JO3317B1 - مركبات تترا هيدروبيرولو ثيازين - Google Patents

مركبات تترا هيدروبيرولو ثيازين

Info

Publication number
JO3317B1
JO3317B1 JOP/2014/0061A JOP20140061A JO3317B1 JO 3317 B1 JO3317 B1 JO 3317B1 JO P20140061 A JOP20140061 A JO P20140061A JO 3317 B1 JO3317 B1 JO 3317B1
Authority
JO
Jordan
Prior art keywords
tetrahydropyrrolothiazine
compounds
tetrahydropyrrolothiazine compounds
compound
formula
Prior art date
Application number
JOP/2014/0061A
Other languages
English (en)
Inventor
Morgan Watson Brian
James Mergott Dustin
James Green Steven
Larry Winneroski Leonard Jr
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of JO3317B1 publication Critical patent/JO3317B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

يتعلق الاختراع الحالي بتوفير مركب وفقًا للصيغة I: حيث تكون R عبارة عن H أو F؛ و تكون A عبارة عن: أو ملح مقبول صيدليًا منه.
JOP/2014/0061A 2013-03-12 2014-02-27 مركبات تترا هيدروبيرولو ثيازين JO3317B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361776819P 2013-03-12 2013-03-12

Publications (1)

Publication Number Publication Date
JO3317B1 true JO3317B1 (ar) 2019-03-13

Family

ID=50382615

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2014/0061A JO3317B1 (ar) 2013-03-12 2014-02-27 مركبات تترا هيدروبيرولو ثيازين

Country Status (38)

Country Link
US (3) US8841293B1 (ar)
EP (1) EP2970336B1 (ar)
JP (1) JP6095844B2 (ar)
KR (1) KR101688761B1 (ar)
CN (1) CN105026404B (ar)
AP (1) AP2015008713A0 (ar)
AR (1) AR094918A1 (ar)
BR (1) BR112015018738A8 (ar)
CA (1) CA2898500C (ar)
CL (1) CL2015002529A1 (ar)
CR (1) CR20150418A (ar)
CY (1) CY1119585T1 (ar)
DK (1) DK2970336T3 (ar)
EA (1) EA026006B1 (ar)
ES (1) ES2653421T3 (ar)
HK (1) HK1212694A1 (ar)
HR (1) HRP20171851T1 (ar)
HU (1) HUE037487T2 (ar)
IL (1) IL240903B (ar)
JO (1) JO3317B1 (ar)
LT (1) LT2970336T (ar)
MA (1) MA38390B1 (ar)
ME (1) ME02910B (ar)
MX (1) MX2015012628A (ar)
MY (1) MY180083A (ar)
NO (1) NO3039297T3 (ar)
NZ (1) NZ712207A (ar)
PE (1) PE20151542A1 (ar)
PH (1) PH12015502031A1 (ar)
PL (1) PL2970336T3 (ar)
PT (1) PT2970336T (ar)
RS (1) RS56645B1 (ar)
SG (1) SG11201507499XA (ar)
SI (1) SI2970336T1 (ar)
TN (1) TN2015000340A1 (ar)
TW (1) TWI593692B (ar)
UA (1) UA112941C2 (ar)
WO (1) WO2014143579A1 (ar)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA37756B1 (fr) 2012-06-13 2018-09-28 Hoffmann La Roche Nouveaux composés diazaspirocycloalcane et azaspirocycloalcane
EP3590940B1 (en) 2012-09-25 2021-06-09 F. Hoffmann-La Roche AG Hexahydropyrrolo[3,4-c]pyrrole derivatives and related compounds as autotaxin (atx) inhibitors and as inhibitors of the lysophosphatidic acid (lpa) production for treating e.g. renal diseases
EP2912041B1 (en) 2012-10-26 2016-12-14 Eli Lilly and Company Tetrahydropyrrolothiazine derivatives as bace inhibitors
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
MA38982A1 (fr) 2013-11-26 2017-09-29 Hoffmann La Roche Nouvel octahydro-cyclobuta [1,2-c; 3,4-c'] dipyrrol-2-yl
TWI684452B (zh) 2014-03-14 2020-02-11 美國禮來大藥廠 胺基噻嗪化合物
MX2016010675A (es) 2014-03-26 2016-11-10 Hoffmann La Roche Compuestos condensados de [1,4]diazepina como inhibidores de produccion de la autotaxina (atx) y acido lisofosfatidico (lpa).
CN106103446B (zh) 2014-03-26 2019-07-30 豪夫迈·罗氏有限公司 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的二环化合物
TWI570127B (zh) * 2014-09-15 2017-02-11 美國禮來大藥廠 結晶型N-[3-[(4aR,7aS)-2-胺基-6-(5-氟嘧啶-2-基)-4,4a,5,7-四氫吡咯并[3,4-d][1,3]噻嗪-7a-基]-4-氟-苯基]-5-甲氧基-吡嗪-2-甲醯胺、其用途及醫藥組合物
TWI599358B (zh) * 2014-09-16 2017-09-21 美國禮來大藥廠 組合療法
TWI574969B (zh) * 2015-01-30 2017-03-21 美國禮來大藥廠 甲苯磺酸鹽
AR103680A1 (es) 2015-02-23 2017-05-24 Lilly Co Eli Inhibidores selectivos de bace1
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
AR104241A1 (es) 2015-04-29 2017-07-05 Lilly Co Eli Derivados de tetrahidrofuro tiazina como inhibidores de bace1 selectivos
CN108026077B (zh) 2015-09-04 2021-11-05 豪夫迈·罗氏有限公司 苯氧基甲基衍生物
MA42923A (fr) 2015-09-24 2021-04-28 Hoffmann La Roche Composés bicycliques comme inhibiteurs mixtes de atx/ca
MA42918A (fr) 2015-09-24 2018-08-01 Hoffmann La Roche Composés bicycliques utilisés en tant qu'inhibiteurs d'atx
WO2017050792A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag Bicyclic compounds as atx inhibitors
JP6845230B2 (ja) 2015-09-24 2021-03-17 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ デュアルａｔｘ／ｃａ阻害剤としての新規な二環式化合物
TW201740954A (zh) 2016-03-16 2017-12-01 美國禮來大藥廠 組合療法
TWI735600B (zh) 2016-07-01 2021-08-11 美商美國禮來大藥廠 抗－N3pGlu類澱粉β肽抗體及其用途
EP3555086B1 (en) 2016-12-15 2021-09-01 Amgen Inc. 1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use
JP7149272B2 (ja) 2016-12-15 2022-10-06 アムジエン・インコーポレーテツド β－セクレターゼ阻害剤としてのチアジン誘導体および使用方法
CA3047287A1 (en) 2016-12-15 2018-06-21 Amgen Inc. Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use
ES2910367T3 (es) * 2016-12-15 2022-05-12 Amgen Inc Derivados de tiazina y oxazina bicíclicos como inhibidores de beta-secretasa y métodos de uso
MX2019007101A (es) 2016-12-15 2019-12-16 Amgen Inc Derivados de oxazina como inhibidores de beta secretasa y metodos de uso.
MA49879A (fr) 2017-03-16 2020-06-24 Hoffmann La Roche Composés hétérocycliques utiles en tant qu'inhibiteurs doubles d'atx/ca
CN110382484B (zh) 2017-03-16 2022-12-06 豪夫迈·罗氏有限公司 新的作为atx抑制剂的二环化合物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284957A (en) * 1992-09-03 1994-02-08 Eli Lilly And Company Excitatory amino acid receptor antagonists
WO2003082856A1 (en) * 2002-03-22 2003-10-09 Eli Lilly And Company Isoquinoline-3-carboxylic acid derivatives as excitatory amino acid receptor antagonists
TWI332005B (en) 2005-06-14 2010-10-21 Schering Corp Aspartyl protease inhibitors
ES2537898T3 (es) 2005-10-25 2015-06-15 Shionogi & Co., Ltd. Derivados de aminotiazolidina y aminotetrahidrotiazepina como inhibidores de BACE 1
JP5383483B2 (ja) 2007-04-24 2014-01-08 塩野義製薬株式会社 アルツハイマー症治療用医薬組成物
CA2711655C (en) 2008-01-18 2013-03-05 Eisai R&D Management Co., Ltd. Condensed aminodihydrothiazine derivative
AU2009239535A1 (en) * 2008-04-22 2009-10-29 Schering Corporation Thiophenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as BACE-1 inhibitors, compositions, and their use
TWI431004B (zh) * 2008-05-02 2014-03-21 Lilly Co Eli Ｂａｃｅ抑制劑
US8637504B2 (en) 2008-06-13 2014-01-28 Shionogi & Co., Ltd. Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity
KR20110076965A (ko) 2008-09-30 2011-07-06 에자이 알앤드디 매니지먼트 가부시키가이샤 신규한 축합 아미노 디하이드로티아진 유도체
AR077277A1 (es) 2009-07-09 2011-08-17 Lilly Co Eli Compuestos de biciclo (1,3)tiazin-2-amina formulacion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de la enfermedad de alzheimer
US20120245155A1 (en) 2009-12-11 2012-09-27 Shionogi & Co., Ltd. Fused heterocyclic compound having amino group
GB201100181D0 (en) 2011-01-06 2011-02-23 Eisai Ltd Fused aminodihydrothiazine derivatives
GB201101139D0 (en) 2011-01-21 2011-03-09 Eisai Ltd Fused aminodihydrothiazine derivatives
GB201101140D0 (en) * 2011-01-21 2011-03-09 Eisai Ltd Fused aminodihydrothiazine derivatives
WO2012138590A1 (en) 2011-04-07 2012-10-11 Merck Sharp & Dohme Corp. Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
US8598161B2 (en) 2011-05-24 2013-12-03 Bristol-Myers Squibb Company Compounds for the reduction of beta-amyloid production
JO3143B1 (ar) * 2012-04-03 2017-09-20 Lilly Co Eli مركبات تتراهيدرو بيرولو ثيازين

Also Published As

Publication number Publication date
MY180083A (en) 2020-11-20
CA2898500A1 (en) 2014-09-18
SI2970336T1 (sl) 2017-11-30
IL240903A0 (en) 2015-10-29
HRP20171851T1 (hr) 2018-01-12
RS56645B1 (sr) 2018-03-30
NO3039297T3 (ar) 2018-03-10
EA026006B1 (ru) 2017-02-28
CR20150418A (es) 2015-09-16
CN105026404A (zh) 2015-11-04
BR112015018738A8 (pt) 2018-01-23
AP2015008713A0 (en) 2015-09-30
JP6095844B2 (ja) 2017-03-15
TW201520217A (zh) 2015-06-01
PH12015502031B1 (en) 2016-01-18
CL2015002529A1 (es) 2016-03-28
PL2970336T3 (pl) 2018-03-30
PE20151542A1 (es) 2015-10-28
TN2015000340A1 (en) 2017-01-03
DK2970336T3 (da) 2017-11-13
JP2016512252A (ja) 2016-04-25
US8841293B1 (en) 2014-09-23
PH12015502031A1 (en) 2016-01-18
KR101688761B1 (ko) 2016-12-21
PT2970336T (pt) 2017-12-21
AU2014228351A1 (en) 2015-09-17
ME02910B (me) 2018-04-20
HUE037487T2 (hu) 2018-08-28
EP2970336B1 (en) 2017-10-04
US20140275044A1 (en) 2014-09-18
SG11201507499XA (en) 2015-10-29
NZ712207A (en) 2019-09-27
WO2014143579A1 (en) 2014-09-18
KR20150119070A (ko) 2015-10-23
UA112941C2 (uk) 2016-11-10
EP2970336A1 (en) 2016-01-20
US20150157641A1 (en) 2015-06-11
AR094918A1 (es) 2015-09-09
CA2898500C (en) 2017-11-14
TWI593692B (zh) 2017-08-01
ES2653421T3 (es) 2018-02-07
US8987254B2 (en) 2015-03-24
LT2970336T (lt) 2018-01-10
MX2015012628A (es) 2016-07-07
CN105026404B (zh) 2016-11-23
BR112015018738A2 (pt) 2017-07-18
IL240903B (en) 2018-12-31
EA201591491A1 (ru) 2016-01-29
HK1212694A1 (zh) 2016-06-17
CY1119585T1 (el) 2018-03-07
US20140350245A1 (en) 2014-11-27
MA38390B1 (fr) 2020-01-31
MA38390A1 (fr) 2018-08-31

Similar Documents

Publication Publication Date Title
JO3317B1 (ar) مركبات تترا هيدروبيرولو ثيازين
MX2017006266A (es) Compuestos de heteroarilo como inhibidores de cinasas asociadas al receptor de interleucina 1(irak) y sus usos.
PH12016500467A1 (en) Aminoheteroarlyl benzamides as kinase inhibitors
PH12016500169A1 (en) Polymorph of syk inhibitors
NZ714283A (en) Novel histone deacetylase inhibitors
EA201591634A1 (ru) Дигидропиридопиримидиновые соединения
PH12017501523A1 (en) Selective bace1 inhibitors
EA201690911A1 (ru) Соединения диметилбензойной кислоты
RS54730B1 (sr) Inhibitori beta sekretaze
IN2015DN00598A (ar)
JO3318B1 (ar) مثبطات bace
MX2015015841A (es) Compuestos de fenoxietil dihidro-1h-isoquinolina.
EA201690894A1 (ru) Феноксиэтилы
IN2014DN07996A (ar)
GB201020397D0 (en) Compounds
TN2019000038A1 (en) Triazolopyrazinone derivative useful as a human pde1 inhibitor
AU2016330503A8 (en) Therapeutic compounds and methods of use thereof
EA201690593A1 (ru) Новые соединения мочевины
MX2015012610A (es) Pacritinib deuterizado.
UA86566U (en) N-hydroxyhomoazaadamantanone and dioxomolybdenum complex thereof