MX2012000766A - Compuestos triazolopiridina, y su accion como inhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina. - Google Patents

Compuestos triazolopiridina, y su accion como inhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina.

Info

Publication number
MX2012000766A
MX2012000766A MX2012000766A MX2012000766A MX2012000766A MX 2012000766 A MX2012000766 A MX 2012000766A MX 2012000766 A MX2012000766 A MX 2012000766A MX 2012000766 A MX2012000766 A MX 2012000766A MX 2012000766 A MX2012000766 A MX 2012000766A
Authority
MX
Mexico
Prior art keywords
compound
erythropoietin production
prolyl hydroxylase
action
hydroxylase inhibitor
Prior art date
Application number
MX2012000766A
Other languages
English (en)
Inventor
Takashi Ito
Masahiro Yokota
Kazuhito Ueyama
Ikuo Mitani
Yosuke Ogoshi
Takuya Matsui
Masakazu Terashita
Dai Motoda
Takahiro Hotta
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of MX2012000766A publication Critical patent/MX2012000766A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)

Abstract

La presente invención provee un compuesto de triazolopiridina que tiene una acción inhibidora de prolil hidroxilasa y la capacidad de inducir la producción de eritropoyetina; la presente invención se refiere a un compuesto representado por la siguiente fórmula [I]: (ver fórmula (I)) donde cada símbolo es como se definió en la especificación, o su sal aceptable farmacéuticamente, o un solvato del mismo, como también un inhibidor de la prolil hidroxilasa o un agente que induce la producción de eritropoyetina que contiene el compuesto; el compuesto de la presente invención muestra una acción inhibidora de prolil hidroxilasa y la capacidad de inducir la producción de eritropoyetina y es útil como agente profiláctico o terapéutico para varias enfermedades y patologías (trastornos) originados por la producción disminuida de la eritropoyetina.
MX2012000766A 2009-07-17 2010-07-16 Compuestos triazolopiridina, y su accion como inhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina. MX2012000766A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009169565 2009-07-17
US27312709P 2009-07-30 2009-07-30
PCT/JP2010/062037 WO2011007856A1 (ja) 2009-07-17 2010-07-16 トリアゾロピリジン化合物、ならびにそのプロリル水酸化酵素阻害剤およびエリスロポエチン産生誘導剤としての作用

Publications (1)

Publication Number Publication Date
MX2012000766A true MX2012000766A (es) 2012-02-08

Family

ID=43449466

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012000766A MX2012000766A (es) 2009-07-17 2010-07-16 Compuestos triazolopiridina, y su accion como inhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina.

Country Status (29)

Country Link
US (3) US8283465B2 (es)
EP (3) EP3594213A1 (es)
JP (8) JP5021797B2 (es)
KR (4) KR101850661B1 (es)
CN (1) CN102471337B (es)
AR (1) AR077417A1 (es)
AU (1) AU2010271732B2 (es)
BR (1) BR112012001157A2 (es)
CA (1) CA2768505C (es)
CO (1) CO6430426A2 (es)
DK (1) DK2455381T5 (es)
ES (1) ES2477968T3 (es)
HK (1) HK1168346A1 (es)
HR (1) HRP20140705T1 (es)
IL (1) IL217541A (es)
ME (1) ME01858B (es)
MX (1) MX2012000766A (es)
MY (1) MY160814A (es)
NZ (1) NZ598242A (es)
PE (1) PE20120629A1 (es)
PL (1) PL2455381T3 (es)
PT (1) PT2455381E (es)
RS (1) RS53499B1 (es)
RU (1) RU2538963C2 (es)
SG (1) SG178049A1 (es)
SI (1) SI2455381T1 (es)
SM (1) SMT201500122B (es)
TW (1) TWI485150B (es)
WO (1) WO2011007856A1 (es)

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JP6814134B2 (ja) * 2015-05-28 2021-01-13 日本たばこ産業株式会社 糖尿病性腎症を治療又は予防する方法
RU2752384C2 (ru) * 2016-11-25 2021-07-26 Джапан Тобакко Инк. Способ получения триазолопиридинового соединения
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CN107739378A (zh) * 2017-11-14 2018-02-27 杭州安道药业有限公司 吲哚嗪衍生物及其在医药上的应用
CN112689637B (zh) * 2018-09-13 2023-11-10 橘生药品工业株式会社 咪唑并吡啶酮化合物
CN110105355B (zh) * 2019-05-24 2021-09-21 烟台大学 一种1,2,3-三唑-[1,5-a]并喹啉类化合物的制备方法
AU2021233433A1 (en) * 2020-03-11 2022-10-06 Kissei Pharmaceutical Co., Ltd. Crystal of imidazopyridinone compound or salt thereof
EP4138825A1 (en) 2020-04-20 2023-03-01 Akebia Therapeutics Inc. Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer
WO2022150623A1 (en) 2021-01-08 2022-07-14 Akebia Therapeutics, Inc. Compounds and composition for the treatment of anemia
CN113387948B (zh) * 2021-02-06 2022-06-10 成都诺和晟泰生物科技有限公司 一种稠环杂芳基衍生物及其药物组合物和治疗方法及用途
CN117999069A (zh) 2021-05-27 2024-05-07 凯克斯生物制药公司 柠檬酸铁的儿科调配物
CN113582843A (zh) * 2021-09-09 2021-11-02 无锡捷化医药科技有限公司 一种5-氯-2-氟-3-羟基苯甲酸乙酯的制备方法
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Also Published As

Publication number Publication date
RU2538963C2 (ru) 2015-01-10
AU2010271732A1 (en) 2012-03-08
EP2455381B1 (en) 2014-05-28
CA2768505A1 (en) 2011-01-20
SMT201500122B (it) 2015-07-09
MY160814A (en) 2017-03-31
CN102471337B (zh) 2014-12-10
JP6434575B2 (ja) 2018-12-05
EP2455381A1 (en) 2012-05-23
DK2455381T5 (en) 2015-02-09
CA2768505C (en) 2018-06-12
JP5021797B2 (ja) 2012-09-12
HK1168346A1 (en) 2012-12-28
PT2455381E (pt) 2014-06-24
JP2015003933A (ja) 2015-01-08
KR101850661B1 (ko) 2018-04-19
US8283465B2 (en) 2012-10-09
PL2455381T3 (pl) 2014-10-31
PE20120629A1 (es) 2012-05-30
JP2012144571A (ja) 2012-08-02
RU2012105467A (ru) 2013-08-27
KR101706803B1 (ko) 2017-02-14
CO6430426A2 (es) 2012-04-30
US20130096155A1 (en) 2013-04-18
JP2022126843A (ja) 2022-08-30
JP2011037841A (ja) 2011-02-24
JP2020111612A (ja) 2020-07-27
KR20120051704A (ko) 2012-05-22
KR20170018105A (ko) 2017-02-15
US20110077267A1 (en) 2011-03-31
ES2477968T3 (es) 2014-07-18
IL217541A0 (en) 2012-02-29
KR20230165366A (ko) 2023-12-05
ME01858B (me) 2014-12-20
EP3594213A1 (en) 2020-01-15
SI2455381T1 (sl) 2014-08-29
BR112012001157A2 (pt) 2016-02-23
US20160145254A1 (en) 2016-05-26
ES2477968T9 (es) 2014-11-13
DK2455381T3 (da) 2014-07-21
TW201105671A (en) 2011-02-16
JP2016040321A (ja) 2016-03-24
EP2746282A1 (en) 2014-06-25
NZ598242A (en) 2013-09-27
EP2455381B9 (en) 2014-10-22
HRP20140705T1 (hr) 2014-09-12
IL217541A (en) 2014-07-31
AR077417A1 (es) 2011-08-24
JP2019019144A (ja) 2019-02-07
TWI485150B (zh) 2015-05-21
KR20180042443A (ko) 2018-04-25
RS53499B1 (en) 2015-02-27
JP2017214404A (ja) 2017-12-07
EP2455381A4 (en) 2012-12-12
WO2011007856A1 (ja) 2011-01-20
AU2010271732B2 (en) 2016-08-25
SG178049A1 (en) 2012-03-29
CN102471337A (zh) 2012-05-23

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