ATE421318T1 - Darreichungsform, welche rasche dispersionseigenschaften entfaltet, anwendungsverfahren sowie verfahren zur herstellung derselben - Google Patents
Darreichungsform, welche rasche dispersionseigenschaften entfaltet, anwendungsverfahren sowie verfahren zur herstellung derselbenInfo
- Publication number
- ATE421318T1 ATE421318T1 AT98907531T AT98907531T ATE421318T1 AT E421318 T1 ATE421318 T1 AT E421318T1 AT 98907531 T AT98907531 T AT 98907531T AT 98907531 T AT98907531 T AT 98907531T AT E421318 T1 ATE421318 T1 AT E421318T1
- Authority
- AT
- Austria
- Prior art keywords
- dosage form
- production
- application
- same
- dispersion properties
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3888397P | 1997-02-20 | 1997-02-20 | |
US3828497P | 1997-02-20 | 1997-02-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE421318T1 true ATE421318T1 (de) | 2009-02-15 |
Family
ID=26715043
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98907531T ATE421318T1 (de) | 1997-02-20 | 1998-02-20 | Darreichungsform, welche rasche dispersionseigenschaften entfaltet, anwendungsverfahren sowie verfahren zur herstellung derselben |
Country Status (9)
Country | Link |
---|---|
US (3) | US6471992B1 (de) |
EP (1) | EP0973507B1 (de) |
JP (3) | JP4563516B2 (de) |
AT (1) | ATE421318T1 (de) |
AU (1) | AU736912B2 (de) |
CA (1) | CA2281473C (de) |
DE (1) | DE69840495D1 (de) |
ES (1) | ES2318869T3 (de) |
WO (1) | WO1998036738A1 (de) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4563516B2 (ja) | 1997-02-20 | 2010-10-13 | マサチューセッツ インスティテュート オブ テクノロジー | 迅速分散性を示す投与剤形、その使用法並びにその製造方法 |
AU3731699A (en) * | 1998-05-18 | 1999-12-06 | Takeda Chemical Industries Ltd. | Orally disintegrable tablets |
US6284270B1 (en) * | 1999-08-04 | 2001-09-04 | Drugtech Corporation | Means for creating a mass having structural integrity |
EP1301177A2 (de) * | 2000-07-10 | 2003-04-16 | Therics, Inc. | Verfahren und materialien zur steuerung der wanderung einer binderflüssigkeit in ein pulver |
KR20090029314A (ko) * | 2001-06-28 | 2009-03-20 | 유씨비 파쉼 소시에떼아노님 | 세티리진 및 슈도에페드린을 포함하는 정제 |
IL159715A0 (en) * | 2001-07-10 | 2004-06-20 | Teva Pharma | Drug delivery system for zero order, zero order-biphasic, ascending or descending drug delivery |
EP1439945B1 (de) * | 2001-10-29 | 2006-04-12 | Therics, Inc. | System und verfahren zum uniaxialen pressen eines gegenstandes wie eine drei-dimensional gedruckte dosierungsform |
CA2463481A1 (en) * | 2001-10-29 | 2003-05-22 | Therics, Inc. | Three-dimensional suspension printing of dosage forms |
DE60323482D1 (de) * | 2002-05-06 | 2008-10-23 | Massachusetts Inst Technology | Diffusionskontrollierte arzneiform sowie herstellungsmethode mittels dreidimensionalem drucken |
AU2003280324A1 (en) * | 2002-11-26 | 2004-06-18 | Alk-Abello A/S | Pharmaceutical allergen product |
MX2007003032A (es) | 2004-09-21 | 2007-05-21 | Hypnion Inc | Analogos de loxapina y metodos de uso de los mismos. |
US7829000B2 (en) * | 2005-02-25 | 2010-11-09 | Hewlett-Packard Development Company, L.P. | Core-shell solid freeform fabrication |
US8187659B2 (en) | 2006-05-02 | 2012-05-29 | Jerry Robertson Real Estate Llc | Solid medicament dosage form consumption aid |
ES2500165T3 (es) | 2006-06-29 | 2014-09-30 | Kinex Pharmaceuticals, Llc | Composiciones de biarilo y métodos para modular una cascada de quinasas |
CN101932319A (zh) | 2007-10-20 | 2010-12-29 | 金克斯医药品有限公司 | 用于调控激酶级联的药物组合物以其使用方法 |
MY150626A (en) | 2009-10-30 | 2014-02-07 | Ix Biopharma Ltd | Fast dissolving solid dosage form |
EP3195858B1 (de) * | 2010-04-03 | 2019-08-07 | Praful Doshi | Medizinische vorrichtungen mit medikamenten sowie verfahren zu ihrer herstellung und verwendung |
WO2012056319A1 (en) | 2010-10-27 | 2012-05-03 | Dynamix Pharmaceuticals Ltd. | Sulfonamides for the modulation of pkm2 |
US8987271B2 (en) | 2010-12-22 | 2015-03-24 | Eutropics Pharmaceuticals, Inc. | 2,2′-biphenazine compounds and methods useful for treating disease |
US8722636B2 (en) | 2011-01-31 | 2014-05-13 | New Market Pharmaceuticals, LLC | Animal treatments |
EP2684167B1 (de) | 2011-03-08 | 2020-09-09 | Eutropics Pharmaceuticals, Inc. | Zusammensetzungen und verfahren zur behandlung von erkrankungen |
ITMI20110793A1 (it) | 2011-05-09 | 2012-11-10 | Probiotical Spa | Ceppi di batteri probiotici e composizione sinbiotica contenente gli stessi destinata alla alimentazione dei neonati. |
ITMI20110791A1 (it) | 2011-05-09 | 2012-11-10 | Probiotical Spa | Ceppi di batteri in grado di metabolizzare gli ossalati. |
ITMI20110792A1 (it) | 2011-05-09 | 2012-11-10 | Probiotical Spa | Ceppi di batteri appartenenti al genere bifidobacterium per uso nel trattamento della ipercolesterolemia. |
WO2012160447A1 (en) | 2011-05-25 | 2012-11-29 | Dynamix Pharmaceuticals Ltd. | 3, 5 -diphenyl- substituted pyrazolines for the treatment of cancer, proliferative, inflammatory or autoimmune diseases |
US8937065B2 (en) | 2011-06-07 | 2015-01-20 | Clevexel Pharma | Compositions and methods for modulating a kinase |
ITMI20111718A1 (it) | 2011-09-23 | 2013-03-24 | Probiotical Spa | Un materiale impermeabile alla umidita e allo ossigeno per confezionare prodotti dietetici, cosmetici e specialita medicinali. |
US9245061B2 (en) * | 2012-04-25 | 2016-01-26 | Shapeways, Inc. | Weight-based identification of three dimensional printed parts |
CA2872396C (en) | 2012-05-02 | 2022-12-13 | Newmarket Pharmaceuticals Llc | Pharmaceutical compositions for direct systemic introduction comprising a proton pump inhibitor |
WO2013192423A2 (en) | 2012-06-20 | 2013-12-27 | Eutropics Pharmaceuticals, Inc. | Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives |
CN105263907B (zh) | 2012-08-30 | 2018-11-20 | 阿西纳斯公司 | 作为蛋白质酪氨酸激酶调节剂的n-(3-氟苄基)-2-(5-(4-吗啉代苯基)吡啶-2-基)乙酰胺 |
US9545376B2 (en) | 2013-01-23 | 2017-01-17 | Arx, Llc | Production of unit dose constructs |
AU2014228861B2 (en) | 2013-03-15 | 2018-05-24 | Aprecia Pharmaceuticals LLC | Rapidly dispersible dosage form of topiramate |
US9339489B2 (en) | 2013-03-15 | 2016-05-17 | Aprecia Pharmaceuticals Company | Rapid disperse dosage form containing levetiracetam |
CA2906107C (en) * | 2013-03-15 | 2021-08-24 | Aprecia Pharmaceuticals Company | Rapidly dispersible dosage form of oxcarbazepine |
CA2906029C (en) * | 2013-03-15 | 2017-09-05 | Aprecia Pharmaceuticals Company | Rapid disperse dosage form containing levetiracetam |
WO2014176389A1 (en) | 2013-04-24 | 2014-10-30 | Temple University - Of The Commonwealth System Of Higher Education | Solid dosage form containing arabinogalactan |
ITMI20130793A1 (it) | 2013-05-14 | 2014-11-15 | Probiotical Spa | Composizione comprendente batteri lattici per uso nel trattamento preventivo e/o curativo delle cistiti ricorrenti. |
JP6233996B2 (ja) | 2013-08-16 | 2017-11-22 | ザ エクスワン カンパニー | 3次元印刷される金属鋳造用鋳型及び同鋳型の製造方法 |
EP3057729A4 (de) | 2013-10-17 | 2017-10-18 | The Exone Company | Isostatische heisspressbehälter mit 3d-druck und verfahren zur herstellung davon |
US20160332373A1 (en) | 2013-12-23 | 2016-11-17 | The Exone Company | Methods and Systems for Three-Dimensional Printing Utilizing Multiple Binder Fluids |
WO2015100084A1 (en) | 2013-12-23 | 2015-07-02 | The Exone Company | Method of three-dimensional printing using a multi-component build powder |
EP3086921B1 (de) * | 2013-12-23 | 2019-07-31 | The Exone Company | Verfahren und systeme zum dreidimensionalen drucken unter verwendung einer bindemittelflüssigkeit mit ausgestrahlten partikeln |
US20160184230A1 (en) * | 2014-04-30 | 2016-06-30 | Aron H. Blaesi | Melt-processed polymeric cellular dosage form |
WO2015183796A1 (en) | 2014-05-29 | 2015-12-03 | The Exone Company | Process for making nickel-based superalloy articles by three-dimensional printing |
WO2016011098A2 (en) | 2014-07-17 | 2016-01-21 | The Exone Company | Methods and apparatuses for curing three-dimensional printed articles |
MX368838B (es) | 2014-11-21 | 2019-10-18 | Biohaven Pharm Holding Co Ltd | Administracion sublingual de riluzol. |
KR102411873B1 (ko) | 2014-12-03 | 2022-06-21 | 더 엑스원 컴퍼니 | 3차원 프린팅에 의해 고밀화 탄소 물품을 제조하는 공정 |
EP3302442A4 (de) | 2015-06-03 | 2019-02-06 | Triastek, Inc. | Darreichungsform und verwendung davon |
EP3108874A1 (de) * | 2015-06-26 | 2016-12-28 | TRB Chemedica AG | Pharmazeutische zubereitung zur anwendung am auge |
US11129798B2 (en) * | 2016-08-19 | 2021-09-28 | Aron H. Blaesi | Fibrous dosage form |
CA3018012A1 (en) * | 2016-03-18 | 2017-09-21 | Grunenthal Gmbh | Combination of drugs having different potency |
EP3441065A4 (de) * | 2016-04-06 | 2019-11-20 | Astellas Pharma Inc. | Schnell eluierendes dreidimensionales formteil, filament für ein schnell eluierendes dreidimensionales formteil und material für ein schnell eluierendes dreidimensionales formteil |
EP3452003A4 (de) | 2016-05-05 | 2019-06-26 | Triastek, Inc. | Dosierungsform mit kontrollierter freisetzung |
RS62935B1 (sr) | 2016-05-20 | 2022-03-31 | Biohaven Therapeutics Ltd | Primena riluzola, prolekova riluzola ili analoga riluzola sa imunoterapijama za lečenje kancera |
TWI755418B (zh) | 2016-08-12 | 2022-02-21 | 美商亞瑟尼克斯公司 | 聯芳組成物和調控激酶級聯之方法 |
EP3529023B1 (de) | 2016-10-19 | 2022-05-25 | Shapeways, Inc. | Systeme und verfahren zur identifizierung dreidimensionaler druckobjekte |
CA3045043A1 (en) | 2016-12-31 | 2018-07-05 | Bioxcel Therapeutics, Inc. | Use of sublingual dexmedetomidine for the treatment of agitation |
US11602502B2 (en) | 2017-02-24 | 2023-03-14 | Hewlett-Packard Development Company, L.P. | Three-dimensional (3D) printing a pharmaceutical tablet |
CN110381925A (zh) | 2017-03-08 | 2019-10-25 | 辛瑞克斯制药有限公司 | 间苯三酚和三甲基间苯三酚的药物制剂 |
EP3635045A1 (de) | 2017-05-26 | 2020-04-15 | Infinite Material Solutions, LLC | Wasserlösliche polymerzusammensetzungen |
EP3706739A4 (de) | 2017-11-12 | 2021-08-04 | Biohaven Pharmaceutical Holding Company Ltd. | Verwendung von riluzolprodrugs zur behandlung von ataxien |
CN108066302B (zh) * | 2017-12-28 | 2020-09-11 | 无限极(中国)有限公司 | 一种快速分散固体制剂的制备方法及制备的快速分散固体制剂 |
US10350822B1 (en) | 2018-01-09 | 2019-07-16 | Triastek Inc. | Dosage forms with desired release profiles and methods of designing and making thereof |
CN116270513A (zh) | 2018-01-09 | 2023-06-23 | 南京三迭纪医药科技有限公司 | 一种包含固定剂量adhd非兴奋剂和adhd兴奋剂的复方口服药物剂型 |
DE102018107585B3 (de) * | 2018-03-29 | 2019-03-28 | Universität Rostock | Vorrichtung zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen mit Wirkstoffdepots, sowie Verfahren zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen |
CN115154440A (zh) | 2018-06-27 | 2022-10-11 | 比奥克斯塞尔医疗股份有限公司 | 含右美托咪定的膜制剂及其制造方法 |
CN112867482B (zh) | 2018-10-15 | 2023-04-25 | 阿普雷奇亚制药有限责任公司 | 在包装内形成剂型的方法和系统 |
US20220016074A1 (en) | 2018-11-21 | 2022-01-20 | Rosemont Pharmaceuticals Limited | Oral topiramate suspension formulations with extended shelf stability and enhanced bioavailability |
JP7287032B2 (ja) | 2019-03-20 | 2023-06-06 | 株式会社リコー | シート、シート積層体、医薬品、シートの製造方法、及びシート積層体の製造方法 |
EP3972567A1 (de) * | 2019-05-21 | 2022-03-30 | DFE Pharma GmbH & Co. KG | Dreidimensionales laktosepulverbettdrucken |
BR112022000992A2 (pt) | 2019-07-19 | 2022-06-14 | Arx Llc | Regimes de tratamento de dexmedetomidina não sedantes |
TWI734309B (zh) * | 2019-12-19 | 2021-07-21 | 水星生醫股份有限公司 | 滲透性噴塗製作藥錠裝置 |
CA3183295A1 (en) | 2020-06-26 | 2021-12-30 | Jaedeok Yoo | Rapidly-orodispersible tablets having an interior cavity |
US20230390193A1 (en) | 2020-10-30 | 2023-12-07 | Triastek, Inc. | Gastroretentive pharmaceutical dosage form |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4642903A (en) | 1985-03-26 | 1987-02-17 | R. P. Scherer Corporation | Freeze-dried foam dosage form |
US4855326A (en) | 1987-04-20 | 1989-08-08 | Fuisz Pharmaceutical Ltd. | Rapidly dissoluble medicinal dosage unit and method of manufacture |
US4990535A (en) * | 1989-05-03 | 1991-02-05 | Schering Corporation | Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine |
FR2647343B1 (fr) * | 1989-05-24 | 1994-05-06 | Rhone Poulenc Sante | Nouvelle forme pharmaceutique poreuse et sa preparation |
US5206025A (en) * | 1989-05-24 | 1993-04-27 | Rhone-Poulenc Sante | Porous pharmaceutical form and its preparation |
EP0418596A3 (en) * | 1989-09-21 | 1991-10-23 | American Cyanamid Company | Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form |
US5204055A (en) | 1989-12-08 | 1993-04-20 | Massachusetts Institute Of Technology | Three-dimensional printing techniques |
US5578322A (en) | 1990-11-30 | 1996-11-26 | Yamanouchi Pharmaceutical Co., Ltd. | Quick release coated preparation |
ES2081564T3 (es) | 1991-01-31 | 1996-03-16 | Texas Instruments Inc | Metodo y sistema para la fabricacion, controlada por ordenador, de objetos tridimensionales a partir de datos de ordenador. |
DK0617613T3 (da) * | 1991-12-20 | 1996-06-17 | Pfizer | Porøse formgivne afgivelsesindretninger og fremgangsmåde til fremstilling deraf |
JP2521612B2 (ja) * | 1992-05-20 | 1996-08-07 | ウエイ・ミン・フアーマシユーテイカル・マニユフアクチヤリング・カンパニー・リミテツド | 直接錠剤形成助剤 |
US5518730A (en) | 1992-06-03 | 1996-05-21 | Fuisz Technologies Ltd. | Biodegradable controlled release flash flow melt-spun delivery system |
US5380473A (en) | 1992-10-23 | 1995-01-10 | Fuisz Technologies Ltd. | Process for making shearform matrix |
DE4303846A1 (de) * | 1993-02-10 | 1994-08-11 | Merck Patent Gmbh | Verfahren zur Herstellung einer S-Ibuprofen enthaltenden Tablette |
WO1995001782A2 (en) * | 1993-07-09 | 1995-01-19 | R.P. Scherer Corporation | Method for making freeze dried drug dosage forms |
US6176874B1 (en) | 1993-10-18 | 2001-01-23 | Masschusetts Institute Of Technology | Vascularized tissue regeneration matrices formed by solid free form fabrication techniques |
US6280771B1 (en) | 1997-02-20 | 2001-08-28 | Therics, Inc. | Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof |
US5490962A (en) | 1993-10-18 | 1996-02-13 | Massachusetts Institute Of Technology | Preparation of medical devices by solid free-form fabrication methods |
US5503785A (en) | 1994-06-02 | 1996-04-02 | Stratasys, Inc. | Process of support removal for fused deposition modeling |
US5633021A (en) | 1994-10-19 | 1997-05-27 | Bpm Technology, Inc. | Apparatus for making a three-dimensional article |
US5607697A (en) | 1995-06-07 | 1997-03-04 | Cima Labs, Incorporated | Taste masking microparticles for oral dosage forms |
US5560927A (en) * | 1995-07-28 | 1996-10-01 | Isp Investments Inc. | Co-processing method for making a free-flowing compressible powder and tablet therefrom |
US5653925A (en) * | 1995-09-26 | 1997-08-05 | Stratasys, Inc. | Method for controlled porosity three-dimensional modeling |
JP4563516B2 (ja) * | 1997-02-20 | 2010-10-13 | マサチューセッツ インスティテュート オブ テクノロジー | 迅速分散性を示す投与剤形、その使用法並びにその製造方法 |
DE19940944B4 (de) * | 1999-08-31 | 2006-10-12 | Grünenthal GmbH | Retardierte, orale, pharmazeutische Darreichungsformen |
-
1998
- 1998-02-20 JP JP53687898A patent/JP4563516B2/ja not_active Expired - Lifetime
- 1998-02-20 AT AT98907531T patent/ATE421318T1/de not_active IP Right Cessation
- 1998-02-20 CA CA002281473A patent/CA2281473C/en not_active Expired - Lifetime
- 1998-02-20 DE DE69840495T patent/DE69840495D1/de not_active Expired - Lifetime
- 1998-02-20 US US09/027,183 patent/US6471992B1/en not_active Expired - Lifetime
- 1998-02-20 EP EP98907531A patent/EP0973507B1/de not_active Expired - Lifetime
- 1998-02-20 ES ES98907531T patent/ES2318869T3/es not_active Expired - Lifetime
- 1998-02-20 AU AU63314/98A patent/AU736912B2/en not_active Ceased
- 1998-02-20 WO PCT/US1998/003256 patent/WO1998036738A1/en active Search and Examination
-
2002
- 2002-07-19 US US10/200,029 patent/US9463160B2/en not_active Expired - Fee Related
-
2009
- 2009-05-11 JP JP2009114753A patent/JP5091910B2/ja not_active Expired - Lifetime
- 2009-11-09 JP JP2009256374A patent/JP2010120938A/ja not_active Withdrawn
-
2012
- 2012-02-09 US US13/369,473 patent/US9114072B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20120207929A1 (en) | 2012-08-16 |
JP2010120938A (ja) | 2010-06-03 |
US20030133975A1 (en) | 2003-07-17 |
EP0973507A1 (de) | 2000-01-26 |
AU736912B2 (en) | 2001-08-02 |
DE69840495D1 (de) | 2009-03-12 |
EP0973507A4 (de) | 2006-08-23 |
JP2009215305A (ja) | 2009-09-24 |
WO1998036738A1 (en) | 1998-08-27 |
US6471992B1 (en) | 2002-10-29 |
ES2318869T3 (es) | 2009-05-01 |
US9463160B2 (en) | 2016-10-11 |
CA2281473C (en) | 2007-01-16 |
AU6331498A (en) | 1998-09-09 |
JP4563516B2 (ja) | 2010-10-13 |
CA2281473A1 (en) | 1998-08-27 |
US9114072B2 (en) | 2015-08-25 |
EP0973507B1 (de) | 2009-01-21 |
JP2001512488A (ja) | 2001-08-21 |
JP5091910B2 (ja) | 2012-12-05 |
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