ATE495153T1 - Arylsulfonylpyrrolidine als 5-ht6-inhibitoren - Google Patents
Arylsulfonylpyrrolidine als 5-ht6-inhibitorenInfo
- Publication number
- ATE495153T1 ATE495153T1 AT07847099T AT07847099T ATE495153T1 AT E495153 T1 ATE495153 T1 AT E495153T1 AT 07847099 T AT07847099 T AT 07847099T AT 07847099 T AT07847099 T AT 07847099T AT E495153 T1 ATE495153 T1 AT E495153T1
- Authority
- AT
- Austria
- Prior art keywords
- arylsulfonylpyrrolidines
- inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85810606P | 2006-11-09 | 2006-11-09 | |
| PCT/EP2007/061813 WO2008055847A1 (en) | 2006-11-09 | 2007-11-02 | Arylsulfonyl pyrrolidines as 5-ht6 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE495153T1 true ATE495153T1 (de) | 2011-01-15 |
Family
ID=39023536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07847099T ATE495153T1 (de) | 2006-11-09 | 2007-11-02 | Arylsulfonylpyrrolidine als 5-ht6-inhibitoren |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7776910B2 (de) |
| EP (1) | EP2081890B1 (de) |
| JP (1) | JP2010509266A (de) |
| KR (1) | KR20090079259A (de) |
| CN (1) | CN101573332A (de) |
| AR (1) | AR063576A1 (de) |
| AT (1) | ATE495153T1 (de) |
| AU (1) | AU2007316688A1 (de) |
| BR (1) | BRPI0718584A2 (de) |
| CA (1) | CA2667710A1 (de) |
| CL (1) | CL2007003190A1 (de) |
| DE (1) | DE602007011962D1 (de) |
| ES (1) | ES2358549T3 (de) |
| IL (1) | IL198322A0 (de) |
| MX (1) | MX2009004947A (de) |
| PE (1) | PE20081160A1 (de) |
| TW (1) | TW200827337A (de) |
| WO (1) | WO2008055847A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8987307B2 (en) | 2011-03-03 | 2015-03-24 | Hoffmann-La Roche Inc. | 3-amino-pyridines as GPBAR1 agonists |
| HK1200821A1 (en) | 2012-04-04 | 2015-08-14 | 霍夫曼-拉罗奇有限公司 | 1,2- pyridazine, 1,6- pyridazine or pyrimidine - benzamide derivatives as gpbar1 modulators |
| CN104557726B (zh) * | 2013-10-19 | 2019-05-24 | 广东东阳光药业有限公司 | 芳杂环类衍生物及其在药物上的应用 |
| WO2015090233A1 (en) | 2013-12-20 | 2015-06-25 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic compounds and their application in pharmaceuticals |
| CN105566182B (zh) * | 2016-02-24 | 2018-02-13 | 苏州天马精细化学品股份有限公司 | 一种2‑氨基‑4‑（乙磺酰基）苯酚的合成方法 |
| CN108689904B (zh) * | 2017-04-12 | 2022-06-17 | 轩竹生物科技股份有限公司 | 手性杂环叔醇中间体的制备方法及其应用 |
| CN109232362B (zh) * | 2017-07-10 | 2022-12-27 | 广东东阳光药业有限公司 | 芳杂环类衍生物及其在药物上的应用 |
| EP3703675A4 (de) * | 2017-10-30 | 2021-06-16 | Neuropore Therapies, Inc. | Substituierte phenylsulfonylphenyltriazolthione und verwendungen davon |
| CN109912487B (zh) * | 2019-03-25 | 2023-01-10 | 山东理工大学 | 一种合成1-对甲苯磺酰基-2-乙烯基-1氢-吡咯的方法 |
| EP4045908A1 (de) | 2019-10-18 | 2022-08-24 | The Regents Of The University Of California | Ex-vivo-tumorangiogenesemodell |
| EP4045485A1 (de) | 2019-10-18 | 2022-08-24 | The Regents Of The University Of California | 3-phenylsulfonylchinolinderivate als mittel zum behandeln von pathogenen blutgefässstörungen |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI0930302T1 (en) * | 1998-01-16 | 2003-10-31 | F. Hoffmann-La Roche Ag | Benzosulfone derivatives |
| PE20020063A1 (es) | 2000-06-20 | 2002-01-30 | Upjohn Co | Bis-arilsulfonas como ligandos del receptor de 5-ht |
| US20040014966A1 (en) * | 2000-06-20 | 2004-01-22 | Jacobsen Eric Jon | Bis-arylsulfones |
| PL376479A1 (en) * | 2002-10-18 | 2005-12-27 | F.Hoffmann-La Roche Ag | 4-piperazinyl benzenesulfonyl indoles with 5-ht6 receptor affinity |
| JP2006518368A (ja) * | 2003-02-21 | 2006-08-10 | ファイザー・インク | プロテインキナーゼ阻害剤としてのｎ−ヘテロシクリル置換アミノチアゾール誘導体 |
| WO2005014578A1 (en) | 2003-08-08 | 2005-02-17 | Glaxo Group Limited | Phenylsulfonyl compounds as antipsychotic agents |
| BRPI0614341A2 (pt) * | 2005-08-15 | 2011-03-29 | Wyeth Corp | composto; método para o tratamento de um distúrbio do sistema nervoso central relacionado com o receptor de 5-ht6 ou afetado por ele em um paciente que deste necessite; composição farmacêutica; e processo |
| CA2648891A1 (en) * | 2006-04-19 | 2007-10-25 | Abbott Gmbh & Co. Kg | Heterocyclic arylsulphones suitable for treating disorders that respond to modulation of the serotonin 5ht6 receptor |
-
2007
- 2007-11-02 ES ES07847099T patent/ES2358549T3/es active Active
- 2007-11-02 MX MX2009004947A patent/MX2009004947A/es active IP Right Grant
- 2007-11-02 CA CA002667710A patent/CA2667710A1/en not_active Abandoned
- 2007-11-02 AU AU2007316688A patent/AU2007316688A1/en not_active Abandoned
- 2007-11-02 WO PCT/EP2007/061813 patent/WO2008055847A1/en not_active Ceased
- 2007-11-02 JP JP2009535689A patent/JP2010509266A/ja active Pending
- 2007-11-02 CN CNA2007800418190A patent/CN101573332A/zh active Pending
- 2007-11-02 EP EP07847099A patent/EP2081890B1/de not_active Not-in-force
- 2007-11-02 DE DE602007011962T patent/DE602007011962D1/de active Active
- 2007-11-02 BR BRPI0718584-7A patent/BRPI0718584A2/pt not_active IP Right Cessation
- 2007-11-02 AT AT07847099T patent/ATE495153T1/de active
- 2007-11-02 KR KR1020097011808A patent/KR20090079259A/ko not_active Abandoned
- 2007-11-06 AR ARP070104931A patent/AR063576A1/es unknown
- 2007-11-06 CL CL200703190A patent/CL2007003190A1/es unknown
- 2007-11-07 TW TW096142128A patent/TW200827337A/zh unknown
- 2007-11-08 US US11/983,347 patent/US7776910B2/en not_active Expired - Fee Related
- 2007-11-08 PE PE2007001539A patent/PE20081160A1/es not_active Application Discontinuation
-
2009
- 2009-04-23 IL IL198322A patent/IL198322A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200827337A (en) | 2008-07-01 |
| WO2008055847A1 (en) | 2008-05-15 |
| EP2081890A1 (de) | 2009-07-29 |
| EP2081890B1 (de) | 2011-01-12 |
| US20080167361A1 (en) | 2008-07-10 |
| MX2009004947A (es) | 2009-05-19 |
| PE20081160A1 (es) | 2008-08-15 |
| CL2007003190A1 (es) | 2008-06-27 |
| BRPI0718584A2 (pt) | 2014-03-11 |
| CA2667710A1 (en) | 2008-05-15 |
| DE602007011962D1 (en) | 2011-02-24 |
| US7776910B2 (en) | 2010-08-17 |
| ES2358549T3 (es) | 2011-05-11 |
| AU2007316688A1 (en) | 2008-05-15 |
| AR063576A1 (es) | 2009-02-04 |
| KR20090079259A (ko) | 2009-07-21 |
| CN101573332A (zh) | 2009-11-04 |
| IL198322A0 (en) | 2010-02-17 |
| JP2010509266A (ja) | 2010-03-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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