DK1959955T3 - Fremgangsmåde til behandling af abnorm cellevækst - Google Patents
Fremgangsmåde til behandling af abnorm cellevækstInfo
- Publication number
- DK1959955T3 DK1959955T3 DK06820997.2T DK06820997T DK1959955T3 DK 1959955 T3 DK1959955 T3 DK 1959955T3 DK 06820997 T DK06820997 T DK 06820997T DK 1959955 T3 DK1959955 T3 DK 1959955T3
- Authority
- DK
- Denmark
- Prior art keywords
- cell growth
- abnormal cell
- treating abnormal
- treating
- growth
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74276605P | 2005-12-05 | 2005-12-05 | |
US86463706P | 2006-11-07 | 2006-11-07 | |
PCT/IB2006/003397 WO2007066187A2 (en) | 2005-12-05 | 2006-11-23 | Method of treating abnormal cell growth |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1959955T3 true DK1959955T3 (da) | 2011-02-07 |
Family
ID=38123250
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK06820997.2T DK1959955T3 (da) | 2005-12-05 | 2006-11-23 | Fremgangsmåde til behandling af abnorm cellevækst |
Country Status (21)
Country | Link |
---|---|
US (1) | US7825137B2 (da) |
EP (1) | EP1959955B1 (da) |
JP (1) | JP4619346B2 (da) |
KR (1) | KR101026676B1 (da) |
AR (1) | AR056832A1 (da) |
AT (1) | ATE488237T1 (da) |
AU (1) | AU2006323027B2 (da) |
BR (1) | BRPI0619424B1 (da) |
CA (1) | CA2632286C (da) |
CY (1) | CY1110931T1 (da) |
DE (1) | DE602006018354D1 (da) |
DK (1) | DK1959955T3 (da) |
HK (1) | HK1126121A1 (da) |
IL (1) | IL191471A (da) |
NZ (1) | NZ568654A (da) |
PL (1) | PL1959955T3 (da) |
PT (1) | PT1959955E (da) |
RU (1) | RU2384331C2 (da) |
SI (1) | SI1959955T1 (da) |
TW (1) | TWI321050B (da) |
WO (1) | WO2007066187A2 (da) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2341351T3 (es) * | 2004-08-26 | 2010-06-18 | Pfizer, Inc. | Compuestos de aminoheteroarilo enantiomericamente puros como inhibidores de proteina cinasas. |
NZ566793A (en) * | 2005-08-24 | 2010-03-26 | Eisai R&D Man Co Ltd | Novel pyridine derivative and pyrimidine derivative |
AU2006323025B2 (en) * | 2005-12-05 | 2012-07-05 | Pfizer Products Inc. | Polymorphs of a c-Met/HGFR inhibitor |
US20120208824A1 (en) | 2006-01-20 | 2012-08-16 | Cell Signaling Technology, Inc. | ROS Kinase in Lung Cancer |
US8168383B2 (en) | 2006-04-14 | 2012-05-01 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
SI2450437T1 (sl) | 2006-04-14 | 2017-12-29 | Cell Signaling Technology Inc. | Okvarjenost genov in mutantna ALK kinaza v človeških solidnih tumorjih |
KR101380444B1 (ko) * | 2006-08-23 | 2014-04-01 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 페녹시피리딘 유도체의 염 또는 그 결정 및 이들의 제조 방법 |
US7790885B2 (en) | 2006-08-31 | 2010-09-07 | Eisai R&D Management Co., Ltd. | Process for preparing phenoxypyridine derivatives |
JP2009132660A (ja) * | 2007-11-30 | 2009-06-18 | Eisai R & D Management Co Ltd | 食道癌治療用組成物 |
DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
US20090227556A1 (en) * | 2008-01-31 | 2009-09-10 | Eisai R&D Management Co., Ltd. | Receptor tyrosine kinase inhibitors comprising pyridine and pyrimidine derivatives |
US20110206691A1 (en) | 2008-02-15 | 2011-08-25 | Mosse Yael P | Methods and Compositions for Treating Neuroblastoma |
WO2009103061A2 (en) * | 2008-02-15 | 2009-08-20 | The Children's Hospital Of Philadelphia | Methods and compositions for identifying, diagnosing, and treating neuroblastoma |
EP2248810A4 (en) * | 2008-02-18 | 2011-05-25 | Eisai R&D Man Co Ltd | METHOD FOR PRODUCING A PHENOXYPYRIDINE DERIVATIVE |
EP2143441A1 (en) * | 2008-07-08 | 2010-01-13 | Pierre Fabre Medicament | Combination of a c-Met antagonist and an aminoheteroaryl compound for the treatment of cancer |
CN101653607B (zh) * | 2008-08-19 | 2013-02-13 | 鼎泓国际投资(香港)有限公司 | 含有肝细胞生长因子受体抑制剂和丝裂原细胞外激酶抑制剂的药物组合物及其用途 |
WO2010064300A1 (ja) * | 2008-12-02 | 2010-06-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 食道癌治療用組成物 |
DE102009003954A1 (de) | 2009-01-07 | 2010-07-08 | Merck Patent Gmbh | Pyridazinonderivate |
DE102009004061A1 (de) | 2009-01-08 | 2010-07-15 | Merck Patent Gmbh | Pyridazinonderivate |
ES2667049T3 (es) | 2010-02-05 | 2018-05-09 | Merck Patent Gmbh | Derivados de heteroaril-[1,8]naftiridina |
US8378104B2 (en) * | 2010-02-11 | 2013-02-19 | OSI Pharmaceuticals, LLC | 7-aminofuropyridine derivatives |
JP2013525476A (ja) | 2010-05-04 | 2013-06-20 | ファイザー・インク | Alk阻害剤としての複素環式誘導体 |
KR101677790B1 (ko) | 2010-06-25 | 2016-11-18 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 키나제 저해 작용을 갖는 화합물의 병용에 의한 항종양제 |
ES2535656T3 (es) | 2010-07-05 | 2015-05-13 | Merck Patent Gmbh | Derivados de bipiridilo útiles para el tratamiento de enfermedades inducidas por quinasas |
US20120101108A1 (en) | 2010-08-06 | 2012-04-26 | Cell Signaling Technology, Inc. | Anaplastic Lymphoma Kinase In Kidney Cancer |
US9145390B2 (en) | 2011-03-03 | 2015-09-29 | Concert Pharmaceuticals, Inc. | Derivatives of pyrazole-substituted amino-heteroaryl compounds |
MX2013010067A (es) * | 2011-03-03 | 2014-01-31 | Concert Pharmaceuticals Inc | Derivados de compuestos de amino-heteroarilo sustituidos con pirazol. |
KR20140022829A (ko) | 2011-03-09 | 2014-02-25 | 메르크 파텐트 게엠베하 | 피리도 [2, 3 - b] 피라진 유도체 및 그 치료적 용도 |
EP2758387A4 (en) * | 2011-09-21 | 2015-03-11 | Teligene Ltd | Pyridine compounds as kinase inhibitors |
JP6006241B2 (ja) | 2012-01-31 | 2016-10-12 | 第一三共株式会社 | ピリドン誘導体 |
JP5823066B2 (ja) | 2012-03-06 | 2015-11-25 | ファイザー・インク | 増殖性疾患の治療のための大環状誘導体 |
WO2013148537A1 (en) * | 2012-03-29 | 2013-10-03 | Ning Xi | Substituted spirobicyclic compounds and methods of use |
HUE037856T2 (hu) | 2012-04-18 | 2018-09-28 | Cell Signaling Technology Inc | EGFR és ROS1 rákban |
CN103509008A (zh) * | 2012-06-22 | 2014-01-15 | 康瑟特制药公司 | 吡唑取代的氨基-杂芳基化合物的衍生物 |
WO2014020467A2 (en) | 2012-07-30 | 2014-02-06 | Fresenius Kabi Oncology Ltd | Process for the preparation of pyrazole substituted aminoheteroaryl compounds |
US9651555B2 (en) | 2012-09-24 | 2017-05-16 | Ventana Medical Systems, Inc. | Method of identifying treatment responsive non-small cell lung cancer using anaplastic lymphoma kinase (ALK) as a marker |
EP2917210B1 (en) * | 2012-11-06 | 2019-02-27 | Shanghai Fochon Pharmaceutical Co. Ltd | Alk kinase inhibitors |
KR20150098605A (ko) | 2012-12-21 | 2015-08-28 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 퀴놀린 유도체의 비정질 형태 및 그의 제조방법 |
EA201201654A1 (ru) * | 2012-12-28 | 2014-06-30 | Ооо "Эн.Си.Фарм" | Противоопухолевое средство (варианты) |
WO2014115169A2 (en) * | 2013-01-24 | 2014-07-31 | Hetero Research Foundation | Crizotinib solid dispersion |
BR112015018418A2 (pt) | 2013-02-22 | 2017-07-18 | Hoffmann La Roche | métodos para tratar câncer, para aumentar a eficácia de um tratamento, para adiar e/ou prevenir o desenvolvimento de câncer, para aumentar a sensibilidade a um terapêutico direcionado, para estender o período de sensibilidade, para estender a duração de resposta a um terapêutico direcionado e produto farmacêutico |
JP2016510787A (ja) * | 2013-03-13 | 2016-04-11 | ラシオファルム ゲーエムベーハー | クリゾチニブを含む剤形 |
SG11201509278XA (en) | 2013-05-14 | 2015-12-30 | Eisai R&D Man Co Ltd | Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds |
JP6291179B2 (ja) * | 2013-07-26 | 2018-03-14 | 関東化學株式会社 | 光学活性2級アルコールの製造方法 |
WO2015036898A2 (en) * | 2013-09-10 | 2015-03-19 | Shilpa Medicare Limited | Novel salts of crizotinib and their preparation |
RU2550346C2 (ru) | 2013-09-26 | 2015-05-10 | Общество с ограниченной ответственностью "Отечественные Фармацевтические Технологии" ООО"ФармТех" | Новые химические соединения (варианты) и их применение для лечения онкологических заболеваний |
US20160280798A1 (en) | 2013-11-06 | 2016-09-29 | The United States Of America, As Represented By The Secretary Department Of Health & Human Service | Alk antibodies, conjugates, and chimeric antigen receptors, and their use |
TWI723572B (zh) | 2014-07-07 | 2021-04-01 | 日商第一三共股份有限公司 | 具有四氫吡喃基甲基之吡啶酮衍生物及其用途 |
WO2016032927A1 (en) | 2014-08-25 | 2016-03-03 | Pfizer Inc. | Combination of a pd-1 antagonist and an alk inhibitor for treating cancer |
SI3524595T1 (sl) | 2014-08-28 | 2022-10-28 | Eisai R&D Management Co., Ltd. | Derivat kinolina visoke čistosti in postopek njegove proizvodnje |
WO2016136745A1 (ja) | 2015-02-25 | 2016-09-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | キノリン誘導体の苦味抑制方法 |
KR102662228B1 (ko) | 2015-03-04 | 2024-05-02 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합 |
CA2988707C (en) | 2015-06-16 | 2023-10-10 | Eisai R&D Management Co., Ltd. | Combination of cbp/catenin inhibitor and immune checkpoint inhibitor for treating cancer |
CA3000386A1 (en) | 2015-09-30 | 2017-04-06 | Merck Patent Gmbh | Combination of a pd-1 axis binding antagonist and an alk inhibitor for treating alk-negative cancer |
US12066428B2 (en) * | 2015-11-20 | 2024-08-20 | Agilent Technologies, Inc. | Cell-substrate impedance monitoring of cancer cells |
ES2905823T3 (es) | 2016-05-20 | 2022-04-12 | Biohaven Therapeutics Ltd | Uso de riluzol, profármacos de riluzol o análogos de riluzol con inmunoterapias para tratar cánceres |
GB201616116D0 (en) * | 2016-09-22 | 2016-11-09 | Astrazeneca Ab | Use of c-Met inhibitors to treat cancers harbouring MET mutations |
CN108047231B (zh) * | 2018-01-02 | 2020-02-11 | 江苏医药职业学院 | [1,2,4]三嗪并[6,1-a]异吲哚化合物的盐酸盐及其应用 |
IT201800003875A1 (it) | 2018-03-22 | 2019-09-22 | Metis Prec Medicine Sb S R L | Nuova combinazione di agenti terapeutici per il trattamento di un tumore e/o metastasi |
US20220354951A1 (en) | 2019-08-02 | 2022-11-10 | Onehealthcompany, Inc. | Treatment of Canine Cancers |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4725601A (en) | 1985-06-04 | 1988-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers |
GB9201693D0 (en) | 1992-01-27 | 1992-03-11 | Smithkline Beecham Intercredit | Compounds |
JPH07109260A (ja) | 1993-10-12 | 1995-04-25 | Fuji Photo Film Co Ltd | 5−アミノ−2−ニトロピリジン誘導体及び2,5−ジアミノ−3−ヒドロキシピリジン誘導体の製造方法 |
SE9700661D0 (sv) | 1997-02-25 | 1997-02-25 | Astra Ab | New compounds |
SE9801526D0 (sv) | 1998-04-29 | 1998-04-29 | Astra Ab | New compounds |
GB9908410D0 (en) | 1999-04-13 | 1999-06-09 | Pfizer Ltd | Pyridines |
AU5636900A (en) | 1999-06-30 | 2001-01-31 | Merck & Co., Inc. | Src kinase inhibitor compounds |
KR20030031886A (ko) | 2000-02-16 | 2003-04-23 | 뉴로젠 코포레이션 | 치환된 아릴피라진 |
GB0101577D0 (en) | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
US6825198B2 (en) | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
US6992087B2 (en) | 2001-11-21 | 2006-01-31 | Pfizer Inc | Substituted aryl 1,4-pyrazine derivatives |
DK1603570T5 (da) | 2003-02-26 | 2013-12-09 | Sugen Inc | Aminoheteroarylforbindelser som proteinkinaseinhibitorer |
ES2341351T3 (es) * | 2004-08-26 | 2010-06-18 | Pfizer, Inc. | Compuestos de aminoheteroarilo enantiomericamente puros como inhibidores de proteina cinasas. |
ES2355923T3 (es) * | 2004-08-26 | 2011-04-01 | Pfizer, Inc. | Compuestos de aminoheteroarilo sustituidos con pirazol como inhibidores de proteina quinasa. |
JP2008510792A (ja) | 2004-08-26 | 2008-04-10 | ファイザー・インク | タンパク質チロシンキナーゼ阻害剤としてのアミノヘテロアリール化合物 |
AU2006323025B2 (en) * | 2005-12-05 | 2012-07-05 | Pfizer Products Inc. | Polymorphs of a c-Met/HGFR inhibitor |
-
2006
- 2006-11-23 PL PL06820997T patent/PL1959955T3/pl unknown
- 2006-11-23 SI SI200630864T patent/SI1959955T1/sl unknown
- 2006-11-23 AU AU2006323027A patent/AU2006323027B2/en active Active
- 2006-11-23 DK DK06820997.2T patent/DK1959955T3/da active
- 2006-11-23 BR BRPI0619424-9A patent/BRPI0619424B1/pt active IP Right Grant
- 2006-11-23 AT AT06820997T patent/ATE488237T1/de active
- 2006-11-23 NZ NZ568654A patent/NZ568654A/en unknown
- 2006-11-23 KR KR20087016376A patent/KR101026676B1/ko active Protection Beyond IP Right Term
- 2006-11-23 RU RU2008122471/14A patent/RU2384331C2/ru active
- 2006-11-23 DE DE602006018354T patent/DE602006018354D1/de active Active
- 2006-11-23 PT PT06820997T patent/PT1959955E/pt unknown
- 2006-11-23 US US12/095,114 patent/US7825137B2/en active Active
- 2006-11-23 EP EP06820997A patent/EP1959955B1/en active Active
- 2006-11-23 CA CA2632286A patent/CA2632286C/en active Active
- 2006-11-23 WO PCT/IB2006/003397 patent/WO2007066187A2/en active Application Filing
- 2006-12-04 JP JP2006327355A patent/JP4619346B2/ja active Active
- 2006-12-04 TW TW095145034A patent/TWI321050B/zh active
- 2006-12-05 AR ARP060105369A patent/AR056832A1/es not_active Application Discontinuation
-
2008
- 2008-05-15 IL IL191471A patent/IL191471A/en active IP Right Grant
-
2009
- 2009-05-15 HK HK09104434.7A patent/HK1126121A1/xx unknown
-
2010
- 2010-11-24 CY CY20101101055T patent/CY1110931T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU2006323027B2 (en) | 2012-08-02 |
AR056832A1 (es) | 2007-10-24 |
CY1110931T1 (el) | 2015-06-10 |
PT1959955E (pt) | 2011-01-04 |
DE602006018354D1 (de) | 2010-12-30 |
JP4619346B2 (ja) | 2011-01-26 |
TWI321050B (en) | 2010-03-01 |
BRPI0619424B1 (pt) | 2022-02-08 |
KR20080072965A (ko) | 2008-08-07 |
EP1959955A2 (en) | 2008-08-27 |
WO2007066187A3 (en) | 2008-01-17 |
NZ568654A (en) | 2012-02-24 |
ATE488237T1 (de) | 2010-12-15 |
US20080300273A1 (en) | 2008-12-04 |
EP1959955B1 (en) | 2010-11-17 |
IL191471A0 (en) | 2009-08-03 |
RU2008122471A (ru) | 2009-12-10 |
WO2007066187A2 (en) | 2007-06-14 |
IL191471A (en) | 2013-03-24 |
PL1959955T3 (pl) | 2011-04-29 |
CA2632286A1 (en) | 2007-06-14 |
US7825137B2 (en) | 2010-11-02 |
HK1126121A1 (en) | 2009-08-28 |
RU2384331C2 (ru) | 2010-03-20 |
JP2007153894A (ja) | 2007-06-21 |
BRPI0619424A2 (pt) | 2011-10-04 |
TW200727899A (en) | 2007-08-01 |
KR101026676B1 (ko) | 2011-04-04 |
AU2006323027A1 (en) | 2007-06-14 |
SI1959955T1 (sl) | 2011-02-28 |
CA2632286C (en) | 2011-11-15 |
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