AR063576A1 - Arilsulfonil- pirrolidinas como inhibidores 5-ht6 - Google Patents

Arilsulfonil- pirrolidinas como inhibidores 5-ht6

Info

Publication number
AR063576A1
AR063576A1 ARP070104931A ARP070104931A AR063576A1 AR 063576 A1 AR063576 A1 AR 063576A1 AR P070104931 A ARP070104931 A AR P070104931A AR P070104931 A ARP070104931 A AR P070104931A AR 063576 A1 AR063576 A1 AR 063576A1
Authority
AR
Argentina
Prior art keywords
alkyl
amino
alkoxy
halo
hydroxy
Prior art date
Application number
ARP070104931A
Other languages
English (en)
Inventor
Dov Nitzan
Francisco Javier Lopez-Tapia
Lee Edwin Lowrie Jr
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR063576A1 publication Critical patent/AR063576A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Reivindicación 1: Un compuesto de la fórmula (1) o una sal farmacéuticamente aceptable del mismo, en la que: m es un número entero entre 0 y 4; n es un número de 0 a 2;Ar es arilo opcionalmente sustituido o heteroarilo opcionalmente sustituido; R1 es hidrógeno; alquilo C1-6; hetero-alquilo C1-6; o -(CH2)p-X-(CH2)q-Ra; en el que: X es -C(O)- o -SO2-; p y q con independencia entre sí son el número 0 o 1; y Ra es: alquilo C1-6, alcoxi C1-6, halo-alquilo C1-6, halo-alcoxi C1-6, hidroxi; amino; N- alquil C1-6-amino; o N,N-di(alquil C1-6)-amino; y cada R2 es con independencia: halógeno; alquilo C1-6; halo-alquilo C1-6; halo-alcoxi C1-6; alcoxi C1-6; hidroxi; hetero-alquilo C1-6, ciano; nitro; amino; N-alquil C1-6-amino; N,N-di(alquil C1-6)- amino; hidroxi-alcoxi C1-6, -O-C(O)-CH(NR2)alquilo C1-6; o -(CH2)r-Y-(CH2)s-Z-(CH2)t-Q-(CH2)u-Rb; en los que r, s, t y u con independencia entre sí son el número 0 o 1; Y y Q con independencia entre sí son -O-, -NRc- o un enlace; Z es -C(O)- o -SO2- ; Rb es: hidrógeno; alquilo C1-6; halo-alquilo C1-6; halo-alcoxi C1-6; alcoxi C1-6, hidroxi; hetero-alquilo C1-6, ciano, amino, alquil C1-6-amino, o N,N-di(alquil C1-69-amino; y Rc es H o alquilo C1-6.
ARP070104931A 2006-11-09 2007-11-06 Arilsulfonil- pirrolidinas como inhibidores 5-ht6 AR063576A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85810606P 2006-11-09 2006-11-09

Publications (1)

Publication Number Publication Date
AR063576A1 true AR063576A1 (es) 2009-02-04

Family

ID=39023536

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070104931A AR063576A1 (es) 2006-11-09 2007-11-06 Arilsulfonil- pirrolidinas como inhibidores 5-ht6

Country Status (18)

Country Link
US (1) US7776910B2 (es)
EP (1) EP2081890B1 (es)
JP (1) JP2010509266A (es)
KR (1) KR20090079259A (es)
CN (1) CN101573332A (es)
AR (1) AR063576A1 (es)
AT (1) ATE495153T1 (es)
AU (1) AU2007316688A1 (es)
BR (1) BRPI0718584A2 (es)
CA (1) CA2667710A1 (es)
CL (1) CL2007003190A1 (es)
DE (1) DE602007011962D1 (es)
ES (1) ES2358549T3 (es)
IL (1) IL198322A0 (es)
MX (1) MX2009004947A (es)
PE (1) PE20081160A1 (es)
TW (1) TW200827337A (es)
WO (1) WO2008055847A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8987307B2 (en) 2011-03-03 2015-03-24 Hoffmann-La Roche Inc. 3-amino-pyridines as GPBAR1 agonists
MX2014009713A (es) 2012-04-04 2014-09-12 Hoffmann La Roche Derivados de 1,2-piridazina, 1,6-piridazina o pirimidina-benzamida como moduladores del receptor de acidos biliares acoplado a la proteina g1 (gpbar1).
CN104557726B (zh) * 2013-10-19 2019-05-24 广东东阳光药业有限公司 芳杂环类衍生物及其在药物上的应用
JP6454346B2 (ja) 2013-12-20 2019-01-16 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． 芳香族複素環式化合物及び医薬におけるその応用
CN105566182B (zh) * 2016-02-24 2018-02-13 苏州天马精细化学品股份有限公司 一种2‑氨基‑4‑（乙磺酰基）苯酚的合成方法
CN108689904B (zh) * 2017-04-12 2022-06-17 轩竹生物科技股份有限公司 手性杂环叔醇中间体的制备方法及其应用
CN109232362B (zh) * 2017-07-10 2022-12-27 广东东阳光药业有限公司 芳杂环类衍生物及其在药物上的应用
CA3080578A1 (en) * 2017-10-30 2019-05-09 Neuropore Therapies, Inc. Substituted phenyl sulfonyl phenyl triazole thiones and uses thereof
CN109912487B (zh) * 2019-03-25 2023-01-10 山东理工大学 一种合成1-对甲苯磺酰基-2-乙烯基-1氢-吡咯的方法
CN114793434A (zh) 2019-10-18 2022-07-26 加利福尼亚大学董事会 作为用于治疗病原性血管病症的药剂的3-苯基磺酰基-喹啉衍生物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0930302T3 (da) * 1998-01-16 2003-07-21 Hoffmann La Roche Benzosulfonderivater
PE20020063A1 (es) 2000-06-20 2002-01-30 Upjohn Co Bis-arilsulfonas como ligandos del receptor de 5-ht
US20040014966A1 (en) * 2000-06-20 2004-01-22 Jacobsen Eric Jon Bis-arylsulfones
PL376479A1 (en) * 2002-10-18 2005-12-27 F.Hoffmann-La Roche Ag 4-piperazinyl benzenesulfonyl indoles with 5-ht6 receptor affinity
MXPA05008878A (es) * 2003-02-21 2005-10-05 Pfizer Derivados de aminotiazol sustituidos con cicloalquilo que contiene n y composiciones farmaceuticas para inhibir la proliferacion celular, y metodos para su uso.
WO2005014578A1 (en) * 2003-08-08 2005-02-17 Glaxo Group Limited Phenylsulfonyl compounds as antipsychotic agents
MX2008002158A (es) * 2005-08-15 2008-04-19 Wyeth Corp Derivados de azinil-3-sulfonilindazol como ligandos de 5-hidroxitriptamina-6.
NZ572761A (en) * 2006-04-19 2011-09-30 Abbott Gmbh & Co Kg Heterocyclic arylsulphones suitable for treating disorders that respond to modulation of the serotonin 5ht6 receptor

Also Published As

Publication number Publication date
EP2081890B1 (en) 2011-01-12
US20080167361A1 (en) 2008-07-10
ES2358549T3 (es) 2011-05-11
BRPI0718584A2 (pt) 2014-03-11
PE20081160A1 (es) 2008-08-15
TW200827337A (en) 2008-07-01
WO2008055847A1 (en) 2008-05-15
US7776910B2 (en) 2010-08-17
CN101573332A (zh) 2009-11-04
IL198322A0 (en) 2010-02-17
AU2007316688A1 (en) 2008-05-15
KR20090079259A (ko) 2009-07-21
JP2010509266A (ja) 2010-03-25
MX2009004947A (es) 2009-05-19
DE602007011962D1 (en) 2011-02-24
CL2007003190A1 (es) 2008-06-27
CA2667710A1 (en) 2008-05-15
ATE495153T1 (de) 2011-01-15
EP2081890A1 (en) 2009-07-29

Similar Documents

Publication Publication Date Title
AR063576A1 (es) Arilsulfonil- pirrolidinas como inhibidores 5-ht6
EA200602060A1 (ru) Производные пирролидин-2-она и пиперидин-2-она, используемые в качестве ингибиторов 11-бета-гидроксистероид-дегидрогеназы
CO6160235A2 (es) Isoxazolinas insecticidas
AR106945A2 (es) Compuestos de isoindolina y composiciones farmacéuticas de los mismos
EA200701176A1 (ru) Новые соединения нафталина, способ их получения и фармацевтические композиции, содержащие их
NO20074718L (no) BCRP/ABCG2 inhibitor
CR7950A (es) Sintesis de los cloruros de 4amino -2butenoilo y su uso en la preparacion of 3- cianoquinolinas
EA200800321A1 (ru) Ингибиторы гистондеацетилазы
CL2012000999A1 (es) Compuestos derivados de pirazoloespirocetona sustituida, inhibidores de acetil-coa carboxilasa; composicion farmaceutica que los comprende; uso para tratar o retrasar la progresion o el inicio de diabetes tipo 2, higado graso no alcoholico (hgna) o la resistencia hepatica a la insulina.
EA200970461A1 (ru) ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 3-ИЗОБУТИЛ-9,10-ДИМЕТОКСИ-1,3,4,6,7,11b-ГЕКСАГИДРО-2Н-ПИРИДО[2,1-a]ИЗОХИНОЛИН-2-ОЛА И СВЯЗАННЫЕ С НИМИ СПОСОБЫ
UY31468A1 (es) Derivados bis-(sulfonilamino) en terapia 065
EA201001013A1 (ru) Бис(сульфониламино)производные для применения в терапии
UY31260A1 (es) Compuestos de pirazol, composiciones conteniendolos y aplicaciones.
EA201000805A1 (ru) Бис-(сульфониламино)производные в терапии 066
PA8607001A1 (es) Derivados de triazolopirimidinas como inhibidores de la glucogeno sintasa quinasa 3
EA200602058A1 (ru) Производные адамантилпирролидин-2-она в качестве ингибиторов 11-бета-гидроксистероид-дегидрогеназы
EA201000413A1 (ru) Способ получения производных лактамида, новые производные лактамида и препараты, содержащие производные лактамида
RS51674B (en) PIPERIDIN-4-IL-PIRIDAZIN-3-ILAMINE DERIVATIVES AS A FAST DISSOCATING DOPAMIN 2 RECEIVER ANTAGONISTS
AR048213A1 (es) 1-(4-mono-y di-halometilsulfonilfenil)-2-acilamino-fluorpropanoles analogos al florfenicol
AR086590A1 (es) Compuestos de ciclohexanona y herbicidas que los comprenden
PA8573501A1 (es) Derivados de benzoxazina y su empleo
EA200900631A1 (ru) Замещённые пиразолы и триазолы, как ингибиторы кбв (кинезин-белок веретена)
RS53414B (en) PIRAZINOOKSAZEPINA DERIVATIVES
CU20210023A7 (es) Inhibidores fenil sustituidos de la piridinil 1,2-oxaborolan-2-ol fosfodiesterasa 4
UY32635A (es) Derivados de bis-(sulfonilamino) en terapia 735

Legal Events

Date Code Title Description
FB Suspension of granting procedure