PE20141935A1 - Compuestos de dioxido de iminotiadiazina como inhibidores de bace, composiciones, y su uso - Google Patents
Compuestos de dioxido de iminotiadiazina como inhibidores de bace, composiciones, y su usoInfo
- Publication number
- PE20141935A1 PE20141935A1 PE2012000800A PE2012000800A PE20141935A1 PE 20141935 A1 PE20141935 A1 PE 20141935A1 PE 2012000800 A PE2012000800 A PE 2012000800A PE 2012000800 A PE2012000800 A PE 2012000800A PE 20141935 A1 PE20141935 A1 PE 20141935A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- monocyclic
- aryl
- iminotiadiazine
- compositions
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms
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Abstract
REFERIDO A UN COMPUESTO, DE FORMULA (I) DONDE L1 Y L2 DE FORMA INDEPENDIENTE REPRESENTA UN ENLACE O UN RESTO DIVALENTE SELECCIONADO DEL GRUPO FORMADO POR ALQUIL, HALOALQUIL, ENTRE OTROS; L3 REPRESENTA UN ENLACE O UN RESTO DIVALENTE SELECCIONADO DE ALQUIL, HALOALQUIL, HALOALQUIL, ENTRE OTROS; m, n y p SON CADA UNO NUMEROS ENTEROS DONDE m ES 0 O MAS, n ES 0 O MAS Y p ES 0 O MAS; R1 SE SELECCIONA DE H, ALQUILO, HETEROALQUILO, ENTRE OTROS; R2 y R3 SE SELECCIONA DE H, HALO, ALQUILO,ENTRE OTROS; R4 SE SELECCIONA DE ALQUILO, ARILO, HETEROARILO, ENTRE OTROS; EL ANILLO A SE SELECCIONA DE ARILO MONOCICLICO, HETEROARILO MONOCICLICO, CICLOALQUILO MONOCICLICO, ENTRE OTROS; ANILLO B SE SELECCIONA DE ARILO MONOCICLICO, HETEROARILO MONOCICLICO, CICLOALQUILO MONOCICLICO, ETRE OTROS; R5 SE SELECCIONA DE HALO, -CN, -SF5, ENTRE OTROS; R9 SE SELECCIONA DE HALOGENO, -CN, SF5 ,ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE ES UTIL PARA EL TRATAMIENTO Y PREVENCION DE DIVERSAS PATOLOGIAS RELACIONADAS CON LA PRODUCCION DE BETA-AMILOIDES, INCLUYENDO ALZHEIMER.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US24968509P | 2009-10-08 | 2009-10-08 |
Publications (1)
Publication Number | Publication Date |
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PE20141935A1 true PE20141935A1 (es) | 2014-12-17 |
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ID=43857101
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PE2012000800A PE20141935A1 (es) | 2009-10-08 | 2010-10-06 | Compuestos de dioxido de iminotiadiazina como inhibidores de bace, composiciones, y su uso |
Country Status (39)
Country | Link |
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US (6) | US8729071B2 (es) |
EP (2) | EP2485736B1 (es) |
JP (4) | JP5592494B2 (es) |
KR (3) | KR101646424B1 (es) |
CN (2) | CN102639135B (es) |
AR (1) | AR078534A1 (es) |
AU (1) | AU2010303591B2 (es) |
BR (1) | BR112012008014B1 (es) |
CA (1) | CA2774579C (es) |
CL (1) | CL2012000872A1 (es) |
CR (1) | CR20120158A (es) |
DK (1) | DK2485736T3 (es) |
DO (1) | DOP2012000067A (es) |
EA (1) | EA025120B1 (es) |
EC (1) | ECSP12011857A (es) |
ES (2) | ES2773908T3 (es) |
GE (1) | GEP20156366B (es) |
HK (2) | HK1167608A1 (es) |
HN (1) | HN2012000612A (es) |
HR (1) | HRP20160185T1 (es) |
HU (1) | HUE028672T2 (es) |
IL (3) | IL218712A (es) |
MA (1) | MA33726B1 (es) |
ME (1) | ME02366B (es) |
MX (1) | MX2012004148A (es) |
MY (1) | MY163744A (es) |
NI (1) | NI201200044A (es) |
NZ (1) | NZ598694A (es) |
PE (1) | PE20141935A1 (es) |
PL (1) | PL2485736T3 (es) |
PT (1) | PT2485736E (es) |
RS (1) | RS54587B1 (es) |
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SI (1) | SI2485736T1 (es) |
TN (1) | TN2012000112A1 (es) |
TW (3) | TW201520192A (es) |
UA (1) | UA108363C2 (es) |
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