AR067838A1 - Compuestos pirrolicos, composiciones farmaceuticas que los contienen y usos - Google Patents
Compuestos pirrolicos, composiciones farmaceuticas que los contienen y usosInfo
- Publication number
- AR067838A1 AR067838A1 ARP080100808A ARP080100808A AR067838A1 AR 067838 A1 AR067838 A1 AR 067838A1 AR P080100808 A ARP080100808 A AR P080100808A AR P080100808 A ARP080100808 A AR P080100808A AR 067838 A1 AR067838 A1 AR 067838A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- methylmethanamine
- pyrrol
- group
- ylsulfonyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Composiciones farmacéuticas y usos de las mismas como antiulcerosos. Reivindicacion 1: Un compuesto caracterizado por la formula (1) donde R1 es un grupo cíclico opcionalmente sustituido, R2 es un sustituyente, R3 es un grupo alquilo opcionalmente sustituido, un grupo acilo, hidroxi opcionalmente sustituido, amino opcionalmente sustituido, un átomo de halogeno, un grupo ciano o nitro, R4 y R5 son iguales o diferentes y cada uno es un átomo de H, un grupo alquilo opcionalmente sustituido, un grupo acilo, hidroxi opcionalmente sustituido, amino opcionalmente sustituido, un átomo de halogeno, un grupo ciano o nitro, R6 y R6' son iguales o diferentes y cada uno es un átomo de H o un grupo alquilo, y n es un numero entero de 0 a 3, con la salvedad que se excluyen 1-[5-(2-fluoropiridin-3-il)-1-(piridin-3-ilsulfonil)-1H-pirrol-3-il]-N-metilmetanamina, 1-[5-(2-cloropiridin-3-il)-1-(piridin-3-ilsulfonil)-1H-pirrol-3-il]-N-metilmetanamina, 1-[5-(2-fluoropiridin-3-il)-1-[(6-metoxipiridin-3-il]sulfonil]-1H-pirrol-3-il]-N-metilmetanamina, N-metil-1-[5-(2-metilpiridin-3-il)-1-(piridin-3-ilsulfonil)-1H-pirrol-3-il]metanamina, 1-{5-(2-fluoropiridin-3-il)-1-[(6-metilpiridin-3-il]sulfonil]-1H-pirrol-3-il}-N-metilmetanamina, y 1-[4-cloro-5-(2-fluoropiridin-3-il)-1-(piridin-3-ilsulfonil)-1H-pirrol-3-il]-N-metilmetanamina, o una sal del mismo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007050326 | 2007-02-28 | ||
JP2007256273 | 2007-09-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR067838A1 true AR067838A1 (es) | 2009-10-28 |
Family
ID=39512511
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080100808A AR067838A1 (es) | 2007-02-28 | 2008-02-27 | Compuestos pirrolicos, composiciones farmaceuticas que los contienen y usos |
Country Status (9)
Country | Link |
---|---|
US (1) | US8933105B2 (es) |
EP (2) | EP2364979A1 (es) |
JP (1) | JP5432718B2 (es) |
AR (1) | AR067838A1 (es) |
CA (1) | CA2679305A1 (es) |
CL (1) | CL2008000592A1 (es) |
PE (1) | PE20090109A1 (es) |
TW (1) | TW200900064A (es) |
WO (1) | WO2008108380A2 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20110591A1 (es) | 2008-07-28 | 2011-09-15 | Takeda Pharmaceutical | Composicion farmaceutica estabilizada a base de un compuesto no peptidico |
NZ591793A (en) * | 2008-08-27 | 2012-11-30 | Takeda Pharmaceutical | Substituted 1-(4-fluoro-5-(2-fluoropyridin-3-yl)-1-((pyrindin-2-yl)sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine compounds |
EP3241826B1 (en) | 2009-02-25 | 2019-10-30 | Takeda Pharmaceutical Company Limited | Process for producing pyrrole compound |
CN102448953B (zh) * | 2009-03-26 | 2014-05-07 | 武田药品工业株式会社 | 吡唑化合物 |
JP5802898B2 (ja) | 2009-07-09 | 2015-11-04 | ラクオリア創薬株式会社 | 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤 |
WO2013119800A1 (en) | 2012-02-07 | 2013-08-15 | Massachusetts Institute Of Technology | Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness |
KR102206928B1 (ko) | 2012-06-27 | 2021-01-22 | 다케다 야쿠힌 고교 가부시키가이샤 | 염에 의해 안정화된 아민과 유기산의 액상 제제 |
EP2921479B1 (en) * | 2012-11-19 | 2017-02-01 | Jiangsu Hansoh Pharmaceutical Co., Ltd. | Pyrrole sulfonamide derivative, preparation method for same, and medical application thereof |
CN105143187B (zh) | 2013-02-28 | 2018-04-03 | 武田药品工业株式会社 | 制备磺酰氯化合物的方法 |
WO2014144231A1 (en) | 2013-03-15 | 2014-09-18 | Massachusetts Institute Of Technology | Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness |
CA2909938A1 (en) | 2013-04-22 | 2014-10-30 | Abbvie Inc. | Thiazoles and uses thereof |
CN104860923B (zh) * | 2015-01-21 | 2018-01-12 | 山东康美乐医药科技有限公司 | 富马酸沃诺拉赞的制备方法 |
CN105985278A (zh) * | 2015-01-27 | 2016-10-05 | 江苏柯菲平医药股份有限公司 | 吡咯磺酰类衍生物、其制备方法及其在医药上的应用 |
US10317418B2 (en) | 2015-02-24 | 2019-06-11 | Massachusetts Institute Of Technology | Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness |
KR101613245B1 (ko) * | 2015-04-27 | 2016-04-18 | 주식회사 대웅제약 | 신규의 4-메톡시 피롤 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
CN105503828A (zh) * | 2015-12-24 | 2016-04-20 | 北京康立生医药技术开发有限公司 | 一种吡咯衍生物的富马酸盐的制备方法 |
KR20170113040A (ko) * | 2016-03-25 | 2017-10-12 | 주식회사 대웅제약 | 1-(5-(2,4-다이플루오로페닐)-1-((3-플루오로페닐)술포닐)-4-메톡시-1h-피롤-3-일)-n-메틸메탄아민의 신규한 산부가염 |
KR102081920B1 (ko) * | 2016-03-25 | 2020-02-26 | 주식회사 대웅제약 | 1-(5-(2,4-다이플루오로페닐)-1-((3-플루오로페닐)술포닐)-4-메톡시-1h-피롤-3-일)-n-메틸메탄아민 염의 신규한 결정형 |
KR102126576B1 (ko) * | 2018-09-19 | 2020-06-24 | 주식회사 대웅제약 | 4-메톡시 피롤 유도체의 제조 방법 |
CN112830920A (zh) * | 2019-11-25 | 2021-05-25 | 杭州华东医药集团新药研究院有限公司 | 一种杂环衍生物、其药物组合物及用途 |
WO2021256861A1 (ko) * | 2020-06-17 | 2021-12-23 | 일동제약(주) | 신규한 산 분비 억제제 및 이의 용도 |
CN111943932B (zh) * | 2020-08-06 | 2023-07-14 | 四川国康药业有限公司 | 一种可以治疗消化性溃疡的3-吡啶磺酰-1-n-杂吡咯衍生物及其制备方法和用途 |
CN113620930B (zh) * | 2021-07-12 | 2022-08-16 | 南京烁慧医药科技有限公司 | 一种含磺酰胺结构的化合物及其制备方法和应用、一种药物组合物及应用 |
KR102556500B1 (ko) * | 2021-11-19 | 2023-07-19 | 하나제약 주식회사 | 피롤 유도체 또는 이의 약학적 또는 식품학적으로 허용 가능한 염, 및 이를 유효성분으로 포함하는 위장 질환의 예방, 개선 또는 치료용 조성물 |
Family Cites Families (39)
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ATE66477T1 (de) | 1986-08-29 | 1991-09-15 | Pfizer | 2-guanidino-4-aryl-thiazole fuer die behandlung von peptischen geschwueren. |
JPH01211581A (ja) * | 1988-02-18 | 1989-08-24 | Meiji Seika Kaisha Ltd | シクロペンテノピリジン誘導体および抗潰瘍剤 |
US5128366A (en) | 1990-07-05 | 1992-07-07 | Shinogi & Co., Ltd. | Pyrrole derivatives |
AU8653891A (en) | 1990-08-31 | 1992-03-30 | Warner-Lambert Company | Amino acid analogs as cck antagonists |
CZ290470B6 (cs) | 1991-10-18 | 2002-07-17 | Monsanto Technology Llc | 5 či 6 členné aromáty jako fungicidy pro kontrolu stéblolamu rostlin, způsob kontroly a fungicidní směs k provedení tohoto způsobu |
CN1071924A (zh) | 1991-10-29 | 1993-05-12 | 纳幕尔杜邦公司 | 除草的三唑羧酸酰胺 |
JPH06135961A (ja) | 1992-10-23 | 1994-05-17 | Nippon Iyakuhin Kogyo Kk | 新規ジフェニルピロリルフラン誘導体 |
US5286742A (en) | 1992-11-03 | 1994-02-15 | American Cyanamid Company | Pyrrole thiocarboxamide insecticidal and acaricidal agents |
US5480902A (en) | 1993-08-31 | 1996-01-02 | American Cyanamid Company | Thienylpyrrole fungicidal agents |
JPH08119936A (ja) | 1994-10-18 | 1996-05-14 | Fujisawa Pharmaceut Co Ltd | 複素環式誘導体 |
JPH0930967A (ja) | 1995-07-17 | 1997-02-04 | Chugai Pharmaceut Co Ltd | 抗潰瘍剤 |
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CN1246847A (zh) | 1996-12-23 | 2000-03-08 | 杜邦药品公司 | 作为Xa因子抑制剂的含氮杂芳族化合物 |
JPH11209344A (ja) | 1998-01-26 | 1999-08-03 | Kyowa Hakko Kogyo Co Ltd | 含窒素複素環化合物 |
GB9817548D0 (en) | 1998-08-12 | 1998-10-07 | Novartis Ag | Organic compounds |
WO2000053573A1 (fr) | 1999-03-10 | 2000-09-14 | Shionogi & Co., Ltd. | Compositions medicinales renfermant des composes a squelette [2.2.1] et [3.1.1] bicycliques possedant des proprietes antagonistes vis-a-vis des recepteurs de pgd2/txa¿2? |
TW575561B (en) | 1999-03-25 | 2004-02-11 | Hoffmann La Roche | 1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives |
AU3783100A (en) | 1999-06-14 | 2000-12-21 | Dow Agrosciences Llc | Substituted triazoles, imidazoles and pyrazoles as herbicides |
CA2383257C (en) | 1999-08-26 | 2010-09-28 | Christopher J. Burns | Substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benozopyrans |
CA2410338A1 (en) | 2000-05-22 | 2001-11-29 | Takeda Chemical Industries, Ltd. | Tyrosine phosphatase inhibitors |
US6589978B2 (en) | 2000-06-30 | 2003-07-08 | Hoffman-La Roche Inc. | 1-sulfonyl pyrrolidine derivatives |
GB0016453D0 (en) | 2000-07-04 | 2000-08-23 | Hoffmann La Roche | Pyrrole derivatives |
JP2005523237A (ja) | 2001-10-01 | 2005-08-04 | 大正製薬株式会社 | Mch受容体アンタゴニスト |
WO2003040147A1 (en) | 2001-11-08 | 2003-05-15 | Pharmacia & Upjohn Company | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease__________________________________________________________________________________________________________________________ |
CA2464314A1 (en) | 2001-11-22 | 2003-05-30 | Ciba Specialty Chemicals Holding Inc. | Pyrrole synthesis |
AU2002367424A1 (en) | 2001-12-28 | 2003-07-24 | Takeda Chemical Industries, Ltd. | Androgen receptor antagonists |
AU2003216274A1 (en) | 2002-02-11 | 2003-09-04 | Neurocrine Biosciences, Inc. | Pyrrole derivatives as ligands of melanocortin receptors |
WO2003068740A1 (en) | 2002-02-14 | 2003-08-21 | Wyeth | Pyrrolylalkylidene-hydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands |
TW200306191A (en) | 2002-02-22 | 2003-11-16 | Teijin Ltd | Pyrrolopyrimidine derivatives |
KR20050009747A (ko) | 2002-06-13 | 2005-01-25 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 피라졸카르복사미드 살충제 |
EP1545515A1 (en) | 2002-08-12 | 2005-06-29 | Sugen, Inc. | 3-pyrrolyl-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors |
JP2004315511A (ja) | 2003-03-31 | 2004-11-11 | Taisho Pharmaceut Co Ltd | Mch受容体アンタゴニスト |
ES2351393T3 (es) | 2003-05-26 | 2011-02-03 | Takeda Pharmaceutical Company Limited | Sulfopirroles. |
ES2402362T3 (es) | 2004-09-30 | 2013-05-03 | Takeda Pharmaceutical Company Limited | Inhibidores de la bomba de protones |
EP1655284A1 (en) | 2004-10-26 | 2006-05-10 | Aponetics AG | 2-Phenylsulfopyrroles |
CA2621182C (en) | 2005-08-30 | 2014-03-18 | Takeda Pharmaceutical Company Limited | 1-heterocyclylsulfonyl, 2-aminomethyl, 5-(hetero-)aryl substituted 1-h-pyrrole derivatives as acid secretion inhibitors |
CN100418090C (zh) | 2005-08-31 | 2008-09-10 | 国际商业机器公司 | 一种存储数据的方法 |
JP4851960B2 (ja) | 2006-02-24 | 2012-01-11 | 株式会社日立ハイテクノロジーズ | 異物検査方法、および異物検査装置 |
US7994205B2 (en) | 2006-03-31 | 2011-08-09 | Takeda Pharmaceutical Company Limited | Aryl-or heteroaryl-sulfonyl compounds as acid secretion inhibitors |
-
2008
- 2008-02-26 US US12/072,421 patent/US8933105B2/en active Active
- 2008-02-27 EP EP11163334A patent/EP2364979A1/en not_active Withdrawn
- 2008-02-27 TW TW097106740A patent/TW200900064A/zh unknown
- 2008-02-27 EP EP08721310.4A patent/EP2114917B1/en active Active
- 2008-02-27 PE PE2008000391A patent/PE20090109A1/es not_active Application Discontinuation
- 2008-02-27 CL CL200800592A patent/CL2008000592A1/es unknown
- 2008-02-27 WO PCT/JP2008/053890 patent/WO2008108380A2/en active Application Filing
- 2008-02-27 JP JP2009536495A patent/JP5432718B2/ja active Active
- 2008-02-27 AR ARP080100808A patent/AR067838A1/es unknown
- 2008-02-27 CA CA002679305A patent/CA2679305A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP5432718B2 (ja) | 2014-03-05 |
CL2008000592A1 (es) | 2008-09-12 |
PE20090109A1 (es) | 2009-03-28 |
US8933105B2 (en) | 2015-01-13 |
CA2679305A1 (en) | 2008-09-12 |
WO2008108380A2 (en) | 2008-09-12 |
EP2114917A2 (en) | 2009-11-11 |
EP2364979A1 (en) | 2011-09-14 |
TW200900064A (en) | 2009-01-01 |
US20080262042A1 (en) | 2008-10-23 |
EP2114917B1 (en) | 2016-08-10 |
WO2008108380A3 (en) | 2009-04-16 |
JP2010520153A (ja) | 2010-06-10 |
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