CO5580824A2 - Derivados de fenil o heteroaril amino alcano como antagonis- tas del receptor ip - Google Patents
Derivados de fenil o heteroaril amino alcano como antagonis- tas del receptor ipInfo
- Publication number
- CO5580824A2 CO5580824A2 CO05055462A CO05055462A CO5580824A2 CO 5580824 A2 CO5580824 A2 CO 5580824A2 CO 05055462 A CO05055462 A CO 05055462A CO 05055462 A CO05055462 A CO 05055462A CO 5580824 A2 CO5580824 A2 CO 5580824A2
- Authority
- CO
- Colombia
- Prior art keywords
- amino
- optionally substituted
- halogen
- alkyl
- nhc
- Prior art date
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
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- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- Organic Chemistry (AREA)
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- Urology & Nephrology (AREA)
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- Diabetes (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
1.- Un derivado de fenil o heteroaril aminoalcano de la fórmula (I), su forma tautomérica o estereoisomérica, o una sal del mismo: en la que Ar representa fenileno o un heteroarilo de 5 ó 6 miembros que contiene 1-3 heteroátomos seleccionados entre el grupo compuesto por O, N y S, donde dicho fenilo o un heteroarilo de 5 ó 6 miembros tiene opcionalmente uno o más sustituyentes seleccionados entre el grupo compuesto por halógeno, hidroxi, ciano, nitro, amino, N-alquil (C1-6)amino, N,N-dialquil (C1-6)amino, formilo, alquiltio (C1-6), alcoxi (C1-6) y alquilo (C1-6) opcionalmente sustituido con hidroxi, o uno, dos o tres átomos de halógeno;Q1, Q2, Q3 y Q4 representan independientemente CH, CR10 o N;donde R10 representa halógeno, ciano, amino, nitro, formilo, hidroximetilo, metiltio, alquilo (C1-6) opcionalmente sustituido con uno, dos o tres átomos de halógeno, o alcoxi (C1-6) opcionalmente sustituido con fenilo;R1 representa -OR11, -CH2NHR11, -C(O)R11, -C(O)NHR11, -SR11, -SOR11, -SO2R11, -NHR11, -NHC(O)OR11, -NHC(O)NR11, -NHC(O)R11, -NHSO2R11, hidrógeno, hidroxi, halógeno, un anillo mono- o bicíclico de 3-10 miembros saturado o insaturado que tiene opcionalmente uno o dos heteroátomos seleccionados independientemente entre O o N, alquilo (C1-6) opcionalmente sustituido con ariloxiimino, alcoxi (C1-6) opcionalmente sustituido con arilo o heteroarilo, o un anillo mono- o bicíclico de 3-10 miembros saturado o insaturado que tiene opcionalmente uno o dos heteroátomos seleccionados independientemente entre O o N, ...
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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EP02025024 | 2002-11-11 | ||
EP03011397 | 2003-05-20 |
Publications (1)
Publication Number | Publication Date |
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CO5580824A2 true CO5580824A2 (es) | 2005-11-30 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CO05055462A CO5580824A2 (es) | 2002-11-11 | 2005-06-08 | Derivados de fenil o heteroaril amino alcano como antagonis- tas del receptor ip |
Country Status (19)
Country | Link |
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US (1) | US20060089371A1 (es) |
EP (1) | EP1575919A1 (es) |
JP (1) | JP2006514110A (es) |
KR (1) | KR20050074571A (es) |
AR (1) | AR042023A1 (es) |
AU (1) | AU2003276201A1 (es) |
BR (1) | BR0316191A (es) |
CA (1) | CA2505361A1 (es) |
CO (1) | CO5580824A2 (es) |
EC (1) | ECSP055789A (es) |
HN (1) | HN2003000353A (es) |
HR (1) | HRP20050529A2 (es) |
MA (1) | MA27491A1 (es) |
NO (1) | NO20052797L (es) |
PE (1) | PE20040672A1 (es) |
PL (1) | PL376993A1 (es) |
TW (1) | TW200418799A (es) |
UY (1) | UY28072A1 (es) |
WO (1) | WO2004043926A1 (es) |
Families Citing this family (28)
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EP1243262B1 (en) | 2001-03-20 | 2006-05-31 | Schwarz Pharma Ag | Novel use of a peptide class of compound for treating non-neuropathic inflammatory pain |
DK1243263T3 (da) | 2001-03-21 | 2003-03-17 | Sanol Arznei Schwarz Gmbh | Hidtil ukendt anvendelse af en klasse af peptidforbindelser til behandling af allodyni eller andre forskellige typer af kronisk- eller fantomsmerte |
WO2005053667A1 (en) | 2003-12-02 | 2005-06-16 | Schwarz Pharma Ag | Novel use of peptide compounds for treating central neuropathic pain |
CN102127056B (zh) | 2003-12-03 | 2013-08-21 | Ym生物科学澳大利亚私人有限公司 | 微管蛋白抑制剂 |
EP1604655A1 (en) | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating pain in trigeminal neuralgia |
BRPI0514721A (pt) | 2004-08-27 | 2008-06-24 | Sanol Arznei Schwarz Gmbh | uso de compostos de peptìdeos para tratar dor de cáncer ósseo, dor induzida por quimioterapia e nucleosìdeo |
WO2006029735A1 (en) * | 2004-09-15 | 2006-03-23 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with prostaglandin 12 receptor (ptgir) |
GT200500284A (es) * | 2004-10-15 | 2006-03-27 | Aventis Pharma Inc | Pirimidinas como antagonistas del receptor de prostaglandina d2 |
PE20070404A1 (es) * | 2005-07-29 | 2007-05-10 | Wyeth Corp | Compuestos derivados de cianopirrol-sulfonamida como moduladores del receptor de progesterona |
PE20070341A1 (es) * | 2005-07-29 | 2007-04-13 | Wyeth Corp | Derivados de pirrol como moduladores del receptor de progesterona |
PE20070182A1 (es) | 2005-07-29 | 2007-03-06 | Wyeth Corp | Derivados cianopirrol-fenil amida como moduladores del receptor de progesterona |
WO2007016674A2 (en) | 2005-08-02 | 2007-02-08 | Lexicon Genetics Incorporated | 2-aminoaryl pyridines as protein kinases inhibitors |
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WO1996033972A1 (en) * | 1995-04-28 | 1996-10-31 | Glaxo Group Limited | Methods for synthesizing diverse collections of pyridines, pyrimidines, 1,4-dihydro derivatives thereof, and piperidine derivatives |
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KR20030051843A (ko) * | 2000-11-17 | 2003-06-25 | 워너-램버트 캄파니 엘엘씨 | 성기능 장애의 치료 |
CN100415770C (zh) * | 2001-05-30 | 2008-09-03 | 诺瓦提斯公司 | 2-{[n-(2-氨基-3-(杂芳基或芳基)丙酰基)-氨基酰基]-氨基}-烷基硼酸衍生物 |
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2003
- 2003-10-29 AU AU2003276201A patent/AU2003276201A1/en not_active Abandoned
- 2003-10-29 JP JP2005506646A patent/JP2006514110A/ja active Pending
- 2003-10-29 US US10/534,174 patent/US20060089371A1/en not_active Abandoned
- 2003-10-29 KR KR1020057008288A patent/KR20050074571A/ko not_active Application Discontinuation
- 2003-10-29 BR BR0316191-9A patent/BR0316191A/pt not_active IP Right Cessation
- 2003-10-29 PL PL376993A patent/PL376993A1/pl unknown
- 2003-10-29 WO PCT/EP2003/011976 patent/WO2004043926A1/en active Application Filing
- 2003-10-29 CA CA002505361A patent/CA2505361A1/en not_active Abandoned
- 2003-10-29 EP EP03810952A patent/EP1575919A1/en not_active Withdrawn
- 2003-11-07 UY UY28072A patent/UY28072A1/es not_active Application Discontinuation
- 2003-11-10 HN HN2003000353A patent/HN2003000353A/es unknown
- 2003-11-10 PE PE2003001135A patent/PE20040672A1/es not_active Application Discontinuation
- 2003-11-10 TW TW092131351A patent/TW200418799A/zh unknown
- 2003-11-10 AR ARP030104130A patent/AR042023A1/es not_active Application Discontinuation
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2005
- 2005-05-11 EC EC2005005789A patent/ECSP055789A/es unknown
- 2005-05-11 MA MA28277A patent/MA27491A1/fr unknown
- 2005-06-08 CO CO05055462A patent/CO5580824A2/es not_active Application Discontinuation
- 2005-06-09 NO NO20052797A patent/NO20052797L/no not_active Application Discontinuation
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UY28072A1 (es) | 2004-06-30 |
PE20040672A1 (es) | 2004-10-29 |
KR20050074571A (ko) | 2005-07-18 |
NO20052797D0 (no) | 2005-06-09 |
HRP20050529A2 (en) | 2006-08-31 |
US20060089371A1 (en) | 2006-04-27 |
AR042023A1 (es) | 2005-06-08 |
EP1575919A1 (en) | 2005-09-21 |
TW200418799A (en) | 2004-10-01 |
BR0316191A (pt) | 2005-09-27 |
CA2505361A1 (en) | 2004-05-27 |
PL376993A1 (pl) | 2006-01-23 |
WO2004043926A1 (en) | 2004-05-27 |
NO20052797L (no) | 2005-06-09 |
HN2003000353A (es) | 2003-11-23 |
ECSP055789A (es) | 2005-08-11 |
MA27491A1 (fr) | 2005-08-01 |
AU2003276201A1 (en) | 2004-06-03 |
JP2006514110A (ja) | 2006-04-27 |
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