HRP20140705T1 - Spoj triazolopiridina i njegovo djelovanje kao inhibitora prolil hidroksilaze i induktora proizvodnje eritropoetina - Google Patents
Spoj triazolopiridina i njegovo djelovanje kao inhibitora prolil hidroksilaze i induktora proizvodnje eritropoetina Download PDFInfo
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- HRP20140705T1 HRP20140705T1 HRP20140705AT HRP20140705T HRP20140705T1 HR P20140705 T1 HRP20140705 T1 HR P20140705T1 HR P20140705A T HRP20140705A T HR P20140705AT HR P20140705 T HRP20140705 T HR P20140705T HR P20140705 T1 HRP20140705 T1 HR P20140705T1
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- Prior art keywords
- group
- solvate
- pharmaceutically acceptable
- acceptable salt
- compound according
- Prior art date
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- 102000003951 Erythropoietin Human genes 0.000 title 1
- 108090000394 Erythropoietin Proteins 0.000 title 1
- 229940078467 Prolyl hydroxylase inhibitor Drugs 0.000 title 1
- -1 Triazolopyridine compound Chemical class 0.000 title 1
- 229940105423 erythropoietin Drugs 0.000 title 1
- 239000000411 inducer Substances 0.000 title 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 32
- 150000003839 salts Chemical class 0.000 claims 32
- 239000012453 solvate Substances 0.000 claims 32
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 13
- 125000001424 substituent group Chemical group 0.000 claims 13
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 10
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 9
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims 7
- 238000011282 treatment Methods 0.000 claims 6
- 125000006621 (C3-C8) cycloalkyl-(C1-C6) alkyl group Chemical group 0.000 claims 5
- 206010058116 Nephrogenic anaemia Diseases 0.000 claims 5
- 208000007502 anemia Diseases 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 3
- 125000006553 (C3-C8) cycloalkenyl group Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
Claims (34)
1. Spoj prikazan slijedećom formulom [I] ili njegova farmaceutski prihvatljiva sol ili njegov solvat:
[image]
u kojem je
parcijalna strukturna formula:
[image]
skupina koja je prikazana bilo kojom od slijedećih formula:
[image]
R1 je
atom vodika,
C1-6 alkil skupina,
C6-14 aril skupina,
C3-8 cikloalkil skupina,
C6-14 aril-C1-6alkil skupina, ili
C3-8 cikloalkil-C1-6alkil skupina;
R2 je
atom vodika,
C1-10 alkil skupina,
C6-14 aril skupina, opcijski supstituirana sa 1 do 5 istih ili različitih supstituenata izabranih iz slijedeće skupine B,
C3-8 cikloalkil skupina, opcijski supstituirana sa 1 do 5 istih ili različitih supstituenta izabranih iz slijedeće skupine B,
C3-8cikloalkenil skupina, opcijski supstituirana sa 1 do 5 istih ili različitih supstituenata izabranih iz slijedeće skupine B,
heteroaril skupina, opcijski supstituirana sa 1 do 5 istih ili različitih supstituenata izabranih iz slijedeće skupine B (gdje heteroaril ima osim ugljikovog atoma, 1 do 6 heteroatoma izabranih od atoma dušika, atoma kisika i atoma sumpora),
C6-14 aril-C1-6alkil skupina (gdje C6-14 aril je opcijski supstituiran sa 1 do 5 istih ili različitih supstituenata izabranih iz slijedeće skupine B) ili
C3-8cikloalkil-C1-6 alkil skupina (gdje C3-8 cikloalkil je opcijski supstituiran sa 1 do 5 istih ili različitih supstituenata izabranih iz slijedeće skupine B);
R3 je
atom vodika,
atom halogena
C1-6 alkil skupina,
C6-14 aril skupina,
C3-8 cikloalkil skupina,
C6-14 aril-C1-6alkil skupina, i
R4 i R5 su svaki nezavisno
atom vodika, ili
C1-6 alkil skupina,
skupina B:
atom halogena
C1-6 alkil skupina
C3-8cikloalkil skupina
cijano skupina, i
halo-C1-6alkil skupina.
2. Spoj prema patentnom zahtjevu 1, u kojem je parcijalna strukturna formula
[image]
skupina prikazana slijedećom formulom
[image]
ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
3. Spoj prema zahtjevu 1, u kojem je parcijalna strukturna formula
[image]
skupina prikazana slijedećom formulom
[image]
ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
4. Spoj prema patentnom zahtjevu 1, u kojem je parcijalna strukturna formula:
[image]
skupina prikazana slijedećom formulom
[image]
ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
5. Spoj prema patentnom zahtjevu 1, u kojem je parcijalna strukturna formula:
[image]
skupina prikazana slijedećom formulom
[image]
ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
6. Spoj prema bilo kojem od patentnih zahtjeva 1 do 5, u kojem su oba R4 i R5 atomi vodika, ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
7. Spoj prema bilo kojem od patentnih zahtjeva 1 do 5, u kojem je R3 atom vodika, ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
8. Spoj prema bilo kojem od patentnih zahtjeva 1 do 5, u kojem je R1 atom vodika, ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
9. Spoj prema bilo kojem od patentnih zahtjeva 1 do 5, u kojem je R2
C1-10 alkil skupina,
C6-14 aril skupina opcijski supstituirana sa 1 do 5 istih ili različitih supstituenata izabranih iz gore navedene skupine B,
C6-14 aril-C1-6alkil skupina (gdje C6-14 aril je opcijski supstituiran sa 1 do 5 istih ili različitih supstituenata izabranih iz gore navedene skupine B) ili
C3-8cikloalkil-C1-6 alkil skupina (gdje C3-8 cikloalkil je opcijski supstituiran sa 1 do 5 istih ili različitih supstituenata izabranih iz gore navedene skupine B), ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
10. Spoj prema patentnom zahtjevu 2, u kojem su oba R4 i R5 vodikovi atomi ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
11. Spoj prema patentnom zahtjevu 10, u kojem je R3 atom vodika, ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
12. Spoj prema patentnom zahtjevu 11, u kojem je R1 atom vodika, ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
13. Spoj prema patentnom zahtjevu 12, u kojem je R2
C1-10 alkil skupina, ili
C6-14 aril-C1-6 alkil skupina (gdje C6-14 aril je opcijski supstituiran sa 1 do 5 istih ili različitih supstituenata izabranih iz gore navedene skupine B),
ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
14. Spoj prema patentnom zahtjevu 1, prikazan slijedećom formulom [I-1], ili njegova farmaceutski prihvatljiva sol ili njegov solvat
[image]
u kojem je parcijalna strukturna formula:
[image]
skupina prikazana bilo kojom od slijedećih formula:
[image]
R11 je
atom vodika,
C1-6 alkil skupina,
fenil skupina,
C3-8 cikloalkil skupina,
fenil-C1-6 alkil skupina, ili
C3-8 cikloalkil-C1-6alkil skupina, ili
R21 je
atom vodika,
C1-10alkil skupina,
fenil skupina opcijski supstituirana sa 1 do 5 istih ili različitih supstituenata izabranih iz slijedeće skupine B,
C3-8 cikloalkil skupina,
C3-8 cikloalkenil skupina,
tienil skupina opcijski supstituirana sa 1 do 5 istih ili različitih supstituenata izabranih iz slijedeće skupine B;
fenil-C1-6 alkil skupina (gdje je fenil opcijski supstituiran sa 1 do 5 istih ili različitih supstituenata izabranih iz slijedeće skupine B), ili
C3-8 cikloalkil-C1-6alkil skupina,
R31 je
atom vodika,
atom halogena,
C1-6 alkil skupina,
fenil skupina,
C3-8 cikloalkil skupina, ili
fenil-C1-6alkil skupina, i
R41 i R51 su svaki nezavisno
vodikov atom ili
C1-6alkil skupina,
skupina B:
atom halogena,
C1-6 alkil skupina,
C3-8cikloalkil skupina,
cijano skupina, i
halo-C1-6alkil skupina.
15. Spoj prema patentnom zahtjevu 1 prikazan slijedećom formulom:
[image]
ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
16. Spoj prema patentnom zahtjevu 1 prikazan slijedećom formulom:
[image]
ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
17. Spoj prema patentom zahtjevu 1 prikazan slijedećom formulom:
[image]
ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
18. Spoj prema patentom zahtjevu 1 prikazan slijedećom formulom:
[image]
ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
19. Spoj prema patentom zahtjevu 1 prikazan slijedećom formulom:
[image]
ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
20. Spoj prema patentom zahtjevu 1 prikazan slijedećom formulom:
[image]
ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
21. Spoj prema patentnom zahtjevu 1 prikazan slijedećom formulom:
[image]
ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
22. Spoj prema patentnom zahtjevu 1 prikazan slijedećom formulom:
[image]
ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
23. Spoj prema patentnom zahtjevu 1 prikazan slijedećom formulom:
[image]
ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
24. Spoj prema patentom zahtjevu 1 prikazan slijedećom formulom:
[image]
ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
25. Spoj prema patentom zahtjevu 1 prikazan slijedećom formulom:
[image]
ili njegova farmaceutski prihvatljiva sol ili njegov solvat.
26. Farmaceutski sastav koji sadrži spoj prema bilo kojem od patentnih zahtjeva 1 do 25, ili njegovu farmaceutski prihvatljivu sol ili njegov solvat i farmaceutski prihvatljiv nosač.
27. Terapeutsko sredstvo za primjenu u liječenju anemije koje sadrži spoj prema bilo kojem od patentnih zahtjeva 1 do 25 ili njegovu farmaceutski prihvatljivu sol ili njegov solvat.
28. Terapeutsko sredstvo za primjenu u liječenju bubrežne anemije koje sadrži spoj prema bilo kojem od patentnih zahtjeva 1 do 25, ili njegovu farmaceutski prihvatljivu sol ili njegov solvat.
29. Upotreba spoja prema bilo kojem od patentnih zahtjeva 1 do 25 ili njegove farmaceutski prihvatljive soli ili njegovog solvata, u proizvodnji terapeutskog sredstva protiv anemije.
30. Upotreba spoja prema bilo kojem od patentnih zahtjeva 1 do 25 ili njegove farmaceutski prihvatljive soli ili njegovog solvata, u proizvodnji terapeutskog sredstva protiv bubrežne anemije.
31. Spoj prema bilo kojem od patentnih zahtjeva 1 do 25, ili njegova farmaceutski prihvatljiva sol ili njegov solvat, za primjenu u liječenju anemije.
32. Spoj prema bilo kojem od patentnih zahtjeva 1 do 25, ili njegova farmaceutski prihvatljiva sol ili njegov solvat, za primjenu u liječenju bubrežne anemije.
33. Komercijalno pakiranje koje sadrži farmaceutski sastav prema patentnom zahtjevu 26 i pisano uputstvo u vezi sa njim, pri čemu je u pisanom uputstvu navedeno da se farmaceutski sastav može ili treba koristiti u liječenju profilakse bolesti izabrane od anemije i bubrežne anemije.
34. Komplet koji sadrži farmaceutski sastav prema patentnom zahtjevu 26 i pisano uputstvo u vezi sa njim, pri čemu je u pisanom uputstvu navedeno da se farmaceutski sastav može ili treba koristiti u liječenju ili profilaksi bolesti izabrane od anemije i bubrežne anemije.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009169565 | 2009-07-17 | ||
US27312709P | 2009-07-30 | 2009-07-30 | |
PCT/JP2010/062037 WO2011007856A1 (ja) | 2009-07-17 | 2010-07-16 | トリアゾロピリジン化合物、ならびにそのプロリル水酸化酵素阻害剤およびエリスロポエチン産生誘導剤としての作用 |
Publications (1)
Publication Number | Publication Date |
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HRP20140705T1 true HRP20140705T1 (hr) | 2014-09-12 |
Family
ID=43449466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20140705AT HRP20140705T1 (hr) | 2009-07-17 | 2014-07-22 | Spoj triazolopiridina i njegovo djelovanje kao inhibitora prolil hidroksilaze i induktora proizvodnje eritropoetina |
Country Status (29)
Country | Link |
---|---|
US (3) | US8283465B2 (hr) |
EP (3) | EP2455381B9 (hr) |
JP (9) | JP5021797B2 (hr) |
KR (4) | KR20180042443A (hr) |
CN (1) | CN102471337B (hr) |
AR (1) | AR077417A1 (hr) |
AU (1) | AU2010271732B2 (hr) |
BR (1) | BR112012001157A2 (hr) |
CA (1) | CA2768505C (hr) |
CO (1) | CO6430426A2 (hr) |
DK (1) | DK2455381T5 (hr) |
ES (1) | ES2477968T3 (hr) |
HK (1) | HK1168346A1 (hr) |
HR (1) | HRP20140705T1 (hr) |
IL (1) | IL217541A (hr) |
ME (1) | ME01858B (hr) |
MX (1) | MX2012000766A (hr) |
MY (1) | MY160814A (hr) |
NZ (1) | NZ598242A (hr) |
PE (1) | PE20120629A1 (hr) |
PL (1) | PL2455381T3 (hr) |
PT (1) | PT2455381E (hr) |
RS (1) | RS53499B1 (hr) |
RU (1) | RU2538963C2 (hr) |
SG (1) | SG178049A1 (hr) |
SI (1) | SI2455381T1 (hr) |
SM (1) | SMT201500122B (hr) |
TW (1) | TWI485150B (hr) |
WO (1) | WO2011007856A1 (hr) |
Families Citing this family (29)
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SG178049A1 (en) * | 2009-07-17 | 2012-03-29 | Japan Tobacco Inc | Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor and erythropoietin production inducer |
JP2011168582A (ja) * | 2010-01-21 | 2011-09-01 | Ishihara Sangyo Kaisha Ltd | トリアゾロピリジン誘導体又はその塩、それらの製造方法及びそれらを含有する有害生物防除剤 |
WO2012065297A1 (en) * | 2010-11-16 | 2012-05-24 | Impact Therapeutics, Inc. | 3-ARYL-6-ARYL-[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF |
CA2896437C (en) * | 2012-11-26 | 2021-01-19 | Takaaki Abe | Erythropoietin expression promoter |
TWI598339B (zh) | 2012-12-24 | 2017-09-11 | 卡地拉保健有限公司 | 新穎喹啉酮衍生物 |
ES2974273T3 (es) | 2013-06-13 | 2024-06-26 | Akebia Therapeutics Inc | Composiciones y métodos para tratar la anemia |
RU2534804C1 (ru) * | 2013-08-05 | 2014-12-10 | Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") | ЗАМЕЩЕННЫЕ [1,2,4]ТРИАЗОЛО[4,3-a]ПИРИДИНЫ, ПРОЯВЛЯЮЩИЕ СВОЙСТВА АНТАГОНИСТОВ АДЕНОЗИНОВЫХ А2А РЕЦЕПТОРОВ, И ИХ ПРИМЕНЕНИЕ |
SG11201602572YA (en) | 2013-10-03 | 2016-04-28 | Kura Oncology Inc | Inhibitors of erk and methods of use |
CN105384687B (zh) | 2014-09-02 | 2018-05-01 | 广东东阳光药业有限公司 | 喹啉酮类化合物及其在药物中应用 |
JP2018039733A (ja) * | 2014-12-22 | 2018-03-15 | 株式会社富士薬品 | 新規複素環誘導体 |
GB201504565D0 (en) * | 2015-03-18 | 2015-05-06 | Takeda Pharmaceutical | Novel compounds |
CN106146395B (zh) * | 2015-03-27 | 2019-01-01 | 沈阳三生制药有限责任公司 | 3-羟基吡啶化合物、其制备方法及其制药用途 |
JP6814134B2 (ja) * | 2015-05-28 | 2021-01-13 | 日本たばこ産業株式会社 | 糖尿病性腎症を治療又は予防する方法 |
MX2019006083A (es) * | 2016-11-25 | 2019-07-10 | Japan Tobacco Inc | Metodo para la produccion de compuesto de triazolopiridina. |
EP3613742B1 (en) | 2017-05-09 | 2022-12-07 | Kind Pharmaceutical | Indolizine derivatives and application thereof in medicine |
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