SI2455381T1 - Triazolopiridinova spojina in njeno delovanje kot zaviralec prolil-hidroksilaze in induktor produkcije eritropoietina - Google Patents
Triazolopiridinova spojina in njeno delovanje kot zaviralec prolil-hidroksilaze in induktor produkcije eritropoietinaInfo
- Publication number
- SI2455381T1 SI2455381T1 SI201030682T SI201030682T SI2455381T1 SI 2455381 T1 SI2455381 T1 SI 2455381T1 SI 201030682 T SI201030682 T SI 201030682T SI 201030682 T SI201030682 T SI 201030682T SI 2455381 T1 SI2455381 T1 SI 2455381T1
- Authority
- SI
- Slovenia
- Prior art keywords
- action
- prolyl hydroxylase
- hydroxylase inhibitor
- erythropoietin production
- production inducer
- Prior art date
Links
- 102000003951 Erythropoietin Human genes 0.000 title 1
- 108090000394 Erythropoietin Proteins 0.000 title 1
- 229940078467 Prolyl hydroxylase inhibitor Drugs 0.000 title 1
- -1 Triazolopyridine compound Chemical class 0.000 title 1
- 229940105423 erythropoietin Drugs 0.000 title 1
- 239000000411 inducer Substances 0.000 title 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009169565 | 2009-07-17 | ||
| US27312709P | 2009-07-30 | 2009-07-30 | |
| EP10799914.6A EP2455381B9 (en) | 2009-07-17 | 2010-07-16 | Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor and erythropoietin production inducer |
| PCT/JP2010/062037 WO2011007856A1 (ja) | 2009-07-17 | 2010-07-16 | トリアゾロピリジン化合物、ならびにそのプロリル水酸化酵素阻害剤およびエリスロポエチン産生誘導剤としての作用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2455381T1 true SI2455381T1 (sl) | 2014-08-29 |
Family
ID=43449466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201030682T SI2455381T1 (sl) | 2009-07-17 | 2010-07-16 | Triazolopiridinova spojina in njeno delovanje kot zaviralec prolil-hidroksilaze in induktor produkcije eritropoietina |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US8283465B2 (sl) |
| EP (3) | EP2455381B9 (sl) |
| JP (8) | JP5021797B2 (sl) |
| KR (4) | KR101706803B1 (sl) |
| CN (1) | CN102471337B (sl) |
| AR (1) | AR077417A1 (sl) |
| AU (1) | AU2010271732B2 (sl) |
| BR (1) | BR112012001157A2 (sl) |
| CA (1) | CA2768505C (sl) |
| CO (1) | CO6430426A2 (sl) |
| DK (1) | DK2455381T5 (sl) |
| ES (1) | ES2477968T3 (sl) |
| HK (1) | HK1168346A1 (sl) |
| HR (1) | HRP20140705T1 (sl) |
| IL (1) | IL217541A (sl) |
| ME (1) | ME01858B (sl) |
| MX (1) | MX2012000766A (sl) |
| MY (1) | MY160814A (sl) |
| NZ (1) | NZ598242A (sl) |
| PE (1) | PE20120629A1 (sl) |
| PL (1) | PL2455381T3 (sl) |
| PT (1) | PT2455381E (sl) |
| RS (1) | RS53499B1 (sl) |
| RU (1) | RU2538963C2 (sl) |
| SG (1) | SG178049A1 (sl) |
| SI (1) | SI2455381T1 (sl) |
| SM (1) | SMT201500122B (sl) |
| TW (1) | TWI485150B (sl) |
| WO (1) | WO2011007856A1 (sl) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ598242A (en) * | 2009-07-17 | 2013-09-27 | Japan Tobacco Inc | Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor and erythropoietin production inducer |
| JP2011168582A (ja) * | 2010-01-21 | 2011-09-01 | Ishihara Sangyo Kaisha Ltd | トリアゾロピリジン誘導体又はその塩、それらの製造方法及びそれらを含有する有害生物防除剤 |
| WO2012065297A1 (en) * | 2010-11-16 | 2012-05-24 | Impact Therapeutics, Inc. | 3-ARYL-6-ARYL-[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF |
| CA2896437C (en) * | 2012-11-26 | 2021-01-19 | Takaaki Abe | Erythropoietin expression promoter |
| JO3781B1 (ar) | 2012-12-24 | 2021-01-31 | Cadila Healthcare Ltd | مشتقات الكينولون |
| RU2019134558A (ru) | 2013-06-13 | 2020-02-20 | Экебиа Терапьютикс, Инк. | Композиции и способы лечения анемии |
| RU2534804C1 (ru) * | 2013-08-05 | 2014-12-10 | Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") | ЗАМЕЩЕННЫЕ [1,2,4]ТРИАЗОЛО[4,3-a]ПИРИДИНЫ, ПРОЯВЛЯЮЩИЕ СВОЙСТВА АНТАГОНИСТОВ АДЕНОЗИНОВЫХ А2А РЕЦЕПТОРОВ, И ИХ ПРИМЕНЕНИЕ |
| SG11201602572YA (en) | 2013-10-03 | 2016-04-28 | Kura Oncology Inc | Inhibitors of erk and methods of use |
| AU2015311333B2 (en) | 2014-09-02 | 2017-11-16 | Sunshine Lake Pharma Co., Ltd. | Quinolinone compound and use thereof |
| JP2018039733A (ja) * | 2014-12-22 | 2018-03-15 | 株式会社富士薬品 | 新規複素環誘導体 |
| GB201504565D0 (en) * | 2015-03-18 | 2015-05-06 | Takeda Pharmaceutical | Novel compounds |
| CN106146395B (zh) * | 2015-03-27 | 2019-01-01 | 沈阳三生制药有限责任公司 | 3-羟基吡啶化合物、其制备方法及其制药用途 |
| US20180243271A1 (en) * | 2015-05-28 | 2018-08-30 | Japan Tobacco Inc. | Method for Treating or Preventing Diabetic Nephropathy |
| WO2018097254A1 (ja) * | 2016-11-25 | 2018-05-31 | 日本たばこ産業株式会社 | トリアゾロピリジン化合物の製造方法 |
| EP3613742B1 (en) | 2017-05-09 | 2022-12-07 | Kind Pharmaceutical | Indolizine derivatives and application thereof in medicine |
| MX2020003816A (es) * | 2017-10-04 | 2020-08-13 | Japan Tobacco Inc | Compuesto de heteroarilo con contenido de nitrogeno, y su uso farmaceutico. |
| CN107739378A (zh) * | 2017-11-14 | 2018-02-27 | 杭州安道药业有限公司 | 吲哚嗪衍生物及其在医药上的应用 |
| SG11202102441VA (en) * | 2018-09-13 | 2021-04-29 | Kissei Pharmaceutical Co Ltd | Imidazopyridinone compound |
| CN110105355B (zh) * | 2019-05-24 | 2021-09-21 | 烟台大学 | 一种1,2,3-三唑-[1,5-a]并喹啉类化合物的制备方法 |
| EP4091670A4 (en) * | 2020-03-11 | 2024-02-28 | Kissei Pharmaceutical | CRYSTAL OF AN IMIDAZOPYRIDINONE COMPOUND OR SALT THEREOF |
| EP4138825A1 (en) | 2020-04-20 | 2023-03-01 | Akebia Therapeutics Inc. | Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer |
| WO2022150623A1 (en) | 2021-01-08 | 2022-07-14 | Akebia Therapeutics, Inc. | Compounds and composition for the treatment of anemia |
| CN113387948B (zh) * | 2021-02-06 | 2022-06-10 | 成都诺和晟泰生物科技有限公司 | 一种稠环杂芳基衍生物及其药物组合物和治疗方法及用途 |
| WO2022251563A1 (en) | 2021-05-27 | 2022-12-01 | Keryx Biopharmaceuticals, Inc. | Pediatric formulations of ferric citrate |
| CN113582843A (zh) * | 2021-09-09 | 2021-11-02 | 无锡捷化医药科技有限公司 | 一种5-氯-2-氟-3-羟基苯甲酸乙酯的制备方法 |
| CN114031619A (zh) * | 2021-12-17 | 2022-02-11 | 山东汇海医药化工有限公司 | 一种图卡替尼中间体的制备方法 |
| WO2024061172A1 (zh) * | 2022-09-19 | 2024-03-28 | 苏中药业集团股份有限公司 | 一种脯氨酰羟化酶抑制剂及其用途 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19746287A1 (de) | 1997-10-20 | 1999-04-22 | Hoechst Marion Roussel De Gmbh | Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US6355653B1 (en) * | 1999-09-06 | 2002-03-12 | Hoffmann-La Roche Inc. | Amino-triazolopyridine derivatives |
| US6514989B1 (en) * | 2001-07-20 | 2003-02-04 | Hoffmann-La Roche Inc. | Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives |
| MXPA04003277A (es) * | 2001-10-08 | 2004-07-23 | Hoffmann La Roche | Amida del acido 8-amino-?1,2,4?triazolo?1,5-a?piridina-6-carboxilico. |
| CA2531796A1 (en) | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
| KR100854864B1 (ko) * | 2004-08-05 | 2008-08-28 | 에프. 호프만-라 로슈 아게 | 인돌, 인다졸 또는 인돌린 유도체 |
| FR2889383A1 (fr) * | 2005-08-01 | 2007-02-02 | France Telecom | Procede et dispositif de detection pour systeme mimo, systeme mimo, programme et support d'information |
| TW200808793A (en) * | 2006-03-07 | 2008-02-16 | Smithkline Beecham Corp | Prolyl hydroxylase inhibitors |
| JP2009537558A (ja) * | 2006-05-16 | 2009-10-29 | スミスクライン・ビーチャム・コーポレイション | プロリルヒドロキシラーゼ阻害剤 |
| JO2934B1 (en) | 2006-06-23 | 2015-09-15 | سميث كلاين بيتشام كوربوريشن | Prolyl hydroxylase inhibitors |
| ES2922078T3 (es) * | 2006-06-26 | 2022-09-07 | Akebia Therapeutics Inc | Inhibidores de prolil hidroxilasa y métodos de uso |
| EP2046788A1 (en) | 2006-07-12 | 2009-04-15 | Syngeta Participations AG | Triazolopyridine derivatives as herbicides |
| CL2008000066A1 (es) * | 2007-01-12 | 2008-08-01 | Smithkline Beecham Corp | Compuestos derivados de (5-hidroxi-3-oxo-2,3-dihidropiridazina-4-carbonil)glicina, inhibidores de hif prolil hidroxilasas; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anem |
| AU2008241483B2 (en) | 2007-04-18 | 2011-03-24 | Amgen Inc. | Quinolones and azaquinolones that inhibit prolyl hydroxylase |
| AU2008248165B2 (en) | 2007-05-04 | 2011-12-08 | Amgen Inc. | Diazaquinolones that inhibit prolyl hydroxylase activity |
| EP2460787A1 (en) | 2007-07-03 | 2012-06-06 | Astellas Pharma Inc. | Amide compounds and their use as PGE2 antagonists. |
| JP2011505367A (ja) * | 2007-11-30 | 2011-02-24 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | プロリルヒドロキシラーゼ阻害剤 |
| CN101983384A (zh) * | 2007-11-30 | 2011-03-02 | 葛兰素史密斯克莱有限责任公司 | 脯氨酰羟化酶抑制剂 |
| WO2009126624A1 (en) * | 2008-04-11 | 2009-10-15 | Bristol-Myers Squibb Company | Triazolo compounds useful as dgat1 inhibitors |
| WO2009134850A1 (en) * | 2008-04-30 | 2009-11-05 | Smithkline Beecham Corporation | Prolyl hydroxylase inhibitors |
| WO2009146358A1 (en) | 2008-05-29 | 2009-12-03 | Sirtris Pharmaceuticals, Inc. | Imidazopyridine and related analogs as sirtuin modulators |
| RS54752B1 (sr) | 2008-12-19 | 2016-10-31 | Leo Pharma As | Triazolopiridini kao inhibitori fosfodiesteraze za lečenje kožnih bolesti |
| NZ598242A (en) * | 2009-07-17 | 2013-09-27 | Japan Tobacco Inc | Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor and erythropoietin production inducer |
-
2010
- 2010-07-16 NZ NZ598242A patent/NZ598242A/xx unknown
- 2010-07-16 MY MYPI2012000223A patent/MY160814A/en unknown
- 2010-07-16 DK DK10799914.6T patent/DK2455381T5/en active
- 2010-07-16 EP EP10799914.6A patent/EP2455381B9/en active Active
- 2010-07-16 PT PT107999146T patent/PT2455381E/pt unknown
- 2010-07-16 PE PE2012000056A patent/PE20120629A1/es active IP Right Grant
- 2010-07-16 KR KR1020127004258A patent/KR101706803B1/ko active IP Right Grant
- 2010-07-16 KR KR1020177003353A patent/KR101850661B1/ko active IP Right Grant
- 2010-07-16 ME MEP-2014-82A patent/ME01858B/me unknown
- 2010-07-16 WO PCT/JP2010/062037 patent/WO2011007856A1/ja active Application Filing
- 2010-07-16 US US12/837,679 patent/US8283465B2/en active Active
- 2010-07-16 EP EP19188636.5A patent/EP3594213A1/en not_active Withdrawn
- 2010-07-16 PL PL10799914T patent/PL2455381T3/pl unknown
- 2010-07-16 ES ES10799914.6T patent/ES2477968T3/es active Active
- 2010-07-16 JP JP2010161144A patent/JP5021797B2/ja active Active
- 2010-07-16 CN CN201080032238.2A patent/CN102471337B/zh active Active
- 2010-07-16 AU AU2010271732A patent/AU2010271732B2/en active Active
- 2010-07-16 SI SI201030682T patent/SI2455381T1/sl unknown
- 2010-07-16 KR KR1020237040564A patent/KR20230165366A/ko not_active Application Discontinuation
- 2010-07-16 EP EP14160395.1A patent/EP2746282A1/en not_active Withdrawn
- 2010-07-16 SG SG2012003570A patent/SG178049A1/en unknown
- 2010-07-16 KR KR1020187010331A patent/KR20180042443A/ko active Application Filing
- 2010-07-16 CA CA2768505A patent/CA2768505C/en active Active
- 2010-07-16 TW TW099123410A patent/TWI485150B/zh active
- 2010-07-16 RS RSP20140406 patent/RS53499B1/en unknown
- 2010-07-16 RU RU2012105467/04A patent/RU2538963C2/ru active
- 2010-07-16 MX MX2012000766A patent/MX2012000766A/es active IP Right Grant
- 2010-07-16 AR ARP100102614A patent/AR077417A1/es active IP Right Grant
- 2010-07-16 BR BR112012001157A patent/BR112012001157A2/pt not_active Application Discontinuation
-
2012
- 2012-01-15 IL IL217541A patent/IL217541A/en active IP Right Grant
- 2012-01-31 CO CO12014916A patent/CO6430426A2/es active IP Right Grant
- 2012-04-26 JP JP2012101381A patent/JP2012144571A/ja not_active Ceased
- 2012-09-06 US US13/605,329 patent/US20130096155A1/en not_active Abandoned
- 2012-09-14 HK HK12109057.7A patent/HK1168346A1/xx unknown
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2014
- 2014-07-22 HR HRP20140705AT patent/HRP20140705T1/hr unknown
- 2014-10-09 JP JP2014207896A patent/JP2015003933A/ja active Pending
-
2015
- 2015-05-22 SM SM201500122T patent/SMT201500122B/xx unknown
- 2015-06-25 US US14/749,966 patent/US20160145254A1/en not_active Abandoned
- 2015-12-08 JP JP2015239065A patent/JP2016040321A/ja active Pending
-
2017
- 2017-07-10 JP JP2017134270A patent/JP6434575B2/ja not_active Expired - Fee Related
-
2018
- 2018-11-08 JP JP2018210486A patent/JP2019019144A/ja active Pending
-
2020
- 2020-04-20 JP JP2020074508A patent/JP2020111612A/ja not_active Ceased
-
2022
- 2022-06-29 JP JP2022104161A patent/JP2022126843A/ja active Pending
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