ATE388708T1 - Piperazinderivate und anwendungsverfahren - Google Patents

Piperazinderivate und anwendungsverfahren

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Publication number
ATE388708T1
ATE388708T1 AT04820712T AT04820712T ATE388708T1 AT E388708 T1 ATE388708 T1 AT E388708T1 AT 04820712 T AT04820712 T AT 04820712T AT 04820712 T AT04820712 T AT 04820712T AT E388708 T1 ATE388708 T1 AT E388708T1
Authority
AT
Austria
Prior art keywords
methods
diseases
compounds
processes
treatment
Prior art date
Application number
AT04820712T
Other languages
English (en)
Inventor
Jian Chen
Ben Askew
Kaustav Biswas
Jennifer Chau
Amico Derin D
Scott Harried
Thomas Nguyen
Wenyuan Qian
Jiawang Zhu
Christopher Fotsch
Nianhe Han
Aiwen Li
Qingyian Liu
Nobuko Nishimura
Rana Nomak
Tanya Peterkin
Babak Riahi
Kevin Yang
Chester Yuan
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ATE388708T1 publication Critical patent/ATE388708T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
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    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/02—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Addiction (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Tropical Medicine & Parasitology (AREA)
AT04820712T 2003-06-20 2004-06-21 Piperazinderivate und anwendungsverfahren ATE388708T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48030303P 2003-06-20 2003-06-20

Publications (1)

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ATE388708T1 true ATE388708T1 (de) 2008-03-15

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AT04820712T ATE388708T1 (de) 2003-06-20 2004-06-21 Piperazinderivate und anwendungsverfahren

Country Status (18)

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US (2) US7393852B2 (de)
EP (1) EP1656355B1 (de)
JP (1) JP2007516176A (de)
KR (1) KR20060036399A (de)
CN (1) CN1849121A (de)
AT (1) ATE388708T1 (de)
AU (1) AU2004303757B2 (de)
BR (1) BRPI0411673A (de)
CA (1) CA2529314A1 (de)
DE (1) DE602004012418T2 (de)
ES (1) ES2302079T3 (de)
IL (1) IL172419A0 (de)
IS (1) IS8175A (de)
MX (1) MXPA05013469A (de)
NO (1) NO20060278L (de)
RU (1) RU2006101541A (de)
WO (1) WO2005061467A2 (de)
ZA (1) ZA200600579B (de)

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US20040073617A1 (en) * 2000-06-19 2004-04-15 Milliken Walter Clark Hash-based systems and methods for detecting and preventing transmission of unwanted e-mail
US7200105B1 (en) * 2001-01-12 2007-04-03 Bbn Technologies Corp. Systems and methods for point of ingress traceback of a network attack
RU2006101541A (ru) * 2003-06-20 2006-06-10 Амген Инк. (US) Производные пиперазина и способ их применения
US7662811B2 (en) * 2004-07-15 2010-02-16 Amgen Inc. 1,2,3,4-tetrahydropyrazin-2-yl acetamides and methods of use
US20060217362A1 (en) * 2004-12-29 2006-09-28 Tung Jay S Novel compounds useful for bradykinin B1 receptor antagonism
US20060173037A1 (en) * 2005-01-10 2006-08-03 Nathalie Schlienger Aminophenyl derivatives as selective androgen receptor modulators
US8059551B2 (en) * 2005-02-15 2011-11-15 Raytheon Bbn Technologies Corp. Method for source-spoofed IP packet traceback
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CA2529314A1 (en) 2005-07-07
AU2004303757B2 (en) 2009-07-23
NO20060278L (no) 2006-03-15
BRPI0411673A (pt) 2006-08-08
EP1656355A2 (de) 2006-05-17
IS8175A (is) 2005-12-12
MXPA05013469A (es) 2006-03-09
US20050014749A1 (en) 2005-01-20
US20090054460A1 (en) 2009-02-26
ZA200600579B (en) 2007-04-25
RU2006101541A (ru) 2006-06-10
DE602004012418D1 (de) 2008-04-24
US7393852B2 (en) 2008-07-01
DE602004012418T2 (de) 2008-06-19
JP2007516176A (ja) 2007-06-21
IL172419A0 (en) 2006-04-10
KR20060036399A (ko) 2006-04-28
CN1849121A (zh) 2006-10-18
EP1656355B1 (de) 2008-03-12

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