NI201100010A - Derivados de indol macrocíclicos útiles como inhibidores del virus de la hepatitis c. - Google Patents

Derivados de indol macrocíclicos útiles como inhibidores del virus de la hepatitis c.

Info

Publication number
NI201100010A
NI201100010A NI2011000101A NI201100010A NI201100010A NI 201100010 A NI201100010 A NI 201100010A NI 2011000101 A NI2011000101 A NI 2011000101A NI 201100010 A NI201100010 A NI 201100010A NI 201100010 A NI201100010 A NI 201100010A
Authority
NI
Nicaragua
Prior art keywords
inhibitors
macrocyclical
hepatitis
virus
hcv
Prior art date
Application number
NI2011000101A
Other languages
English (en)
Inventor
Marie Helene Vendeville Sandrine
Jean-Marie Bernard Raboisson Pierre
Lin Tse-I
Tahri Abdellah
Ingrid Eduard Amssoms Katie
Original Assignee
Janssen R&D Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen R&D Ireland filed Critical Janssen R&D Ireland
Publication of NI201100010A publication Critical patent/NI201100010A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D515/18—Bridged systems

Abstract

Inhibidores de la replicación del HCV de fórmula (I) incluyendo las formas estereoquímicamente isoméricas, y las sales, hidratos, y solvatos de dichos inhibidores, en donde R1, R2, R4, R5, R6 y R7 tienen el significado definido en las reivindicaciones. La presente invención también se refiere a procesos para preparar dichos compuestos, a composiciones farmacéuticas que los contienen y a su uso en la terapia contra el HCV.
NI2011000101A 2008-07-08 2011-01-06 Derivados de indol macrocíclicos útiles como inhibidores del virus de la hepatitis c. NI201100010A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08159965 2008-07-08
EP08160254 2008-07-11
EP08161743 2008-08-04

Publications (1)

Publication Number Publication Date
NI201100010A true NI201100010A (es) 2011-09-07

Family

ID=40972916

Family Applications (1)

Application Number Title Priority Date Filing Date
NI2011000101A NI201100010A (es) 2008-07-08 2011-01-06 Derivados de indol macrocíclicos útiles como inhibidores del virus de la hepatitis c.

Country Status (32)

Country Link
US (2) US8921355B2 (es)
EP (1) EP2310396B1 (es)
JP (2) JP5426671B2 (es)
KR (1) KR101640374B1 (es)
CN (1) CN102089314B (es)
AP (1) AP2743A (es)
AR (1) AR072726A1 (es)
AU (1) AU2009267389B8 (es)
BR (1) BRPI0915887B8 (es)
CA (1) CA2729307C (es)
CL (1) CL2011000032A1 (es)
CO (1) CO6351793A2 (es)
CR (1) CR20110076A (es)
DK (1) DK2310396T3 (es)
EA (1) EA019008B1 (es)
EC (1) ECSP11010750A (es)
ES (1) ES2651038T3 (es)
HK (1) HK1155734A1 (es)
HN (1) HN2011000072A (es)
HR (1) HRP20171892T1 (es)
HU (1) HUE035244T2 (es)
IL (1) IL210086A (es)
LT (1) LT2310396T (es)
MX (1) MX2011000276A (es)
NI (1) NI201100010A (es)
NO (1) NO2310396T3 (es)
NZ (2) NZ590073A (es)
SI (1) SI2310396T1 (es)
SV (1) SV2011003796A (es)
TW (1) TWI454476B (es)
UY (1) UY31973A (es)
WO (1) WO2010003658A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2710644C (en) 2007-12-24 2016-03-29 Tibotec Pharmaceuticals Macrocyclic indoles as hepatitis c virus inhibitors
TWI454476B (zh) * 2008-07-08 2014-10-01 Tibotec Pharm Ltd 用作ｃ型肝炎病毒抑制劑之巨環吲哚衍生物
UA108211C2 (uk) * 2009-11-04 2015-04-10 Янссен Рід Айрленд Бензімідазолімідазольні похідні
KR20130057990A (ko) * 2010-04-13 2013-06-03 얀센 파마슈티칼즈, 인코포레이티드 마크로사이클릭 ｈｃｖ 저해제, 비뉴클레오시드 및 뉴클레오시드의 배합물
AU2011268922B2 (en) * 2010-06-24 2014-06-12 Janssen Sciences Ireland Uc Preparation of 13-cyclohexyl-3-methoxy-6-[methyl-(2-{2-[methyl-(sulphamoyl)-amino]-ethoxy}-ethyl)-carbamoyl]-7H-indolo-[2,1-a]-[2]-benzazepine-10-carboxylic acid
BR112014004963A2 (pt) 2011-09-02 2017-03-21 Novartis Ag sal de colina do composto anti-inflamatório ciclobutanodiona substituído
US8716275B2 (en) * 2011-10-20 2014-05-06 Bristol-Myers Squibb Company Compound for the treatment of hepatitis C
KR20150046083A (ko) 2012-08-31 2015-04-29 얀센 파마슈티칼즈, 인코포레이티드 Ｈｃｖ의 거대환형 프로테아제 저해제, 비­뉴클레오시드계 ｈｃｖ 저해제 및 리토나비르의 조합물
WO2014152275A1 (en) * 2013-03-14 2014-09-25 Concert Pharmaceuticals, Inc. Deuterium modified derivatives of the ns5b polymerase inhibitor tmc647055
US10450263B2 (en) 2017-02-10 2019-10-22 Southern Research Institute Benzo annulenes as antiviral agents
KR101974388B1 (ko) 2017-06-23 2019-05-02 (주)에니켐텍 알킬 디에틸렌 트리아민 유도체 및 이의 제조방법
WO2019133574A2 (en) * 2017-12-26 2019-07-04 Southern Research Institute Benzoannulene derivatives as antiviral agents

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
US6054472A (en) * 1996-04-23 2000-04-25 Vertex Pharmaceuticals, Incorporated Inhibitors of IMPDH enzyme
US5807876A (en) * 1996-04-23 1998-09-15 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
US20050267836A1 (en) 1996-03-25 2005-12-01 Cfph, Llc Method and system for transacting with a trading application
CN1116288C (zh) 1996-04-23 2003-07-30 沃泰克斯药物股份有限公司 用作肌苷－5'－一磷酸脱氢酶抑制剂的脲衍生物
DE69816280T2 (de) 1997-03-14 2004-05-27 Vertex Pharmaceuticals Inc., Cambridge Inhibitoren des impdh-enzyms
IL145475A0 (en) * 1999-03-19 2002-06-30 Vertex Pharma Compounds that inhibit impdh enzyme and pharmaceutical compositions containing the same
KR100891240B1 (ko) 2000-08-30 2009-04-01 파나소닉 주식회사 플라즈마 디스플레이 표시장치 및 그 제조방법
AR048401A1 (es) 2004-01-30 2006-04-26 Medivir Ab Inhibidores de la serina-proteasa ns3 del vhc
US7153848B2 (en) * 2004-08-09 2006-12-26 Bristol-Myers Squibb Company Inhibitors of HCV replication
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
EP1937272A2 (en) 2005-09-02 2008-07-02 Tibotec Pharmaceuticals Ltd. Benzodiazepines as hcv inhibitors
US7399758B2 (en) * 2005-09-12 2008-07-15 Meanwell Nicholas A Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
GB0522881D0 (en) 2005-11-10 2005-12-21 Angeletti P Ist Richerche Bio Therapeutic compounds
WO2007092000A1 (en) 2006-02-06 2007-08-16 Bristol-Myers Squibb Company Inhibitors of hcv replication
US7521443B2 (en) 2006-05-17 2009-04-21 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
US7456166B2 (en) * 2006-05-17 2008-11-25 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
US7521441B2 (en) * 2006-05-22 2009-04-21 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
WO2007140200A2 (en) * 2006-05-25 2007-12-06 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors
WO2008043704A1 (en) 2006-10-10 2008-04-17 Medivir Ab Hcv nucleoside inhibitor
AU2007335962B2 (en) 2006-12-20 2012-09-06 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Antiviral indoles
EP2178885A1 (en) * 2007-07-17 2010-04-28 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Macrocyclic indole derivatives for the treatment of hepatitis c infections
TWI454476B (zh) * 2008-07-08 2014-10-01 Tibotec Pharm Ltd 用作ｃ型肝炎病毒抑制劑之巨環吲哚衍生物
TW201023858A (en) 2008-09-18 2010-07-01 Ortho Mcneil Janssen Pharm Synergistic combinations of a macrocyclic inhibitor of HCV and a nucleoside
SG2014008981A (en) 2009-02-27 2014-04-28 Ortho Mcneil Janssen Pharm Amorphous salt of a macrocyclic inhibitor of hcv
KR20130057990A (ko) 2010-04-13 2013-06-03 얀센 파마슈티칼즈, 인코포레이티드 마크로사이클릭 ｈｃｖ 저해제, 비뉴클레오시드 및 뉴클레오시드의 배합물
AU2011268922B2 (en) 2010-06-24 2014-06-12 Janssen Sciences Ireland Uc Preparation of 13-cyclohexyl-3-methoxy-6-[methyl-(2-{2-[methyl-(sulphamoyl)-amino]-ethoxy}-ethyl)-carbamoyl]-7H-indolo-[2,1-a]-[2]-benzazepine-10-carboxylic acid
KR20150046083A (ko) 2012-08-31 2015-04-29 얀센 파마슈티칼즈, 인코포레이티드 Ｈｃｖ의 거대환형 프로테아제 저해제, 비­뉴클레오시드계 ｈｃｖ 저해제 및 리토나비르의 조합물

Also Published As

Publication number Publication date
HRP20171892T1 (hr) 2018-01-12
CL2011000032A1 (es) 2011-07-15
TW201014865A (en) 2010-04-16
UY31973A (es) 2010-01-29
TWI454476B (zh) 2014-10-01
SI2310396T1 (en) 2018-01-31
DK2310396T3 (en) 2017-12-11
CA2729307C (en) 2017-08-29
MX2011000276A (es) 2011-03-02
JP2014028818A (ja) 2014-02-13
EP2310396A1 (en) 2011-04-20
AU2009267389A1 (en) 2010-01-14
AU2009267389A8 (en) 2013-07-04
JP5426671B2 (ja) 2014-02-26
NZ603343A (en) 2013-08-30
NZ590073A (en) 2012-11-30
BRPI0915887B1 (pt) 2020-02-18
LT2310396T (lt) 2017-12-27
KR20110040889A (ko) 2011-04-20
SV2011003796A (es) 2011-04-08
CR20110076A (es) 2011-11-10
EA201170153A1 (ru) 2011-08-30
CA2729307A1 (en) 2010-01-14
IL210086A (en) 2014-05-28
US9427440B2 (en) 2016-08-30
CN102089314B (zh) 2014-07-23
US20140107101A1 (en) 2014-04-17
AP2010005521A0 (en) 2010-12-31
US20110105473A1 (en) 2011-05-05
AP2743A (en) 2013-09-30
HK1155734A1 (en) 2012-05-25
WO2010003658A1 (en) 2010-01-14
AR072726A1 (es) 2010-09-15
KR101640374B1 (ko) 2016-07-18
ECSP11010750A (es) 2011-08-31
JP5808370B2 (ja) 2015-11-10
HUE035244T2 (hu) 2018-05-02
EP2310396B1 (en) 2017-09-06
NO2310396T3 (es) 2018-02-03
BRPI0915887A2 (pt) 2015-11-03
CN102089314A (zh) 2011-06-08
AU2009267389B8 (en) 2013-07-04
BRPI0915887B8 (pt) 2021-05-25
CO6351793A2 (es) 2011-12-20
EA019008B1 (ru) 2013-12-30
US8921355B2 (en) 2014-12-30
IL210086A0 (en) 2011-02-28
HN2011000072A (es) 2013-09-01
ES2651038T3 (es) 2018-01-23
JP2011527299A (ja) 2011-10-27
AU2009267389B2 (en) 2013-05-30

Similar Documents

Publication Publication Date Title
NI201100010A (es) Derivados de indol macrocíclicos útiles como inhibidores del virus de la hepatitis c.
NI201500029A (es) Sulfamoilarilamidas y su uso como medicamentos para el tratamiento de la hepatitis b.
CR20160237A (es) Derivados de la carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b
NI201600115A (es) Derivados de sulfamoilpirrolamida y su uso como medicamentos para el tratamiento de la hepatitis b.
NI201600018A (es) Derivados de pirrolamida sustituidos con glioxamida y su uso como medicamentos para el tratamiento de la hepatitis b.
CO2017012268A2 (es) Derivados de sulfamoilarilamida ciclados y su uso como medicamentos para el tratamiento de la hepatitis b
UY32759A (es) Inhibidores del virus de la hepatitis c
UY35573A (es) Derivados de sulfamoilpirrolamida y su uso como m edicamentos para el tratamiento de la hepatitis b
UY32793A (es) Compuestos inhibidores de los virus flaviviridae, composición farmacéutica que los contiene y sus usos
CR20170118A (es) Derivados espirodiamina como inhibidores de la aldosterona sintasa
CO6561788A2 (es) Inhibidores del virus de la hepatitis c
ECSP15002066A (es) Inhibidores de virus de hepatitis c
CO6761335A2 (es) Inhibidores del virus de la hepatitis c
GT201400009A (es) 4-imidazopiridazin-1-il-benzamidas y 4-imidazotriazin-1-il-benzamidas como inhibidores de btk
CO6561783A2 (es) Inhibidores del virus flaviviridae
ECSP109903A (es) Derivados de pirazinona y su uso en el tratamiento de enfermedades pulmonares
UY32119A (es) Formas cristalinas de un potente inhibidor de hcv
CR20120302A (es) Derivados bencimidazol-imidazol
ECSP14013245A (es) Nuevos derivados dihidroquinolina-2-ona
AR065498A1 (es) Co- critales de vx-950 (un inhibidor del virus de la hepatitis c) y composiciones farmaceuticas que los comprenden
UY34066A (es) Inhibidores del virus de la hepatitis c
UY30922A1 (es) 1,1-dioxo-1-tia-5,10-diazadibenzocicloheptenos utiles como inhibidores del virus de la hepatitis c"
CR20150059A (es) Sulfamoilarilamidas y su uso como medicamentos para el tratamiento de la hepatitis b
CR20150584A (es) Derivados de sulfamoilpirrolamiday su uso como medicamentos para el tratamiento de la hepatitis b
MY158567A (en) Macrocyclic indole derivatives useful as hepatitis c virus inhibitors