AR067838A1 - Compuestos pirrolicos, composiciones farmaceuticas que los contienen y usos - Google Patents

Compuestos pirrolicos, composiciones farmaceuticas que los contienen y usos

Info

Publication number
AR067838A1
AR067838A1 ARP080100808A ARP080100808A AR067838A1 AR 067838 A1 AR067838 A1 AR 067838A1 AR P080100808 A ARP080100808 A AR P080100808A AR P080100808 A ARP080100808 A AR P080100808A AR 067838 A1 AR067838 A1 AR 067838A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
methylmethanamine
pyrrol
group
ylsulfonyl
Prior art date
Application number
ARP080100808A
Other languages
English (en)
Inventor
Masahiro Kajino
Haruyuki Nishida
Koji Ono
Keizo Hirase
Yasuyoshi Arikawa
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of AR067838A1 publication Critical patent/AR067838A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Composiciones farmacéuticas y usos de las mismas como antiulcerosos. Reivindicacion 1: Un compuesto caracterizado por la formula (1) donde R1 es un grupo cíclico opcionalmente sustituido, R2 es un sustituyente, R3 es un grupo alquilo opcionalmente sustituido, un grupo acilo, hidroxi opcionalmente sustituido, amino opcionalmente sustituido, un átomo de halogeno, un grupo ciano o nitro, R4 y R5 son iguales o diferentes y cada uno es un átomo de H, un grupo alquilo opcionalmente sustituido, un grupo acilo, hidroxi opcionalmente sustituido, amino opcionalmente sustituido, un átomo de halogeno, un grupo ciano o nitro, R6 y R6' son iguales o diferentes y cada uno es un átomo de H o un grupo alquilo, y n es un numero entero de 0 a 3, con la salvedad que se excluyen 1-[5-(2-fluoropiridin-3-il)-1-(piridin-3-ilsulfonil)-1H-pirrol-3-il]-N-metilmetanamina, 1-[5-(2-cloropiridin-3-il)-1-(piridin-3-ilsulfonil)-1H-pirrol-3-il]-N-metilmetanamina, 1-[5-(2-fluoropiridin-3-il)-1-[(6-metoxipiridin-3-il]sulfonil]-1H-pirrol-3-il]-N-metilmetanamina, N-metil-1-[5-(2-metilpiridin-3-il)-1-(piridin-3-ilsulfonil)-1H-pirrol-3-il]metanamina, 1-{5-(2-fluoropiridin-3-il)-1-[(6-metilpiridin-3-il]sulfonil]-1H-pirrol-3-il}-N-metilmetanamina, y 1-[4-cloro-5-(2-fluoropiridin-3-il)-1-(piridin-3-ilsulfonil)-1H-pirrol-3-il]-N-metilmetanamina, o una sal del mismo.
ARP080100808A 2007-02-28 2008-02-27 Compuestos pirrolicos, composiciones farmaceuticas que los contienen y usos AR067838A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007050326 2007-02-28
JP2007256273 2007-09-28

Publications (1)

Publication Number Publication Date
AR067838A1 true AR067838A1 (es) 2009-10-28

Family

ID=39512511

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080100808A AR067838A1 (es) 2007-02-28 2008-02-27 Compuestos pirrolicos, composiciones farmaceuticas que los contienen y usos

Country Status (9)

Country Link
US (1) US8933105B2 (es)
EP (2) EP2364979A1 (es)
JP (1) JP5432718B2 (es)
AR (1) AR067838A1 (es)
CA (1) CA2679305A1 (es)
CL (1) CL2008000592A1 (es)
PE (1) PE20090109A1 (es)
TW (1) TW200900064A (es)
WO (1) WO2008108380A2 (es)

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NZ591793A (en) * 2008-08-27 2012-11-30 Takeda Pharmaceutical Substituted 1-(4-fluoro-5-(2-fluoropyridin-3-yl)-1-((pyrindin-2-yl)sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine compounds
EP3241826B1 (en) 2009-02-25 2019-10-30 Takeda Pharmaceutical Company Limited Process for producing pyrrole compound
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WO2013119800A1 (en) 2012-02-07 2013-08-15 Massachusetts Institute Of Technology Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness
KR102206928B1 (ko) 2012-06-27 2021-01-22 다케다 야쿠힌 고교 가부시키가이샤 염에 의해 안정화된 아민과 유기산의 액상 제제
EP2921479B1 (en) * 2012-11-19 2017-02-01 Jiangsu Hansoh Pharmaceutical Co., Ltd. Pyrrole sulfonamide derivative, preparation method for same, and medical application thereof
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WO2014144231A1 (en) 2013-03-15 2014-09-18 Massachusetts Institute Of Technology Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness
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CN104860923B (zh) * 2015-01-21 2018-01-12 山东康美乐医药科技有限公司 富马酸沃诺拉赞的制备方法
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US10317418B2 (en) 2015-02-24 2019-06-11 Massachusetts Institute Of Technology Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness
KR101613245B1 (ko) * 2015-04-27 2016-04-18 주식회사 대웅제약 신규의 4-메톡시 피롤 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
CN105503828A (zh) * 2015-12-24 2016-04-20 北京康立生医药技术开发有限公司 一种吡咯衍生物的富马酸盐的制备方法
KR20170113040A (ko) * 2016-03-25 2017-10-12 주식회사 대웅제약 1-(5-(2,4-다이플루오로페닐)-1-((3-플루오로페닐)술포닐)-4-메톡시-1h-피롤-3-일)-n-메틸메탄아민의 신규한 산부가염
KR102081920B1 (ko) * 2016-03-25 2020-02-26 주식회사 대웅제약 1-(5-(2,4-다이플루오로페닐)-1-((3-플루오로페닐)술포닐)-4-메톡시-1h-피롤-3-일)-n-메틸메탄아민 염의 신규한 결정형
KR102126576B1 (ko) * 2018-09-19 2020-06-24 주식회사 대웅제약 4-메톡시 피롤 유도체의 제조 방법
CN112830920A (zh) * 2019-11-25 2021-05-25 杭州华东医药集团新药研究院有限公司 一种杂环衍生物、其药物组合物及用途
WO2021256861A1 (ko) * 2020-06-17 2021-12-23 일동제약(주) 신규한 산 분비 억제제 및 이의 용도
CN111943932B (zh) * 2020-08-06 2023-07-14 四川国康药业有限公司 一种可以治疗消化性溃疡的3-吡啶磺酰-1-n-杂吡咯衍生物及其制备方法和用途
CN113620930B (zh) * 2021-07-12 2022-08-16 南京烁慧医药科技有限公司 一种含磺酰胺结构的化合物及其制备方法和应用、一种药物组合物及应用
KR102556500B1 (ko) * 2021-11-19 2023-07-19 하나제약 주식회사 피롤 유도체 또는 이의 약학적 또는 식품학적으로 허용 가능한 염, 및 이를 유효성분으로 포함하는 위장 질환의 예방, 개선 또는 치료용 조성물

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Also Published As

Publication number Publication date
JP5432718B2 (ja) 2014-03-05
CL2008000592A1 (es) 2008-09-12
PE20090109A1 (es) 2009-03-28
US8933105B2 (en) 2015-01-13
CA2679305A1 (en) 2008-09-12
WO2008108380A2 (en) 2008-09-12
EP2114917A2 (en) 2009-11-11
EP2364979A1 (en) 2011-09-14
TW200900064A (en) 2009-01-01
US20080262042A1 (en) 2008-10-23
EP2114917B1 (en) 2016-08-10
WO2008108380A3 (en) 2009-04-16
JP2010520153A (ja) 2010-06-10

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