CO5690607A2 - Compuestos de piridina como inhibidores de dipeptidil peptidasa iv - Google Patents
Compuestos de piridina como inhibidores de dipeptidil peptidasa ivInfo
- Publication number
- CO5690607A2 CO5690607A2 CO06050514A CO06050514A CO5690607A2 CO 5690607 A2 CO5690607 A2 CO 5690607A2 CO 06050514 A CO06050514 A CO 06050514A CO 06050514 A CO06050514 A CO 06050514A CO 5690607 A2 CO5690607 A2 CO 5690607A2
- Authority
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- Colombia
- Prior art keywords
- group
- optionally substituted
- diisopropyl
- fluorophenyl
- optionally
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 2
- FYANCCWYXYLERB-UHFFFAOYSA-N 1-[4-(4-fluorophenyl)-5-pentyl-2,6-di(propan-2-yl)pyridin-3-yl]-n,n-dimethylmethanamine Chemical compound CCCCCC1=C(C(C)C)N=C(C(C)C)C(CN(C)C)=C1C1=CC=C(F)C=C1 FYANCCWYXYLERB-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- UTIZDWVVZSUELO-UHFFFAOYSA-N n-[[4-(4-fluorophenyl)-5-pentyl-2,6-di(propan-2-yl)pyridin-3-yl]methyl]ethanamine Chemical compound CCCCCC1=C(C(C)C)N=C(C(C)C)C(CNCC)=C1C1=CC=C(F)C=C1 UTIZDWVVZSUELO-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005750 substituted cyclic group Chemical group 0.000 abstract 1
- -1 tert-butyldimethylsilyloxymethyl Chemical group 0.000 abstract 1
Classifications
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
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- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/59—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with at least one of the bonds being to sulfur
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- Pyridine Compounds (AREA)
Abstract
1.- Un compuesto representado por la fórmula caracterizado por que R1 y R2 son iguales o diferentes y cada uno es un grupo de hidrocarburo opcionalmente sustituido o un grupo hidroxilo opcionalmente sustituido;R3 es un grupo aromático opcionalmente sustituido;R4 es un grupo amino opcionalmente sustituido;L es un grupo de hidrocarburo de cadena bivalente;Q es un enlace o un grupo hidrocarburo de cadena bivalente; y X es un átomo de hidrógeno, un grupo ciano, un grupo nitro, un grupo acilo, un grupo hidroxilo sustituido, un grupo tiol opcionalmente sustituido, un grupo amino opcionalmente sustituido o un grupo cíclico opcionalmente sustituido;con la condición que cuando X es un grupo etoxicarbonilo, entonces Q es un grupo hidrocarburo de cadena bivalente, y el compuesto no es 2,6-diisopropil-3-metilaminometil-4-(4-fluorofenil)-5-pentiIpiridina;2,6-diisopropil-3-aminometil-4-(4-fluorofeniI)-5-pentiIpiridina;2,6-diisopropil-3-(dimetilamino)metil-4-(4-fluorofenil)-5-pentilpiridina;2,6-diisopropil-3-(etilamino)metil-4-(4-fluorofenil)-5-pentilpiridina; y 3-(terc-butildimetilsililoximetil)-2;6diisopropil-4-(4- fluorofenil)-5-(indolil-5-aminometil)piridina;o una sal del mismo.2.- Un compuesto de acuerdo con la reivindicación 1, caracterizado por que R1 y R2 son iguales o diferentes y cada uno es un grupo hidrocarburo opcionalmente sustituido, y X es un grupo ciano, un grupo nitro, un grupo acilo, un grupo hidroxilo sustituido, un grupo tiol opcionalmente sustituido o un grupo cíclico opcionalmente sustituido.
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JP2003373776 | 2003-10-31 | ||
JP2004030491 | 2004-02-06 | ||
JP2004165977 | 2004-06-03 |
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CO5690607A2 true CO5690607A2 (es) | 2006-10-31 |
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CO06050514A CO5690607A2 (es) | 2003-10-31 | 2006-05-25 | Compuestos de piridina como inhibidores de dipeptidil peptidasa iv |
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US (1) | US20070037807A1 (es) |
EP (1) | EP1678138A1 (es) |
KR (2) | KR20080067013A (es) |
AR (1) | AR046819A1 (es) |
AU (1) | AU2004285807A1 (es) |
BR (1) | BRPI0415960A (es) |
CA (1) | CA2543529A1 (es) |
CO (1) | CO5690607A2 (es) |
IL (1) | IL174608A0 (es) |
MX (1) | MXPA06003979A (es) |
NO (1) | NO20062516L (es) |
NZ (1) | NZ546787A (es) |
PE (1) | PE20050444A1 (es) |
TW (1) | TW200523252A (es) |
WO (1) | WO2005042488A1 (es) |
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2004
- 2004-10-27 TW TW093132496A patent/TW200523252A/zh unknown
- 2004-10-27 PE PE2004001030A patent/PE20050444A1/es not_active Application Discontinuation
- 2004-10-28 AR ARP040103931A patent/AR046819A1/es not_active Application Discontinuation
- 2004-10-29 KR KR1020087015446A patent/KR20080067013A/ko not_active Application Discontinuation
- 2004-10-29 KR KR1020067008423A patent/KR100858259B1/ko not_active IP Right Cessation
- 2004-10-29 EP EP04793377A patent/EP1678138A1/en not_active Withdrawn
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- 2004-10-29 WO PCT/JP2004/016457 patent/WO2005042488A1/en active Application Filing
- 2004-10-29 CA CA002543529A patent/CA2543529A1/en not_active Abandoned
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KR20060064022A (ko) | 2006-06-12 |
PE20050444A1 (es) | 2005-08-09 |
MXPA06003979A (es) | 2006-07-05 |
BRPI0415960A (pt) | 2007-01-16 |
WO2005042488A1 (en) | 2005-05-12 |
KR20080067013A (ko) | 2008-07-17 |
IL174608A0 (en) | 2006-08-20 |
EP1678138A1 (en) | 2006-07-12 |
AU2004285807A1 (en) | 2005-05-12 |
CA2543529A1 (en) | 2005-05-12 |
KR100858259B1 (ko) | 2008-09-11 |
US20070037807A1 (en) | 2007-02-15 |
TW200523252A (en) | 2005-07-16 |
NZ546787A (en) | 2009-06-26 |
NO20062516L (no) | 2006-07-25 |
AR046819A1 (es) | 2005-12-28 |
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