HK1187910A1 - Aryl benzocycloalkyl amide derivatives - Google Patents

Aryl benzocycloalkyl amide derivatives

Info

Publication number
HK1187910A1
HK1187910A1 HK14101020.6A HK14101020A HK1187910A1 HK 1187910 A1 HK1187910 A1 HK 1187910A1 HK 14101020 A HK14101020 A HK 14101020A HK 1187910 A1 HK1187910 A1 HK 1187910A1
Authority
HK
Hong Kong
Prior art keywords
benzocycloalkyl
aryl
amide derivatives
amide
derivatives
Prior art date
Application number
HK14101020.6A
Other languages
English (en)
Chinese (zh)
Inventor
約翰尼斯．埃比
阿爾弗雷德．賓格里
科妮莉亞．赫特爾
安尼施．阿索克．康卡爾
豪格．屈內
貝恩德．庫恩
漢斯．
．梅爾基
王海燕
Original Assignee
霍夫曼-拉羅奇有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 霍夫曼-拉羅奇有限公司 filed Critical 霍夫曼-拉羅奇有限公司
Publication of HK1187910A1 publication Critical patent/HK1187910A1/xx

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    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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EP3283464B1 (en) * 2015-04-16 2019-10-23 Merck Sharp & Dohme Corp. Factor xia inhibitors
EP3484859B1 (en) * 2016-07-18 2021-09-15 F. Hoffmann-La Roche AG New difluoroketamide derivatives as htra1 inhibitors
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JP7447089B2 (ja) 2018-08-31 2024-03-11 サイトキネティックス， インコーポレイテッド 心筋サルコメア阻害剤
EP3936192A4 (en) 2019-03-06 2022-11-16 Daiichi Sankyo Company, Limited PYRROLOPYRAZOL DERIVATIVES
CN110256288A (zh) * 2019-05-13 2019-09-20 苏州山青竹生物医药有限公司 一种制备(s)-1-氨基-2,3-二氢-1h-茚-4-甲腈的方法
JP2024501257A (ja) * 2020-12-23 2024-01-11 セルジーン コーポレーション 神経変性疾患の治療のための、インダニルを含むカルボン酸化合物
KR20240015622A (ko) 2021-03-04 2024-02-05 싸이토키네틱스, 인코포레이티드 심장 근절 억제제
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EP2668155B1 (en) 2014-11-26
CA2823781A1 (en) 2012-08-02
WO2012101011A3 (en) 2012-09-20
CN103328436A (zh) 2013-09-25
MX2013008312A (es) 2013-09-06
JP2014511359A (ja) 2014-05-15
AR084913A1 (es) 2013-07-10
KR20140005271A (ko) 2014-01-14
ES2529509T3 (es) 2015-02-20
US20130018055A1 (en) 2013-01-17
WO2012101011A2 (en) 2012-08-02
BR112013018732A2 (pt) 2016-10-25
CN103328436B (zh) 2015-06-10
US8592426B2 (en) 2013-11-26
JP5986108B2 (ja) 2016-09-06
MX343225B (es) 2016-10-28
RU2013136777A (ru) 2015-03-10
EP2668155A2 (en) 2013-12-04

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