UY34278A - Derivados novedosos de oxazina y su uso en el tratamiento de enfermedades - Google Patents
Derivados novedosos de oxazina y su uso en el tratamiento de enfermedadesInfo
- Publication number
- UY34278A UY34278A UY0001034278A UY34278A UY34278A UY 34278 A UY34278 A UY 34278A UY 0001034278 A UY0001034278 A UY 0001034278A UY 34278 A UY34278 A UY 34278A UY 34278 A UY34278 A UY 34278A
- Authority
- UY
- Uruguay
- Prior art keywords
- noxedine
- oxazine
- diseases
- derivatives
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
La invención se relaciona con derivados novedosos de oxazina de la fórmula (I), y sales farmacéuicamente aceptables de los mismos, en donde todas las variables son como se definen en la especificación, composiciones farmacéuticas de las mismas, combinaciones de las mismas, y su uso como medicamentos, particularmente para el tratamiento de la Enfermedad de Alzheimer o diabetes a través de la inhibición de la BACE- 1 o la BACE- 2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161527172P | 2011-08-25 | 2011-08-25 | |
US201261665395P | 2012-06-28 | 2012-06-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY34278A true UY34278A (es) | 2013-04-05 |
Family
ID=47018309
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001034278A UY34278A (es) | 2011-08-25 | 2012-08-20 | Derivados novedosos de oxazina y su uso en el tratamiento de enfermedades |
Country Status (28)
Country | Link |
---|---|
US (2) | US9163011B2 (es) |
EP (2) | EP3023423B1 (es) |
JP (1) | JP5816369B2 (es) |
KR (1) | KR101601571B1 (es) |
CN (1) | CN103906748B (es) |
AP (1) | AP2014007507A0 (es) |
AR (1) | AR087668A1 (es) |
AU (1) | AU2012298177B2 (es) |
BR (1) | BR112014004131A2 (es) |
CA (1) | CA2845093A1 (es) |
CL (1) | CL2014000458A1 (es) |
CO (1) | CO6890097A2 (es) |
CR (1) | CR20140084A (es) |
EA (1) | EA024580B1 (es) |
ES (2) | ES2565229T3 (es) |
GT (1) | GT201400031A (es) |
HK (1) | HK1195903A1 (es) |
IL (1) | IL230975A0 (es) |
MA (1) | MA35356B1 (es) |
MX (1) | MX339303B (es) |
PE (1) | PE20141540A1 (es) |
PL (1) | PL2748162T3 (es) |
SG (1) | SG2014012108A (es) |
TN (1) | TN2014000062A1 (es) |
TW (1) | TW201313706A (es) |
UY (1) | UY34278A (es) |
WO (1) | WO2013027188A1 (es) |
ZA (1) | ZA201401139B (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ589590A (en) | 2008-06-13 | 2012-05-25 | Shionogi & Co | Sulfur-containing heterocyclic derivative having beta-secretase-inhibiting activity |
CA2783958A1 (en) | 2009-12-11 | 2011-06-16 | Shionogi & Co., Ltd. | Oxazine derivative |
SI2663561T1 (sl) | 2011-01-13 | 2016-07-29 | Novartis Ag | Novi heterociklični derivati in njihova uporaba v zdravljenju nevroloških obolenj |
EP2912035A4 (en) | 2012-10-24 | 2016-06-15 | Shionogi & Co | DERIVATIVES OF DIHYDROOXAZINE OR OXAZEPINE HAVING BACE1 INHIBITING ACTIVITY |
AU2014223334C1 (en) * | 2013-03-01 | 2018-10-18 | Amgen Inc. | Perfluorinated 5,6-dihydro-4H-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use |
CN105164121A (zh) | 2013-03-08 | 2015-12-16 | 美国安进公司 | 作为β分泌酶抑制剂的全氟化环丙基稠合的1,3-噁嗪-2-胺化合物以及其使用方法 |
KR102247765B1 (ko) | 2013-04-11 | 2021-05-06 | 에프. 호프만-라 로슈 아게 | Bace1 억제제 |
JO3318B1 (ar) | 2013-06-18 | 2019-03-13 | Lilly Co Eli | مثبطات bace |
EA031132B1 (ru) * | 2014-02-19 | 2018-11-30 | Х. Лундбекк А/С | 2-амино-3,5,5-трифтор-3,4,5,6-тетрагидропиридины в качестве ингибиторов bace1 для лечения болезни альцгеймера |
TW201623295A (zh) | 2014-04-11 | 2016-07-01 | 塩野義製藥股份有限公司 | 具有bace1抑制活性之二氫噻及二氫衍生物 |
MX2017001794A (es) | 2014-08-08 | 2017-06-29 | Amgen Inc | Compuestos de tiazin-2-amina fusionados con ciclopropilo como inhibidores de beta-secretasa y metodos de uso. |
MA40941A (fr) | 2014-11-10 | 2017-09-19 | H Lundbeck As | 2-amino-5,5-difluoro-6-(fluorométhyl)-6-phényl-3,4,5,6-tétrahydropyridines comme inhibiteurs de bace1 |
CR20170187A (es) | 2014-11-10 | 2018-02-01 | H Lundbeck As | 2-Amino-3,5-difluoro-6-metil-6-fenil-3,4,5,6-tetrahidropiridinas en calidad de inhibidores de BACE1 para el tratamiento de la enfermedad de Alzheimer |
JO3458B1 (ar) | 2014-11-10 | 2020-07-05 | H Lundbeck As | 2- أمينو-6- (دايفلوروميثيل) – 5، 5- ديفلورو-6-فينيل-3،4، 5، 6-تيتراهيدروبيريدين كمثبطات bace1 |
US11471449B2 (en) | 2015-02-25 | 2022-10-18 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine to improve cognitive function and for treating Alzheimer's disease |
HUE060353T2 (hu) * | 2015-02-25 | 2023-02-28 | Prilenia Neurotherapeutics Ltd | Pridopidin alkalmazása memória javítására |
TW201717948A (zh) | 2015-08-10 | 2017-06-01 | H 朗德貝克公司 | 包括給予2-胺基-3,5,5-三氟-3,4,5,6-四氫吡啶的聯合治療 |
US10011596B2 (en) | 2015-08-12 | 2018-07-03 | H. Lundbeck A/S | 2-amino-3-fluoro-3-(fluoromethyl)-6-methyl-6-phenyl-3,4,5,6-tetrahydropyridines as BACE1 inhibitors |
US20190055231A1 (en) * | 2016-03-01 | 2019-02-21 | Hoffmann-La Roche Inc. | Bace1 inhibitors |
AU2017378316B2 (en) | 2016-12-15 | 2021-04-01 | Amgen Inc. | Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use |
JP7177773B2 (ja) * | 2016-12-15 | 2022-11-24 | アムジエン・インコーポレーテツド | β-セクレターゼ阻害剤としてのオキサジン誘導体および使用方法 |
MA54101A (fr) | 2016-12-15 | 2021-10-27 | Amgen Inc | Dérivés de thiazine et d'oxazine bicycliques en tant qu'inhibiteurs de bêta-sécrétase et procédés d'utilisation |
MA54100A (fr) | 2016-12-15 | 2021-10-20 | Amgen Inc | Dérivés de thiazine en tant qu'inhibiteurs de bêta-sécrétase et procédés d'utilisation |
US11021493B2 (en) | 2016-12-15 | 2021-06-01 | Amgen Inc. | 1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use |
WO2019208693A1 (en) | 2018-04-27 | 2019-10-31 | Shionogi & Co., Ltd. | Tetrahydropyranooxazine derivatives having selective bace1 inhibitory activity |
CN109725092A (zh) * | 2019-03-19 | 2019-05-07 | 北京和合医学诊断技术股份有限公司 | 检测血液中齐拉西酮含量的液相色谱分析方法 |
CN113173852B (zh) * | 2021-04-26 | 2022-07-12 | 深圳市华先医药科技有限公司 | 二氟丙二酸酯类化合物的制备方法 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL6911868A (es) | 1968-08-31 | 1970-03-03 | ||
WO2003006426A1 (en) * | 2001-07-13 | 2003-01-23 | Axxima Pharmaceuticals Ag | Aromatic guanylhydrazones as effective compounds against neurodiseases |
TW200303742A (en) | 2001-11-21 | 2003-09-16 | Novartis Ag | Organic compounds |
CA2514733A1 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
AR044399A1 (es) | 2003-05-20 | 2005-09-14 | Novartis Ag | Compuestos heterociclicos y su uso como activadores de receptores de ppar. composiciones farmaceuticas que los contienen |
BRPI0617852A2 (pt) | 2005-10-25 | 2011-08-09 | Shionogi & Co | compostos derivados de aminodi-hidrotiazina assim como composições contendo os mesmos |
AU2008245082B8 (en) * | 2007-04-24 | 2012-09-13 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivatives substituted with a cyclic group |
WO2008133273A1 (ja) | 2007-04-24 | 2008-11-06 | Shionogi & Co., Ltd. | アルツハイマー症治療用医薬組成物 |
JPWO2010047372A1 (ja) * | 2008-10-22 | 2012-03-22 | 塩野義製薬株式会社 | Bace1阻害活性を有する2−アミノピリミジン−4−オンおよび2−アミノピリジン誘導体 |
WO2010063718A1 (en) | 2008-12-02 | 2010-06-10 | ETH Zürich | Screening assay for metabolic disease therapeuticals |
US8461160B2 (en) * | 2009-05-08 | 2013-06-11 | Hoffmann-La Roche, Inc. | Dihydropyrimidinones |
GB0912778D0 (en) | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydro-oxazine derivatives |
UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
US7964594B1 (en) | 2009-12-10 | 2011-06-21 | Hoffmann-La Roche Inc. | Amino oxazine derivatives |
CA2783958A1 (en) | 2009-12-11 | 2011-06-16 | Shionogi & Co., Ltd. | Oxazine derivative |
UA103272C2 (uk) * | 2009-12-11 | 2013-09-25 | Ф. Хоффманн-Ля Рош Аг | 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2 |
EP2663308A1 (en) | 2011-01-13 | 2013-11-20 | Novartis AG | Bace-2 inhibitors for the treatment of metabolic disorders |
WO2012100179A1 (en) | 2011-01-21 | 2012-07-26 | Eisai R&D Management Co., Ltd. | Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives |
US8404680B2 (en) | 2011-02-08 | 2013-03-26 | Hoffmann-La Roche Inc. | N-[3-(5-amino-3,3a,7,7a-tetrahydro-1H-2,4-dioxa-6-aza-inden-7-yl)-phenyl]-amides as BACE1 and/or BACE2 inhibitors |
US8754075B2 (en) | 2011-04-11 | 2014-06-17 | Hoffmann-La Roche Inc. | 1,3-oxazines as BACE1 and/or BACE2 inhibitors |
EP2703399A4 (en) | 2011-04-26 | 2014-10-15 | Shionogi & Co | OXAZINE DERIVATIVE AND BACE-1 HEMMER THEREOF |
US8785436B2 (en) | 2011-05-16 | 2014-07-22 | Hoffmann-La Roche Inc. | 1,3-oxazines as BACE 1 and/or BACE2 inhibitors |
US9073909B2 (en) | 2011-06-07 | 2015-07-07 | Hoffmann-La Roche Inc. | [1,3]oxazines |
KR20140041687A (ko) | 2011-06-07 | 2014-04-04 | 에프. 호프만-라 로슈 아게 | Bace1 및/또는 bace2 억제제로서의 할로겐-알킬-1,3-옥사진 |
-
2012
- 2012-08-20 UY UY0001034278A patent/UY34278A/es not_active Application Discontinuation
- 2012-08-23 EP EP15197854.1A patent/EP3023423B1/en active Active
- 2012-08-23 EP EP12772462.3A patent/EP2748162B1/en active Active
- 2012-08-23 AU AU2012298177A patent/AU2012298177B2/en not_active Ceased
- 2012-08-23 JP JP2014526591A patent/JP5816369B2/ja not_active Expired - Fee Related
- 2012-08-23 EA EA201490491A patent/EA024580B1/ru not_active IP Right Cessation
- 2012-08-23 PL PL12772462T patent/PL2748162T3/pl unknown
- 2012-08-23 MX MX2014002230A patent/MX339303B/es active IP Right Grant
- 2012-08-23 US US13/592,580 patent/US9163011B2/en active Active
- 2012-08-23 KR KR1020147007405A patent/KR101601571B1/ko active IP Right Grant
- 2012-08-23 ES ES12772462.3T patent/ES2565229T3/es active Active
- 2012-08-23 CA CA2845093A patent/CA2845093A1/en not_active Abandoned
- 2012-08-23 AP AP2014007507A patent/AP2014007507A0/xx unknown
- 2012-08-23 CN CN201280052486.2A patent/CN103906748B/zh not_active Expired - Fee Related
- 2012-08-23 BR BR112014004131A patent/BR112014004131A2/pt unknown
- 2012-08-23 WO PCT/IB2012/054269 patent/WO2013027188A1/en active Application Filing
- 2012-08-23 PE PE2014000256A patent/PE20141540A1/es not_active Application Discontinuation
- 2012-08-23 ES ES15197854.1T patent/ES2638832T3/es active Active
- 2012-08-23 SG SG2014012108A patent/SG2014012108A/en unknown
- 2012-08-24 TW TW101130894A patent/TW201313706A/zh unknown
- 2012-08-24 AR ARP120103130A patent/AR087668A1/es unknown
-
2014
- 2014-02-11 TN TNP2014000062A patent/TN2014000062A1/en unknown
- 2014-02-13 IL IL230975A patent/IL230975A0/en unknown
- 2014-02-14 ZA ZA2014/01139A patent/ZA201401139B/en unknown
- 2014-02-20 MA MA36766A patent/MA35356B1/fr unknown
- 2014-02-21 CO CO14037398A patent/CO6890097A2/es active IP Right Grant
- 2014-02-24 CR CR20140084A patent/CR20140084A/es unknown
- 2014-02-24 GT GT201400031A patent/GT201400031A/es unknown
- 2014-02-25 CL CL2014000458A patent/CL2014000458A1/es unknown
- 2014-09-10 HK HK14109142.2A patent/HK1195903A1/xx not_active IP Right Cessation
-
2015
- 2015-02-05 US US14/615,418 patent/US20150150877A1/en not_active Abandoned
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20201020 |