CO6430426A2 - Compuestos de triazolopiridina, y su accion comominhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina - Google Patents

Compuestos de triazolopiridina, y su accion comominhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina

Info

Publication number
CO6430426A2
CO6430426A2 CO12014916A CO12014916A CO6430426A2 CO 6430426 A2 CO6430426 A2 CO 6430426A2 CO 12014916 A CO12014916 A CO 12014916A CO 12014916 A CO12014916 A CO 12014916A CO 6430426 A2 CO6430426 A2 CO 6430426A2
Authority
CO
Colombia
Prior art keywords
production
erythropoietin
compound
triazolopiridine
proomil
Prior art date
Application number
CO12014916A
Other languages
English (en)
Inventor
Ikuo Mitani
Yosuke Ogoshi
Takuya Matsui
Masahiro Yokota
Masakazu Terashita
Dai Motoda
Kazuhito Ueyama
Hiroyuki Abe
Takahiro Hotta
Takashi Ito
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of CO6430426A2 publication Critical patent/CO6430426A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)

Abstract

La presente invención provee un compuesto de triazolopiridina que tiene una acción inhibidora de prolil hidroxilasa y la capacidad de inducir la producción de eritropoyetina; la presente invención se refiere a un compuesto representado por la siguiente fórmula [I]:donde cada símbolo es como se definió en la especificación, o su sal aceptable farmacéuticamente, o un solvato del mismo, como también un inhibidor de la prolil hidroxilasa o un agente que induce la producción de eritropoyetina que contiene el compuesto; el compuesto de la presente invención muestra una acción inhibidora de prolil hidroxilasa y la capacidad de inducir la producción de eritropoyetina y es útil como agente profiláctico o terapéutico para varias enfermedades y patologías (trastornos) originados por la producción disminuida de la eritropoyetina.
CO12014916A 2009-07-17 2012-01-31 Compuestos de triazolopiridina, y su accion comominhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina CO6430426A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009169565 2009-07-17
US27312709P 2009-07-30 2009-07-30

Publications (1)

Publication Number Publication Date
CO6430426A2 true CO6430426A2 (es) 2012-04-30

Family

ID=43449466

Family Applications (1)

Application Number Title Priority Date Filing Date
CO12014916A CO6430426A2 (es) 2009-07-17 2012-01-31 Compuestos de triazolopiridina, y su accion comominhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina

Country Status (29)

Country Link
US (3) US8283465B2 (es)
EP (3) EP3594213A1 (es)
JP (9) JP5021797B2 (es)
KR (4) KR20230165366A (es)
CN (1) CN102471337B (es)
AR (1) AR077417A1 (es)
AU (1) AU2010271732B2 (es)
BR (1) BR112012001157A2 (es)
CA (1) CA2768505C (es)
CO (1) CO6430426A2 (es)
DK (1) DK2455381T5 (es)
ES (1) ES2477968T3 (es)
HK (1) HK1168346A1 (es)
HR (1) HRP20140705T1 (es)
IL (1) IL217541A (es)
ME (1) ME01858B (es)
MX (1) MX2012000766A (es)
MY (1) MY160814A (es)
NZ (1) NZ598242A (es)
PE (1) PE20120629A1 (es)
PL (1) PL2455381T3 (es)
PT (1) PT2455381E (es)
RS (1) RS53499B1 (es)
RU (1) RU2538963C2 (es)
SG (1) SG178049A1 (es)
SI (1) SI2455381T1 (es)
SM (1) SMT201500122B (es)
TW (1) TWI485150B (es)
WO (1) WO2011007856A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20120629A1 (es) * 2009-07-17 2012-05-30 Japan Tobacco Inc Compuesto triazolopiridina y su accion como inhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina
JP2011168582A (ja) * 2010-01-21 2011-09-01 Ishihara Sangyo Kaisha Ltd トリアゾロピリジン誘導体又はその塩、それらの製造方法及びそれらを含有する有害生物防除剤
WO2012065297A1 (en) * 2010-11-16 2012-05-24 Impact Therapeutics, Inc. 3-ARYL-6-ARYL-[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF
CN104936591B (zh) 2012-11-26 2018-05-29 国立大学法人东北大学 促红细胞生成素表达增强剂
WO2014102818A1 (en) 2012-12-24 2014-07-03 Cadila Healthcare Limited Novel quinolone derivatives
NZ714963A (en) 2013-06-13 2020-07-31 Akebia Therapeutics Inc Compositions and methods for treating anemia
RU2534804C1 (ru) * 2013-08-05 2014-12-10 Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") ЗАМЕЩЕННЫЕ [1,2,4]ТРИАЗОЛО[4,3-a]ПИРИДИНЫ, ПРОЯВЛЯЮЩИЕ СВОЙСТВА АНТАГОНИСТОВ АДЕНОЗИНОВЫХ А2А РЕЦЕПТОРОВ, И ИХ ПРИМЕНЕНИЕ
US9624228B2 (en) * 2013-10-03 2017-04-18 Kura Oncology, Inc. Inhibitors of ERK and methods of use
ES2898476T3 (es) 2014-09-02 2022-03-07 Sunshine Lake Pharma Co Ltd Compuesto de quinolona y uso del mismo
JP2018039733A (ja) * 2014-12-22 2018-03-15 株式会社富士薬品 新規複素環誘導体
GB201504565D0 (en) * 2015-03-18 2015-05-06 Takeda Pharmaceutical Novel compounds
CN106146395B (zh) * 2015-03-27 2019-01-01 沈阳三生制药有限责任公司 3-羟基吡啶化合物、其制备方法及其制药用途
KR102473897B1 (ko) 2015-05-28 2022-12-06 니뽄 다바코 산교 가부시키가이샤 당뇨병성 신증을 치료 또는 예방하는 방법
WO2018097254A1 (ja) * 2016-11-25 2018-05-31 日本たばこ産業株式会社 トリアゾロピリジン化合物の製造方法
AU2018264313B2 (en) 2017-05-09 2020-06-04 Kind Pharmaceutical Indolizine derivatives and application thereof in medicine
SG11202003005PA (en) * 2017-10-04 2020-04-29 Japan Tobacco Inc Nitrogen-containing heteroaryl compound, and pharmaceutical use thereof
CN107739378A (zh) * 2017-11-14 2018-02-27 杭州安道药业有限公司 吲哚嗪衍生物及其在医药上的应用
AU2019340173B2 (en) * 2018-09-13 2024-02-08 Kissei Pharmaceutical Co., Ltd. Imidazopyridinone compound
CN110105355B (zh) * 2019-05-24 2021-09-21 烟台大学 一种1,2,3-三唑-[1,5-a]并喹啉类化合物的制备方法
JP7566008B2 (ja) * 2020-03-11 2024-10-11 キッセイ薬品工業株式会社 イミダゾピリジノン化合物又はその塩の結晶
JP7504822B2 (ja) 2020-03-12 2024-06-24 キッセイ薬品工業株式会社 イミダゾピリジノン化合物を含む医薬組成物
US20230218592A1 (en) 2020-04-20 2023-07-13 Akebia Therapeutics, Inc. Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer
WO2022150623A1 (en) 2021-01-08 2022-07-14 Akebia Therapeutics, Inc. Compounds and composition for the treatment of anemia
CN113387948B (zh) * 2021-02-06 2022-06-10 成都诺和晟泰生物科技有限公司 一种稠环杂芳基衍生物及其药物组合物和治疗方法及用途
TW202313072A (zh) 2021-05-27 2023-04-01 美商凱立克斯生物製藥股份有限公司 檸檬酸鐵之兒科調配物
CN113582843A (zh) * 2021-09-09 2021-11-02 无锡捷化医药科技有限公司 一种5-氯-2-氟-3-羟基苯甲酸乙酯的制备方法
CN116496269A (zh) * 2021-12-02 2023-07-28 苏中药业集团股份有限公司 一种脯氨酰羟化酶抑制剂及其用途
CN114031619A (zh) * 2021-12-17 2022-02-11 山东汇海医药化工有限公司 一种图卡替尼中间体的制备方法
TW202412778A (zh) * 2022-09-19 2024-04-01 大陸商蘇中藥業集團股份有限公司 一種脯氨醯羥化酶抑制劑及其用途

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19746287A1 (de) 1997-10-20 1999-04-22 Hoechst Marion Roussel De Gmbh Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
US6355653B1 (en) * 1999-09-06 2002-03-12 Hoffmann-La Roche Inc. Amino-triazolopyridine derivatives
US6514989B1 (en) * 2001-07-20 2003-02-04 Hoffmann-La Roche Inc. Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives
PL370067A1 (en) * 2001-10-08 2005-05-16 F.Hoffmann-La Roche Ag 8-amino-[1,2,4]triazolo[1,5-a]pyridine-6-carboxylic acid amide
WO2005014533A2 (en) 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
CA2575329A1 (en) * 2004-08-05 2006-02-09 F. Hoffmann-La Roche Ag Indole, indazole or indoline derivatives
FR2889383A1 (fr) * 2005-08-01 2007-02-02 France Telecom Procede et dispositif de detection pour systeme mimo, systeme mimo, programme et support d'information
TW200808793A (en) 2006-03-07 2008-02-16 Smithkline Beecham Corp Prolyl hydroxylase inhibitors
US20090176825A1 (en) 2006-05-16 2009-07-09 Fitch Duke M Prolyl hydroxylase inhibitors
PE20080209A1 (es) * 2006-06-23 2008-05-15 Smithkline Beecham Corp Derivados de glicina como inhibidores de prolil hidroxilasa
HUE041300T2 (hu) * 2006-06-26 2019-05-28 Akebia Therapeutics Inc Prolilhidroxiláz inhibitorok és alkalmazási eljárások
US20100035756A1 (en) 2006-07-12 2010-02-11 Syngenta Limited Triazolophyridine derivatives as herbicides
CL2008000066A1 (es) 2007-01-12 2008-08-01 Smithkline Beecham Corp Compuestos derivados de (5-hidroxi-3-oxo-2,3-dihidropiridazina-4-carbonil)glicina, inhibidores de hif prolil hidroxilasas; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anem
CA2683956C (en) 2007-04-18 2012-12-18 Amgen Inc. Quinolones and azaquinolones that inhibit prolyl hydroxylase
CA2685219C (en) 2007-05-04 2012-06-19 Amgen Inc. Diazaquinolones that inhibit prolyl hydroxylase activity
EP2460787A1 (en) 2007-07-03 2012-06-06 Astellas Pharma Inc. Amide compounds and their use as PGE2 antagonists.
WO2009073497A2 (en) * 2007-11-30 2009-06-11 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
CN101932324A (zh) * 2007-11-30 2010-12-29 葛兰素史密斯克莱有限责任公司 脯氨酰羟化酶抑制剂
WO2009126624A1 (en) * 2008-04-11 2009-10-15 Bristol-Myers Squibb Company Triazolo compounds useful as dgat1 inhibitors
WO2009134850A1 (en) 2008-04-30 2009-11-05 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
US20110077248A1 (en) 2008-05-29 2011-03-31 Sirtris Pharmaceuticals, Inc. Imidazopyridine and related analogs as sirtuin modulators
SI2379548T1 (sl) 2008-12-19 2016-06-30 Leo Pharma A/S Triazolopiridini kot fosfodiesterazni inhibitorji za zdravljenje kožnih bolezni
PE20120629A1 (es) * 2009-07-17 2012-05-30 Japan Tobacco Inc Compuesto triazolopiridina y su accion como inhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina

Also Published As

Publication number Publication date
JP6434575B2 (ja) 2018-12-05
KR20120051704A (ko) 2012-05-22
EP2455381B9 (en) 2014-10-22
DK2455381T5 (en) 2015-02-09
KR20170018105A (ko) 2017-02-15
NZ598242A (en) 2013-09-27
RU2538963C2 (ru) 2015-01-10
JP2012144571A (ja) 2012-08-02
US8283465B2 (en) 2012-10-09
JP2016040321A (ja) 2016-03-24
EP2455381B1 (en) 2014-05-28
TW201105671A (en) 2011-02-16
MX2012000766A (es) 2012-02-08
SI2455381T1 (sl) 2014-08-29
JP5021797B2 (ja) 2012-09-12
HRP20140705T1 (hr) 2014-09-12
PE20120629A1 (es) 2012-05-30
AR077417A1 (es) 2011-08-24
JP2017214404A (ja) 2017-12-07
DK2455381T3 (da) 2014-07-21
WO2011007856A1 (ja) 2011-01-20
PT2455381E (pt) 2014-06-24
PL2455381T3 (pl) 2014-10-31
KR101850661B1 (ko) 2018-04-19
EP2746282A1 (en) 2014-06-25
MY160814A (en) 2017-03-31
TWI485150B (zh) 2015-05-21
JP2019019144A (ja) 2019-02-07
JP2020111612A (ja) 2020-07-27
ME01858B (me) 2014-12-20
CN102471337B (zh) 2014-12-10
RU2012105467A (ru) 2013-08-27
CA2768505C (en) 2018-06-12
ES2477968T9 (es) 2014-11-13
HK1168346A1 (en) 2012-12-28
RS53499B1 (en) 2015-02-27
KR20180042443A (ko) 2018-04-25
IL217541A (en) 2014-07-31
ES2477968T3 (es) 2014-07-18
IL217541A0 (en) 2012-02-29
US20160145254A1 (en) 2016-05-26
US20130096155A1 (en) 2013-04-18
AU2010271732B2 (en) 2016-08-25
KR101706803B1 (ko) 2017-02-14
JP2024091878A (ja) 2024-07-05
SMT201500122B (it) 2015-07-09
SG178049A1 (en) 2012-03-29
CA2768505A1 (en) 2011-01-20
BR112012001157A2 (pt) 2016-02-23
EP2455381A1 (en) 2012-05-23
US20110077267A1 (en) 2011-03-31
EP2455381A4 (en) 2012-12-12
JP2015003933A (ja) 2015-01-08
JP2011037841A (ja) 2011-02-24
EP3594213A1 (en) 2020-01-15
CN102471337A (zh) 2012-05-23
KR20230165366A (ko) 2023-12-05
JP2022126843A (ja) 2022-08-30
AU2010271732A1 (en) 2012-03-08

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