MX2012000766A - Compuestos triazolopiridina, y su accion como inhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina. - Google Patents

Compuestos triazolopiridina, y su accion como inhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina.

Info

Publication number
MX2012000766A
MX2012000766A MX2012000766A MX2012000766A MX2012000766A MX 2012000766 A MX2012000766 A MX 2012000766A MX 2012000766 A MX2012000766 A MX 2012000766A MX 2012000766 A MX2012000766 A MX 2012000766A MX 2012000766 A MX2012000766 A MX 2012000766A
Authority
MX
Mexico
Prior art keywords
compound
erythropoietin production
prolyl hydroxylase
action
hydroxylase inhibitor
Prior art date
Application number
MX2012000766A
Other languages
English (en)
Inventor
Takashi Ito
Masahiro Yokota
Kazuhito Ueyama
Ikuo Mitani
Yosuke Ogoshi
Takuya Matsui
Masakazu Terashita
Dai Motoda
Takahiro Hotta
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of MX2012000766A publication Critical patent/MX2012000766A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)

Abstract

La presente invención provee un compuesto de triazolopiridina que tiene una acción inhibidora de prolil hidroxilasa y la capacidad de inducir la producción de eritropoyetina; la presente invención se refiere a un compuesto representado por la siguiente fórmula [I]: (ver fórmula (I)) donde cada símbolo es como se definió en la especificación, o su sal aceptable farmacéuticamente, o un solvato del mismo, como también un inhibidor de la prolil hidroxilasa o un agente que induce la producción de eritropoyetina que contiene el compuesto; el compuesto de la presente invención muestra una acción inhibidora de prolil hidroxilasa y la capacidad de inducir la producción de eritropoyetina y es útil como agente profiláctico o terapéutico para varias enfermedades y patologías (trastornos) originados por la producción disminuida de la eritropoyetina.
MX2012000766A 2009-07-17 2010-07-16 Compuestos triazolopiridina, y su accion como inhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina. MX2012000766A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009169565 2009-07-17
US27312709P 2009-07-30 2009-07-30
PCT/JP2010/062037 WO2011007856A1 (ja) 2009-07-17 2010-07-16 トリアゾロピリジン化合物、ならびにそのプロリル水酸化酵素阻害剤およびエリスロポエチン産生誘導剤としての作用

Publications (1)

Publication Number Publication Date
MX2012000766A true MX2012000766A (es) 2012-02-08

Family

ID=43449466

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012000766A MX2012000766A (es) 2009-07-17 2010-07-16 Compuestos triazolopiridina, y su accion como inhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina.

Country Status (29)

Country Link
US (3) US8283465B2 (es)
EP (3) EP3594213A1 (es)
JP (8) JP5021797B2 (es)
KR (4) KR101850661B1 (es)
CN (1) CN102471337B (es)
AR (1) AR077417A1 (es)
AU (1) AU2010271732B2 (es)
BR (1) BR112012001157A2 (es)
CA (1) CA2768505C (es)
CO (1) CO6430426A2 (es)
DK (1) DK2455381T5 (es)
ES (1) ES2477968T3 (es)
HK (1) HK1168346A1 (es)
HR (1) HRP20140705T1 (es)
IL (1) IL217541A (es)
ME (1) ME01858B (es)
MX (1) MX2012000766A (es)
MY (1) MY160814A (es)
NZ (1) NZ598242A (es)
PE (1) PE20120629A1 (es)
PL (1) PL2455381T3 (es)
PT (1) PT2455381E (es)
RS (1) RS53499B1 (es)
RU (1) RU2538963C2 (es)
SG (1) SG178049A1 (es)
SI (1) SI2455381T1 (es)
SM (1) SMT201500122B (es)
TW (1) TWI485150B (es)
WO (1) WO2011007856A1 (es)

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WO2021182490A1 (ja) * 2020-03-11 2021-09-16 キッセイ薬品工業株式会社 イミダゾピリジノン化合物又はその塩の結晶
JP7504822B2 (ja) 2020-03-12 2024-06-24 キッセイ薬品工業株式会社 イミダゾピリジノン化合物を含む医薬組成物
WO2021216530A1 (en) 2020-04-20 2021-10-28 Akebia Therapeutics, Inc. Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer
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Also Published As

Publication number Publication date
CA2768505C (en) 2018-06-12
RU2012105467A (ru) 2013-08-27
JP6434575B2 (ja) 2018-12-05
ME01858B (me) 2014-12-20
DK2455381T5 (en) 2015-02-09
HRP20140705T1 (hr) 2014-09-12
CA2768505A1 (en) 2011-01-20
EP2746282A1 (en) 2014-06-25
ES2477968T9 (es) 2014-11-13
JP2015003933A (ja) 2015-01-08
AU2010271732B2 (en) 2016-08-25
AU2010271732A1 (en) 2012-03-08
JP2017214404A (ja) 2017-12-07
EP2455381B9 (en) 2014-10-22
NZ598242A (en) 2013-09-27
KR20180042443A (ko) 2018-04-25
RU2538963C2 (ru) 2015-01-10
US20130096155A1 (en) 2013-04-18
JP2022126843A (ja) 2022-08-30
EP2455381B1 (en) 2014-05-28
JP2011037841A (ja) 2011-02-24
PT2455381E (pt) 2014-06-24
SMT201500122B (it) 2015-07-09
KR20120051704A (ko) 2012-05-22
CO6430426A2 (es) 2012-04-30
DK2455381T3 (da) 2014-07-21
AR077417A1 (es) 2011-08-24
JP5021797B2 (ja) 2012-09-12
MY160814A (en) 2017-03-31
KR101850661B1 (ko) 2018-04-19
KR20170018105A (ko) 2017-02-15
PE20120629A1 (es) 2012-05-30
CN102471337A (zh) 2012-05-23
TW201105671A (en) 2011-02-16
JP2012144571A (ja) 2012-08-02
JP2016040321A (ja) 2016-03-24
US8283465B2 (en) 2012-10-09
JP2020111612A (ja) 2020-07-27
RS53499B1 (en) 2015-02-27
CN102471337B (zh) 2014-12-10
BR112012001157A2 (pt) 2016-02-23
HK1168346A1 (en) 2012-12-28
EP2455381A1 (en) 2012-05-23
US20110077267A1 (en) 2011-03-31
PL2455381T3 (pl) 2014-10-31
EP3594213A1 (en) 2020-01-15
SG178049A1 (en) 2012-03-29
JP2019019144A (ja) 2019-02-07
SI2455381T1 (sl) 2014-08-29
IL217541A (en) 2014-07-31
TWI485150B (zh) 2015-05-21
ES2477968T3 (es) 2014-07-18
IL217541A0 (en) 2012-02-29
WO2011007856A1 (ja) 2011-01-20
EP2455381A4 (en) 2012-12-12
KR101706803B1 (ko) 2017-02-14
US20160145254A1 (en) 2016-05-26
KR20230165366A (ko) 2023-12-05

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