DK2455381T3 - Triazolopyridinforbindelse samt dens virkning som inhibitor af prolylhydroxylase og fremkalder af erythropoietinproduktion - Google Patents
Triazolopyridinforbindelse samt dens virkning som inhibitor af prolylhydroxylase og fremkalder af erythropoietinproduktionInfo
- Publication number
- DK2455381T3 DK2455381T3 DK10799914.6T DK10799914T DK2455381T3 DK 2455381 T3 DK2455381 T3 DK 2455381T3 DK 10799914 T DK10799914 T DK 10799914T DK 2455381 T3 DK2455381 T3 DK 2455381T3
- Authority
- DK
- Denmark
- Prior art keywords
- inducer
- inhibitor
- well
- effect
- prolyl hydroxylase
- Prior art date
Links
- 102000003951 Erythropoietin Human genes 0.000 title 1
- 108090000394 Erythropoietin Proteins 0.000 title 1
- 102000004079 Prolyl Hydroxylases Human genes 0.000 title 1
- 108010043005 Prolyl Hydroxylases Proteins 0.000 title 1
- -1 Triazolopyridine Compound Chemical class 0.000 title 1
- 229940105423 erythropoietin Drugs 0.000 title 1
- 239000000411 inducer Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009169565 | 2009-07-17 | ||
| US27312709P | 2009-07-30 | 2009-07-30 | |
| PCT/JP2010/062037 WO2011007856A1 (ja) | 2009-07-17 | 2010-07-16 | トリアゾロピリジン化合物、ならびにそのプロリル水酸化酵素阻害剤およびエリスロポエチン産生誘導剤としての作用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK2455381T3 true DK2455381T3 (da) | 2014-07-21 |
| DK2455381T5 DK2455381T5 (da) | 2015-02-09 |
Family
ID=43449466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10799914.6T DK2455381T5 (da) | 2009-07-17 | 2010-07-16 | Triazolopyridinforbindelse samt dens virkning som inhibitor af prolylhydroxylase og fremkalder af erythropoietinproduktion |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US8283465B2 (da) |
| EP (3) | EP3594213A1 (da) |
| JP (8) | JP5021797B2 (da) |
| KR (4) | KR101850661B1 (da) |
| CN (1) | CN102471337B (da) |
| AR (1) | AR077417A1 (da) |
| AU (1) | AU2010271732B2 (da) |
| BR (1) | BR112012001157A2 (da) |
| CA (1) | CA2768505C (da) |
| CO (1) | CO6430426A2 (da) |
| DK (1) | DK2455381T5 (da) |
| ES (1) | ES2477968T3 (da) |
| HK (1) | HK1168346A1 (da) |
| HR (1) | HRP20140705T1 (da) |
| IL (1) | IL217541A (da) |
| ME (1) | ME01858B (da) |
| MX (1) | MX2012000766A (da) |
| MY (1) | MY160814A (da) |
| NZ (1) | NZ598242A (da) |
| PE (1) | PE20120629A1 (da) |
| PL (1) | PL2455381T3 (da) |
| PT (1) | PT2455381E (da) |
| RS (1) | RS53499B1 (da) |
| RU (1) | RU2538963C2 (da) |
| SG (1) | SG178049A1 (da) |
| SI (1) | SI2455381T1 (da) |
| SM (1) | SMT201500122B (da) |
| TW (1) | TWI485150B (da) |
| WO (1) | WO2011007856A1 (da) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ME01858B (me) * | 2009-07-17 | 2014-12-20 | Japan Tobacco Inc | Jedinjenje triazolopiridina i njegovo dejstvo kao inhibitora prolil hidroksilaze i induktora proizvodnje eritropoetina |
| JP2011168582A (ja) * | 2010-01-21 | 2011-09-01 | Ishihara Sangyo Kaisha Ltd | トリアゾロピリジン誘導体又はその塩、それらの製造方法及びそれらを含有する有害生物防除剤 |
| WO2012065297A1 (en) * | 2010-11-16 | 2012-05-24 | Impact Therapeutics, Inc. | 3-ARYL-6-ARYL-[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF |
| WO2014080640A1 (ja) | 2012-11-26 | 2014-05-30 | 国立大学法人東北大学 | エリスロポエチン発現増強剤 |
| NZ708605A (en) | 2012-12-24 | 2016-07-29 | Cadila Healthcare Ltd | Novel quinolone derivatives |
| SG10201910773VA (en) | 2013-06-13 | 2020-01-30 | Akebia Therapeutics Inc | Compositions and methods for treating anemia |
| RU2534804C1 (ru) * | 2013-08-05 | 2014-12-10 | Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") | ЗАМЕЩЕННЫЕ [1,2,4]ТРИАЗОЛО[4,3-a]ПИРИДИНЫ, ПРОЯВЛЯЮЩИЕ СВОЙСТВА АНТАГОНИСТОВ АДЕНОЗИНОВЫХ А2А РЕЦЕПТОРОВ, И ИХ ПРИМЕНЕНИЕ |
| HUE036600T2 (hu) * | 2013-10-03 | 2018-07-30 | Kura Oncology Inc | ERK inhibitorok és alkalmazási eljárások |
| AU2015311333B2 (en) | 2014-09-02 | 2017-11-16 | Sunshine Lake Pharma Co., Ltd. | Quinolinone compound and use thereof |
| JP2018039733A (ja) * | 2014-12-22 | 2018-03-15 | 株式会社富士薬品 | 新規複素環誘導体 |
| GB201504565D0 (en) * | 2015-03-18 | 2015-05-06 | Takeda Pharmaceutical | Novel compounds |
| CN106146395B (zh) * | 2015-03-27 | 2019-01-01 | 沈阳三生制药有限责任公司 | 3-羟基吡啶化合物、其制备方法及其制药用途 |
| JP6814134B2 (ja) * | 2015-05-28 | 2021-01-13 | 日本たばこ産業株式会社 | 糖尿病性腎症を治療又は予防する方法 |
| RU2752384C2 (ru) * | 2016-11-25 | 2021-07-26 | Джапан Тобакко Инк. | Способ получения триазолопиридинового соединения |
| WO2018205928A1 (zh) | 2017-05-09 | 2018-11-15 | 杭州安道药业有限公司 | 吲哚嗪衍生物及其在医药上的应用 |
| US10752596B2 (en) * | 2017-10-04 | 2020-08-25 | Japan Tobacco Inc. | Nitrogen-containing heteroaryl compound and pharmaceutical use thereof |
| CN107739378A (zh) * | 2017-11-14 | 2018-02-27 | 杭州安道药业有限公司 | 吲哚嗪衍生物及其在医药上的应用 |
| CN112689637B (zh) * | 2018-09-13 | 2023-11-10 | 橘生药品工业株式会社 | 咪唑并吡啶酮化合物 |
| CN110105355B (zh) * | 2019-05-24 | 2021-09-21 | 烟台大学 | 一种1,2,3-三唑-[1,5-a]并喹啉类化合物的制备方法 |
| AU2021233433A1 (en) * | 2020-03-11 | 2022-10-06 | Kissei Pharmaceutical Co., Ltd. | Crystal of imidazopyridinone compound or salt thereof |
| EP4138825A1 (en) | 2020-04-20 | 2023-03-01 | Akebia Therapeutics Inc. | Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer |
| WO2022150623A1 (en) | 2021-01-08 | 2022-07-14 | Akebia Therapeutics, Inc. | Compounds and composition for the treatment of anemia |
| CN113387948B (zh) * | 2021-02-06 | 2022-06-10 | 成都诺和晟泰生物科技有限公司 | 一种稠环杂芳基衍生物及其药物组合物和治疗方法及用途 |
| CN117999069A (zh) | 2021-05-27 | 2024-05-07 | 凯克斯生物制药公司 | 柠檬酸铁的儿科调配物 |
| CN113582843A (zh) * | 2021-09-09 | 2021-11-02 | 无锡捷化医药科技有限公司 | 一种5-氯-2-氟-3-羟基苯甲酸乙酯的制备方法 |
| CN114031619A (zh) * | 2021-12-17 | 2022-02-11 | 山东汇海医药化工有限公司 | 一种图卡替尼中间体的制备方法 |
| WO2024061172A1 (zh) * | 2022-09-19 | 2024-03-28 | 苏中药业集团股份有限公司 | 一种脯氨酰羟化酶抑制剂及其用途 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19746287A1 (de) * | 1997-10-20 | 1999-04-22 | Hoechst Marion Roussel De Gmbh | Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US6355653B1 (en) * | 1999-09-06 | 2002-03-12 | Hoffmann-La Roche Inc. | Amino-triazolopyridine derivatives |
| US6514989B1 (en) * | 2001-07-20 | 2003-02-04 | Hoffmann-La Roche Inc. | Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives |
| JP4101755B2 (ja) * | 2001-10-08 | 2008-06-18 | エフ．ホフマン−ラ ロシュ アーゲー | ８−アミノ−〔１，２，４〕トリアゾロ〔１，５−ａ〕ピリジン−６−カルボン酸アミド |
| WO2005014533A2 (en) | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
| CN1993323B (zh) * | 2004-08-05 | 2011-04-20 | 霍夫曼-拉罗奇有限公司 | 吲哚，吲唑或二氢吲哚衍生物 |
| FR2889383A1 (fr) * | 2005-08-01 | 2007-02-02 | France Telecom | Procede et dispositif de detection pour systeme mimo, systeme mimo, programme et support d'information |
| TW200808793A (en) * | 2006-03-07 | 2008-02-16 | Smithkline Beecham Corp | Prolyl hydroxylase inhibitors |
| US20090176825A1 (en) | 2006-05-16 | 2009-07-09 | Fitch Duke M | Prolyl hydroxylase inhibitors |
| PE20080209A1 (es) * | 2006-06-23 | 2008-05-15 | Smithkline Beecham Corp | Derivados de glicina como inhibidores de prolil hidroxilasa |
| SI2044005T1 (sl) * | 2006-06-26 | 2011-01-31 | Warner Chilcott Co Llc | Inhibitorji prolilhidroksilaze in postopki uporabe |
| EP2046788A1 (en) | 2006-07-12 | 2009-04-15 | Syngeta Participations AG | Triazolopyridine derivatives as herbicides |
| CL2008000066A1 (es) * | 2007-01-12 | 2008-08-01 | Smithkline Beecham Corp | Compuestos derivados de (5-hidroxi-3-oxo-2,3-dihidropiridazina-4-carbonil)glicina, inhibidores de hif prolil hidroxilasas; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anem |
| US8048894B2 (en) | 2007-04-18 | 2011-11-01 | Amgen Inc. | Quinolones and azaquinolones that inhibit prolyl hydroxylase |
| WO2008137084A2 (en) | 2007-05-04 | 2008-11-13 | Amgen Inc. | Diazaquinolones that inhibit prolyl hydroxylase activity |
| CA2692265A1 (en) | 2007-07-03 | 2009-01-08 | Astellas Pharma Inc. | Amide compounds |
| WO2009070644A1 (en) * | 2007-11-30 | 2009-06-04 | Smithkline Beecham Corporation | Prolyl hydroxylase inhibitors |
| US20100305133A1 (en) * | 2007-11-30 | 2010-12-02 | Smithkline Beecham Corporation | Prolyl Hydroxylase Inhibitors |
| WO2009126624A1 (en) * | 2008-04-11 | 2009-10-15 | Bristol-Myers Squibb Company | Triazolo compounds useful as dgat1 inhibitors |
| WO2009134850A1 (en) | 2008-04-30 | 2009-11-05 | Smithkline Beecham Corporation | Prolyl hydroxylase inhibitors |
| CN102112475A (zh) | 2008-05-29 | 2011-06-29 | 西特里斯药业公司 | 作为沉默调节蛋白调节剂的咪唑并吡啶和相关的类似物 |
| CN102317287B (zh) | 2008-12-19 | 2014-10-08 | 利奥制药有限公司 | 作为磷酸二酯酶抑制剂、用于治疗皮肤病的三唑并吡啶化合物 |
| ME01858B (me) * | 2009-07-17 | 2014-12-20 | Japan Tobacco Inc | Jedinjenje triazolopiridina i njegovo dejstvo kao inhibitora prolil hidroksilaze i induktora proizvodnje eritropoetina |
-
2010
- 2010-07-16 ME MEP-2014-82A patent/ME01858B/me unknown
- 2010-07-16 US US12/837,679 patent/US8283465B2/en active Active
- 2010-07-16 DK DK10799914.6T patent/DK2455381T5/da active
- 2010-07-16 EP EP19188636.5A patent/EP3594213A1/en not_active Withdrawn
- 2010-07-16 NZ NZ598242A patent/NZ598242A/xx unknown
- 2010-07-16 PE PE2012000056A patent/PE20120629A1/es active IP Right Grant
- 2010-07-16 SG SG2012003570A patent/SG178049A1/en unknown
- 2010-07-16 AU AU2010271732A patent/AU2010271732B2/en active Active
- 2010-07-16 KR KR1020177003353A patent/KR101850661B1/ko active IP Right Grant
- 2010-07-16 EP EP14160395.1A patent/EP2746282A1/en not_active Withdrawn
- 2010-07-16 AR ARP100102614A patent/AR077417A1/es active IP Right Grant
- 2010-07-16 ES ES10799914.6T patent/ES2477968T3/es active Active
- 2010-07-16 RS RSP20140406 patent/RS53499B1/en unknown
- 2010-07-16 WO PCT/JP2010/062037 patent/WO2011007856A1/ja active Application Filing
- 2010-07-16 KR KR1020237040564A patent/KR20230165366A/ko not_active Application Discontinuation
- 2010-07-16 PT PT107999146T patent/PT2455381E/pt unknown
- 2010-07-16 MY MYPI2012000223A patent/MY160814A/en unknown
- 2010-07-16 PL PL10799914T patent/PL2455381T3/pl unknown
- 2010-07-16 MX MX2012000766A patent/MX2012000766A/es active IP Right Grant
- 2010-07-16 EP EP10799914.6A patent/EP2455381B9/en active Active
- 2010-07-16 CN CN201080032238.2A patent/CN102471337B/zh active Active
- 2010-07-16 JP JP2010161144A patent/JP5021797B2/ja active Active
- 2010-07-16 KR KR1020187010331A patent/KR20180042443A/ko active Application Filing
- 2010-07-16 KR KR1020127004258A patent/KR101706803B1/ko active IP Right Grant
- 2010-07-16 CA CA2768505A patent/CA2768505C/en active Active
- 2010-07-16 BR BR112012001157A patent/BR112012001157A2/pt not_active Application Discontinuation
- 2010-07-16 TW TW099123410A patent/TWI485150B/zh active
- 2010-07-16 RU RU2012105467/04A patent/RU2538963C2/ru active
- 2010-07-16 SI SI201030682T patent/SI2455381T1/sl unknown
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2012
- 2012-01-15 IL IL217541A patent/IL217541A/en active IP Right Grant
- 2012-01-31 CO CO12014916A patent/CO6430426A2/es active IP Right Grant
- 2012-04-26 JP JP2012101381A patent/JP2012144571A/ja not_active Ceased
- 2012-09-06 US US13/605,329 patent/US20130096155A1/en not_active Abandoned
- 2012-09-14 HK HK12109057.7A patent/HK1168346A1/xx unknown
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2014
- 2014-07-22 HR HRP20140705AT patent/HRP20140705T1/hr unknown
- 2014-10-09 JP JP2014207896A patent/JP2015003933A/ja active Pending
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2015
- 2015-05-22 SM SM201500122T patent/SMT201500122B/xx unknown
- 2015-06-25 US US14/749,966 patent/US20160145254A1/en not_active Abandoned
- 2015-12-08 JP JP2015239065A patent/JP2016040321A/ja active Pending
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2017
- 2017-07-10 JP JP2017134270A patent/JP6434575B2/ja not_active Expired - Fee Related
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2018
- 2018-11-08 JP JP2018210486A patent/JP2019019144A/ja active Pending
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2020
- 2020-04-20 JP JP2020074508A patent/JP2020111612A/ja not_active Ceased
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2022
- 2022-06-29 JP JP2022104161A patent/JP2022126843A/ja active Pending
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