ATE488237T1 - Verfahren zur behandlung von abnormalem zellwachstum - Google Patents
Verfahren zur behandlung von abnormalem zellwachstumInfo
- Publication number
- ATE488237T1 ATE488237T1 AT06820997T AT06820997T ATE488237T1 AT E488237 T1 ATE488237 T1 AT E488237T1 AT 06820997 T AT06820997 T AT 06820997T AT 06820997 T AT06820997 T AT 06820997T AT E488237 T1 ATE488237 T1 AT E488237T1
- Authority
- AT
- Austria
- Prior art keywords
- cell growth
- abnormal cell
- treating abnormal
- treating
- growth
- Prior art date
Links
- 230000002159 abnormal effect Effects 0.000 title 1
- 230000010261 cell growth Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74276605P | 2005-12-05 | 2005-12-05 | |
| US86463706P | 2006-11-07 | 2006-11-07 | |
| PCT/IB2006/003397 WO2007066187A2 (en) | 2005-12-05 | 2006-11-23 | Method of treating abnormal cell growth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE488237T1 true ATE488237T1 (de) | 2010-12-15 |
Family
ID=38123250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06820997T ATE488237T1 (de) | 2005-12-05 | 2006-11-23 | Verfahren zur behandlung von abnormalem zellwachstum |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7825137B2 (de) |
| EP (1) | EP1959955B1 (de) |
| JP (1) | JP4619346B2 (de) |
| KR (1) | KR101026676B1 (de) |
| AR (1) | AR056832A1 (de) |
| AT (1) | ATE488237T1 (de) |
| AU (1) | AU2006323027B2 (de) |
| BR (1) | BRPI0619424B1 (de) |
| CA (1) | CA2632286C (de) |
| CY (1) | CY1110931T1 (de) |
| DE (1) | DE602006018354D1 (de) |
| DK (1) | DK1959955T3 (de) |
| IL (1) | IL191471A (de) |
| NZ (1) | NZ568654A (de) |
| PL (1) | PL1959955T3 (de) |
| PT (1) | PT1959955E (de) |
| RU (1) | RU2384331C2 (de) |
| SI (1) | SI1959955T1 (de) |
| TW (1) | TWI321050B (de) |
| WO (1) | WO2007066187A2 (de) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP2373A (en) * | 2004-08-26 | 2012-03-07 | Pfizer | Enantiomerically pure aminoheteroaryl compounds asprotein kinase inhibitors. |
| JP4077028B2 (ja) * | 2005-08-24 | 2008-04-16 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 新規ピリジン誘導体およびピリミジン誘導体(3) |
| US8217057B2 (en) * | 2005-12-05 | 2012-07-10 | Pfizer Inc. | Polymorphs of a c-MET/HGFR inhibitor |
| US20120208824A1 (en) | 2006-01-20 | 2012-08-16 | Cell Signaling Technology, Inc. | ROS Kinase in Lung Cancer |
| US8168383B2 (en) | 2006-04-14 | 2012-05-01 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
| US7700339B2 (en) | 2006-04-14 | 2010-04-20 | Cell Signaling Technology, Inc. | Gene defects and mutant ALK kinase in human solid tumors |
| CA2661333C (en) * | 2006-08-23 | 2014-08-05 | Eisai R&D Management Co., Ltd. | Salt of phenoxypyridine derivative or crystal thereof and process for producing the same |
| US7790885B2 (en) | 2006-08-31 | 2010-09-07 | Eisai R&D Management Co., Ltd. | Process for preparing phenoxypyridine derivatives |
| JP2009132660A (ja) * | 2007-11-30 | 2009-06-18 | Eisai R & D Management Co Ltd | 食道癌治療用組成物 |
| DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
| US20090227556A1 (en) * | 2008-01-31 | 2009-09-10 | Eisai R&D Management Co., Ltd. | Receptor tyrosine kinase inhibitors comprising pyridine and pyrimidine derivatives |
| WO2009103061A2 (en) * | 2008-02-15 | 2009-08-20 | The Children's Hospital Of Philadelphia | Methods and compositions for identifying, diagnosing, and treating neuroblastoma |
| US20110206691A1 (en) * | 2008-02-15 | 2011-08-25 | Mosse Yael P | Methods and Compositions for Treating Neuroblastoma |
| US20100311972A1 (en) * | 2008-02-18 | 2010-12-09 | Mitsuo Nagai | Method for producing phenoxypyridine derivative |
| EP2143441A1 (de) * | 2008-07-08 | 2010-01-13 | Pierre Fabre Medicament | Kombination aus einem c-MET-Antagonisten und einer Aminoheteroaryl-Verbindung zur Krebsbehandlung |
| CN101653607B (zh) * | 2008-08-19 | 2013-02-13 | 鼎泓国际投资(香港)有限公司 | 含有肝细胞生长因子受体抑制剂和丝裂原细胞外激酶抑制剂的药物组合物及其用途 |
| WO2010064300A1 (ja) * | 2008-12-02 | 2010-06-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 食道癌治療用組成物 |
| DE102009003954A1 (de) | 2009-01-07 | 2010-07-08 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102009004061A1 (de) | 2009-01-08 | 2010-07-15 | Merck Patent Gmbh | Pyridazinonderivate |
| AU2010344973B2 (en) | 2010-02-05 | 2016-06-16 | Merck Patent Gmbh | Hetaryl-[1,8]naphthyridine derivatives |
| EP2534156A1 (de) * | 2010-02-11 | 2012-12-19 | OSI Pharmaceuticals, LLC | 7-aminofuropyridinderivate |
| US8916593B2 (en) | 2010-05-04 | 2014-12-23 | Pfizer Inc. | Alkoxy-substituted 2-aminopyridines as ALK inhibitors |
| MX2012014776A (es) | 2010-06-25 | 2013-01-29 | Eisai R&D Man Co Ltd | Agente antitumoral que emplea compuestos con efecto inhibidor de cinasas combinados. |
| AU2011276193B2 (en) | 2010-07-05 | 2015-01-22 | Merck Patent Gmbh | Bipyridyl derivatives useful for the treatment of kinase - induced diseases |
| WO2012019132A2 (en) | 2010-08-06 | 2012-02-09 | Cell Signaling Technology, Inc. | Anaplastic lymphoma kinase in kidney cancer |
| US9145390B2 (en) | 2011-03-03 | 2015-09-29 | Concert Pharmaceuticals, Inc. | Derivatives of pyrazole-substituted amino-heteroaryl compounds |
| CA2829025A1 (en) * | 2011-03-03 | 2012-09-07 | Concert Pharmaceuticals, Inc. | Derivatives of pyrazole-substituted amino-heteroaryl compounds |
| AU2012224979B2 (en) | 2011-03-09 | 2017-01-19 | Merck Patent Gmbh | Pyrido [2, 3 - b] pyrazine derivatives and their therapeutical uses |
| US20140350050A1 (en) * | 2011-09-21 | 2014-11-27 | Teligene Ltd. | Pyridine compounds as inhibitors of kinase |
| NZ627586A (en) | 2012-01-31 | 2016-08-26 | Daiichi Sankyo Co Ltd | Pyridone derivatives |
| ES2621220T3 (es) | 2012-03-06 | 2017-07-03 | Pfizer Inc. | Derivados macrocíclicos para el tratamiento de enfermedades proliferativas |
| WO2013148537A1 (en) * | 2012-03-29 | 2013-10-03 | Ning Xi | Substituted spirobicyclic compounds and methods of use |
| DK2838998T3 (en) | 2012-04-18 | 2018-01-15 | Cell Signaling Technology Inc | EGFR AND ROS1 IN CANCER |
| CN103509008A (zh) * | 2012-06-22 | 2014-01-15 | 康瑟特制药公司 | 吡唑取代的氨基-杂芳基化合物的衍生物 |
| WO2014020467A2 (en) | 2012-07-30 | 2014-02-06 | Fresenius Kabi Oncology Ltd | Process for the preparation of pyrazole substituted aminoheteroaryl compounds |
| WO2014046730A1 (en) | 2012-09-24 | 2014-03-27 | Ventana Medical Systems, Inc. | Method of identifying treatment responsive non-small cell lung cancer using anaplastic lymphoma kinase (alk) as a marker |
| JP6359020B6 (ja) * | 2012-11-06 | 2018-08-15 | シャンハイ フォチョン ファーマシューティカル カンパニー リミテッド | Alkキナーゼ阻害剤 |
| US9334239B2 (en) | 2012-12-21 | 2016-05-10 | Eisai R&D Management Co., Ltd. | Amorphous form of quinoline derivative, and method for producing same |
| EA201201654A1 (ru) * | 2012-12-28 | 2014-06-30 | Ооо "Эн.Си.Фарм" | Противоопухолевое средство (варианты) |
| WO2014115169A2 (en) * | 2013-01-24 | 2014-07-31 | Hetero Research Foundation | Crizotinib solid dispersion |
| HK1211235A1 (en) | 2013-02-22 | 2016-05-20 | 霍夫曼-拉罗奇有限公司 | Methods of treating cancer and preventing drug resistance |
| US20160022661A1 (en) * | 2013-03-13 | 2016-01-28 | Ratiopharm Gmbh | Dosage Form Comprising Crizotinib |
| US10517861B2 (en) | 2013-05-14 | 2019-12-31 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds |
| JP6291179B2 (ja) * | 2013-07-26 | 2018-03-14 | 関東化學株式会社 | 光学活性2級アルコールの製造方法 |
| US20160214961A1 (en) * | 2013-09-10 | 2016-07-28 | Shilpa Medicare Limited | Novel salts of crizotinib and their preparation |
| RU2550346C2 (ru) | 2013-09-26 | 2015-05-10 | Общество с ограниченной ответственностью "Отечественные Фармацевтические Технологии" ООО"ФармТех" | Новые химические соединения (варианты) и их применение для лечения онкологических заболеваний |
| WO2015069922A2 (en) | 2013-11-06 | 2015-05-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Alk antibodies, conjugates, and chimeric antigen receptors, and their use |
| TWI723572B (zh) | 2014-07-07 | 2021-04-01 | 日商第一三共股份有限公司 | 具有四氫吡喃基甲基之吡啶酮衍生物及其用途 |
| CA2955676A1 (en) | 2014-08-25 | 2016-03-03 | Pfizer Inc. | Combination of a pd-1 antagonist and an alk inhibitor for treating cancer |
| CN106660964B (zh) | 2014-08-28 | 2021-09-03 | 卫材R&D管理有限公司 | 高纯度喹啉衍生物及其生产方法 |
| PL3263106T3 (pl) | 2015-02-25 | 2024-04-02 | Eisai R&D Management Co., Ltd. | Sposób tłumienia goryczy pochodnej chinoliny |
| KR102662228B1 (ko) | 2015-03-04 | 2024-05-02 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합 |
| ES2886107T3 (es) | 2015-06-16 | 2021-12-16 | Prism Biolab Co Ltd | Antineoplásico |
| AU2016309356B2 (en) | 2015-08-20 | 2021-06-24 | Eisai R&D Management Co., Ltd. | Tumor therapeutic agent |
| JP2018529719A (ja) | 2015-09-30 | 2018-10-11 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | Alk陰性がんを処置するためのpd−1系結合アンタゴニストおよびalk阻害剤の組合せ |
| US12066428B2 (en) * | 2015-11-20 | 2024-08-20 | Agilent Technologies, Inc. | Cell-substrate impedance monitoring of cancer cells |
| EA201892587A1 (ru) | 2016-05-20 | 2019-04-30 | Биохэйвен Фармасьютикал Холдинг Компани Лтд. | Использование глутамат-модулирующих средств вместе с иммунотерапией для лечения рака |
| GB201616116D0 (en) * | 2016-09-22 | 2016-11-09 | Astrazeneca Ab | Use of c-Met inhibitors to treat cancers harbouring MET mutations |
| MX380144B (es) | 2017-02-08 | 2025-03-12 | Eisai R&D Man Co Ltd | Composicion farmaceutica de tratamiento de tumores. |
| CA3061888A1 (en) | 2017-05-16 | 2018-11-22 | Eisai R&D Management Co., Ltd. | Treatment of hepatocellular carcinoma |
| CN108047231B (zh) * | 2018-01-02 | 2020-02-11 | 江苏医药职业学院 | [1,2,4]三嗪并[6,1-a]异吲哚化合物的盐酸盐及其应用 |
| IT201800003875A1 (it) | 2018-03-22 | 2019-09-22 | Metis Prec Medicine Sb S R L | Nuova combinazione di agenti terapeutici per il trattamento di un tumore e/o metastasi |
| EP4007585A4 (de) | 2019-08-02 | 2023-11-08 | OneHealthCompany, Inc. | Behandlung von krebserkrankungen beim hund |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4725601A (en) | 1985-06-04 | 1988-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers |
| GB9201693D0 (en) | 1992-01-27 | 1992-03-11 | Smithkline Beecham Intercredit | Compounds |
| JPH07109260A (ja) | 1993-10-12 | 1995-04-25 | Fuji Photo Film Co Ltd | 5−アミノ−2−ニトロピリジン誘導体及び2,5−ジアミノ−3−ヒドロキシピリジン誘導体の製造方法 |
| ATE205483T1 (de) * | 1995-03-30 | 2001-09-15 | Pfizer | Chinazolinderivate |
| SE9700661D0 (sv) | 1997-02-25 | 1997-02-25 | Astra Ab | New compounds |
| SE9801526D0 (sv) | 1998-04-29 | 1998-04-29 | Astra Ab | New compounds |
| GB9908410D0 (en) | 1999-04-13 | 1999-06-09 | Pfizer Ltd | Pyridines |
| CN1348370A (zh) * | 1999-04-15 | 2002-05-08 | 布里斯托尔-迈尔斯斯奎布公司 | 环状蛋白酪氨酸激酶抑制剂 |
| CA2383546A1 (en) | 1999-06-30 | 2001-01-04 | William H. Parsons | Src kinase inhibitor compounds |
| AU783915B2 (en) | 2000-02-16 | 2005-12-22 | Neurogen Corporation | Substituted arylpyrazines |
| GB0101577D0 (en) | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
| US6825198B2 (en) | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
| US6992087B2 (en) | 2001-11-21 | 2006-01-31 | Pfizer Inc | Substituted aryl 1,4-pyrazine derivatives |
| US7230098B2 (en) | 2003-02-26 | 2007-06-12 | Sugen, Inc. | Aminoheteroaryl compounds as protein kinase inhibitors |
| EP1678147B1 (de) * | 2003-09-15 | 2012-08-08 | Lead Discovery Center GmbH | Pharmazeutisch wirksame 4,6-disubstituierte aminopyrimidinderivate als modulatoren von proteinkinasen |
| US20080267905A1 (en) * | 2004-05-05 | 2008-10-30 | Celgene Corporation | Methods and Compositions Using Selective Cytokine Inhibitory Drugs for Treatment and Management of Cancers and Other Diseases |
| JP2008510792A (ja) | 2004-08-26 | 2008-04-10 | ファイザー・インク | タンパク質チロシンキナーゼ阻害剤としてのアミノヘテロアリール化合物 |
| NZ552946A (en) * | 2004-08-26 | 2010-09-30 | Pfizer | Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors |
| AP2373A (en) * | 2004-08-26 | 2012-03-07 | Pfizer | Enantiomerically pure aminoheteroaryl compounds asprotein kinase inhibitors. |
| US8217057B2 (en) * | 2005-12-05 | 2012-07-10 | Pfizer Inc. | Polymorphs of a c-MET/HGFR inhibitor |
-
2006
- 2006-11-23 BR BRPI0619424-9A patent/BRPI0619424B1/pt active IP Right Grant
- 2006-11-23 CA CA2632286A patent/CA2632286C/en active Active
- 2006-11-23 AU AU2006323027A patent/AU2006323027B2/en active Active
- 2006-11-23 SI SI200630864T patent/SI1959955T1/sl unknown
- 2006-11-23 PL PL06820997T patent/PL1959955T3/pl unknown
- 2006-11-23 PT PT06820997T patent/PT1959955E/pt unknown
- 2006-11-23 US US12/095,114 patent/US7825137B2/en active Active
- 2006-11-23 RU RU2008122471/14A patent/RU2384331C2/ru active
- 2006-11-23 WO PCT/IB2006/003397 patent/WO2007066187A2/en not_active Ceased
- 2006-11-23 DK DK06820997.2T patent/DK1959955T3/da active
- 2006-11-23 KR KR20087016376A patent/KR101026676B1/ko active Active
- 2006-11-23 NZ NZ568654A patent/NZ568654A/en unknown
- 2006-11-23 EP EP06820997A patent/EP1959955B1/de active Active
- 2006-11-23 AT AT06820997T patent/ATE488237T1/de active
- 2006-11-23 DE DE602006018354T patent/DE602006018354D1/de active Active
- 2006-12-04 JP JP2006327355A patent/JP4619346B2/ja active Active
- 2006-12-04 TW TW095145034A patent/TWI321050B/zh active
- 2006-12-05 AR ARP060105369A patent/AR056832A1/es not_active Application Discontinuation
-
2008
- 2008-05-15 IL IL191471A patent/IL191471A/en active IP Right Grant
-
2010
- 2010-11-24 CY CY20101101055T patent/CY1110931T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR101026676B1 (ko) | 2011-04-04 |
| PL1959955T3 (pl) | 2011-04-29 |
| AU2006323027B2 (en) | 2012-08-02 |
| RU2384331C2 (ru) | 2010-03-20 |
| AU2006323027A1 (en) | 2007-06-14 |
| WO2007066187A2 (en) | 2007-06-14 |
| CA2632286C (en) | 2011-11-15 |
| JP4619346B2 (ja) | 2011-01-26 |
| SI1959955T1 (sl) | 2011-02-28 |
| DE602006018354D1 (de) | 2010-12-30 |
| US7825137B2 (en) | 2010-11-02 |
| WO2007066187A3 (en) | 2008-01-17 |
| PT1959955E (pt) | 2011-01-04 |
| TWI321050B (en) | 2010-03-01 |
| IL191471A (en) | 2013-03-24 |
| NZ568654A (en) | 2012-02-24 |
| AR056832A1 (es) | 2007-10-24 |
| CY1110931T1 (el) | 2015-06-10 |
| EP1959955A2 (de) | 2008-08-27 |
| TW200727899A (en) | 2007-08-01 |
| BRPI0619424B1 (pt) | 2022-02-08 |
| US20080300273A1 (en) | 2008-12-04 |
| RU2008122471A (ru) | 2009-12-10 |
| EP1959955B1 (de) | 2010-11-17 |
| JP2007153894A (ja) | 2007-06-21 |
| BRPI0619424A2 (pt) | 2011-10-04 |
| CA2632286A1 (en) | 2007-06-14 |
| HK1126121A1 (en) | 2009-08-28 |
| KR20080072965A (ko) | 2008-08-07 |
| DK1959955T3 (da) | 2011-02-07 |
| IL191471A0 (en) | 2009-08-03 |
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