PE20090218A1 - Compuestos mimeticos de glucocorticoides, metodos de preparacion y composiciones farmaceuticas - Google Patents
Compuestos mimeticos de glucocorticoides, metodos de preparacion y composiciones farmaceuticasInfo
- Publication number
- PE20090218A1 PE20090218A1 PE2008001806A PE2008001806A PE20090218A1 PE 20090218 A1 PE20090218 A1 PE 20090218A1 PE 2008001806 A PE2008001806 A PE 2008001806A PE 2008001806 A PE2008001806 A PE 2008001806A PE 20090218 A1 PE20090218 A1 PE 20090218A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- diabetes
- hydroxy
- optionally substituted
- ona
- Prior art date
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
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- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Abstract
SE REFIERE A COMPUESTOS DE FORMULA (IC) DONDE R1 ES ARILO O HETEROARILO, OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C5, ALQUENILO C2-C5, ALQUINILO C2-C5, ENTRE OTROS; R2 Y R3 SON CADA UNO ALQUILO C1-C5; R4 ES ALQUILO C1-C5, ALQUENILO C2-C5, ALQUINILO C2-C5, OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C3, HIDROXI, HALOGENO, AMINO, OXO; R5 ES HETEROARILO OPCIONALMENTE SUSTITUIDO CON HETEROCICLILCARBONILO, AROILO, AMINOCARBONILO, ENTRE OTROS; R6 ES H, ALQUILO C1-C8, TRIFLUOROMETILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C5, ALQUENILO C2-C5, ALQUINILO C2-C5, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 1-[4-(5-FLUORO-2-METOXIFENIL)-2-HIDROXI-4-METIL-2-TRIFLUOROMETILPENTIL]-1,5,6,7-TETRAHIDROINDOL-4-ONA, 1-[4-(2,3-DIHIDROBENZOFURAN-7-IL)-2-HIDROXI-4-METIL-2-TRIFLUOROMETILPENTIL]-1,5,6,7-TETRAHIDROINDOL-4-ONA, 1-[2-HIDROXI-4-(5-METANSULFONIL-2,3-DIHIDROBENZOFURAN-7-IL)-4-METIL-2-TRIFLUOROMETILPENTIL]-1,5,6,7-TETRAHIDROINDOL-4-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON MODULADORES DEL RECEPTOR DE GLUCOCORTICOIDES SIENDO UTILES PARA EL TRATAMIENTO DE ENFERMEDADES PULMONARES, REUMATICAS, ALERGICAS, RENALES, HEPATICAS, CARDIOVASCULARES, NEUROLOGICAS, DIABETES TIPO I y II, OBESIDAD, ENFERMEDAD DE ALZHEIMER, ARTERIOESCLEROSIS, OSTEOARTRITIS, DOLOR GRAVE Y CRONICO
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- 2004-09-21 PE PE2008001805A patent/PE20090217A1/es not_active Application Discontinuation
- 2004-09-21 PE PE2008001807A patent/PE20090219A1/es not_active Application Discontinuation
- 2004-09-22 US US10/947,420 patent/US8741897B2/en active Active
- 2004-09-22 RU RU2006113696/04A patent/RU2006113696A/ru not_active Application Discontinuation
- 2004-09-22 CA CA2539909A patent/CA2539909C/en not_active Expired - Fee Related
- 2004-09-22 KR KR1020067007921A patent/KR101152690B1/ko not_active IP Right Cessation
- 2004-09-22 JP JP2006528127A patent/JP4778430B2/ja not_active Expired - Fee Related
- 2004-09-22 CN CN2010102426640A patent/CN101948425A/zh active Pending
- 2004-09-22 SG SG200807363-7A patent/SG146694A1/en unknown
- 2004-09-22 NZ NZ546666A patent/NZ546666A/en not_active IP Right Cessation
- 2004-09-22 RS YUP-2006/0201A patent/RS20060201A/sr unknown
- 2004-09-22 BR BRPI0414591-7A patent/BRPI0414591A/pt not_active IP Right Cessation
- 2004-09-22 AU AU2004275757A patent/AU2004275757B2/en not_active Ceased
- 2004-09-22 TW TW093128656A patent/TWI340138B/zh not_active IP Right Cessation
- 2004-09-22 MX MXPA06002880A patent/MXPA06002880A/es not_active Application Discontinuation
- 2004-09-22 EP EP04788894A patent/EP1673088A1/en not_active Withdrawn
- 2004-09-22 WO PCT/US2004/031009 patent/WO2005030213A1/en active Application Filing
- 2004-09-23 AR ARP040103429A patent/AR046020A1/es active Pending
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2006
- 2006-03-21 IL IL174475A patent/IL174475A0/en unknown
- 2006-03-24 EC EC2006006459A patent/ECSP066459A/es unknown
- 2006-04-21 NO NO20061766A patent/NO20061766L/no not_active Application Discontinuation
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Also Published As
Publication number | Publication date |
---|---|
KR101152690B1 (ko) | 2012-07-05 |
PE20050951A1 (es) | 2005-12-12 |
WO2005030213A1 (en) | 2005-04-07 |
MXPA06002880A (es) | 2006-06-05 |
PE20090219A1 (es) | 2009-03-26 |
CN101948425A (zh) | 2011-01-19 |
SG146694A1 (en) | 2008-10-30 |
TW200526655A (en) | 2005-08-16 |
JP4778430B2 (ja) | 2011-09-21 |
NO20061766L (no) | 2006-06-21 |
NZ546666A (en) | 2010-02-26 |
PE20090217A1 (es) | 2009-03-26 |
JP2010209100A (ja) | 2010-09-24 |
RS20060201A (en) | 2008-08-07 |
TWI340138B (en) | 2011-04-11 |
AR046020A1 (es) | 2005-11-23 |
IL174475A0 (en) | 2006-08-01 |
RU2006113696A (ru) | 2007-11-20 |
US20050176706A1 (en) | 2005-08-11 |
UY28526A1 (es) | 2005-04-29 |
JP2007506750A (ja) | 2007-03-22 |
CA2539909A1 (en) | 2005-04-07 |
AU2004275757B2 (en) | 2011-03-24 |
AU2004275757A1 (en) | 2005-04-07 |
EP1673088A1 (en) | 2006-06-28 |
ECSP066459A (es) | 2006-09-18 |
KR20060115858A (ko) | 2006-11-10 |
CA2539909C (en) | 2012-07-31 |
US8741897B2 (en) | 2014-06-03 |
BRPI0414591A (pt) | 2006-11-07 |
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