SG11202003005PA - Nitrogen-containing heteroaryl compound, and pharmaceutical use thereof - Google Patents
Nitrogen-containing heteroaryl compound, and pharmaceutical use thereofInfo
- Publication number
- SG11202003005PA SG11202003005PA SG11202003005PA SG11202003005PA SG11202003005PA SG 11202003005P A SG11202003005P A SG 11202003005PA SG 11202003005P A SG11202003005P A SG 11202003005PA SG 11202003005P A SG11202003005P A SG 11202003005PA SG 11202003005P A SG11202003005P A SG 11202003005PA
- Authority
- SG
- Singapore
- Prior art keywords
- nitrogen
- pharmaceutical use
- containing heteroaryl
- heteroaryl compound
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017194005 | 2017-10-04 | ||
| PCT/JP2018/037007 WO2019069973A1 (en) | 2017-10-04 | 2018-10-03 | Nitrogen-containing heteroaryl compound, and pharmaceutical use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202003005PA true SG11202003005PA (en) | 2020-04-29 |
Family
ID=65994698
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202003005PA SG11202003005PA (en) | 2017-10-04 | 2018-10-03 | Nitrogen-containing heteroaryl compound, and pharmaceutical use thereof |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US10752596B2 (en) |
| EP (1) | EP3693358B1 (en) |
| JP (1) | JP7125882B2 (en) |
| KR (1) | KR20200064101A (en) |
| CN (1) | CN111148735B (en) |
| AR (1) | AR113270A1 (en) |
| AU (1) | AU2018345221A1 (en) |
| BR (1) | BR112020004857A2 (en) |
| CA (1) | CA3074989A1 (en) |
| CL (1) | CL2020000898A1 (en) |
| CO (1) | CO2020003977A2 (en) |
| IL (1) | IL273573A (en) |
| MX (1) | MX2020003816A (en) |
| PH (1) | PH12020550403A1 (en) |
| RU (1) | RU2020115045A (en) |
| SG (1) | SG11202003005PA (en) |
| TW (1) | TW201922706A (en) |
| WO (1) | WO2019069973A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110156698B (en) * | 2019-06-06 | 2020-10-13 | 沈阳海诺威医药科技有限公司 | Preparation method and application of 2-phenyl-1, 6-dihydropyrimidine-5-formic acid derivative |
| CN113181206B (en) * | 2021-04-30 | 2023-07-14 | 青岛大学 | SiRNA of gene SLC2A9 related to hyperuricemia accompanied with hyperlipidemia and hyperglycemia treatment and application thereof |
| AU2023205378A1 (en) * | 2022-01-07 | 2024-07-04 | Horizon Therapeutics Ireland Dac | Heterocyclic inhibitors of glut9 for treatment of disease |
| CN114805192B (en) * | 2022-03-30 | 2023-05-23 | 华南理工大学 | Tricyclic XOR/URAT1 dual inhibitor containing 2-hydroxybenzoic acid and preparation method and application thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ292843B6 (en) * | 1996-07-18 | 2003-12-17 | Merck Frosst Canada & Co. | Pyridine derivative and pharmaceutical preparation in which it is comprised |
| US5861419A (en) | 1996-07-18 | 1999-01-19 | Merck Frosst Canad, Inc. | Substituted pyridines as selective cyclooxygenase-2 inhibitors |
| CN1305470A (en) * | 1998-04-10 | 2001-07-25 | 日本烟草产业株式会社 | Amidine compounds |
| WO2005013907A2 (en) * | 2003-08-07 | 2005-02-17 | Japan Tobacco Inc. | Pyrrolo[1,2-b]pyridazine derivatives |
| JP2008536950A (en) | 2005-04-18 | 2008-09-11 | ニューロジェン・コーポレーション | Substituted heteroaryl CB1 antagonists |
| JP2007176933A (en) | 2005-11-29 | 2007-07-12 | Tanabe Seiyaku Co Ltd | Medicinal composition |
| JP5162827B2 (en) | 2005-12-27 | 2013-03-13 | ぺんてる株式会社 | Pencil lead manufacturing method |
| JP5330990B2 (en) * | 2007-04-11 | 2013-10-30 | キッセイ薬品工業株式会社 | Nitrogen-containing heterocyclic compound and pharmaceutical composition containing the same |
| JP2009016193A (en) * | 2007-07-05 | 2009-01-22 | Daihen Corp | Resin bushing for electric appliance |
| SG178049A1 (en) * | 2009-07-17 | 2012-03-29 | Japan Tobacco Inc | Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor and erythropoietin production inducer |
| CN105837411B (en) * | 2010-03-24 | 2019-06-18 | 俄亥俄州立大学 | The composition and method inhibited for glucose transport |
| AR081930A1 (en) | 2010-06-16 | 2012-10-31 | Ardea Biosciences Inc | THIOACETATE COMPOUNDS |
| CN105439946B (en) | 2014-08-13 | 2018-02-02 | 益方生物科技（上海）有限公司 | Carboxylic acid compound and its production and use |
| CN104306363B (en) * | 2014-10-31 | 2017-06-06 | 南京葆赫生物技术有限公司 | The application of stilbene analog derivative and its pharmaceutically acceptable salt in treatment antihyperuricemic disease drug is prepared |
-
2018
- 2018-10-03 WO PCT/JP2018/037007 patent/WO2019069973A1/en unknown
- 2018-10-03 EP EP18864398.5A patent/EP3693358B1/en active Active
- 2018-10-03 MX MX2020003816A patent/MX2020003816A/en unknown
- 2018-10-03 CA CA3074989A patent/CA3074989A1/en not_active Abandoned
- 2018-10-03 AU AU2018345221A patent/AU2018345221A1/en not_active Abandoned
- 2018-10-03 AR ARP180102853A patent/AR113270A1/en unknown
- 2018-10-03 US US16/150,989 patent/US10752596B2/en active Active
- 2018-10-03 CN CN201880064738.0A patent/CN111148735B/en active Active
- 2018-10-03 TW TW107134941A patent/TW201922706A/en unknown
- 2018-10-03 SG SG11202003005PA patent/SG11202003005PA/en unknown
- 2018-10-03 RU RU2020115045A patent/RU2020115045A/en unknown
- 2018-10-03 BR BR112020004857-7A patent/BR112020004857A2/en not_active Application Discontinuation
- 2018-10-03 JP JP2018188038A patent/JP7125882B2/en active Active
- 2018-10-03 KR KR1020207012149A patent/KR20200064101A/en unknown
-
2020
- 2020-03-24 IL IL273573A patent/IL273573A/en unknown
- 2020-03-31 CO CONC2020/0003977A patent/CO2020003977A2/en unknown
- 2020-04-02 CL CL2020000898A patent/CL2020000898A1/en unknown
- 2020-04-06 PH PH12020550403A patent/PH12020550403A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20200064101A (en) | 2020-06-05 |
| CN111148735A (en) | 2020-05-12 |
| RU2020115045A (en) | 2021-11-08 |
| AR113270A1 (en) | 2020-03-11 |
| IL273573A (en) | 2020-05-31 |
| EP3693358A4 (en) | 2021-06-02 |
| PH12020550403A1 (en) | 2021-02-15 |
| US10752596B2 (en) | 2020-08-25 |
| AU2018345221A1 (en) | 2020-05-07 |
| JP7125882B2 (en) | 2022-08-25 |
| CO2020003977A2 (en) | 2020-04-24 |
| MX2020003816A (en) | 2020-08-13 |
| CA3074989A1 (en) | 2019-04-11 |
| CL2020000898A1 (en) | 2020-08-14 |
| EP3693358A1 (en) | 2020-08-12 |
| BR112020004857A2 (en) | 2020-09-15 |
| WO2019069973A1 (en) | 2019-04-11 |
| JP2019065009A (en) | 2019-04-25 |
| US20190152926A1 (en) | 2019-05-23 |
| CN111148735B (en) | 2023-08-08 |
| EP3693358B1 (en) | 2023-02-22 |
| TW201922706A (en) | 2019-06-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3539963A4 (en) | Nitrogen-containing heterocyclic compound, preparation method, intermediate, pharmaceutical composition and use | |
| IL272089B1 (en) | Compounds, compositions and methods | |
| ZA201806576B (en) | Antibodies, pharmaceutical compositions and methods | |
| HUE062446T2 (en) | Compounds, compositions and methods | |
| GB2572305B (en) | Heterocyclic urea compound, and drug composition and application thereof | |
| EP3466943A4 (en) | Diphenylaminopyrimidine and triazine compound, and pharmaceutical composition and use thereof | |
| IL290745A (en) | Pyrimidine compound and pharmaceutical use thereof | |
| PT3580208T (en) | Novel heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same | |
| HK1258545A1 (en) | Urea compound, preparation method therefor and medical use thereof | |
| IL272446A (en) | Substituted penta- fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof | |
| IL273573A (en) | Nitrogen-containing heteroaryl compound, and pharmaceutical use thereof | |
| ZA202007547B (en) | Heteroaryl compounds and uses thereof | |
| PL3421038T3 (en) | Naphthyridine compound, pharmaceutical composition and use thereof | |
| HK1256674A1 (en) | Deuterium-modified brigatinib derivatives, pharmaceutical compositions comprising same, and use thereof | |
| IL273339A (en) | Griseofulvin compound and pharmaceutical use thereof | |
| IL272385A (en) | Drug compound and purification methods thereof | |
| IL276753A (en) | Afibrotic compounds, devices, and uses thereof | |
| PL3320903T3 (en) | Pharmaceutical composition containing amlodipine, valsartan, and rosuvastatin | |
| IL267626A (en) | Heteroaryl compounds and their use | |
| ZA201901543B (en) | Heterocyclic compound, and harmful-arthropod-controlling agent containing same | |
| EP3670500A4 (en) | Chemical compound, pharmaceutical composition thereof, and use and application thereof | |
| ZA202004349B (en) | Fluoralkenyl compounds, process for preparation and use thereof | |
| IL262929B1 (en) | Composition, and application and pharmaceutical preparation thereof | |
| PL3386988T3 (en) | Novel dihydropyranopyrimidinone derivatives, and use thereof | |
| IL282999A (en) | 1,3,4-oxadiazolone compound and pharmaceutical |