PE20040672A1 - Derivados de fenil o heteroaril amino alcano - Google Patents

Derivados de fenil o heteroaril amino alcano

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Publication number
PE20040672A1
PE20040672A1 PE2003001135A PE2003001135A PE20040672A1 PE 20040672 A1 PE20040672 A1 PE 20040672A1 PE 2003001135 A PE2003001135 A PE 2003001135A PE 2003001135 A PE2003001135 A PE 2003001135A PE 20040672 A1 PE20040672 A1 PE 20040672A1
Authority
PE
Peru
Prior art keywords
amino
alkyl
phenyl
hydroxy
pyrimidin
Prior art date
Application number
PE2003001135A
Other languages
English (en)
Inventor
Toshiki Murata
Masaomi Umeda
Klaus Urbahns
Osamu Sakurai
Jang Gupta
Satoru Yoshikawa
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PE20040672A1 publication Critical patent/PE20040672A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
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    • A61P13/10—Drugs for disorders of the urinary system of the bladder
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • Urology & Nephrology (AREA)
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Abstract

SE REFIERE A UN DERIVADO DE FENIL O HETEROARIL AMINO ALCANO DE FORMULA (I), DONDE Ar ES FENILENO O HETEROARILO DE 5-6 MIEMBROS CON 1 A 3 HETEROATOMOS DE O, N Y S, QUE PUEDE ESTAR SUSTITUIDO POR HALOGENO, HIDROXI, CIANO, NITRO, AMINO, N-ALQUIL(C1-C6)AMINO, ENTRE OTROS; Q1, Q2, Q3 Y Q4 SON CH, CR10 O N; R1 ES OR11, CH2NHR11, -C(O)R11, -C(O)R11,-SR11, ENTRE OTROS; R2 ES H, HIDROXI, AMINO, N-ALQUIL(C1-C6)AMINO, ALQUENILO(C2-C6), ENTRE OTROS; R3 Y R6 SON INDEPENDIENTEMENTE H O ALQUILO (C1-C6) OPCIONALMENTE SUSTITUIDOS CON HALOGENO; R4 ES CARBOXI, TETRAZOLILO O N-(HIDROXI)AMINOCARBONILO; R5 ES H, ALCOXI(C1-C6), ARILO, HETEROARILO O ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON HALOGENOS; R7 ES H O ALQUILO; ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-(2-AMINOETOXI)-N-{6-[4-(BENCILOXI)FENIL]PIRIMIDIN-4-IL}FENILALANINA, 4-CLORO-N-{6-[4-(CICLOPROPILMETOXI)FENIL]PIRIMIDIN-4-IL}FENILALANINA, N-(6-{4-[(3,5-DIFLUOROBENCIL)OXI]FENIL}PIRIMIDIN-4-IL)-3-PIRIDIN-2-ILALANINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN MEDICAMENTO QUE LO CONTIENE. ESTOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR IP (RECEPTOR DE PROSTACICLINA) Y SON UTILES PARA LA PROFILAXIS Y/O TRATAMIENTO DE UN TRASTORNO O ENFERMEDAD UROLOGICA, DEL DOLOR, DE LA HIPOTENSION, DE LA HEMOFILIA Y HEMORRAGIAS E INFLAMACION
PE2003001135A 2002-11-11 2003-11-10 Derivados de fenil o heteroaril amino alcano PE20040672A1 (es)

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EP02025024 2002-11-11
EP03011397 2003-05-20

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EP (1) EP1575919A1 (es)
JP (1) JP2006514110A (es)
KR (1) KR20050074571A (es)
AR (1) AR042023A1 (es)
AU (1) AU2003276201A1 (es)
BR (1) BR0316191A (es)
CA (1) CA2505361A1 (es)
CO (1) CO5580824A2 (es)
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PL (1) PL376993A1 (es)
TW (1) TW200418799A (es)
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WO (1) WO2004043926A1 (es)

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EP1243263B1 (en) 2001-03-21 2002-11-27 Schwarz Pharma Ag Novel use of a peptide class of compound for treating allodynia or other different types of chronic or phantom pain
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BRPI0417354A (pt) 2003-12-03 2007-03-13 Cytopia Res Pty Ltd compostos inibidores de tubulina, composições e seus usos
EP1604655A1 (en) 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating pain in trigeminal neuralgia
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