AR072726A1 - Derivados de indol macrociclicos utiles como inhibidores del virus de la hepatitis c - Google Patents

Derivados de indol macrociclicos utiles como inhibidores del virus de la hepatitis c

Info

Publication number
AR072726A1
AR072726A1 ARP090102596A ARP090102596A AR072726A1 AR 072726 A1 AR072726 A1 AR 072726A1 AR P090102596 A ARP090102596 A AR P090102596A AR P090102596 A ARP090102596 A AR P090102596A AR 072726 A1 AR072726 A1 AR 072726A1
Authority
AR
Argentina
Prior art keywords
hydrogen
independently
macrociclic
indol
hepatitis
Prior art date
Application number
ARP090102596A
Other languages
English (en)
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of AR072726A1 publication Critical patent/AR072726A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D515/18—Bridged systems

Abstract

La presente invencion también se refiere a procesos para preparar dichos compuestos, a composiciones farmacéuticas que los contienen y a su uso en la terapia contra el HCV. Reivindicacion 1: Un compuesto de formula (1): incluyendo las formas estereoquímicamente isoméricas, y los N-oxidos, sales, hidratos y solvatos de dicho compuesto, en donde R1 es una cadena bivalente seleccionada del grupo de formulas 2: cada R3 se selecciona independientemente del grupo que comprende hidrogeno, alquilo C1-4 y cicloalquilo C3-5; a es 3, 4, 5 o 6; cada b es independientemente 1 o 2; c es 1 o 2; el macrociclo A tiene entre 14 y 18 átomos miembro, en particular el macrociclo A tiene 17 o 18 átomos miembro; cada R2 es independientemente hidrogeno, halo o alcoxi C1-4; R4 y R5 son hidrogeno, o R4 y R5 juntos forman un enlace doble o un grupo metileno para formar un ciclopropilo fusionado; R6 es hidrogeno o metilo; y R7 es un cicloalquilo C3-7 opcionalmente sustituido con halo.
ARP090102596A 2008-07-08 2009-07-08 Derivados de indol macrociclicos utiles como inhibidores del virus de la hepatitis c AR072726A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08159965 2008-07-08
EP08160254 2008-07-11
EP08161743 2008-08-04

Publications (1)

Publication Number Publication Date
AR072726A1 true AR072726A1 (es) 2010-09-15

Family

ID=40972916

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090102596A AR072726A1 (es) 2008-07-08 2009-07-08 Derivados de indol macrociclicos utiles como inhibidores del virus de la hepatitis c

Country Status (32)

Country Link
US (2) US8921355B2 (es)
EP (1) EP2310396B1 (es)
JP (2) JP5426671B2 (es)
KR (1) KR101640374B1 (es)
CN (1) CN102089314B (es)
AP (1) AP2743A (es)
AR (1) AR072726A1 (es)
AU (1) AU2009267389B8 (es)
BR (1) BRPI0915887B8 (es)
CA (1) CA2729307C (es)
CL (1) CL2011000032A1 (es)
CO (1) CO6351793A2 (es)
CR (1) CR20110076A (es)
DK (1) DK2310396T3 (es)
EA (1) EA019008B1 (es)
EC (1) ECSP11010750A (es)
ES (1) ES2651038T3 (es)
HK (1) HK1155734A1 (es)
HN (1) HN2011000072A (es)
HR (1) HRP20171892T1 (es)
HU (1) HUE035244T2 (es)
IL (1) IL210086A (es)
LT (1) LT2310396T (es)
MX (1) MX2011000276A (es)
NI (1) NI201100010A (es)
NO (1) NO2310396T3 (es)
NZ (2) NZ590073A (es)
SI (1) SI2310396T1 (es)
SV (1) SV2011003796A (es)
TW (1) TWI454476B (es)
UY (1) UY31973A (es)
WO (1) WO2010003658A1 (es)

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TWI454476B (zh) * 2008-07-08 2014-10-01 Tibotec Pharm Ltd 用作ｃ型肝炎病毒抑制劑之巨環吲哚衍生物
UA108211C2 (uk) * 2009-11-04 2015-04-10 Янссен Рід Айрленд Бензімідазолімідазольні похідні
KR20130057990A (ko) * 2010-04-13 2013-06-03 얀센 파마슈티칼즈, 인코포레이티드 마크로사이클릭 ｈｃｖ 저해제, 비뉴클레오시드 및 뉴클레오시드의 배합물
CN103097356B (zh) * 2010-06-24 2016-01-13 爱尔兰詹森科学公司 13-环己基-3-甲氧基-6-[甲基-(2-{2-[甲基-(氨磺酰基)-氨基]-乙氧基}-乙基)-氨基甲酰基]-7H-吲哚并-[2,1-a]-[2]-苯并氮杂*-10-羧酸的制备
PT2760821T (pt) 2011-09-02 2018-01-11 Novartis Ag Sal de colina de um composto anti-inflamatório de ciclobutenodiona substituída
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CN103097356B (zh) 2010-06-24 2016-01-13 爱尔兰詹森科学公司 13-环己基-3-甲氧基-6-[甲基-(2-{2-[甲基-(氨磺酰基)-氨基]-乙氧基}-乙基)-氨基甲酰基]-7H-吲哚并-[2,1-a]-[2]-苯并氮杂*-10-羧酸的制备
CN104780921A (zh) 2012-08-31 2015-07-15 杨森制药公司 Hcv的大环蛋白酶抑制剂、非核苷hcv抑制剂和利托那韦的组合

Also Published As

Publication number Publication date
NZ590073A (en) 2012-11-30
NZ603343A (en) 2013-08-30
US20140107101A1 (en) 2014-04-17
DK2310396T3 (en) 2017-12-11
NI201100010A (es) 2011-09-07
US8921355B2 (en) 2014-12-30
AU2009267389B8 (en) 2013-07-04
HUE035244T2 (hu) 2018-05-02
AU2009267389A8 (en) 2013-07-04
HN2011000072A (es) 2013-09-01
JP2014028818A (ja) 2014-02-13
KR20110040889A (ko) 2011-04-20
NO2310396T3 (es) 2018-02-03
KR101640374B1 (ko) 2016-07-18
IL210086A (en) 2014-05-28
BRPI0915887A2 (pt) 2015-11-03
CN102089314B (zh) 2014-07-23
BRPI0915887B8 (pt) 2021-05-25
EA019008B1 (ru) 2013-12-30
UY31973A (es) 2010-01-29
SV2011003796A (es) 2011-04-08
WO2010003658A1 (en) 2010-01-14
US20110105473A1 (en) 2011-05-05
ECSP11010750A (es) 2011-08-31
JP5426671B2 (ja) 2014-02-26
CA2729307A1 (en) 2010-01-14
TW201014865A (en) 2010-04-16
CL2011000032A1 (es) 2011-07-15
LT2310396T (lt) 2017-12-27
AU2009267389A1 (en) 2010-01-14
MX2011000276A (es) 2011-03-02
HRP20171892T1 (hr) 2018-01-12
CR20110076A (es) 2011-11-10
JP5808370B2 (ja) 2015-11-10
CA2729307C (en) 2017-08-29
BRPI0915887B1 (pt) 2020-02-18
TWI454476B (zh) 2014-10-01
EP2310396B1 (en) 2017-09-06
EA201170153A1 (ru) 2011-08-30
AP2743A (en) 2013-09-30
ES2651038T3 (es) 2018-01-23
JP2011527299A (ja) 2011-10-27
US9427440B2 (en) 2016-08-30
HK1155734A1 (en) 2012-05-25
AP2010005521A0 (en) 2010-12-31
SI2310396T1 (en) 2018-01-31
CO6351793A2 (es) 2011-12-20
IL210086A0 (en) 2011-02-28
AU2009267389B2 (en) 2013-05-30
CN102089314A (zh) 2011-06-08
EP2310396A1 (en) 2011-04-20

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