1176070A1 (es) |
IL (1) | IL216412A (es) |
MA (1) | MA33360B1 (es) |
MX (1) | MX2011013209A (es) |
MY (1) | MY157435A (es) |
NZ (1) | NZ596646A (es) |
PE (2) | PE20120937A1 (es) |
RU (1) | RU2540332C2 (es) |
SG (1) | SG176762A1 (es) |
TW (1) | TWI428332B (es) |
WO (1) | WO2010142656A1 (es) |
ZA (1) | ZA201108921B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2752443A1 (en) * | 2009-03-06 | 2010-09-10 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
ES2481411T3 (es) | 2010-07-07 | 2014-07-30 | F. Hoffmann-La Roche Ag | Compuestos heterocíclicos antivíricos |
BR112013003113A2 (pt) * | 2010-08-13 | 2019-09-24 | Hoffmann La Roche | compostos antivirais heterocíclicos |
WO2013090929A1 (en) * | 2011-12-15 | 2013-06-20 | Gilead Sciences, Inc. | Amino quinoline derivatives inhibitors of hcv |
US20140128431A1 (en) | 2012-04-03 | 2014-05-08 | Hoffmann-Laroche Inc. | Pharmaceutical composition with improved bioavailability, safety and tolerability |
ES2628365T3 (es) | 2012-10-16 | 2017-08-02 | Janssen Pharmaceutica N.V. | Moduladores de quinolinilo unidos a fenilo de ROR-GAMA-T |
AU2013331493A1 (en) | 2012-10-16 | 2015-04-09 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORyt |
PL2909192T3 (pl) | 2012-10-16 | 2017-09-29 | Janssen Pharmaceutica Nv | Połączone metylenem modulatory chinolinylowe ROR-GAMMA-T |
US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
BR112016008258A2 (pt) | 2013-10-15 | 2017-10-10 | Janssen Pharmaceutica Nv | moduladores de ror?t de quinolinila |
AU2014334619A1 (en) | 2013-10-15 | 2016-04-21 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORyt |
US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
CN106458974B (zh) * | 2014-03-24 | 2019-07-16 | 广东众生药业股份有限公司 | 作为smo抑制剂的喹啉衍生物 |
US10517870B2 (en) * | 2015-07-30 | 2019-12-31 | Bristol-Myers Squibb Company | Aryl substituted bicycle heteroaryl compounds |
WO2021198981A1 (en) | 2020-04-01 | 2021-10-07 | Janssen Biopharma, Inc. | Antiviral compounds and uses thereof |
CN111777549A (zh) * | 2020-07-07 | 2020-10-16 | 中瀚(齐河县)生物医药科技有限公司 | 一种2-甲氧基-3-溴-5-氟吡啶的合成工艺 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB558009A (en) * | 1942-05-08 | 1943-12-15 | Harold Coates | Quinoline derivatives |
NZ235444A (en) * | 1989-09-26 | 1992-07-28 | Sumitomo Chemical Co | Heterocyclically-substituted 1,2,3,6 tetrahydropyrimidine 2,6-diones, intermediates and herbicides |
US6323180B1 (en) * | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
US20040034041A1 (en) * | 2000-05-10 | 2004-02-19 | Dashyant Dhanak | Novel anti-infectives |
US8143305B2 (en) | 2007-08-29 | 2012-03-27 | Schering Corporation | 2,3-substituted indole derivatives for treating viral infections |
AR068109A1 (es) | 2007-08-29 | 2009-11-04 | Schering Corp | Derivados tetraciclicos de indol y una composicion farmaceutica |
US8404845B2 (en) | 2007-08-29 | 2013-03-26 | Merck Sharp & Dohme Corp. | 2,3-substituted azaindole derivatives for treating viral infections |
PT2203430E (pt) | 2007-09-17 | 2011-09-02 | Abbott Lab | N-fenildioxohidropirimidinas úteis como inibidores do vírus da hepatite c (vhc) |
PT2203431E (pt) | 2007-09-17 | 2011-10-12 | Abbott Lab | Pirimidinas anti-infecciosas e seus usos |
PA8796201A1 (es) | 2007-09-17 | 2009-04-23 | Abbott Lab | Agentes anti-infecciosos y su uso |
CN102099351A (zh) | 2007-11-16 | 2011-06-15 | 先灵公司 | 3-杂环取代的吲哚衍生物及其使用方法 |
WO2009064852A1 (en) | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-aminosulfonyl substituted indole derivatives and methods of use thereof |
CN102448920B (zh) | 2009-03-25 | 2016-04-06 | Abbvie公司 | 抗病毒化合物和其用途 |
CN102448952B (zh) | 2009-03-25 | 2014-10-29 | Abbvie公司 | 抗病毒化合物和其用途 |
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2010
- 2010-06-07 AR ARP100101992A patent/AR077004A1/es unknown
- 2010-06-07 TW TW099118427A patent/TWI428332B/zh not_active IP Right Cessation
- 2010-06-08 MY MYPI2011005928A patent/MY157435A/en unknown
- 2010-06-08 MA MA34447A patent/MA33360B1/fr unknown
- 2010-06-08 PE PE2011002042A patent/PE20120937A1/es active IP Right Grant
- 2010-06-08 CA CA2764141A patent/CA2764141C/en not_active Expired - Fee Related
- 2010-06-08 BR BRPI1010852A patent/BRPI1010852A2/pt not_active IP Right Cessation
- 2010-06-08 KR KR1020127000604A patent/KR101431343B1/ko not_active IP Right Cessation
- 2010-06-08 EP EP10720797.9A patent/EP2440528B1/en active Active
- 2010-06-08 CN CN201080025186.6A patent/CN102803216B/zh active Active
- 2010-06-08 AU AU2010257592A patent/AU2010257592B2/en not_active Ceased
- 2010-06-08 RU RU2011153788/04A patent/RU2540332C2/ru not_active IP Right Cessation
- 2010-06-08 MX MX2011013209A patent/MX2011013209A/es active IP Right Grant
- 2010-06-08 SG SG2011091212A patent/SG176762A1/en unknown
- 2010-06-08 NZ NZ596646A patent/NZ596646A/en not_active IP Right Cessation
- 2010-06-08 PE PE2015001204A patent/PE20151092A1/es not_active Application Discontinuation
- 2010-06-08 JP JP2012514440A patent/JP5612678B2/ja active Active
- 2010-06-08 WO PCT/EP2010/057958 patent/WO2010142656A1/en active Application Filing
- 2010-06-08 ES ES10720797.9T patent/ES2525254T3/es active Active
- 2010-06-09 US US12/797,308 patent/US8026253B2/en not_active Expired - Fee Related
-
2011
- 2011-08-18 US US13/212,742 patent/US8487103B2/en active Active
- 2011-11-16 CR CR20110605A patent/CR20110605A/es unknown
- 2011-11-17 IL IL216412A patent/IL216412A/en not_active IP Right Cessation
- 2011-11-24 CO CO11161639A patent/CO6400218A2/es active IP Right Grant
- 2011-12-05 ZA ZA2011/08921A patent/ZA201108921B/en unknown
- 2011-12-09 EC EC2011011513A patent/ECSP11011513A/es unknown
-
2013
- 2013-03-22 HK HK13103620.7A patent/HK1176070A1/zh not_active IP Right Cessation
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Legal Events
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FG | Grant, registration |