HRP20220237T1 - Primjena riluzola, prolijekova riluzola ili analoga riluzola sa imunoterapijama za liječenje raka - Google Patents
Primjena riluzola, prolijekova riluzola ili analoga riluzola sa imunoterapijama za liječenje raka Download PDFInfo
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- HRP20220237T1 HRP20220237T1 HRP20220237TT HRP20220237T HRP20220237T1 HR P20220237 T1 HRP20220237 T1 HR P20220237T1 HR P20220237T T HRP20220237T T HR P20220237TT HR P20220237 T HRP20220237 T HR P20220237T HR P20220237 T1 HRP20220237 T1 HR P20220237T1
- Authority
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- Croatia
- Prior art keywords
- riluzole
- prodrug
- checkpoint inhibitor
- solvate
- hydrate
- Prior art date
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- FTALBRSUTCGOEG-UHFFFAOYSA-N Riluzole Chemical compound C1=C(OC(F)(F)F)C=C2SC(N)=NC2=C1 FTALBRSUTCGOEG-UHFFFAOYSA-N 0.000 title claims 23
- 229960004181 riluzole Drugs 0.000 title claims 22
- 229940002612 prodrug Drugs 0.000 title claims 21
- 239000000651 prodrug Substances 0.000 title claims 21
- 206010028980 Neoplasm Diseases 0.000 title claims 6
- 238000009169 immunotherapy Methods 0.000 title 1
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 21
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 21
- 150000003839 salts Chemical class 0.000 claims 17
- 239000012453 solvate Substances 0.000 claims 17
- 201000011510 cancer Diseases 0.000 claims 5
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229960003301 nivolumab Drugs 0.000 claims 2
- 229960002621 pembrolizumab Drugs 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- 102100023990 60S ribosomal protein L17 Human genes 0.000 claims 1
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 1
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 1
- -1 CH2CCH Chemical group 0.000 claims 1
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims 1
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 1
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 1
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 1
- 229960003852 atezolizumab Drugs 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 229950009791 durvalumab Drugs 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 1
- 229960005386 ipilimumab Drugs 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 229950010773 pidilizumab Drugs 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 229950007213 spartalizumab Drugs 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Claims (13)
1. Riluzol ili farmaceutski prihvatljiva sol, solvat, anomer, enantiomer, hidrat ili prolijek istog i inhibitor kontrolne točke za primjenu u postupku liječenja raka kod pacijenta, pri čemu su prolijekovi riluzola spojevi koji imaju sljedeću formulu;
[image]
ili enantiomer, dijastereomer, hidrat, solvat, farmaceutski prihvatljiva sol ili kompleks istog;
pri čemu R23 je odabrano iz grupe koja se sastoji od H, CH3, CH2CH3, CH2CH2CH3, CH2CCH, CH(CH3)2, CH2CH(CH3)2, CH(CH3)CH2CH3, CH2OH, CH2OCH2Ph, CH2CH2OCH2Ph, CH(OH)CH3, CH2Ph, CH2(cikloheksil), CH2(4-OH-Ph), (CH2)4NH2, (CH2)3NHC(NH2)NH, CH2(3-indol), CH2(5-imidazol), CH2CO2H, CH2CH2CO2H, CH2CONH2, i CH2CH2CONH2.
2. Riluzol ili farmaceutski prihvatljiva sol, solvat, anomer, enantiomer, hidrat ili prolijek istog i inhibitor kontrolne točke za primjenu prema zahtjevu 1, pri čemu riluzol ili farmaceutski prihvatljiva sol, solvat, anomer, enantiomer, hidrat ili prolijek istog i inhibitor kontrolne točke se administriraju bilo istovremeno ili uzastopno u vremenu.
3. Riluzol ili farmaceutski prihvatljiva sol, solvat, anomer, enantiomer, hidrat ili prolijek istog i inhibitor kontrolne točke za primjenu prema zahtjevu 1, pri čemu inhibitor kontrolne točke cilja PD-1, PD-L1 ili CTLA-4.
4. Riluzol ili farmaceutski prihvatljiva sol, solvat, anomer, enantiomer, hidrat ili prolijek istog i inhibitor kontrolne točke za primjenu prema zahtjevu 1, pri čemu inhibitor kontrolne točke je odabran iz grupe koja se sastoji od nivolumaba, pembrolizumaba, pidilizumaba, ipilimumaba, PDR001, MEDI0680, atezolizumaba, durvalumaba i kombinacija istih.
5. Riluzol ili farmaceutski prihvatljiva sol, solvat, anomer, enantiomer, hidrat ili prolijek istog i inhibitor kontrolne točke za primjenu prema zahtjevu 1, pri čemu riluzol ili farmaceutski prihvatljiva sol, solvat, anomer, enantiomer, hidrat ili prolijek istog i inhibitor kontrolne točke se administriraju u kombinaciji ili uzastopno sa drugim standardnim tretmanima njege protiv raka.
6. Riluzol ili farmaceutski prihvatljiva sol, solvat, anomer, enantiomer, hidrat ili prolijek istog i inhibitor kontrolne točke za primjenu prema zahtjevu 1, pri čemu je inhibitor kontrolne točke anti-PD1 ili anti-PD-L1 i tretirani rak je glioblastom.
7. Riluzol ili farmaceutski prihvatljiva sol, solvat, anomer, enantiomer, hidrat ili prolijek istog i inhibitor kontrolne točke za primjenu prema zahtjevu 1, pri čemu je inhibitor kontrolne točke anti-PD1 ili anti-PD-L1 i tretirani rak je melanom.
8. Riluzol ili farmaceutski prihvatljiva sol, solvat, anomer, enantiomer, hidrat ili prolijek istog i inhibitor kontrolne točke za primjenu prema zahtjevu 1, pri čemu riluzol ili farmaceutski prihvatljiva sol, solvat, anomer, enantiomer, hidrat ili prolijek istog i inhibitor kontrolne točke su sposobni da osiguraju odnos preživljavanja miševa od najmanje 2.0 na dan 60 (MSR60).
9. Riluzol ili farmaceutski prihvatljiva sol, solvat, anomer, enantiomer, hidrat ili prolijek istog i inhibitor kontrolne točke za primjenu prema zahtjevu 1 pri čemu je prolijek riluzola;
[image]
ili hidrat, solvat, farmaceutski prihvatljiva sol ili kompleks istog.
10. Prolijek riluzola i inhibitor kontrolne točke za primjenu prema zahtjevu 9, pri čemu je prolijek riluzola;
[image]
ili hidrat, solvat, farmaceutski prihvatljiva sol ili kompleks istog.
11. Prolijek riluzola i inhibitor kontrolne točke za primjenu prema zahtjevu 10, pri čemu je prolijek riluzola;
[image]
12. Riluzol ili farmaceutski prihvatljiva sol, solvat, anomer, enantiomer, hidrat ili prolijek istog i inhibitor kontrolne točke za primjenu prema bilo kojem od prethodnih zahtjeva, pri čemu je inhibitor kontrolne točke nivolumab ili pembrolizumab.
13. Riluzol ili farmaceutski prihvatljiva sol, solvat, anomer, enantiomer, hidrat ili prolijek istog i inhibitor kontrolne točke za primjenu prema bilo kojem od prethodnih zahtjeva 1 do 5 i 8 do 12, pri čemu je rak glioblastom ili melanom.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662339433P | 2016-05-20 | 2016-05-20 | |
| PCT/US2017/033688 WO2017201501A1 (en) | 2016-05-20 | 2017-05-19 | Use of riluzole, riluzole prodrugs or riluzole analogs with immunotherapies to treat cancers |
| EP17800310.9A EP3458053B1 (en) | 2016-05-20 | 2017-05-19 | Use of riluzole, riluzole prodrugs or riluzole analogs with immunotherapies to treat cancers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20220237T1 true HRP20220237T1 (hr) | 2022-04-29 |
Family
ID=60326148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20220237TT HRP20220237T1 (hr) | 2016-05-20 | 2017-05-19 | Primjena riluzola, prolijekova riluzola ili analoga riluzola sa imunoterapijama za liječenje raka |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US20190175731A1 (hr) |
| EP (3) | EP3458054B1 (hr) |
| JP (4) | JP7224186B2 (hr) |
| KR (2) | KR102369735B1 (hr) |
| CN (2) | CN109890387B (hr) |
| AU (2) | AU2017266951B2 (hr) |
| BR (1) | BR112018073781A2 (hr) |
| CA (1) | CA3025019A1 (hr) |
| CY (1) | CY1124999T1 (hr) |
| DK (1) | DK3458053T3 (hr) |
| EA (1) | EA201892587A1 (hr) |
| ES (2) | ES2912131T3 (hr) |
| HR (1) | HRP20220237T1 (hr) |
| HU (1) | HUE058184T2 (hr) |
| IL (2) | IL292302B2 (hr) |
| LT (1) | LT3458053T (hr) |
| MX (2) | MX2018013868A (hr) |
| PH (1) | PH12018502409A1 (hr) |
| PL (1) | PL3458053T3 (hr) |
| PT (1) | PT3458053T (hr) |
| RS (1) | RS62935B1 (hr) |
| SG (1) | SG11201809669RA (hr) |
| SI (1) | SI3458053T1 (hr) |
| WO (2) | WO2017201501A1 (hr) |
| ZA (1) | ZA201807398B (hr) |
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| SG11201706831RA (en) * | 2015-03-03 | 2017-09-28 | Biohaven Pharm Holding Co Ltd | Riluzole prodrugs and their use |
| LT3303394T (lt) | 2015-05-29 | 2020-10-12 | Agenus Inc. | Anti-ctla-4 antikūnai ir jų naudojimo būdai |
| BR112018000768A2 (pt) | 2015-07-13 | 2018-09-25 | Cytomx Therapeutics Inc | anticorpos anti-pd-1, anticorpos anti-pd-1 ativáveis e métodos de uso dos mesmos |
| SG11201802830QA (en) | 2015-10-05 | 2018-05-30 | Calithera Biosciences Inc | Combination therapy with glutaminase inhibitors and immuno-oncology agents |
| AU2017266951B2 (en) * | 2016-05-20 | 2021-05-27 | Biohaven Pharmaceutical Holding Company Ltd. | Use of Glutamate modulating agents with Immunotherapies to treat cancer |
| US10844119B2 (en) | 2016-10-11 | 2020-11-24 | Agenus Inc. | Anti-LAG-3 antibodies and methods of use thereof |
| IL307242A (en) | 2016-12-07 | 2023-11-01 | Agenus Inc | Anti-CTLA-4 antibodies and methods of using them |
| US11168144B2 (en) | 2017-06-01 | 2021-11-09 | Cytomx Therapeutics, Inc. | Activatable anti-PDL1 antibodies, and methods of use thereof |
| MA49950A (fr) | 2017-08-25 | 2020-07-01 | Five Prime Therapeutics Inc | Anticorps anti-b7-h4 et leurs procédés d'utilisation |
| EP3703822A4 (en) * | 2017-11-03 | 2021-11-10 | Calithera Biosciences, Inc. | CONJOINT THERAPY WITH GLUTAMINASE INHIBITORS |
| MX2020008680A (es) * | 2018-02-21 | 2020-09-25 | Ai Therapeutics Inc | Terapia de combinacion con apilimod y agentes glutamatergicos. |
| WO2019169212A1 (en) | 2018-03-02 | 2019-09-06 | Five Prime Therapeutics, Inc. | B7-h4 antibodies and methods of use thereof |
| JP2021530543A (ja) * | 2018-07-22 | 2021-11-11 | バイオヘイブン・セラピューティクス・リミテッドBiohaven Therapeutics Ltd. | アルツハイマー病を処置するためのリルゾールプロドラッグの使用 |
| EP3914266A4 (en) * | 2019-01-24 | 2022-12-07 | University of Cincinnati | AUTOLOGOUS TUMORORGANOID AND IMMUNE CELL COCULTURES AND METHODS FOR USE AS PREDICTIVE MODELS FOR TREATMENT OF PANCREA CANCER |
| EP3983084A1 (en) * | 2019-06-12 | 2022-04-20 | Vanderbilt University | Amino acid transport inhibitors and the uses thereof |
| CN110646557A (zh) * | 2019-10-12 | 2020-01-03 | 北京航空航天大学 | 携带idh基因突变的胶质母细胞瘤患者的尿液代谢标志物及其用途 |
| JP7431412B2 (ja) | 2019-12-23 | 2024-02-15 | 三菱マテリアル株式会社 | 被覆電線の分離方法 |
| WO2021188616A1 (en) * | 2020-03-17 | 2021-09-23 | Ohio State Innovation Foundation | Designer extracellular vesicles for treating excitotoxicity |
| KR102441650B1 (ko) * | 2020-07-31 | 2022-09-08 | 서울대학교병원 | 다중약물 화학요법에 있어서 항암제의 유효 용량 정보의 제공 방법 |
| WO2022197767A1 (en) * | 2021-03-17 | 2022-09-22 | Memorial Sloan-Kettering Cancer Center | Methods for improving survival in lung cancer patients via ketamine oncoprotection |
| TW202320782A (zh) * | 2021-07-21 | 2023-06-01 | 美商維拉克塔股份有限公司 | 癌症治療組合 |
| WO2023202652A1 (en) * | 2022-04-21 | 2023-10-26 | Jacobio Pharmaceuticals Co., Ltd. | Pharmaceutical combination and use thereof |
| CN116492322A (zh) * | 2023-05-10 | 2023-07-28 | 徐州医科大学 | 小分子阻滞剂mem在制备治疗肿瘤药物的应用 |
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