ATE423114T1 - Aminocyclopropancarbonsäureamidderivate als bradykininantagonisten - Google Patents

Aminocyclopropancarbonsäureamidderivate als bradykininantagonisten

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Publication number
ATE423114T1
ATE423114T1 AT05714101T AT05714101T ATE423114T1 AT E423114 T1 ATE423114 T1 AT E423114T1 AT 05714101 T AT05714101 T AT 05714101T AT 05714101 T AT05714101 T AT 05714101T AT E423114 T1 ATE423114 T1 AT E423114T1
Authority
AT
Austria
Prior art keywords
aminocyclopropane
acid amide
carbonic acid
amide derivatives
bradykinin antagonists
Prior art date
Application number
AT05714101T
Other languages
English (en)
Inventor
Mark Bock
Dong-Mei Feng
Scott Kuduk
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE423114T1 publication Critical patent/ATE423114T1/de

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • General Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Physical Education & Sports Medicine (AREA)
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  • Diabetes (AREA)
  • Cardiology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
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AT05714101T 2004-03-02 2005-02-25 Aminocyclopropancarbonsäureamidderivate als bradykininantagonisten ATE423114T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54937904P 2004-03-02 2004-03-02

Publications (1)

Publication Number Publication Date
ATE423114T1 true ATE423114T1 (de) 2009-03-15

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AT05714101T ATE423114T1 (de) 2004-03-02 2005-02-25 Aminocyclopropancarbonsäureamidderivate als bradykininantagonisten

Country Status (9)

Country Link
US (1) US20070189865A1 (de)
EP (1) EP1723143B1 (de)
JP (1) JP2007526311A (de)
CN (1) CN1926136A (de)
AT (1) ATE423114T1 (de)
AU (1) AU2005219836A1 (de)
CA (1) CA2557858A1 (de)
DE (1) DE602005012806D1 (de)
WO (1) WO2005085198A2 (de)

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DE602004016192D1 (de) * 2003-10-07 2008-10-09 Lensbabies Llc Flexibles linsenanbringsystem für die schnellneigungsphotographie
US7429604B2 (en) * 2004-06-15 2008-09-30 Bristol Myers Squibb Company Six-membered heterocycles useful as serine protease inhibitors
WO2009027450A1 (de) 2007-08-29 2009-03-05 Boehringer Ingelheim International Gmbh Neue bradykinin b1-antagonisten
WO2009132453A1 (en) * 2008-04-28 2009-11-05 Neuromed Pharmaceuticals Ltd. Cyclylamine derivatives as calcium channel blockers
GB0807828D0 (en) * 2008-04-29 2008-06-04 Vantia Ltd Aminopyridine derivatives
EP2344176A1 (de) * 2008-09-18 2011-07-20 Jerini AG Verwendung von bradykinin-b1-rezeptor-antagoniten bei der behandlung von darmfibrose
WO2010097373A1 (de) * 2009-02-26 2010-09-02 Boehringer Ingelheim International Gmbh Verbindungen als bradykinin b1 antagonisten
AP2011005808A0 (en) * 2009-02-26 2011-08-31 Boehringer Ingelheim Int Compounds as bradykinin B1 antagonists.
AU2011219885C1 (en) * 2010-02-23 2017-06-29 Boehringer Ingelheim International Gmbh Compounds as bradykinin B1 antagonists
AU2015271888B2 (en) * 2010-02-23 2017-06-15 Boehringer Ingelheim International Gmbh Compounds as bradykinin B1 antagonists
EP2606043B1 (de) 2010-08-20 2014-07-09 Boehringer Ingelheim International GmbH Pyridazinderivative als bradykinin b1 rezeptor antagonsiten
US8937073B2 (en) 2010-08-20 2015-01-20 Boehringer Ingelheim International Gmbh Disubstituted tetrahydrofuranyl compounds and their use as B1-receptor antagonists
HUP1000598A2 (en) * 2010-11-05 2012-09-28 Richter Gedeon Nyrt Indole derivatives
US8912221B2 (en) * 2010-12-27 2014-12-16 Hoffmann-La Roche Inc. Biaryl amide derivatives
US8592426B2 (en) * 2011-01-24 2013-11-26 Hoffmann—La Roche Inc. Aryl-benzocycloalkyl amide derivatives
CN107382844A (zh) * 2017-08-28 2017-11-24 天津科技大学 一种以烟酸胺为原料生产烟酸的方法

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AR038377A1 (es) * 2002-02-08 2005-01-12 Merck & Co Inc Derivados de n-bifenil-aminocicloalcancarboxamida (con sustitucion con metilo)
CA2473778A1 (en) * 2002-02-08 2003-08-14 Merck & Co., Inc. N-biphenylmethyl aminocycloalkanecarboxamide derivatives
US7163951B2 (en) * 2002-08-29 2007-01-16 Merck & Co., Inc. N-biarylmethyl aminocycloalkanecarboxamide derivatives
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EP1723143A2 (de) 2006-11-22
CN1926136A (zh) 2007-03-07
JP2007526311A (ja) 2007-09-13
CA2557858A1 (en) 2005-09-15
DE602005012806D1 (en) 2009-04-02
WO2005085198A3 (en) 2005-11-24
EP1723143B1 (de) 2009-02-18
US20070189865A1 (en) 2007-08-16
WO2005085198A2 (en) 2005-09-15
AU2005219836A1 (en) 2005-09-15

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