AR046027A1 - Derivados de benzofurano de tipo carbamoilo - Google Patents

Derivados de benzofurano de tipo carbamoilo

Info

Publication number
AR046027A1
AR046027A1 ARP040103461A ARP040103461A AR046027A1 AR 046027 A1 AR046027 A1 AR 046027A1 AR P040103461 A ARP040103461 A AR P040103461A AR P040103461 A ARP040103461 A AR P040103461A AR 046027 A1 AR046027 A1 AR 046027A1
Authority
AR
Argentina
Prior art keywords
group
optionally substituted
lower alkyl
formula
hydrogen atom
Prior art date
Application number
ARP040103461A
Other languages
English (en)
Inventor
Takayuki Kawaguchi
H Akatsuka
Masayuki Morimoto
T Watanabe
T Lijima
J Murakami
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of AR046027A1 publication Critical patent/AR046027A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

El presente se refiere a sales farmacéuticamente aceptables del mismo, estos son útiles como inhibidores de Fxa. Reivindicación 1: Un derivado benzofurano del tipo carbamoilo caracterizado porque posee la fórmula (1), en donde el anillo Z es un grupo de la fórmulas (2); A es un enlace simple o un grupo de la fórmula: -NH-; Y es un grupo alquileno inferior, un grupo cicloalcandiilo, un grupo fenilo o un grupo heterocíclico saturado; R4 y R5 son iguales o diferentes y cada uno es un átomo de hidrógeno, un grupo alquilo inferior opcionalmente sustituido o un grupo heterocíclico saturado opcionalmente sustituido, ó R4 y R5 se combinan entre sí en los extremos para formar un grupo heterocíclico saturado conteniendo nitrógeno opcionalmente sustituido junto con el átomo de nitrógeno adyacente; R1 es un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo inferior, grupo alcoxilo inferior, un grupo ciano, o un grupo amino opcionalmente sustituido por 1 a 2 grupos alquilo inferior; El anillo B posee la fórmula (3), es un anillo de benceno opcionalmente sustituido; y R3 es un átomo de hidrógeno o un grupo alquilo inferior, o una sal farmacéuticamente aceptable del mismo.
ARP040103461A 2003-09-26 2004-09-24 Derivados de benzofurano de tipo carbamoilo AR046027A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2003334597 2003-09-26

Publications (1)

Publication Number Publication Date
AR046027A1 true AR046027A1 (es) 2005-11-23

Family

ID=34386035

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040103461A AR046027A1 (es) 2003-09-26 2004-09-24 Derivados de benzofurano de tipo carbamoilo

Country Status (18)

Country Link
US (1) US7605158B2 (es)
EP (1) EP1666478A4 (es)
JP (1) JP4277022B2 (es)
KR (1) KR100763294B1 (es)
CN (1) CN100430392C (es)
AR (1) AR046027A1 (es)
AU (1) AU2004276127B2 (es)
BR (1) BRPI0414597A (es)
CA (1) CA2539471A1 (es)
IL (1) IL174187A0 (es)
MX (1) MXPA06003378A (es)
MY (1) MY139258A (es)
NO (1) NO20061831L (es)
NZ (1) NZ546159A (es)
RU (1) RU2319700C1 (es)
TW (1) TW200524915A (es)
WO (1) WO2005030759A1 (es)
ZA (1) ZA200602130B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003082847A1 (fr) * 2002-03-28 2003-10-09 Tanabe Seiyaku Co., Ltd. Derive de benzofurane
US20070049748A1 (en) * 2005-08-26 2007-03-01 Uppala Venkata Bhaskara R Preparation of ezetimibe
US9647851B2 (en) 2008-10-13 2017-05-09 Ppc Broadband, Inc. Ingress noise inhibiting network interface device and method for cable television networks
US9505735B2 (en) * 2012-06-21 2016-11-29 Whitehead Institute For Biomedical Research Compounds for treating infectious diseases
BR112017009501A2 (pt) * 2014-11-10 2018-02-06 Glaxosmithkline Ip No 2 Ltd método para tratar uma infecção por hcv, método para curar uma infecção por hcv, e, composição farmacêutica.
WO2019087129A1 (en) * 2017-11-03 2019-05-09 Universite De Montreal Compounds and use thereof in the expansion of stem cells and/or progenitor cells
CN110407697A (zh) * 2019-08-28 2019-11-05 上海毕得医药科技有限公司 一种4-甲酰基-3-羟基苯甲酸甲酯的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2168858A1 (en) 1994-06-06 1995-12-14 Shinichiro Ono Novel fused-ring carboxylic acid compound or salt thereof, and medicinal use thereof
WO1999032477A1 (en) * 1997-12-19 1999-07-01 Schering Aktiengesellschaft Ortho-anthranilamide derivatives as anti-coagulants
US6140351A (en) 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
EP0937711A1 (de) * 1998-02-18 1999-08-25 Roche Diagnostics GmbH Neue Thiobenzamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
AU2055500A (en) 1998-12-23 2000-07-31 Eli Lilly And Company Aromatic amides
CA2385592C (en) 1999-09-17 2011-01-11 Bing-Yan Zhu Benzamides and related inhibitors of factor xa
US6720317B1 (en) 1999-09-17 2004-04-13 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
AU2001277731A1 (en) 2000-08-09 2002-02-18 Welfide Corporation Fused bicyclic amide compounds and medicinal use thereof
EP1373194B1 (en) 2001-03-30 2007-08-01 Millennium Pharmaceuticals, Inc. BENZAMIDE INHIBITORS OF FACTOR Xa
WO2003082847A1 (fr) 2002-03-28 2003-10-09 Tanabe Seiyaku Co., Ltd. Derive de benzofurane
JP2005104838A (ja) 2003-01-09 2005-04-21 Tanabe Seiyaku Co Ltd 縮合フラン化合物

Also Published As

Publication number Publication date
MY139258A (en) 2009-09-30
RU2319700C1 (ru) 2008-03-20
WO2005030759A1 (ja) 2005-04-07
ZA200602130B (en) 2007-03-28
CA2539471A1 (en) 2005-04-07
CN100430392C (zh) 2008-11-05
AU2004276127A1 (en) 2005-04-07
KR100763294B1 (ko) 2007-10-04
AU2004276127B2 (en) 2008-02-07
JP4277022B2 (ja) 2009-06-10
US20060247273A1 (en) 2006-11-02
KR20060073963A (ko) 2006-06-29
TW200524915A (en) 2005-08-01
IL174187A0 (en) 2006-08-01
JPWO2005030759A1 (ja) 2006-12-07
NO20061831L (no) 2006-04-25
BRPI0414597A (pt) 2006-11-07
US7605158B2 (en) 2009-10-20
CN1856488A (zh) 2006-11-01
EP1666478A1 (en) 2006-06-07
NZ546159A (en) 2009-06-26
MXPA06003378A (es) 2006-06-08
EP1666478A4 (en) 2008-12-03
RU2006114056A (ru) 2007-11-10

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